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Gene: TLR1 (toll like receptor 1) Homo sapiens
Symbol: TLR1
Name: toll like receptor 1
Description: Exhibits Toll-like receptor 2 binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in several processes, including positive regulation of interleukin-8 secretion; positive regulation of toll-like receptor 2 signaling pathway; and response to triacyl bacterial lipopeptide. Localizes to the Golgi apparatus; Toll-like receptor 1-Toll-like receptor 2 protein complex; and membrane raft. Implicated in several diseases, including IgA glomerulonephritis; aspergillosis; asthma; leprosy; and pyelonephritis. Biomarker of pulmonary tuberculosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD281; DKFZp547I0610; DKFZp564I0682; KIAA0012; MGC104956; MGC126311; MGC126312; rsc786; TIL; TIL. LPRS5; toll-like receptor 1; toll/interleukin-1 receptor-like protein
Mus musculus (house mouse) : Tlr1 (toll-like receptor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tlr1 (toll-like receptor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlr1 (toll like receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TLR1 (toll like receptor 1)
Canis lupus familiaris (dog) : TLR1 (toll like receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlr1 (toll like receptor 1)
Sus scrofa (pig) : TLR1 (toll like receptor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38438,791,055 - 38,806,262 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37438,797,876 - 38,806,814 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36438,474,271 - 38,482,807 (-)NCBINCBI36hg18NCBI36
Build 34438,620,443 - 38,628,978NCBI
Cytogenetic Map4p14NCBI
HuRef438,122,243 - 38,130,779 (-)NCBIHuRef
CHM1_1438,797,457 - 38,805,993 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TLR1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1320607
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.