Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of SEC14L2 mRNA] | CTD | PMID:31150632 | (R)-linalyl acetate | multiple interactions | ISO | SEC14L2 (Homo sapiens) | 6480464 | linalyl acetate inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] | CTD | PMID:31393563 | 1,8-cineole | multiple interactions | ISO | SEC14L2 (Homo sapiens) | 6480464 | Eucalyptol inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] | CTD | PMID:31393563 | 17beta-estradiol | multiple interactions | ISO | SEC14L2 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of SEC14L2 mRNA | CTD | PMID:30165855 | 17beta-estradiol | increases expression | ISO | SEC14L2 (Homo sapiens) | 6480464 | Estradiol results in increased expression of SEC14L2 mRNA | CTD | PMID:31614463 | 17beta-estradiol 3-benzoate | decreases methylation | EXP | | 6480464 | estradiol 3-benzoate results in decreased methylation of SEC14L2 promoter | CTD | PMID:27415467 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SEC14L2 mRNA | CTD | PMID:18796159 more ... | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Sec14l2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin affects the methylation of SEC14L2 intron] which results in increased expression of SEC14L2 mRNA | CTD | PMID:33017471 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Sec14l2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SEC14L2 mRNA | CTD | PMID:21570461 | 2-butoxyethanol | increases expression | ISO | Sec14l2 (Mus musculus) | 6480464 | n-butoxyethanol results in increased expression of SEC14L2 mRNA | CTD | PMID:19812364 | 2-ethoxyethanol | increases expression | EXP | | 6480464 | 2-ethoxyethanol results in increased expression of SEC14L2 mRNA | CTD | PMID:19643169 | 2-hydroxypropanoic acid | decreases expression | ISO | SEC14L2 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of SEC14L2 mRNA | CTD | PMID:30851411 | 2-methoxyethanol | increases expression | EXP | | 6480464 | methyl cellosolve results in increased expression of SEC14L2 mRNA | CTD | PMID:19643169 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Sec14l2 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of SEC14L2 mRNA | CTD | PMID:20188158 | 4,4'-sulfonyldiphenol | increases expression | ISO | Sec14l2 (Mus musculus) | 6480464 | bisphenol S results in increased expression of SEC14L2 mRNA | CTD | PMID:30951980 | 4-terpineol | multiple interactions | ISO | SEC14L2 (Homo sapiens) | 6480464 | terpinenol-4 inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] | CTD | PMID:31393563 | aflatoxin B1 | increases methylation | ISO | SEC14L2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of SEC14L2 intron | CTD | PMID:30157460 | all-trans-retinoic acid | increases expression | ISO | SEC14L2 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of SEC14L2 mRNA | CTD | PMID:33167477 | alpha-terpineol | multiple interactions | ISO | SEC14L2 (Homo sapiens) | 6480464 | alpha-terpineol inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] | CTD | PMID:31393563 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SEC14L2 mRNA | CTD | PMID:16483693 | aristolochic acid A | increases expression | ISO | SEC14L2 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of SEC14L2 mRNA | CTD | PMID:33212167 | benzo[a]pyrene | decreases expression | ISO | SEC14L2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of SEC14L2 mRNA | CTD | PMID:17879257 and PMID:20106945 | benzo[a]pyrene | increases methylation | ISO | SEC14L2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of SEC14L2 promoter | CTD | PMID:27901495 | bis(2-ethylhexyl) phthalate | increases expression | ISO | Sec14l2 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in increased expression of SEC14L2 mRNA | CTD | PMID:19850644 | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | Sec14l2 (Mus musculus) | 6480464 | PPARA protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of SEC14L2 mRNA] | CTD | PMID:19850644 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SEC14L2 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | Sec14l2 (Mus musculus) | 6480464 | bisphenol A results in increased expression of SEC14L2 mRNA | CTD | PMID:34585602 | bisphenol A | decreases expression | ISO | SEC14L2 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of SEC14L2 mRNA | CTD | PMID:29275510 | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of SEC14L2 mRNA | CTD | PMID:19167457 | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of SEC14L2 mRNA | CTD | PMID:33453195 | calcitriol | increases expression | ISO | SEC14L2 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of SEC14L2 mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | ISO | SEC14L2 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of SEC14L2 mRNA | CTD | PMID:21592394 | chlorpyrifos | increases expression | EXP | | 6480464 | Chlorpyrifos results in increased expression of SEC14L2 mRNA | CTD | PMID:18668222 | chlorpyrifos | decreases expression | ISO | Sec14l2 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of SEC14L2 mRNA | CTD | PMID:37019170 | chromium(6+) | affects expression | ISO | Sec14l2 (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of SEC14L2 mRNA | CTD | PMID:28472532 | cisplatin | multiple interactions | ISO | Sec14l2 (Mus musculus) | 6480464 | [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of SEC14L2 mRNA | CTD | PMID:23625948 | cisplatin | increases expression | ISO | SEC14L2 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of SEC14L2 mRNA | CTD | PMID:27392435 | clofibrate | multiple interactions | ISO | Sec14l2 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of SEC14L2 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SEC14L2 mRNA] | CTD | PMID:17585979 | clofibrate | increases expression | ISO | Sec14l2 (Mus musculus) | 6480464 | Clofibrate results in increased expression of SEC14L2 mRNA | CTD | PMID:17585979 | clofibric acid | affects expression | EXP | | 6480464 | Clofibric Acid affects the expression of SEC14L2 mRNA | CTD | PMID:17602206 | crocidolite asbestos | affects expression | ISO | SEC14L2 (Homo sapiens) | 6480464 | Asbestos and Crocidolite affects the expression of SEC14L2 mRNA | CTD | PMID:17331233 | cyclosporin A | decreases expression | ISO | SEC14L2 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of SEC14L2 mRNA | CTD | PMID:20106945 | cyclosporin A | decreases expression | ISO | Sec14l2 (Mus musculus) | 6480464 | Cyclosporine results in decreased expression of SEC14L2 mRNA | CTD | PMID:23308384 | dicrotophos | decreases expression | ISO | SEC14L2 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of SEC14L2 mRNA | CTD | PMID:28302478 | dorsomorphin | multiple interactions | ISO | SEC14L2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEC14L2 mRNA | CTD | PMID:27188386 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of SEC14L2 mRNA | CTD | PMID:29391264 | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of SEC14L2 mRNA | CTD | PMID:24136188 | flutamide | multiple interactions | ISO | SEC14L2 (Homo sapiens) | 6480464 | Flutamide inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] | CTD | PMID:31393563 | gamma-terpinene | multiple interactions | ISO | SEC14L2 (Homo sapiens) | 6480464 | gamma-terpinene inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] | CTD | PMID:31393563 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of SEC14L2 mRNA | CTD | PMID:33387578 | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of SEC14L2 mRNA | CTD | PMID:24136188 | inulin | multiple interactions | ISO | Sec14l2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of SEC14L2 mRNA | CTD | PMID:36331819 | ivermectin | decreases expression | ISO | SEC14L2 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of SEC14L2 protein | CTD | PMID:32959892 | limonene | multiple interactions | ISO | SEC14L2 (Homo sapiens) | 6480464 | Limonene inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] | CTD | PMID:31393563 | linalool | multiple interactions | ISO | SEC14L2 (Homo sapiens) | 6480464 | linalool inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] | CTD | PMID:31393563 | linalyl acetate | multiple interactions | ISO | SEC14L2 (Homo sapiens) | 6480464 | linalyl acetate inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] | CTD | PMID:31393563 | methyl methanesulfonate | increases expression | ISO | SEC14L2 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of SEC14L2 mRNA | CTD | PMID:23649840 | N-nitrosodiethylamine | decreases expression | EXP | | 6480464 | Diethylnitrosamine results in decreased expression of SEC14L2 mRNA | CTD | PMID:19638242 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of SEC14L2 mRNA | CTD | PMID:25729387 | oxaliplatin | decreases expression | EXP | | 6480464 | oxaliplatin results in decreased expression of SEC14L2 mRNA | CTD | PMID:25729387 | paracetamol | multiple interactions | ISO | Sec14l2 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of SEC14L2 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SEC14L2 mRNA] | CTD | PMID:17585979 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of SEC14L2 mRNA | CTD | PMID:33387578 | paracetamol | increases secretion | ISO | Sec14l2 (Mus musculus) | 6480464 | Acetaminophen results in increased secretion of SEC14L2 protein | CTD | PMID:24038040 