SEC14L2 (SEC14 like lipid binding 2) - Rat Genome Database
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Gene: SEC14L2 (SEC14 like lipid binding 2) Homo sapiens
Analyze
Symbol: SEC14L2
Name: SEC14 like lipid binding 2
RGD ID: 736725
HGNC Page HGNC
Description: Localizes to cytosol and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha-tocopherol-associated protein; C22orf6; hTAP; KIAA1186; KIAA1658; MGC65053; sec14 (s. cerevisiae)-like 2; SEC14-like lipid binding 2; SEC14-like protein 2; SPF; squalene transfer protein; supernatant protein factor; TAP; TAP1; tocopherol-associated protein; tocopherol-associated protein 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2230,396,941 - 30,425,303 (+)EnsemblGRCh38hg38GRCh38
GRCh382230,397,018 - 30,425,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372230,792,930 - 30,821,291 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,122,933 - 29,149,828 (+)NCBINCBI36hg18NCBI36
Build 342229,117,486 - 29,144,382NCBI
Celera2214,592,619 - 14,620,968 (+)NCBI
Cytogenetic Map22q12.2NCBI
HuRef2213,754,252 - 13,782,494 (+)NCBIHuRef
CHM1_12230,752,095 - 30,780,850 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. GOA_HUMAN data from the GO Consortium
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7364757   PMID:8125298   PMID:8889548   PMID:9036970   PMID:9847074   PMID:10574461   PMID:10591208   PMID:10829015   PMID:11226224   PMID:11258795   PMID:11444841   PMID:12429094  
PMID:12454003   PMID:12477932   PMID:12757856   PMID:12972248   PMID:14702039   PMID:15033454   PMID:15461802   PMID:15790807   PMID:15998911   PMID:16267002   PMID:17334589   PMID:17428729  
PMID:18676680   PMID:19170196   PMID:19190344   PMID:19305383   PMID:19625176   PMID:19692168   PMID:19909011   PMID:22747683   PMID:23401652   PMID:23411208   PMID:23533145   PMID:24983950  
PMID:25290554   PMID:26266980   PMID:26760575   PMID:28463110   PMID:28514442   PMID:28986522   PMID:30472319   PMID:31851620  


Genomics

Comparative Map Data
SEC14L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2230,396,941 - 30,425,303 (+)EnsemblGRCh38hg38GRCh38
GRCh382230,397,018 - 30,425,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372230,792,930 - 30,821,291 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,122,933 - 29,149,828 (+)NCBINCBI36hg18NCBI36
Build 342229,117,486 - 29,144,382NCBI
Celera2214,592,619 - 14,620,968 (+)NCBI
Cytogenetic Map22q12.2NCBI
HuRef2213,754,252 - 13,782,494 (+)NCBIHuRef
CHM1_12230,752,095 - 30,780,850 (+)NCBICHM1_1
Sec14l2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,047,039 - 4,068,729 (-)NCBIGRCm39mm39
GRCm38114,097,039 - 4,118,729 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,097,039 - 4,123,415 (-)EnsemblGRCm38mm10GRCm38
MGSCv37113,997,042 - 4,018,732 (-)NCBIGRCm37mm9NCBIm37
MGSCv36113,997,042 - 4,018,732 (-)NCBImm8
Celera114,592,969 - 4,615,073 (-)NCBICelera
Cytogenetic Map11A1NCBI
Sec14l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01484,335,594 - 84,360,354 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,335,597 - 84,355,528 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,017,259 - 85,041,827 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,728,484 - 84,748,418 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11484,747,628 - 84,767,563 (-)NCBI
Celera1477,884,808 - 77,904,737 (-)NCBICelera
Cytogenetic Map14q21NCBI
Sec14l2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554554,636,709 - 4,660,058 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554554,637,062 - 4,660,064 (+)NCBIChiLan1.0ChiLan1.0
SEC14L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12229,234,162 - 29,261,937 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2229,234,162 - 29,261,937 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02211,432,608 - 11,460,973 (+)NCBIMhudiblu_PPA_v0panPan3
LOC477539
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12623,542,555 - 23,563,579 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Sec14l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936904254,979 - 276,267 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SEC14L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11447,369,663 - 47,391,335 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21450,454,593 - 50,475,848 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SEC14L2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11913,276,712 - 13,302,737 (+)NCBI
ChlSab1.1 Ensembl1913,276,913 - 13,305,003 (+)Ensembl
Sec14l2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247476,719,549 - 6,742,794 (+)NCBI

Position Markers
D22S1023E.1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372230,818,433 - 30,818,553UniSTSGRCh37
Build 362229,148,433 - 29,148,553RGDNCBI36
Celera2214,618,122 - 14,618,242RGD
Cytogenetic Map22q12.2UniSTS
HuRef2213,779,635 - 13,779,755UniSTS
SHGC-58605  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372230,814,220 - 30,814,341UniSTSGRCh37
Build 362229,144,220 - 29,144,341RGDNCBI36
Celera2214,613,909 - 14,614,030RGD
Cytogenetic Map22q12.2UniSTS
HuRef2213,775,424 - 13,775,545UniSTS
A004Y09  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372230,820,355 - 30,820,513UniSTSGRCh37
Build 362229,150,355 - 29,150,513RGDNCBI36
Celera2214,620,045 - 14,620,203RGD
Cytogenetic Map22q12.2UniSTS
Cytogenetic Map22qUniSTS
HuRef2213,781,558 - 13,781,716UniSTS
GeneMap99-GB4 RH Map2285.97UniSTS
Whitehead-RH Map2287.2UniSTS
NCBI RH Map22129.6UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5217
Count of miRNA genes:1194
Interacting mature miRNAs:1526
Transcripts:ENST00000312932, ENST00000402592, ENST00000403484, ENST00000405717, ENST00000415072, ENST00000416523, ENST00000428195, ENST00000429917, ENST00000437022, ENST00000452649, ENST00000459728, ENST00000464335, ENST00000467218, ENST00000478762, ENST00000483116, ENST00000484486, ENST00000485482
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 86 92 685 430 32 396 348 27 2461 42 359 259 45 1 10 189
Low 2341 2301 1034 193 1554 68 3511 1356 1269 375 1095 1351 130 1187 2107 4 2
Below cutoff 12 596 7 1 353 1 497 811 4 2 3 2 7 492

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001204204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001291932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_033382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA610131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB033012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC004832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK056163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK091402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK092576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL096881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY203959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY927430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY927434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY927435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY927436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY927437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY927438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY927439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY927441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM680990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU734336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC375707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF511442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000402592   ⟹   ENSP00000383882
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2230,397,045 - 30,422,601 (+)Ensembl
RefSeq Acc Id: ENST00000405717   ⟹   ENSP00000385186
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2230,397,037 - 30,416,975 (+)Ensembl
RefSeq Acc Id: ENST00000415072   ⟹   ENSP00000399596
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2230,398,577 - 30,407,477 (+)Ensembl
RefSeq Acc Id: ENST00000416523
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2230,397,018 - 30,409,136 (+)Ensembl
RefSeq Acc Id: ENST00000428195   ⟹   ENSP00000387781
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2230,396,941 - 30,415,865 (+)Ensembl
RefSeq Acc Id: ENST00000429917   ⟹   ENSP00000407857
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2230,397,538 - 30,407,542 (+)Ensembl
RefSeq Acc Id: ENST00000437022   ⟹   ENSP00000388719
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2230,397,018 - 30,409,249 (+)Ensembl
RefSeq Acc Id: ENST00000452649   ⟹   ENSP00000388888
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2230,397,018 - 30,409,477 (+)Ensembl
RefSeq Acc Id: ENST00000459728
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2230,397,051 - 30,409,282 (+)Ensembl
