Aebp1 (AE binding protein 1) - Rat Genome Database

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Gene: Aebp1 (AE binding protein 1) Rattus norvegicus
Analyze
Symbol: Aebp1
Name: AE binding protein 1
RGD ID: 1306922
Description: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; carboxypeptidase activity; and collagen binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and regulation of collagen fibril organization. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome classic-like 2. Orthologous to human AEBP1 (AE binding protein 1); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adipocyte enhancer-binding protein 1; AE-binding protein 1; aortic carboxypeptidase-like protein; LOC305494
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21480,738,800 - 80,748,878 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1480,738,892 - 80,748,877 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1485,140,975 - 85,150,961 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01486,381,063 - 86,391,049 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01482,830,385 - 82,840,371 (+)NCBIRnor_WKY
Rnor_6.01486,101,253 - 86,111,323 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1486,101,277 - 86,111,306 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01486,792,909 - 86,802,767 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41486,525,748 - 86,535,664 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11486,544,861 - 86,554,594 (+)NCBI
Celera1479,623,720 - 79,633,706 (+)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7477299   PMID:12477932   PMID:15654748   PMID:19199708   PMID:20551380   PMID:24006456   PMID:27068509   PMID:29606302  


Genomics

Comparative Map Data
Aebp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21480,738,800 - 80,748,878 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1480,738,892 - 80,748,877 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1485,140,975 - 85,150,961 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01486,381,063 - 86,391,049 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01482,830,385 - 82,840,371 (+)NCBIRnor_WKY
Rnor_6.01486,101,253 - 86,111,323 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1486,101,277 - 86,111,306 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01486,792,909 - 86,802,767 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41486,525,748 - 86,535,664 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11486,544,861 - 86,554,594 (+)NCBI
Celera1479,623,720 - 79,633,706 (+)NCBICelera
Cytogenetic Map14q21NCBI
AEBP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38744,104,345 - 44,114,560 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl744,104,345 - 44,114,562 (+)EnsemblGRCh38hg38GRCh38
GRCh37744,143,944 - 44,154,159 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36744,110,485 - 44,120,684 (+)NCBINCBI36Build 36hg18NCBI36
Build 34743,917,199 - 43,927,398NCBI
Celera744,241,911 - 44,252,113 (+)NCBICelera
Cytogenetic Map7p13NCBI
HuRef744,029,222 - 44,039,430 (+)NCBIHuRef
CHM1_1744,147,805 - 44,158,013 (+)NCBICHM1_1
T2T-CHM13v2.0744,262,871 - 44,273,091 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2744,183,452 - 44,193,659 (+)NCBI
Aebp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39115,806,085 - 5,822,248 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl115,811,947 - 5,822,088 (+)EnsemblGRCm39 Ensembl
GRCm38115,861,866 - 5,872,248 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl115,861,947 - 5,872,088 (+)EnsemblGRCm38mm10GRCm38
MGSCv37115,761,869 - 5,772,228 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36115,761,950 - 5,772,053 (+)NCBIMGSCv36mm8
Celera116,353,502 - 6,363,861 (+)NCBICelera
Cytogenetic Map11A1NCBI
Aebp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554567,860,414 - 7,868,337 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554567,860,191 - 7,868,526 (-)NCBIChiLan1.0ChiLan1.0
AEBP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1744,886,238 - 44,896,194 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl744,886,238 - 44,896,194 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0744,818,620 - 44,828,914 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
AEBP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha162,045,084 - 2,054,558 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01614,807,414 - 14,816,892 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1614,807,398 - 14,817,822 (-)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.01614,438,625 - 14,448,091 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01614,419,106 - 14,428,582 (-)NCBIUU_Cfam_GSD_1.0
Aebp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511899,853,346 - 99,863,052 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647819,065,441 - 19,074,541 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647819,065,092 - 19,074,783 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AEBP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1851,046,899 - 51,056,698 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11851,046,895 - 51,056,789 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21855,940,587 - 55,950,114 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AEBP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12114,553,441 - 14,563,599 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2114,553,744 - 14,563,399 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660627,951,209 - 7,961,621 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aebp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247407,908,033 - 7,915,787 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247407,907,823 - 7,915,911 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aebp1
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:97
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000018846
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat

Markers in Region
RH130406  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21480,748,674 - 80,748,860 (+)MAPPERmRatBN7.2
Rnor_6.01486,111,120 - 86,111,305NCBIRnor6.0
Rnor_5.01486,802,564 - 86,802,749UniSTSRnor5.0
RGSC_v3.41486,535,461 - 86,535,646UniSTSRGSC3.4
Celera1479,633,503 - 79,633,688UniSTS
RH 3.4 Map14573.4UniSTS
Cytogenetic Map14q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 38 18 8 14 8 5 8 30 35 34 11 5
Low 5 39 33 5 33 3 3 44 7 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018846   ⟹   ENSRNOP00000018846
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1480,738,892 - 80,748,877 (+)Ensembl
Rnor_6.0 Ensembl1486,101,277 - 86,111,306 (+)Ensembl
RefSeq Acc Id: NM_001100970   ⟹   NP_001094440
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21480,738,892 - 80,748,878 (+)NCBI
Rnor_6.01486,101,332 - 86,111,323 (+)NCBI
Rnor_5.01486,792,909 - 86,802,767 (+)NCBI
RGSC_v3.41486,525,748 - 86,535,664 (+)RGD
Celera1479,623,720 - 79,633,706 (+)RGD
Sequence:
RefSeq Acc Id: XM_006251316   ⟹   XP_006251378
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21480,738,800 - 80,748,875 (+)NCBI
Rnor_6.01486,101,253 - 86,111,320 (+)NCBI
Rnor_5.01486,792,909 - 86,802,767 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001094440 (Get FASTA)   NCBI Sequence Viewer  
  XP_006251378 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A2RUV9 (Get FASTA)   NCBI Sequence Viewer  
  AAI33066 (Get FASTA)   NCBI Sequence Viewer  
  EDM00315 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001094440   ⟸   NM_001100970
- Peptide Label: precursor
- UniProtKB: A2RUV9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006251378   ⟸   XM_006251316
- Peptide Label: isoform X1
- UniProtKB: A0A0H2UHL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018846   ⟸   ENSRNOT00000018846
Protein Domains
F5/8 type C

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A2RUV9-F1-model_v2 AlphaFold A2RUV9 1-1128 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699464
Promoter ID:EPDNEW_R9988
Type:initiation region
Name:Aebp1_1
Description:AE binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01486,101,327 - 86,101,387EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306922 AgrOrtholog
BioCyc Gene G2FUF-15118 BioCyc
Ensembl Genes ENSRNOG00000013720 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000018846 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018846 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7124847 IMAGE-MGC_LOAD
InterPro CarboxyPept-like_regulatory UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:305494 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156778 IMAGE-MGC_LOAD
NCBI Gene 305494 ENTREZGENE
Pfam F5_F8_type_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aebp1 PhenoGen
PROSITE CARBOXYPEPT_ZN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FA58C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zn_pept UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49464 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHL3 ENTREZGENE, UniProtKB/TrEMBL
  A2RUV9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Aebp1  AE binding protein 1   Aebp1_predicted  AE binding protein 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Aebp1_predicted  AE binding protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED