Sod3 (superoxide dismutase 3) - Rat Genome Database

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Gene: Sod3 (superoxide dismutase 3) Rattus norvegicus
Symbol: Sod3
Name: superoxide dismutase 3
RGD ID: 3733
Description: Enables superoxide dismutase activity. Involved in blood vessel diameter maintenance; response to copper ion; and response to oxidative stress. Located in collagen-containing extracellular matrix and extracellular space. Used to study hypertension. Human ortholog(s) of this gene implicated in several diseases, including coronary artery disease (multiple); diabetes mellitus (multiple); diabetic retinopathy; lung disease (multiple); and polyneuropathy. Orthologous to human SOD3 (superoxide dismutase 3); PARTICIPATES IN cardiovascular system disease pathway; diabetes mellitus pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
Previously known as: EC-SOD; ECSODPT; extracellular superoxide dismutase; extracellular superoxide dismutase [Cu-Zn]; Superoxide dimutase 3; superoxide dismutase 3, extracellular; superoxide dismutase B
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Sod3m1Mcwi  
Genetic Models: SS-Sod3m1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81462,822,865 - 62,828,602 (-)NCBIGRCr8
mRatBN7.21458,610,104 - 58,615,845 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1458,609,958 - 58,615,990 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1463,014,801 - 63,020,544 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01464,328,499 - 64,334,244 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01460,725,263 - 60,731,010 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01460,958,583 - 60,971,143 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1460,958,592 - 60,964,324 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01461,071,304 - 61,083,776 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41463,381,447 - 63,387,180 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11463,383,838 - 63,389,571 (-)NCBI
Celera1457,707,717 - 57,713,440 (-)NCBICelera
Cytogenetic Map14q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(E)-cinnamyl alcohol  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-hexanedione  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (EXP)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
Actein  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
azoxystrobin  (EXP)
Bandrowski's base  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butylated hydroxyanisole  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbendazim  (EXP)
CGP 52608  (ISO)
chloroethene  (ISO)
chlorogenic acid  (ISO)
chlorpyrifos  (EXP)
cholic acid  (ISO)
ciglitazone  (EXP)
cinnamyl alcohol  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clozapine  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cumene  (ISO)
D-glucose  (EXP)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dimethyl sulfoxide  (EXP)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (EXP)
donepezil hydrochloride  (EXP)
doxorubicin  (EXP,ISO)
ellagic acid  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
eugenol  (ISO)
fenthion  (ISO)
finasteride  (EXP)
flutamide  (EXP)
formaldehyde  (ISO)
fulvestrant  (EXP)
genistein  (ISO)
glucose  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyphosate  (EXP)
GW 4064  (ISO)
GW 501516  (ISO)
haloperidol  (EXP)
hexachlorobenzene  (EXP)
hyaluronic acid  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
inulin  (ISO)
isoeugenol  (ISO)
ketamine  (EXP)
L-ascorbic acid  (EXP,ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
losartan  (ISO)
lutein  (ISO)
lycopene  (ISO)
mercury dichloride  (EXP)
methotrexate  (ISO)
methyl tert-butyl ether  (EXP)
methylmercury chloride  (EXP)
mifepristone  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-phosphocreatine  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
ochratoxin A  (ISO)
Osajin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
paricalcitol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
peroxynitrous acid  (ISO)
phenobarbital  (EXP,ISO)
phosgene  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
Pomiferin  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
probucol  (EXP)
progesterone  (EXP,ISO)
puerarin  (ISO)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
raloxifene  (EXP)
resveratrol  (EXP,ISO)
Rosavin  (ISO)
rotenone  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP,ISO)
sulfadimethoxine  (EXP)
sulfasalazine  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
tamibarotene  (ISO)
tetrachloromethane  (ISO)
thiabendazole  (EXP)
thymoquinone  (EXP)
trans-isoeugenol  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Relationship of plasma extracellular-superoxide dismutase level with insulin resistance in type 2 diabetic patients. Adachi T, etal., J Endocrinol. 2004 Jun;181(3):413-7.
2. Transgenic extracellular superoxide dismutase protects postnatal alveolar epithelial proliferation and development during hyperoxia. Auten RL, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L32-40. Epub 2005 Aug 12.
3. Amelioration of salt-induced vascular dysfunction in mesenteric arteries of Dahl salt-sensitive rats by missense mutation of extracellular superoxide dismutase. Beyer AM, etal., Am J Physiol Heart Circ Physiol. 2014 Feb;306(3):H339-47. doi: 10.1152/ajpheart.00619.2012. Epub 2013 Dec 6.