RefSeq Acc Id: ENST00000464335
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2230,399,684 - 30,416,673 (+)Ensembl
RefSeq Acc Id: ENST00000483116
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2230,409,022 - 30,416,007 (+)Ensembl
RefSeq Acc Id: ENST00000484486
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2230,399,684 - 30,400,467 (+)Ensembl
RefSeq Acc Id: ENST00000485482
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2230,399,684 - 30,400,467 (+)Ensembl
RefSeq Acc Id: ENST00000615189   ⟹   ENSP00000478755
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2230,397,018 - 30,425,303 (+)Ensembl
RefSeq Acc Id: ENST00000617837   ⟹   ENSP00000482467
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2230,396,992 - 30,423,838 (+)Ensembl
RefSeq Acc Id: ENST00000619483
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2230,396,995 - 30,423,840 (+)Ensembl
RefSeq Acc Id: ENST00000620251
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2230,409,115 - 30,423,838 (+)Ensembl
RefSeq Acc Id: NM_001204204   ⟹   NP_001191133
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382230,397,018 - 30,425,303 (+)NCBI
GRCh372230,792,930 - 30,821,291 (+)ENTREZGENE
HuRef2213,754,252 - 13,782,494 (+)ENTREZGENE
CHM1_12230,752,095 - 30,780,850 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001291932   ⟹   NP_001278861
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382230,397,018 - 30,425,303 (+)NCBI
CHM1_12230,752,095 - 30,780,850 (+)NCBI
Sequence:
RefSeq Acc Id: NM_012429   ⟹   NP_036561
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382230,397,018 - 30,425,303 (+)NCBI
GRCh372230,792,930 - 30,821,291 (+)ENTREZGENE
Build 362229,122,933 - 29,149,828 (+)NCBI Archive
HuRef2213,754,252 - 13,782,494 (+)ENTREZGENE
CHM1_12230,752,095 - 30,780,850 (+)NCBI
Sequence:
RefSeq Acc Id: NM_033382   ⟹   NP_203740
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382230,397,018 - 30,416,975 (+)NCBI
GRCh372230,792,930 - 30,821,291 (+)ENTREZGENE
HuRef2213,754,252 - 13,782,494 (+)ENTREZGENE
CHM1_12230,752,095 - 30,772,522 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036561   ⟸   NM_012429
- Peptide Label: isoform 1
- UniProtKB: O76054 (UniProtKB/Swiss-Prot),   A0A024R1I5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001191133   ⟸   NM_001204204
- Peptide Label: isoform 3
- UniProtKB: O76054 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_203740   ⟸   NM_033382
- Peptide Label: isoform 2
- UniProtKB: O76054 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001278861   ⟸   NM_001291932
- Peptide Label: isoform 4
- UniProtKB: B7Z3Z8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000388888   ⟸   ENST00000452649
RefSeq Acc Id: ENSP00000387781   ⟸   ENST00000428195
RefSeq Acc Id: ENSP00000407857   ⟸   ENST00000429917
RefSeq Acc Id: ENSP00000399596   ⟸   ENST00000415072
RefSeq Acc Id: ENSP00000383882   ⟸   ENST00000402592
RefSeq Acc Id: ENSP00000478755   ⟸   ENST00000615189
RefSeq Acc Id: ENSP00000385186   ⟸   ENST00000405717
RefSeq Acc Id: ENSP00000482467   ⟸   ENST00000617837
RefSeq Acc Id: ENSP00000388719   ⟸   ENST00000437022
Protein Domains
CRAL-TRIO   CRAL_TRIO_N   GOLD

Promoters
RGD ID:6800362
Promoter ID:HG_KWN:42315
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:ENST00000405717,   OTTHUMT00000321018,   OTTHUMT00000321019,   OTTHUMT00000321120,   OTTHUMT00000321121,   OTTHUMT00000321122,   OTTHUMT00000321123,   OTTHUMT00000321124,   OTTHUMT00000321125,   OTTHUMT00000321180,   UC003AHS.1
Position:
Human AssemblyChrPosition (strand)Source
Build 362229,122,951 - 29,123,752 (+)MPROMDB
RGD ID:6800343
Promoter ID:HG_KWN:42316
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid
Transcripts:OTTHUMT00000321163
Position:
Human AssemblyChrPosition (strand)Source
Build 362229,123,876 - 29,124,652 (+)MPROMDB
RGD ID:6800342
Promoter ID:HG_KWN:42317
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:OTTHUMT00000321022,   OTTHUMT00000321023,   OTTHUMT00000321119
Position:
Human AssemblyChrPosition (strand)Source
Build 362229,124,896 - 29,126,077 (+)MPROMDB
RGD ID:6800405
Promoter ID:HG_KWN:42318
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:OTTHUMT00000321118,   OTTHUMT00000321164,   OTTHUMT00000321181,   OTTHUMT00000321182,   UC003AHT.1,   UC003AHU.2,   UC003AHV.1,   UC010GVV.1,   UC010GVW.1,   UC010GVX.1,   UC010GVY.1
Position:
