TLR1 (toll like receptor 1) - Rat Genome Database

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Gene: TLR1 (toll like receptor 1) Pan paniscus
Analyze
Symbol: TLR1
Name: toll like receptor 1
RGD ID: 11864861
Description: ENCODES a protein that exhibits lipopeptide binding (ortholog); INVOLVED IN cellular response to triacyl bacterial lipopeptide (ortholog); defense response (ortholog); detection of triacyl bacterial lipopeptide (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH aspergillosis (ortholog); asthma (ortholog); Brain Injuries (ortholog); FOUND IN Golgi apparatus (inferred); membrane (inferred); membrane raft (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC103783955; toll-like receptor 1; uncharacterized LOC103783955
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2338,984,530 - 39,034,230 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1439,177,045 - 39,226,757 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0433,119,485 - 33,133,541 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1438,973,623 - 38,981,413 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl438,979,006 - 38,981,366 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:18810425   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TLR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2338,984,530 - 39,034,230 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1439,177,045 - 39,226,757 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0433,119,485 - 33,133,541 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1438,973,623 - 38,981,413 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl438,979,006 - 38,981,366 (-)Ensemblpanpan1.1panPan2
TLR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38438,787,569 - 38,805,644 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl438,787,555 - 38,856,817 (-)EnsemblGRCh38hg38GRCh38
GRCh37438,797,876 - 38,806,412 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36438,474,271 - 38,482,807 (-)NCBINCBI36Build 36hg18NCBI36
Build 34438,620,443 - 38,628,978NCBI
Cytogenetic Map4p14NCBI
HuRef438,122,243 - 38,130,779 (-)NCBIHuRef
CHM1_1438,797,457 - 38,805,993 (-)NCBICHM1_1
T2T-CHM13v2.0438,758,769 - 38,775,212 (-)NCBIT2T-CHM13v2.0
Tlr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39565,082,023 - 65,090,945 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl565,082,022 - 65,090,906 (-)EnsemblGRCm39 Ensembl
GRCm38564,924,680 - 64,933,600 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl564,924,679 - 64,933,563 (-)EnsemblGRCm38mm10GRCm38
MGSCv37565,316,073 - 65,323,938 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36565,203,969 - 65,211,834 (-)NCBIMGSCv36mm8
Celera562,197,667 - 62,205,494 (-)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map533.53NCBI
Tlr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81443,737,761 - 43,750,389 (+)NCBIGRCr8
mRatBN7.21443,384,127 - 43,396,765 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1443,384,932 - 43,397,125 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1443,753,982 - 43,756,546 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01445,053,936 - 45,056,500 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01443,534,102 - 43,536,666 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01445,062,662 - 45,065,014 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1445,062,662 - 45,081,991 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01444,871,931 - 44,874,283 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41446,114,913 - 46,124,820 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1442,538,240 - 42,540,804 (+)NCBICelera
Cytogenetic Map14p11NCBI
Tlr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554438,447,956 - 8,450,382 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554438,442,419 - 8,450,318 (+)NCBIChiLan1.0ChiLan1.0
TLR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1373,504,359 - 73,544,822 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl373,539,715 - 73,544,624 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha376,089,340 - 76,091,709 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0374,285,167 - 74,325,228 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl374,315,975 - 74,325,027 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1373,588,991 - 73,591,359 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0373,735,203 - 73,737,572 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0374,115,278 - 74,117,647 (+)NCBIUU_Cfam_GSD_1.0
Tlr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528539,707,097 - 39,715,850 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364826,582,584 - 6,584,971 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364826,582,430 - 6,591,128 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl830,147,624 - 30,155,466 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1830,147,600 - 30,155,454 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2831,627,675 - 31,660,825 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12711,482,307 - 11,490,847 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2711,488,294 - 11,490,654 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604757,897,098 - 57,911,767 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248407,287,781 - 7,290,162 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248407,287,772 - 7,349,282 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001279215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034958058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055111055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055111057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055111058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055111059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055111060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055111061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055111063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063603473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063603474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063603475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004670919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004670920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB445619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JARIFH020000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000020149   ⟹   ENSPPAP00000004374
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl438,979,006 - 38,981,366 (-)Ensembl
RefSeq Acc Id: NM_001279215   ⟹   NP_001266144
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2338,984,903 - 38,987,263 (-)NCBI
NHGRI_mPanPan1439,177,418 - 39,179,778 (-)NCBI
Mhudiblu_PPA_v0433,124,838 - 33,127,198 (-)NCBI
PanPan1.1438,979,006 - 38,981,366 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034958058   ⟹   XP_034813949
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2338,984,530 - 39,034,230 (-)NCBI
NHGRI_mPanPan1439,177,045 - 39,226,757 (-)NCBI
Mhudiblu_PPA_v0433,124,465 - 33,133,541 (-)NCBI
RefSeq Acc Id: XM_055111055   ⟹   XP_054967030
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2338,984,530 - 39,034,230 (-)NCBI
NHGRI_mPanPan1439,177,045 - 39,226,757 (-)NCBI
RefSeq Acc Id: XM_055111057   ⟹   XP_054967032
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2338,984,530 - 39,034,230 (-)NCBI
NHGRI_mPanPan1439,177,045 - 39,226,757 (-)NCBI
RefSeq Acc Id: XM_055111058   ⟹   XP_054967033
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2338,984,530 - 39,034,230 (-)NCBI
NHGRI_mPanPan1439,177,045 - 39,226,757 (-)NCBI
RefSeq Acc Id: XM_055111059   ⟹   XP_054967034
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2338,984,530 - 39,034,230 (-)NCBI
NHGRI_mPanPan1439,177,045 - 39,226,757 (-)NCBI
RefSeq Acc Id: XM_055111060   ⟹   XP_054967035
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2338,984,530 - 39,034,230 (-)NCBI
NHGRI_mPanPan1439,177,045 - 39,226,757 (-)NCBI
RefSeq Acc Id: XM_055111061   ⟹   XP_054967036
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2338,984,530 - 38,994,009 (-)NCBI
NHGRI_mPanPan1439,177,045 - 39,186,449 (-)NCBI
RefSeq Acc Id: XM_055111063   ⟹   XP_054967038
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2338,984,530 - 39,034,230 (-)NCBI
NHGRI_mPanPan1439,177,045 - 39,226,757 (-)NCBI
RefSeq Acc Id: XM_063603473   ⟹   XP_063459543
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2338,984,530 - 38,994,009 (-)NCBI
RefSeq Acc Id: XM_063603474   ⟹   XP_063459544
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2338,984,530 - 39,034,230 (-)NCBI
RefSeq Acc Id: XM_063603475   ⟹   XP_063459545
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2338,984,530 - 38,993,201 (-)NCBI
RefSeq Acc Id: NP_001266144   ⟸   NM_001279215
- Peptide Label: precursor
- UniProtKB: B3Y607 (UniProtKB/TrEMBL),   A0A2R8ZHB2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034813949   ⟸   XM_034958058
- Peptide Label: isoform X1
Ensembl Acc Id: ENSPPAP00000004374   ⟸   ENSPPAT00000020149
RefSeq Acc Id: XP_054967038   ⟸   XM_055111063
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054967034   ⟸   XM_055111059
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054967032   ⟸   XM_055111057
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054967030   ⟸   XM_055111055
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054967035   ⟸   XM_055111060
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054967033   ⟸   XM_055111058
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054967036   ⟸   XM_055111061
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063459544   ⟸   XM_063603474
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063459543   ⟸   XM_063603473
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063459545   ⟸   XM_063603475
- Peptide Label: isoform X1
Protein Domains
TIR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000018402 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000020149 ENTREZGENE
  ENSPPAT00000020149.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  TIR_dom UniProtKB/TrEMBL
  Toll-like_receptor UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100968591 UniProtKB/TrEMBL
NCBI Gene TLR1 ENTREZGENE
PANTHER PTHR24365 UniProtKB/TrEMBL
  PTHR24365:SF261 UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
PIRSF Toll-like_receptor UniProtKB/TrEMBL
PRINTS INTRLKN1R1F UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
SMART LRR_BAC UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  SSF52200 UniProtKB/TrEMBL
UniProt A0A2R8ZHB2 ENTREZGENE, UniProtKB/TrEMBL
  B3Y607 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-06-11 TLR1  toll like receptor 1  LOC103783955  uncharacterized LOC103783955  Data merged from RGD:11831318 737654 PROVISIONAL