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Gene: TLR5 (toll like receptor 5) Homo sapiens
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Symbol: TLR5
Name: toll like receptor 5
Description: Exhibits interleukin-1 receptor binding activity. Involved in cellular response to mechanical stimulus; positive regulation of interleukin-8 production; and positive regulation of toll-like receptor signaling pathway. Predicted to localize to the integral component of plasma membrane. Implicated in Legionnaires' disease; cystic fibrosis; cystitis; melioidosis; and systemic lupus erythematosus. Biomarker of ankylosing spondylitis; chronic granulomatous disease; cystic fibrosis; and melioidosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ10052; MELIOS; MGC126430; MGC126431; SLE1; SLEB1; systemic lupus erythematosus susceptibility 1; TIL3; toll-like receptor 5; toll/interleukin-1 receptor-like protein 3
Orthologs:
Mus musculus (house mouse) : Tlr5 (toll-like receptor 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tlr5 (toll-like receptor 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlr5 (toll like receptor 5)
Pan paniscus (bonobo/pygmy chimpanzee) : TLR5 (toll like receptor 5)
Canis lupus familiaris (dog) : TLR5 (toll like receptor 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlr5 (toll like receptor 5)
Sus scrofa (pig) : TLR5 (toll like receptor 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381223,108,401 - 223,143,281 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371223,282,748 - 223,316,624 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361221,350,207 - 221,383,247 (-)NCBINCBI36hg18NCBI36
Celera1196,502,104 - 196,535,977 (-)NCBI
Cytogenetic Map1q41NCBI
HuRef1193,957,238 - 193,991,230 (-)NCBIHuRef
CHM1_11224,555,804 - 224,589,771 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TLR5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1348706
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.