Ppia (peptidylprolyl isomerase A) - Rat Genome Database

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Gene: Ppia (peptidylprolyl isomerase A) Rattus norvegicus
Analyze
Symbol: Ppia
Name: peptidylprolyl isomerase A
RGD ID: 3372
Description: Enables cyclosporin A binding activity. Involved in negative regulation of calcineurin-mediated signaling. Predicted to be located in cytosol; extracellular space; and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Used to study epilepsy. Human ortholog(s) of this gene implicated in cholangiocarcinoma and human immunodeficiency virus infectious disease. Orthologous to human PPIA (peptidylprolyl isomerase A); INTERACTS WITH (R,R,R)-alpha-tocopherol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CYCA; cyclophilin A; cyclosporin A-binding protein; CyP-A; MGC72881; p1B15; p31; peptidyl-prolyl cis-trans isomerase A; peptidylprolyl isomerase A (cyclophilin A); PPIase A; rotamase A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Ppia-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81485,491,223 - 85,496,884 (+)NCBIGRCr8
mRatBN7.21481,279,292 - 81,282,960 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1481,275,091 - 81,299,601 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1485,680,216 - 85,683,897 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01486,920,016 - 86,923,697 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01483,369,616 - 83,373,297 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01486,673,775 - 86,677,443 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1486,673,775 - 86,677,443 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01480,306,923 - 80,310,652 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41487,165,998 - 87,169,995 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11487,185,142 - 87,189,140 (+)NCBI
Celera1480,161,152 - 80,164,810 (+)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-dimethoxyphenol  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
alprazolam  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Bandrowski's base  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP)
bucladesine  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorophyllin  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cumene hydroperoxide  (EXP)
cyclosporin A  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dihydroartemisinin  (ISO)
disulfiram  (ISO)
diuron  (ISO)
doxorubicin  (EXP,ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
ferric ammonium citrate  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
furfural  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glyphosate  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
ibuprofen  (ISO)
indometacin  (ISO)
iodide salt  (EXP)
iron(III) nitrilotriacetate  (EXP)
ivermectin  (ISO)
L-glutamic acid  (EXP)
limonene  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
medroxyprogesterone acetate  (ISO)
megestrol acetate  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
morphine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
picoxystrobin  (ISO)
potassium dichromate  (EXP)
Propiverine  (EXP)
quercetin  (ISO)
Rebamipide  (EXP)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (EXP,ISO)
sulfadimethoxine  (EXP)
T-2 toxin  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trichostatin A  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
cytosol  (ISS)
extracellular region  (IEA,ISO,ISS)
extracellular space  (ISO)
nucleus  (ISO,ISS)
protein-containing complex  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS. An P, etal., PLoS Pathog. 2007 Jun;3(6):e88. doi: 10.1371/journal.ppat.0030088.
2. Cyclophillin A deficiency accelerates RML-induced prion disease. Bouybayoune I, etal., Neurobiol Dis. 2019 Oct;130:104498. doi: 10.1016/j.nbd.2019.104498. Epub 2019 Jun 8.
3. p1B15: a cDNA clone of the rat mRNA encoding cyclophilin. Danielson PE, etal., DNA 1988 May;7(4):261-7.
4. Concentrations of Serum Cyclophilin A in Patients With Bell Palsy. Demir B, etal., J Craniofac Surg. 2020 Jun;31(4):e368-e370. doi: 10.1097/SCS.0000000000006308.
5. Completion of the entire hepatitis C virus life cycle in genetically humanized mice. Dorner M, etal., Nature. 2013 Sep 12;501(7466):237-41. doi: 10.1038/nature12427. Epub 2013 Jul 31.
6. Evaluation of gingival crevicular fluid cyclophilin a and extracellular matrix metalloproteinase inducer levels in different periodontal diseases. Eren G, etal., Arch Oral Biol. 2016 Aug;68:162-6. doi: 10.1016/j.archoralbio.2016.05.004. Epub 2016 May 4.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Clonorchis sinensis cyclophilin A immunization protected mice from CLP-induced sepsis. Jiang J, etal., Int Immunopharmacol. 2018 Jun;59:347-353. doi: 10.1016/j.intimp.2018.03.039. Epub 2018 Apr 19.
9. Cyclophilin A protects mice against infection by influenza A virus. Li J, etal., Sci Rep. 2016 Jun 29;6:28978. doi: 10.1038/srep28978.
10. Exosomal cyclophilin A as a novel noninvasive biomarker for Epstein-Barr virus associated nasopharyngeal carcinoma. Liu L, etal., Cancer Med. 2019 Jun;8(6):3142-3151. doi: 10.1002/cam4.2185. Epub 2019 May 7.
11. Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses. Liu W, etal., Elife. 2017 Jun 8;6. doi: 10.7554/eLife.24425.
12. Uncaria rhynchophylla upregulates the expression of MIF and cyclophilin A in kainic acid-induced epilepsy rats: A proteomic analysis. Lo WY, etal., Am J Chin Med. 2010;38(4):745-59.
13. Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation. Malouitre S, etal., Biochem J. 2009 Dec 14;425(1):137-48. doi: 10.1042/BJ20090332.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma. Obchoei S, etal., Mol Cancer. 2011 Aug 26;10:102. doi: 10.1186/1476-4598-10-102.
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Cyclophilin A affects inflammation, virus elimination and myocardial fibrosis in coxsackievirus B3-induced myocarditis. Seizer P, etal., J Mol Cell Cardiol. 2012 Jul;53(1):6-14. doi: 10.1016/j.yjmcc.2012.03.004. Epub 2012 Mar 15.
20. P31, a mammalian housekeeping protein encoded by a multigene family containing a high proportion of pseudogenes. Theodor L, etal., Biochim Biophys Acta 1985 Nov 13;826(2-3):137-46.
Additional References at PubMed
PMID:1599421   PMID:1851525   PMID:11250896   PMID:12218175   PMID:12357034   PMID:12477932   PMID:14993672   PMID:15489334   PMID:16352598   PMID:16502470   PMID:16780588   PMID:17634366  
PMID:19056867   PMID:19190083   PMID:19199708   PMID:19932913   PMID:19946888   PMID:19968957   PMID:20458337   PMID:20676357   PMID:21330604   PMID:21423176   PMID:21711559   PMID:22139963  
PMID:22658674   PMID:22681889   PMID:22871113   PMID:23106098   PMID:23376485   PMID:23533145   PMID:23846495   PMID:24006456   PMID:24434144   PMID:26173747   PMID:27825172   PMID:29476059  
PMID:29914983   PMID:30221707   PMID:31686426   PMID:32357304   PMID:37993081  