4. Role of extracellular superoxide dismutase in bleomycin-induced pulmonary fibrosis. Bowler RP, etal., Am J Physiol Lung Cell Mol Physiol. 2002 Apr;282(4):L719-26.
5. Furin proteolytically processes the heparin-binding region of extracellular superoxide dismutase. Bowler RP, etal., J Biol Chem 2002 May 10;277(19):16505-11.
6. The rat extracellular superoxide dismutase dimer is converted to a tetramer by the exchange of a single amino acid. Carlsson LM, etal., Proc Natl Acad Sci U S A 1996 May 28;93(11):5219-22.
7. Altered expression profile of superoxide dismutase isoforms in nasal polyps from nonallergic patients. Cheng YK, etal., Laryngoscope. 2006 Mar;116(3):417-22.
8. Gene transfer of extracellular superoxide dismutase reduces arterial pressure in spontaneously hypertensive rats: role of heparin-binding domain. Chu Y, etal., Circ Res. 2003 Mar 7;92(4):461-8. Epub 2003 Jan 23.
9. Long-term hyperglycaemia decreases vascular fraction of extracellular superoxide dismutase. Ciechanowski K, etal., Diabetologia. 2003 Jul;46(7):1026-7. Epub 2003 Jun 27.
10. Regulation of lung oxidative damage by endogenous superoxide dismutase in sepsis. Constantino L, etal., Intensive Care Med Exp. 2014 Dec;2(1):17. doi: 10.1186/2197-425X-2-17. Epub 2014 May 23.
11. Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease. Decharatchakul N, etal., PeerJ. 2019 Aug 1;7:e7407. doi: 10.7717/peerj.7407. eCollection 2019.
12. Superoxide dismutase responds to hyperoxia in rat hippocampus. Freiberger J, etal., Undersea Hyperb Med. 2004 Summer;31(2):227-32.
13. Reduction of renal superoxide dismutase in progressive diabetic nephropathy. Fujita H, etal., J Am Soc Nephrol. 2009 Jun;20(6):1303-13. Epub 2009 May 21.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Role of extracellular superoxide dismutase in hypertension. Gongora MC, etal., Hypertension. 2006 Sep;48(3):473-81. Epub 2006 Jul 24.
17. Kidney failure, arterial hypertension and left ventricular hypertrophy in rats with loss of function mutation of SOD3. Guo H, etal., Free Radic Biol Med. 2020 May 20;152:787-796. doi: 10.1016/j.freeradbiomed.2020.01.023. Epub 2020 Jan 21.
18. Upregulation of vascular extracellular superoxide dismutase in patients with acute coronary syndromes. Horiuchi M, etal., Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):106-11. Epub 2003 Oct 30.
19. Gene transfer of extracellular superoxide dismutase improves endothelial function in rats with heart failure. Iida S, etal., Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H525-32.
20. Vascular effects of a common gene variant of extracellular superoxide dismutase in heart failure. Iida S, etal., Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H914-20.
21. Serum superoxide dismutase 3 (extracellular superoxide dismutase) activity is a sensitive indicator of Cu status in rats. Johnson WT, etal., J Nutr Biochem. 2005 Nov;16(11):682-92. Epub 2005 Aug 2.
22. Genetically increased antioxidative protection and decreased chronic obstructive pulmonary disease. Juul K, etal., Am J Respir Crit Care Med. 2006 Apr 15;173(8):858-64. Epub 2006 Jan 6.
23. Serum extracellular superoxide dismutase in patients with type 2 diabetes: relationship to the development of micro- and macrovascular complications. Kimura F, etal., Diabetes Care. 2003 Apr;26(4):1246-50.
24. Extracellular superoxide dismutase has a highly specific localization in idiopathic pulmonary fibrosis/usual interstitial pneumonia. Kinnula VL, etal., Histopathology. 2006 Jul;49(1):66-74.
25. Vascular extracellular superoxide dismutase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation. Landmesser U, etal., Circulation. 2000 May 16;101(19):2264-70.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. Skeletal muscle reperfusion injury is enhanced in extracellular superoxide dismutase knockout mouse. Park JW, etal., Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H181-7. Epub 2005 Mar 18.
29. Superoxide dismutase in the prostate lobes of aging Brown Norway rats. Pechenino AS and Brown TR, Prostate. 2006 Apr 1;66(5):522-35.
30. Isolation and characterization of a rat cDNA clone encoding a secreted superoxide dismutase reveals the epididymis to be a major site of its expression. Perry AC, etal., Biochem J 1993 Jul 1;293 ( Pt 1):21-5.
31. GOA pipeline RGD automated data pipeline
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Mice overexpressing extracellular superoxide dismutase have increased resistance to global cerebral ischemia. Sheng H, etal., Exp Neurol. 2000 Jun;163(2):392-8.
34. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
35. Extracellular superoxide dismutase gene polymorphism is associated with insulin resistance and the susceptibility to type 2 diabetes. Tamai M, etal., Diabetes Res Clin Pract. 2006 Feb;71(2):140-5. Epub 2005 Jun 28.
36. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
37. Comparison of the effect of adenoviral delivery of three superoxide dismutase genes against hepatic ischemia-reperfusion injury. Wheeler MD, etal., Hum Gene Ther. 2001 Dec 10;12(18):2167-77.
38. Purification and sequence of rat extracellular superoxide dismutase B secreted by C6 glioma. Willems J, etal., J Biol Chem 1993 Nov 25;268(33):24614-21.
39. Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase. Xu D, etal., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5.
40. Extracellular superoxide dismutase functions as a major repressor of hypoxia-induced erythropoietin gene expression. Zelko IN and Folz RJ, Endocrinology. 2005 Jan;146(1):332-40. Epub 2004 Sep 16.
41. [Correlation of the polymorphism of EC-SOD and GSTM1 and smoking with oral cancer risk]. Zhang C, etal., Wei Sheng Yan Jiu. 2012 Jul;41(4):555-61.
42. [Association of the SOD2 Ala(-9)Val and SOD3 Arg213Gly polymorphisms with diabetic polyneuropathy in patients with diabetes mellitus type 1] Zotova EV, etal., Mol Biol (Mosk). 2003 May-Jun;37(3):404-8.
Additional References at PubMed
PMID:9699963   PMID:15016652   PMID:15489334   PMID:15528465   PMID:16371425   PMID:17196988   PMID:19198181   PMID:19495415   PMID:20033309   PMID:20551380   PMID:21736484   PMID:21909393  
PMID:22540739   PMID:23376485   PMID:23533145   PMID:24006456   PMID:27068509   PMID:27559042   PMID:31714656   PMID:36251410   PMID:36989187  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81462,822,865 - 62,828,602 (-)NCBIGRCr8
mRatBN7.21458,610,104 - 58,615,845 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1458,609,958 - 58,615,990 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1463,014,801 - 63,020,544 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01464,328,499 - 64,334,244 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01460,725,263 - 60,731,010 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01460,958,583 - 60,971,143 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1460,958,592 - 60,964,324 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01461,071,304 - 61,083,776 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41463,381,447 - 63,387,180 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11463,383,838 - 63,389,571 (-)NCBI
Celera1457,707,717 - 57,713,440 (-)NCBICelera
Cytogenetic Map14q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38424,795,573 - 24,800,842 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl424,789,912 - 24,800,842 (+)EnsemblGRCh38hg38GRCh38
GRCh37424,797,195 - 24,802,464 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36424,406,183 - 24,411,565 (+)NCBINCBI36Build 36hg18NCBI36
Build 34424,472,323 - 24,478,733NCBI
Celera425,246,551 - 25,251,936 (+)NCBICelera
Cytogenetic Map4p15.2NCBI
HuRef424,139,594 - 24,144,972 (+)NCBIHuRef
CHM1_1424,796,442 - 24,801,824 (+)NCBICHM1_1
T2T-CHM13v2.0424,777,502 - 24,782,774 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39552,521,146 - 52,527,080 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl552,521,133 - 52,528,760 (+)EnsemblGRCm39 Ensembl
GRCm38552,363,804 - 52,369,738 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl552,363,791 - 52,371,418 (+)EnsemblGRCm38mm10GRCm38
MGSCv37552,755,043 - 52,760,977 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36552,652,052 - 52,657,986 (+)NCBIMGSCv36mm8
Celera549,732,370 - 49,738,292 (+)NCBICelera
Cytogenetic Map5C1NCBI
cM Map527.92NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_004955480257,716 - 263,149 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2325,042,416 - 25,047,841 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1425,239,089 - 25,248,284 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0419,195,941 - 19,201,298 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1424,480,912 - 24,486,382 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl424,485,059 - 24,485,781 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1385,382,698 - 85,387,144 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl385,382,484 - 85,387,455 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha387,896,595 - 87,901,009 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0386,357,866 - 86,362,385 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl386,357,992 - 86,359,248 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1385,490,694 - 85,495,210 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0385,596,388 - 85,600,748 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0385,980,631 - 85,986,057 (-)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl818,796,637 - 18,802,152 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1818,796,633 - 18,802,156 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2819,293,239 - 19,293,972 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12725,554,474 - 25,559,873 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2725,555,082 - 25,555,804 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604772,074,072 - 72,079,449 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247557,535,044 - 7,541,221 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247557,535,044 - 7,541,298 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Sod3
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:287
Count of miRNA genes:163
Interacting mature miRNAs:180
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143999825175582726Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat

Genetic Models
This gene Sod3 is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 21 31 19 5 19 8 11 20 31 33 11 8
Low 22 26 22 14 22 54 4 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000005155   ⟹   ENSRNOP00000005155
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1458,609,958 - 58,615,990 (-)Ensembl
Rnor_6.0 Ensembl1460,958,592 - 60,964,324 (-)Ensembl
RefSeq Acc Id: NM_012880   ⟹   NP_037012
Rat AssemblyChrPosition (strand)Source
GRCr81462,822,865 - 62,828,602 (-)NCBI
mRatBN7.21458,610,104 - 58,615,845 (-)NCBI
Rnor_6.01460,958,591 - 60,964,324 (-)NCBI
Rnor_5.01461,071,304 - 61,083,776 (-)NCBI
RGSC_v3.41463,381,447 - 63,387,180 (-)RGD
Celera1457,707,717 - 57,713,440 (-)RGD
RefSeq Acc Id: NP_037012   ⟸   NM_012880
- Peptide Label: precursor
- UniProtKB: Q64667 (UniProtKB/Swiss-Prot),   Q08420 (UniProtKB/Swiss-Prot),   A6IJH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005155   ⟸   ENSRNOT00000005155
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q08420-F1-model_v2 AlphaFold Q08420 1-244 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699337
Promoter ID:EPDNEW_R9862
Type:initiation region
Description:superoxide dismutase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01460,964,292 - 60,964,352EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3733 AgrOrtholog
BioCyc Gene G2FUF-15590 BioCyc
BioCyc Pathway DETOX1-PWY [superoxide radicals degradation] BioCyc
  DETOX1-PWY-1 [reactive oxygen species degradation] BioCyc
BioCyc Pathway Image DETOX1-PWY BioCyc
  DETOX1-PWY-1 BioCyc
Ensembl Genes ENSRNOG00000003869 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055011318 UniProtKB/Swiss-Prot
  ENSRNOG00060016186 UniProtKB/Swiss-Prot
  ENSRNOG00065003240 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005155 ENTREZGENE
  ENSRNOT00000005155.4 UniProtKB/Swiss-Prot
  ENSRNOT00055019165 UniProtKB/Swiss-Prot
  ENSRNOT00060027730 UniProtKB/Swiss-Prot
  ENSRNOT00065004598 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro SOD-like_Cu/Zn_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOD_Cu/Zn_/chaperone UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOD_Cu/Zn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOD_Cu_Zn_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25352 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10003 UniProtKB/Swiss-Prot
  PTHR10003:SF77 UniProtKB/Swiss-Prot
Pfam Sod_Cu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sod3 PhenoGen
PROSITE SOD_CU_ZN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOD_CU_ZN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003869 RatGTEx
  ENSRNOG00055011318 RatGTEx
  ENSRNOG00060016186 RatGTEx
  ENSRNOG00065003240 RatGTEx
Superfamily-SCOP Cu,Zn superoxide dismutase-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC218284
  SODE_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q64667 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-24 Sod3  superoxide dismutase 3  Sod3  superoxide dismutase 3, extracellular  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Sod3  superoxide dismutase 3, extracellular    superoxide dismutase 3  Name updated 1299863 APPROVED
2003-04-09 Sod3  superoxide dismutase 3    Superoxide dismutase 3  Name updated 629478 APPROVED
2001-12-21 Sod3  Superoxide dismutase 3      Name updated 69729 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in epididymis 730184
gene_homology presence of Asp28 is associated with dimerization of the rat protein rather than tetramer formation observed in mice and human homologs, which contain Val28 730025
gene_mutations_overexpression D28V mutant forms a tetramer and has high affinity for heparin sulfate 730025
gene_physical_interaction binds to heparin 730119
gene_process may be involved in preserving spermatozoa fertility by preventing lipid peroxidation 730184
gene_protein forms a dimer; a copper-zinc containing glycoprotein 730025