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of SEC14L2 mRNA | CTD | PMID:32479839 | paracetamol | affects expression | ISO | Sec14l2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of SEC14L2 mRNA | CTD | PMID:17562736 | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of SEC14L2 mRNA | CTD | PMID:32680482 | perfluorononanoic acid | decreases expression | ISO | SEC14L2 (Homo sapiens) | 6480464 | perfluoro-n-nonanoic acid results in decreased expression of SEC14L2 mRNA | CTD | PMID:32588087 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Sec14l2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of SEC14L2 mRNA | CTD | PMID:36331819 | perfluorooctanoic acid | increases expression | EXP | | 6480464 | perfluorooctanoic acid results in increased expression of SEC14L2 protein | CTD | PMID:34958885 | pirinixic acid | decreases expression | ISO | Sec14l2 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of SEC14L2 mRNA | CTD | PMID:18445702 | pirinixic acid | increases expression | ISO | Sec14l2 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of SEC14L2 mRNA | CTD | PMID:17426115 and PMID:18301758 | pirinixic acid | multiple interactions | ISO | SEC14L2 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SEC14L2 mRNA | CTD | PMID:19710929 | potassium chromate | decreases expression | ISO | SEC14L2 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of SEC14L2 mRNA | CTD | PMID:22714537 | pregnenolone 16alpha-carbonitrile | decreases expression | ISO | Sec14l2 (Mus musculus) | 6480464 | Pregnenolone Carbonitrile results in decreased expression of SEC14L2 mRNA | CTD | PMID:28903501 | progesterone | increases expression | ISO | SEC14L2 (Homo sapiens) | 6480464 | Progesterone results in increased expression of SEC14L2 mRNA | CTD | PMID:21795739 | rac-lactic acid | decreases expression | ISO | SEC14L2 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of SEC14L2 mRNA | CTD | PMID:30851411 | rotenone | increases expression | EXP | | 6480464 | Rotenone results in increased expression of SEC14L2 mRNA | CTD | PMID:28374803 | SB 431542 | multiple interactions | ISO | SEC14L2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEC14L2 mRNA | CTD | PMID:27188386 | SB 431542 | multiple interactions | ISO | Sec14l2 (Mus musculus) | 6480464 | 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB1 protein results in increased expression of SEC14L2 mRNA] | CTD | PMID:16872693 | Soman | decreases expression | EXP | | 6480464 | Soman results in decreased expression of SEC14L2 mRNA | CTD | PMID:19281266 | sotorasib | multiple interactions | ISO | SEC14L2 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SEC14L2 mRNA | CTD | PMID:36139627 | tea tree oil | multiple interactions | ISO | SEC14L2 (Homo sapiens) | 6480464 | Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] | CTD | PMID:31393563 | terbufos | affects response to substance | ISO | SEC14L2 (Homo sapiens) | 6480464 | SEC14L2 gene SNP affects the susceptibility to terbufos | CTD | PMID:22919386 | testosterone | multiple interactions | ISO | SEC14L2 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of SEC14L2 mRNA more ... | CTD | PMID:21592394 and PMID:31393563 | testosterone | increases expression | ISO | SEC14L2 (Homo sapiens) | 6480464 | Testosterone results in increased expression of SEC14L2 mRNA | CTD | PMID:21592394 and PMID:31393563 | tetrachloromethane | decreases expression | ISO | Sec14l2 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of SEC14L2 mRNA | CTD | PMID:27339419 more ... | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of SEC14L2 mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of SEC14L2 mRNA] | CTD | PMID:31150632 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of SEC14L2 mRNA | CTD | PMID:23411599 and PMID:34492290 | topotecan | decreases expression | EXP | | 6480464 | Topotecan results in decreased expression of SEC14L2 mRNA | CTD | PMID:25729387 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of SEC14L2 mRNA | CTD | PMID:25729387 | trametinib | multiple interactions | ISO | SEC14L2 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SEC14L2 mRNA | CTD | PMID:36139627 | valproic acid | increases expression | ISO | SEC14L2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of SEC14L2 mRNA | CTD | PMID:23179753 | valproic acid | multiple interactions | ISO | SEC14L2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEC14L2 mRNA | CTD | PMID:27188386 | valproic acid | decreases expression | ISO | SEC14L2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of SEC14L2 mRNA | CTD | PMID:26272509 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of SEC14L2 mRNA | CTD | PMID:19015723 | |