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Gene: TLR1 (toll like receptor 1) Homo sapiens
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Symbol: TLR1
Name: toll like receptor 1
Description: Exhibits Toll-like receptor 2 binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in several processes, including positive regulation of interleukin-8 secretion; positive regulation of toll-like receptor 2 signaling pathway; and response to triacyl bacterial lipopeptide. Localizes to the Golgi apparatus; Toll-like receptor 1-Toll-like receptor 2 protein complex; and membrane raft. Implicated in several diseases, including IgA glomerulonephritis; aspergillosis; asthma; leprosy; and pyelonephritis. Biomarker of pulmonary tuberculosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD281; DKFZp547I0610; DKFZp564I0682; KIAA0012; MGC104956; MGC126311; MGC126312; rsc786; TIL; TIL. LPRS5; toll-like receptor 1; toll/interleukin-1 receptor-like protein
Orthologs:
Mus musculus (house mouse) : Tlr1 (toll-like receptor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tlr1 (toll-like receptor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlr1 (toll like receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TLR1 (toll like receptor 1)
Canis lupus familiaris (dog) : TLR1 (toll like receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlr1 (toll like receptor 1)
Sus scrofa (pig) : TLR1 (toll like receptor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38438,791,055 - 38,806,262 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37438,797,876 - 38,806,814 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36438,474,271 - 38,482,807 (-)NCBINCBI36hg18NCBI36
Build 34438,620,443 - 38,628,978NCBI
Cytogenetic Map4p14NCBI
HuRef438,122,243 - 38,130,779 (-)NCBIHuRef
CHM1_1438,797,457 - 38,805,993 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TLR1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1320607
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.