Genomics

Comparative Map Data
Ppia
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81485,491,223 - 85,496,884 (+)NCBIGRCr8
mRatBN7.21481,279,292 - 81,282,960 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1481,275,091 - 81,299,601 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1485,680,216 - 85,683,897 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01486,920,016 - 86,923,697 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01483,369,616 - 83,373,297 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01486,673,775 - 86,677,443 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1486,673,775 - 86,677,443 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01480,306,923 - 80,310,652 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41487,165,998 - 87,169,995 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11487,185,142 - 87,189,140 (+)NCBI
Celera1480,161,152 - 80,164,810 (+)NCBICelera
Cytogenetic Map14q21NCBI
PPIA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38744,796,681 - 44,803,117 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl744,796,680 - 44,824,564 (+)EnsemblGRCh38hg38GRCh38
GRCh37744,836,280 - 44,842,716 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36744,802,766 - 44,809,241 (+)NCBINCBI36Build 36hg18NCBI36
Build 34744,609,504 - 44,615,343NCBI
Celera744,935,095 - 44,941,571 (+)NCBICelera
Cytogenetic Map7p13NCBI
HuRef744,721,292 - 44,727,768 (+)NCBIHuRef
CHM1_1744,840,586 - 44,847,069 (+)NCBICHM1_1
T2T-CHM13v2.0744,957,232 - 44,963,670 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2744,875,748 - 44,882,224 (+)NCBI
Ppia
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39116,365,867 - 6,369,817 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl116,365,443 - 6,369,817 (+)EnsemblGRCm39 Ensembl
GRCm38116,415,867 - 6,419,817 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl116,415,443 - 6,419,817 (+)EnsemblGRCm38mm10GRCm38
MGSCv37116,315,873 - 6,319,813 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36116,315,873 - 6,319,813 (+)NCBIMGSCv36mm8
Celera116,899,520 - 6,903,460 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.97NCBI
Ppia
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554567,381,923 - 7,383,203 (-)NCBIChiLan1.0ChiLan1.0
PPIA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2649,708,848 - 49,714,864 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1798,034,551 - 98,039,602 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0745,510,450 - 45,515,448 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1745,578,764 - 45,583,516 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl745,578,765 - 45,605,545 (+)Ensemblpanpan1.1panPan2
LOC403581
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1780,937,433 - 80,938,175 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0781,027,063 - 81,027,805 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1780,741,873 - 80,742,615 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01764,379,529 - 64,380,271 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0781,058,591 - 81,059,333 (-)NCBIUU_Cfam_GSD_1.0
Ppia
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118100,457,966 - 100,461,621 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647819,669,506 - 19,673,398 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647819,669,727 - 19,673,355 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPIA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11850,563,130 - 50,566,857 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21855,286,994 - 55,290,557 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPIA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12113,876,099 - 13,883,546 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2113,876,099 - 13,883,462 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660628,652,515 - 8,658,073 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppia
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247407,447,554 - 7,450,641 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247407,447,554 - 7,450,707 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppia
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:22
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000009179
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat

Markers in Region
UniSTS:265677  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21421,006,765 - 21,007,058 (+)MAPPERmRatBN7.2
mRatBN7.2441,829,100 - 41,829,392 (+)MAPPERmRatBN7.2
Rnor_6.01422,707,130 - 22,707,422NCBIRnor6.0
Rnor_5.01422,609,939 - 22,610,231UniSTSRnor5.0
RGSC_v3.41422,613,076 - 22,613,368UniSTSRGSC3.4
Cytogenetic Map14q21UniSTS
Ppia  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21421,006,634 - 21,006,784 (+)MAPPERmRatBN7.2
Rnor_6.01422,706,999 - 22,707,148NCBIRnor6.0
Rnor_5.01422,609,808 - 22,609,957UniSTSRnor5.0
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 22 86 164 114 120 82 38 82 320 146 148 70 82 38

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC106663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC091153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M19533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000038275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1481,278,349 - 81,282,951 (+)Ensembl
Rnor_6.0 Ensembl1486,675,818 - 86,677,438 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079015   ⟹   ENSRNOP00000071920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1481,278,928 - 81,299,601 (+)Ensembl
Rnor_6.0 Ensembl1486,673,817 - 86,677,237 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091873   ⟹   ENSRNOP00000073930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1481,275,091 - 81,282,954 (+)Ensembl
Rnor_6.0 Ensembl1486,673,775 - 86,677,443 (+)Ensembl
RefSeq Acc Id: NM_017101   ⟹   NP_058797
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81485,493,216 - 85,496,884 (+)NCBI
mRatBN7.21481,279,292 - 81,282,960 (+)NCBI
Rnor_6.01486,673,775 - 86,677,443 (+)NCBI
Rnor_5.01480,306,923 - 80,310,652 (+)NCBI
RGSC_v3.41487,165,998 - 87,169,995 (+)RGD
Celera1480,161,152 - 80,164,810 (+)RGD
Sequence:
RefSeq Acc Id: XM_017599085   ⟹   XP_017454574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81485,491,223 - 85,495,360 (+)NCBI
mRatBN7.21481,279,733 - 81,282,959 (+)NCBI
Rnor_6.01486,674,258 - 86,677,443 (+)NCBI
Sequence:
RefSeq Acc Id: NP_058797   ⟸   NM_017101
- UniProtKB: P18303 (UniProtKB/Swiss-Prot),   Q5BK98 (UniProtKB/Swiss-Prot),   P10111 (UniProtKB/Swiss-Prot),   A6IKU0 (UniProtKB/TrEMBL),   A6IKT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454574   ⟸   XM_017599085
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000071920   ⟸   ENSRNOT00000079015
Ensembl Acc Id: ENSRNOP00000073930   ⟸   ENSRNOT00000091873
Protein Domains
PPIase cyclophilin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10111-F1-model_v2 AlphaFold P10111 1-164 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699474
Promoter ID:EPDNEW_R9998
Type:multiple initiation site
Name:Ppia_1
Description:peptidylprolyl isomerase A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01486,673,774 - 86,673,834EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3372 AgrOrtholog
BioCyc Gene G2FUF-15091 BioCyc
Ensembl Genes ENSRNOG00000027864 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000068764 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000038275.6 UniProtKB/TrEMBL
  ENSRNOT00000079015.2 UniProtKB/TrEMBL
  ENSRNOT00000091873.2 UniProtKB/TrEMBL
  ENSRNOT00000106407.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6919594 IMAGE-MGC_LOAD
  IMAGE:7308693 IMAGE-MGC_LOAD
InterPro Cyclophilin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclophilin-type_PPIase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclophilin-type_PPIase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclophilin-type_PPIase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:100360977 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  rno:25518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108714 IMAGE-MGC_LOAD
  MGC:72881 IMAGE-MGC_LOAD
NCBI Gene 25518 ENTREZGENE
PANTHER PEPTIDYL-PROLYL CIS-TRANS ISOMERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pro_isomerase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppia PhenoGen
PIRSF Peptidylpro_ismrse UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CSAPPISMRASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CSA_PPIASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CSA_PPIASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027864 RatGTEx
  ENSRNOG00000068764 RatGTEx
Superfamily-SCOP SSF50891 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K1P0_RAT UniProtKB/TrEMBL
  A0A8I5ZPK0_RAT UniProtKB/TrEMBL
  A0A8L2R8V9_RAT UniProtKB/TrEMBL
  A6IKT9 ENTREZGENE, UniProtKB/TrEMBL
  A6IKU0 ENTREZGENE, UniProtKB/TrEMBL
  P10111 ENTREZGENE
  P18303 ENTREZGENE
  PPIA_RAT UniProtKB/Swiss-Prot
  Q5BK98 ENTREZGENE
UniProt Secondary P18303 UniProtKB/Swiss-Prot
  Q5BK98 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-21 Ppia  peptidylprolyl isomerase A  Ppia  peptidylprolyl isomerase A (cyclophilin A)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Ppia  peptidylprolyl isomerase A (cyclophilin A)  Ppia  peptidylprolyl isomerase A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ppia  Peptidylprolyl isomerase A (cyclophilin A)      Symbol and Name status set to approved 70586 APPROVED