Gene: Npc1l1 (NPC1 like intracellular cholesterol transporter 1) Rattus norvegicus
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Symbol: Npc1l1
Name: NPC1 like intracellular cholesterol transporter 1
Description: ENCODES a protein that exhibits drug binding; myosin V binding (ortholog); Rab GTPase binding (ortholog); INVOLVED IN response to drug; cellular response to sterol depletion (ortholog); cholesterol biosynthetic process (ortholog); ASSOCIATED WITH Diabetes Mellitus, Experimental ; arteriosclerosis (ortholog); Hypercholesterolemia (ortholog); FOUND IN brush border membrane; spanning component of plasma membrane (ortholog); INTERACTS WITH endosulfan; furan; N-methyl-4-phenylpyridinium
AGR Description: Exhibits drug binding activity; involved in response to drug; localizes to the brush border membrane; orthologous to human NPC1L1 (NPC1 like intracellular cholesterol transporter 1).
Merged Description: Exhibits drug binding activity; involved in response to drug; localizes to the brush border membrane; orthologous to human NPC1L1 (NPC1 like intracellular cholesterol transporter 1); INTERACTS WITH endosulfan; furan; N-methyl-4-phenylpyridinium.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: niemann-Pick C1-like protein 1; Niemann-Pick disease, type C1-like 1; NPC1 (Niemann-Pick disease, type C1, gene)-like 1; NPC1-like 1; NPC1-like intracellular cholesterol transporter 1; SLC66A2; solute carrier family 66 member 2
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01486,345,946 - 86,560,694 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01487,307,372 - 87,319,081 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01487,516,291 - 87,523,225 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1479,954,434 - 79,974,086 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Npc1l1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1303135
Created: 2004-12-03
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.