Human AssemblyChrPosition (strand)Source
Build 362229,134,531 - 29,135,031 (+)MPROMDB
RGD ID:13603694
Promoter ID:EPDNEW_H28031
Type:initiation region
Name:SEC14L2_1
Description:SEC14 like lipid binding 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H28032  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382230,397,018 - 30,397,078EPDNEW
RGD ID:13603696
Promoter ID:EPDNEW_H28032
Type:initiation region
Name:SEC14L2_2
Description:SEC14 like lipid binding 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H28031  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382230,409,234 - 30,409,294EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 22q11.21-12.3(chr22:18178957-31821193)x3 copy number gain See cases [RCV000050768] Chr22:18178957..31821193 [GRCh38]
Chr22:18661724..32217179 [GRCh37]
Chr22:17041724..30547179 [NCBI36]
Chr22:22q11.21-12.3
pathogenic
GRCh38/hg38 22q12.1-12.3(chr22:26979579-33992220)x3 copy number gain See cases [RCV000050553] Chr22:26979579..33992220 [GRCh38]
Chr22:27375542..34388209 [GRCh37]
Chr22:25705542..32718209 [NCBI36]
Chr22:22q12.1-12.3
pathogenic
GRCh38/hg38 22q12.1-12.2(chr22:28278805-31742328)x1 copy number loss See cases [RCV000052870] Chr22:28278805..31742328 [GRCh38]
Chr22:28674793..32138314 [GRCh37]
Chr22:27004793..30468314 [NCBI36]
Chr22:22q12.1-12.2
pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916608-50739836)x3 copy number gain See cases [RCV000133646] Chr22:16916608..50739836 [GRCh38]
Chr22:17397498..51178264 [GRCh37]
Chr22:15777498..49525130 [NCBI36]
Chr22:22q11.1-13.33
pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916743-50739785)x3 copy number gain See cases [RCV000134730] Chr22:16916743..50739785 [GRCh38]
Chr22:17397633..51178213 [GRCh37]
Chr22:15777633..49525079 [NCBI36]
Chr22:22q11.1-13.33
pathogenic
GRCh38/hg38 22q11.23-12.3(chr22:23279231-36247369)x3 copy number gain See cases [RCV000138172] Chr22:23279231..36247369 [GRCh38]
Chr22:23621418..36643415 [GRCh37]
Chr22:21951418..34973361 [NCBI36]
Chr22:22q11.23-12.3
pathogenic
GRCh38/hg38 22q11.21-12.3(chr22:20907226-37187347)x3 copy number gain See cases [RCV000137926] Chr22:20907226..37187347 [GRCh38]
Chr22:21261514..37583387 [GRCh37]
Chr22:19591514..35913333 [NCBI36]
Chr22:22q11.21-12.3
pathogenic
GRCh38/hg38 22q12.2(chr22:30312256-30950316)x3 copy number gain See cases [RCV000138556] Chr22:30312256..30950316 [GRCh38]
Chr22:30708245..31346302 [GRCh37]
Chr22:29038245..29676302 [NCBI36]
Chr22:22q12.2
uncertain significance
GRCh38/hg38 22q12.1-12.2(chr22:26451042-31451926)x1 copy number loss See cases [RCV000143415] Chr22:26451042..31451926 [GRCh38]
Chr22:26847008..31847912 [GRCh37]
Chr22:25177008..30177912 [NCBI36]
Chr22:22q12.1-12.2
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237518)x3 copy number gain See cases [RCV000240091] Chr22:16054691..51237518 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51220902)x3 copy number gain See cases [RCV000446956] Chr22:16054691..51220902 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q12.1-12.2(chr22:29537064-30994320)x3 copy number gain See cases [RCV000448504] Chr22:29537064..30994320 [GRCh37]
Chr22:22q12.1-12.2
uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237463)x3 copy number gain See cases [RCV000448847] Chr22:16054691..51237463 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q12.2(chr22:30323089-31092425)x3 copy number gain See cases [RCV000448760] Chr22:30323089..31092425 [GRCh37]
Chr22:22q12.2
uncertain significance
GRCh37/hg19 22q12.1-12.3(chr22:28349854-33013062)x3 copy number gain See cases [RCV000510523] Chr22:28349854..33013062 [GRCh37]
Chr22:22q12.1-12.3
likely pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838) copy number gain See cases [RCV000510873] Chr22:16888900..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.23-12.3(chr22:23637907-36614412)x3 copy number gain See cases [RCV000511098] Chr22:23637907..36614412 [GRCh37]
Chr22:22q11.23-12.3
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838)x3 copy number gain See cases [RCV000512333] Chr22:16888900..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q12.2(chr22:29644625-31051719)x1 copy number loss not provided [RCV000684497] Chr22:29644625..31051719 [GRCh37]
Chr22:22q12.2
pathogenic
GRCh37/hg19 22q11.22-12.3(chr22:22460754-35198232)x3 copy number gain not provided [RCV000684530] Chr22:22460754..35198232 [GRCh37]
Chr22:22q11.22-12.3
