Tlr1 (toll-like receptor 1) - Rat Genome Database

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Gene: Tlr1 (toll-like receptor 1) Rattus norvegicus
Analyze
Symbol: Tlr1
Name: toll-like receptor 1
RGD ID: 1309975
Description: Enables lipopeptide binding activity. Involved in microglial cell activation; response to bacterial lipoprotein; and toll-like receptor signaling pathway. Predicted to be located in Golgi apparatus and membrane raft. Predicted to be part of Toll-like receptor 1-Toll-like receptor 2 protein complex. Biomarker of perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; aspergillosis; leprosy; pyelonephritis; and tuberculosis. Orthologous to human TLR1 (toll like receptor 1); PARTICIPATES IN Toll-like receptor signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC305354; rCG56938-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81443,737,761 - 43,750,389 (+)NCBIGRCr8
mRatBN7.21443,384,127 - 43,396,765 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1443,384,932 - 43,397,125 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1443,753,982 - 43,756,546 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01445,053,936 - 45,056,500 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01443,534,102 - 43,536,666 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01445,062,662 - 45,065,014 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1445,062,662 - 45,081,991 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01444,871,931 - 44,874,283 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41446,114,913 - 46,124,820 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1442,538,240 - 42,540,804 (+)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
bleomycin A2  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
choline  (ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diiodine  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
graphene oxide  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
o-anisidine  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pirinixic acid  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Modulation of inflammatory responses by a cannabinoid-2-selective agonist after spinal cord injury. Adhikary S, etal., J Neurotrauma. 2011 Dec;28(12):2417-27. doi: 10.1089/neu.2011.1853. Epub 2011 Oct 4.
2. TLR4 links podocytes with the innate immune system to mediate glomerular injury. Banas MC, etal., J Am Soc Nephrol. 2008 Apr;19(4):704-13. doi: 10.1681/ASN.2007040395. Epub 2008 Feb 6.
3. Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family. Ben-Ali M, etal., Hum Mutat. 2011 Jun;32(6):643-52. doi: 10.1002/humu.21486.
4. Myobacterium tuberculosis induces selective up-regulation of TLRs in the mononuclear leukocytes of patients with active pulmonary tuberculosis. Chang JS, etal., J Immunol. 2006 Mar 1;176(5):3010-8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression. Guo LH, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):1156-62. Epub 2006 Sep 1.
8. Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women. Hawn TR, etal., PLoS One. 2009 Jun 22;4(6):e5990. doi: 10.1371/journal.pone.0005990.
9. Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy. Johnson CM, etal., J Immunol. 2007 Jun 15;178(12):7520-4.
10. TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation. Kesh S, etal., Ann N Y Acad Sci. 2005 Dec;1062:95-103.
11. Toll-like receptor heterodimer variants protect from childhood asthma. Kormann MS, etal., J Allergy Clin Immunol. 2008 Jul;122(1):86-92, 92.e1-8. Epub 2008 Jun 10.
12. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
13. Toll-like receptor 1 gene polymorphisms in childhood IgA nephropathy: a case-control study in the Korean population. Lee JS, etal., Int J Immunogenet. 2011 Apr;38(2):133-8. doi: 10.1111/j.1744-313X.2010.00978.x. Epub 2010 Nov 25.
14. Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis. Liu Y, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G442-50. Epub 2009 Jul 16.
15. Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease. Ma X, etal., PLoS One. 2007 Dec 19;2(12):e1318.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12077222   PMID:12091878   PMID:15294986   PMID:15632090   PMID:16880211   PMID:17889651   PMID:19931471   PMID:22198949   PMID:23155421   PMID:24091496   PMID:28822965   PMID:32329822  


Genomics

Comparative Map Data
Tlr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81443,737,761 - 43,750,389 (+)NCBIGRCr8
mRatBN7.21443,384,127 - 43,396,765 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1443,384,932 - 43,397,125 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1443,753,982 - 43,756,546 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01445,053,936 - 45,056,500 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01443,534,102 - 43,536,666 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01445,062,662 - 45,065,014 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1445,062,662 - 45,081,991 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01444,871,931 - 44,874,283 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41446,114,913 - 46,124,820 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1442,538,240 - 42,540,804 (+)NCBICelera
Cytogenetic Map14p11NCBI
TLR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38438,787,569 - 38,805,644 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl438,790,677 - 38,856,817 (-)EnsemblGRCh38hg38GRCh38
GRCh37438,797,876 - 38,806,412 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36438,474,271 - 38,482,807 (-)NCBINCBI36Build 36hg18NCBI36
Build 34438,620,443 - 38,628,978NCBI
Cytogenetic Map4p14NCBI
HuRef438,122,243 - 38,130,779 (-)NCBIHuRef
CHM1_1438,797,457 - 38,805,993 (-)NCBICHM1_1
T2T-CHM13v2.0438,758,769 - 38,775,212 (-)NCBIT2T-CHM13v2.0
Tlr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39565,082,023 - 65,090,945 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl565,082,022 - 65,090,906 (-)EnsemblGRCm39 Ensembl
GRCm38564,924,680 - 64,933,600 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl564,924,679 - 64,933,563 (-)EnsemblGRCm38mm10GRCm38
MGSCv37565,316,073 - 65,323,938 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36565,203,969 - 65,211,834 (-)NCBIMGSCv36mm8
Celera562,197,667 - 62,205,494 (-)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map533.53NCBI
Tlr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554438,447,956 - 8,450,382 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554438,442,419 - 8,450,318 (+)NCBIChiLan1.0ChiLan1.0
TLR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2338,984,530 - 39,034,230 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1439,177,045 - 39,226,757 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0433,119,485 - 33,133,541 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1438,973,623 - 38,981,413 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl438,979,006 - 38,981,366 (-)Ensemblpanpan1.1panPan2
TLR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1373,504,359 - 73,544,822 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl373,539,715 - 73,544,624 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha376,089,340 - 76,091,709 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0374,285,167 - 74,325,228 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl374,315,975 - 74,325,027 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1373,588,991 - 73,591,359 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0373,735,203 - 73,737,572 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0374,115,278 - 74,117,647 (+)NCBIUU_Cfam_GSD_1.0
Tlr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528539,707,097 - 39,715,850 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364826,582,584 - 6,584,971 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364826,582,430 - 6,591,128 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl830,147,624 - 30,155,466 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1830,147,600 - 30,155,454 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2831,627,675 - 31,660,825 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12711,482,307 - 11,490,847 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2711,488,294 - 11,490,654 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604757,897,098 - 57,911,767 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248407,287,781 - 7,290,162 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248407,287,772 - 7,349,282 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tlr1
27 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143999825175582726Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat

Markers in Region
RH131387  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21443,396,538 - 43,396,723 (+)MAPPERmRatBN7.2
Rnor_6.01445,064,807 - 45,064,991NCBIRnor6.0
Rnor_5.01444,874,076 - 44,874,260UniSTSRnor5.0
RGSC_v3.41446,124,614 - 46,124,798UniSTSRGSC3.4
Celera1442,540,597 - 42,540,781UniSTS
Cytogenetic Map14p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8
Low 3 1 55 39 11 39 14 35 26 11
Below cutoff 38 2 2 2 5 6 60 12 5

Sequence


Ensembl Acc Id: ENSRNOT00000059124   ⟹   ENSRNOP00000055898
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1443,386,158 - 43,397,125 (+)Ensembl
Rnor_6.0 Ensembl1445,062,662 - 45,081,991 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101868   ⟹   ENSRNOP00000079338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1443,384,932 - 43,397,125 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112411   ⟹   ENSRNOP00000097749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1443,386,242 - 43,397,125 (+)Ensembl
RefSeq Acc Id: NM_001172120   ⟹   NP_001165591
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81443,747,821 - 43,750,385 (+)NCBI
mRatBN7.21443,394,182 - 43,396,746 (+)NCBI
Rnor_6.01445,062,662 - 45,065,014 (+)NCBI
Rnor_5.01444,871,931 - 44,874,283 (+)NCBI
Celera1442,538,240 - 42,540,804 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039091925   ⟹   XP_038947853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81443,737,761 - 43,750,389 (+)NCBI
mRatBN7.21443,384,127 - 43,396,765 (+)NCBI
RefSeq Acc Id: XM_039091926   ⟹   XP_038947854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81443,737,761 - 43,750,389 (+)NCBI
mRatBN7.21443,384,127 - 43,396,765 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001165591 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947853 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947854 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL90081 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000055898.4
  ENSRNOP00000079338.1
  ENSRNOP00000097749.1
RefSeq Acc Id: NP_001165591   ⟸   NM_001172120
- Peptide Label: precursor
- UniProtKB: A6JDF9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000055898   ⟸   ENSRNOT00000059124
RefSeq Acc Id: XP_038947854   ⟸   XM_039091926
- Peptide Label: isoform X1
- UniProtKB: E9PTL5 (UniProtKB/TrEMBL),   A6JDF9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947853   ⟸   XM_039091925
- Peptide Label: isoform X1
- UniProtKB: E9PTL5 (UniProtKB/TrEMBL),   A6JDF9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079338   ⟸   ENSRNOT00000101868
Ensembl Acc Id: ENSRNOP00000097749   ⟸   ENSRNOT00000112411
Protein Domains
TIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PTL5-F1-model_v2 AlphaFold E9PTL5 1-783 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309975 AgrOrtholog
BioCyc Gene G2FUF-15726 BioCyc
Ensembl Genes ENSRNOG00000038722 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059124.4 UniProtKB/TrEMBL
  ENSRNOT00000101868.1 UniProtKB/TrEMBL
  ENSRNOT00000112411.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  TIR_dom UniProtKB/TrEMBL
  Toll-like_receptor UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
NCBI Gene 305354 ENTREZGENE
PANTHER PTHR24365 UniProtKB/TrEMBL
  PTHR24365:SF261 UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
PhenoGen Tlr1 PhenoGen
PIRSF Toll-like_receptor UniProtKB/TrEMBL
PRINTS INTRLKN1R1F UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038722 RatGTEx
SMART LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  SSF52200 UniProtKB/TrEMBL
UniProt A6JDF9 ENTREZGENE, UniProtKB/TrEMBL
  E9PTL5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Tlr1  toll-like receptor 1  LOC100363942  rCG56938-like  Data merged from RGD:2322015 1643240 APPROVED
2013-05-24 Tlr1  toll-like receptor 1  LOC100363038  rCG56938-like  Data merged from RGD:2323557 1643240 APPROVED
2010-05-06 LOC100363942  rCG56938-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-05-06 LOC100363038  rCG56938-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Tlr1  toll-like receptor 1   Tlr1_predicted  toll-like receptor 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tlr1_predicted  toll-like receptor 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED