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Gene: TLR5 (toll like receptor 5) Homo sapiens
Symbol: TLR5
Name: toll like receptor 5
Description: Exhibits interleukin-1 receptor binding activity. Involved in cellular response to mechanical stimulus; positive regulation of interleukin-8 production; and positive regulation of toll-like receptor signaling pathway. Predicted to localize to the integral component of plasma membrane. Implicated in Legionnaires' disease; cystic fibrosis; cystitis; melioidosis; and systemic lupus erythematosus. Biomarker of ankylosing spondylitis; chronic granulomatous disease; cystic fibrosis; and melioidosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ10052; MELIOS; MGC126430; MGC126431; SLE1; SLEB1; systemic lupus erythematosus susceptibility 1; TIL3; toll-like receptor 5; toll/interleukin-1 receptor-like protein 3
Mus musculus (house mouse) : Tlr5 (toll-like receptor 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tlr5 (toll-like receptor 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlr5 (toll like receptor 5)
Pan paniscus (bonobo/pygmy chimpanzee) : TLR5 (toll like receptor 5)
Canis lupus familiaris (dog) : TLR5 (toll like receptor 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlr5 (toll like receptor 5)
Sus scrofa (pig) : TLR5 (toll like receptor 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381223,108,401 - 223,143,281 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371223,282,748 - 223,316,624 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361221,350,207 - 221,383,247 (-)NCBINCBI36hg18NCBI36
Celera1196,502,104 - 196,535,977 (-)NCBI
Cytogenetic Map1q41NCBI
HuRef1193,957,238 - 193,991,230 (-)NCBIHuRef
CHM1_11224,555,804 - 224,589,771 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TLR5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1348706
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.