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054667-51243435)x3 copy number gain not provided [RCV000741689] Chr22:16054667..51243435 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51195728)x3 copy number gain not provided [RCV000741691] Chr22:16114244..51195728 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51211392)x3 copy number gain not provided [RCV000741692] Chr22:16114244..51211392 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
NM_012429.5(SEC14L2):c.519+10A>T single nucleotide variant not provided [RCV000939103] Chr22:30409292 [GRCh38]
Chr22:30805281 [GRCh37]
Chr22:22q12.2
likely benign
inv(22)(q12.2q12.2) inversion Anaplastic ependymoma [RCV000785873] Chr22:29684716..31740655 [GRCh37]
Chr22:22q12.2
likely pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888899-51197838)x3 copy number gain not provided [RCV000846344] Chr22:16888899..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
NM_012429.5(SEC14L2):c.410A>G (p.His137Arg) single nucleotide variant not provided [RCV000974330] Chr22:30407590 [GRCh38]
Chr22:30803579 [GRCh37]
Chr22:22q12.2
benign
GRCh37/hg19 22q12.2-13.33(chr22:30654764-51197838)x3 copy number gain not provided [RCV001007181] Chr22:30654764..51197838 [GRCh37]
Chr22:22q12.2-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16197005-51224252)x3 copy number gain See cases [RCV001263056] Chr22:16197005..51224252 [GRCh37]
Chr22:22q11.1-13.33
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10699 AgrOrtholog
COSMIC SEC14L2 COSMIC
Ensembl Genes ENSG00000100003 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000383882 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000385186 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000387781 UniProtKB/TrEMBL
  ENSP00000388719 UniProtKB/TrEMBL
  ENSP00000388888 UniProtKB/TrEMBL
  ENSP00000399596 UniProtKB/TrEMBL
  ENSP00000407857 UniProtKB/TrEMBL
  ENSP00000478755 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000482467 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENST00000402592 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000405717 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000415072 UniProtKB/TrEMBL
  ENST00000428195 UniProtKB/TrEMBL
  ENST00000429917 UniProtKB/TrEMBL
  ENST00000437022 UniProtKB/TrEMBL
  ENST00000452649 UniProtKB/TrEMBL
  ENST00000615189 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000617837 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.40.525.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000100003 GTEx
HGNC ID HGNC:10699 ENTREZGENE
Human Proteome Map SEC14L2 Human Proteome Map
InterPro CRAL-TRIO_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRAL-TRIO_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRAL/TRIO_N_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRAL/TRIO_N_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GOLD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GOLD_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:23541 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 23541 ENTREZGENE
OMIM 607558 OMIM
Pfam CRAL_TRIO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRAL_TRIO_N UniProtKB/TrEMBL
PharmGKB PA35622 PharmGKB
PROSITE CRAL_TRIO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GOLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CRAL_TRIO_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEC14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF101576 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF46938 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52087 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R1I5 ENTREZGENE, UniProtKB/TrEMBL
  B3KRD8_HUMAN UniProtKB/TrEMBL
  B7Z3Z8 ENTREZGENE, UniProtKB/TrEMBL
  C9JTM4_HUMAN UniProtKB/TrEMBL
  C9JYY7_HUMAN UniProtKB/TrEMBL
  C9JZI9_HUMAN UniProtKB/TrEMBL
  F8WED8_HUMAN UniProtKB/TrEMBL
  F8WEE7_HUMAN UniProtKB/TrEMBL
  O76054 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B7Z8Q1 UniProtKB/Swiss-Prot
  F5H3U4 UniProtKB/Swiss-Prot
  Q53EQ2 UniProtKB/Swiss-Prot
  Q6PD61 UniProtKB/Swiss-Prot
  Q9ULN4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 SEC14L2  SEC14 like lipid binding 2  SEC14L2  SEC14-like lipid binding 2  Symbol and/or name change 5135510 APPROVED
2015-07-28 SEC14L2  SEC14-like lipid binding 2  SEC14L2  SEC14-like 2 (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED