Sec14l2 (SEC14-like lipid binding 2) - Rat Genome Database

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Gene: Sec14l2 (SEC14-like lipid binding 2) Mus musculus
Analyze
Symbol: Sec14l2
Name: SEC14-like lipid binding 2
RGD ID: 736726
MGI Page MGI
Description: Predicted to enable enzyme activator activity and transferase activity, transferring alkyl or aryl (other than methyl) groups. Predicted to be involved in positive regulation of cholesterol biosynthetic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in 1st branchial arch maxillary component; nasal pit; otocyst; and trunk somite. Orthologous to human SEC14L2 (SEC14 like lipid binding 2).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1300013M05Rik; alpha-tocopherol-associated protein; S; SEC14-like 2; SEC14-like protein 2; Spf; t; TAP
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,047,039 - 4,068,729 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl114,047,039 - 4,073,415 (-)EnsemblGRCm39 Ensembl
GRCm38114,097,039 - 4,118,729 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,097,039 - 4,123,415 (-)EnsemblGRCm38mm10GRCm38
MGSCv37113,997,042 - 4,018,732 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36113,997,042 - 4,018,732 (-)NCBIMGSCv36mm8
Celera114,592,969 - 4,615,073 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.87NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(R)-linalyl acetate  (ISO)
1,8-cineole  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (EXP)
2-ethoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-terpineol  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-terpineol  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clofibric acid  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
flutamide  (ISO)
gamma-terpinene  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
inulin  (EXP)
ivermectin  (ISO)
limonene  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
rac-lactic acid  (ISO)
rotenone  (ISO)
SB 431542  (EXP,ISO)
Soman  (ISO)
sotorasib  (ISO)
tea tree oil  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
topotecan  (ISO)
trametinib  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (IBA,ISO)
nucleoplasm  (ISO)
nucleus  (IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7364757   PMID:10349636   PMID:10829015   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11226224   PMID:11444841   PMID:12477932   PMID:14610273   PMID:15489334   PMID:16141072  
PMID:16141073   PMID:17077281   PMID:20059953   PMID:21267068   PMID:21677750   PMID:21873635   PMID:32325033   PMID:38187761  


Genomics

Comparative Map Data
Sec14l2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,047,039 - 4,068,729 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl114,047,039 - 4,073,415 (-)EnsemblGRCm39 Ensembl
GRCm38114,097,039 - 4,118,729 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,097,039 - 4,123,415 (-)EnsemblGRCm38mm10GRCm38
MGSCv37113,997,042 - 4,018,732 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36113,997,042 - 4,018,732 (-)NCBIMGSCv36mm8
Celera114,592,969 - 4,615,073 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.87NCBI
SEC14L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382230,397,018 - 30,425,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2230,396,941 - 30,425,303 (+)EnsemblGRCh38hg38GRCh38
GRCh372230,793,007 - 30,821,291 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,122,933 - 29,149,828 (+)NCBINCBI36Build 36hg18NCBI36
Build 342229,117,486 - 29,144,382NCBI
Celera2214,592,619 - 14,620,968 (+)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2213,754,252 - 13,782,494 (+)NCBIHuRef
CHM1_12230,752,095 - 30,780,850 (+)NCBICHM1_1
T2T-CHM13v2.02230,860,348 - 30,888,644 (+)NCBIT2T-CHM13v2.0
Sec14l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81483,197,384 - 83,222,059 (-)NCBIGRCr8
mRatBN7.21478,973,805 - 78,998,480 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1478,973,808 - 78,993,788 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1483,414,439 - 83,434,399 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01484,654,518 - 84,674,478 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01481,100,444 - 81,120,373 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01484,335,594 - 84,360,354 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,335,597 - 84,355,528 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,017,259 - 85,041,827 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,728,484 - 84,748,418 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11484,747,628 - 84,767,563 (-)NCBI
Celera1477,884,808 - 77,904,737 (-)NCBICelera
Cytogenetic Map14q21NCBI
Sec14l2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554554,636,709 - 4,660,058 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554554,637,062 - 4,660,064 (+)NCBIChiLan1.0ChiLan1.0
SEC14L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22340,363,958 - 40,390,569 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12243,062,594 - 43,090,650 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02211,432,608 - 11,460,973 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12229,234,162 - 29,261,937 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2229,234,162 - 29,261,937 (+)Ensemblpanpan1.1panPan2
LOC477539
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12623,542,555 - 23,563,579 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,413,626 - 23,433,383 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02623,926,643 - 23,946,387 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2623,926,486 - 23,946,800 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12623,628,117 - 23,647,869 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02623,890,926 - 23,910,663 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02623,951,320 - 23,971,099 (+)NCBIUU_Cfam_GSD_1.0
Sec14l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118116,457,964 - 116,479,252 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936904253,436 - 276,897 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936904254,979 - 276,267 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SEC14L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,370,055 - 47,392,499 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,369,663 - 47,391,335 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21450,454,593 - 50,475,848 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SEC14L2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11913,276,712 - 13,302,737 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1913,276,913 - 13,305,003 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045112,841,789 - 112,869,976 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sec14l2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247476,719,498 - 6,742,794 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247476,719,549 - 6,742,794 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sec14l2
582 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1329
Count of miRNA genes:591
Interacting mature miRNAs:734
Transcripts:ENSMUST00000003681, ENSMUST00000123901, ENSMUST00000132421, ENSMUST00000133631, ENSMUST00000136420, ENSMUST00000145173
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
27095914Pglq16_mpelvic girdle length QTL 16, 16 week (mouse)11325000018150000Mouse
27095919Pglq10_mpelvic girdle length QTL 10, 10 week (mouse)11325000018450000Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11325000019750000Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse


Expression


Sequence


RefSeq Acc Id: ENSMUST00000003681   ⟹   ENSMUSP00000003681
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,047,039 - 4,068,831 (-)Ensembl
GRCm38.p6 Ensembl114,097,039 - 4,118,831 (-)Ensembl
RefSeq Acc Id: ENSMUST00000123901
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,047,775 - 4,068,696 (-)Ensembl
GRCm38.p6 Ensembl114,097,775 - 4,118,696 (-)Ensembl
RefSeq Acc Id: ENSMUST00000132421
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,047,775 - 4,059,261 (-)Ensembl
GRCm38.p6 Ensembl114,097,775 - 4,109,261 (-)Ensembl
RefSeq Acc Id: ENSMUST00000133631
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,053,440 - 4,059,011 (-)Ensembl
GRCm38.p6 Ensembl114,103,440 - 4,109,011 (-)Ensembl
RefSeq Acc Id: ENSMUST00000136420
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,066,457 - 4,068,753 (-)Ensembl
GRCm38.p6 Ensembl114,116,457 - 4,118,753 (-)Ensembl
RefSeq Acc Id: ENSMUST00000145173
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,061,157 - 4,073,415 (-)Ensembl
GRCm38.p6 Ensembl114,111,157 - 4,123,415 (-)Ensembl
RefSeq Acc Id: NM_144520   ⟹   NP_653103
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39114,047,039 - 4,068,729 (-)NCBI
GRCm38114,097,039 - 4,118,729 (-)ENTREZGENE
MGSCv37113,997,042 - 4,018,732 (-)RGD
Celera114,592,969 - 4,615,073 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_653103 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH05759 (Get FASTA)   NCBI Sequence Viewer  
  EDL40458 (Get FASTA)   NCBI Sequence Viewer  
  EDL40459 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000003681
  ENSMUSP00000003681.8
GenBank Protein Q99J08 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_653103   ⟸   NM_144520
- UniProtKB: Q99J08 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000003681   ⟸   ENSMUST00000003681
Protein Domains
CRAL-TRIO   GOLD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99J08-F1-model_v2 AlphaFold Q99J08 1-403 view protein structure

Promoters
RGD ID:6822039
Promoter ID:MM_KWN:6212
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Liver
Transcripts:OTTMUST00000011240,   OTTMUST00000011244
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36114,008,781 - 4,009,782 (-)MPROMDB
RGD ID:6822041
Promoter ID:MM_KWN:6213
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell,   Liver,   Lung
Transcripts:OTTMUST00000011241,   OTTMUST00000011243,   OTTMUST00000011245
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36114,018,454 - 4,018,954 (-)MPROMDB
RGD ID:6822040
Promoter ID:MM_KWN:6214
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Liver,   Lung,   Spleen
Transcripts:OTTMUST00000011242
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36114,023,194 - 4,023,694 (-)MPROMDB
RGD ID:8673774
Promoter ID:EPDNEW_M14918
Type:initiation region
Name:Sec14l2_1
Description:Mus musculus SEC14-like lipid binding 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38114,118,758 - 4,118,818EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915065 AgrOrtholog
Ensembl Genes ENSMUSG00000003585 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000003681 ENTREZGENE
  ENSMUST00000003681.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.525.10 UniProtKB/Swiss-Prot
  GOLD domain UniProtKB/Swiss-Prot
InterPro CRAL-TRIO_dom UniProtKB/Swiss-Prot
  CRAL-TRIO_dom_sf UniProtKB/Swiss-Prot
  CRAL/TRIO_N_dom UniProtKB/Swiss-Prot
  CRAL/TRIO_N_dom_sf UniProtKB/Swiss-Prot
  GOLD_dom UniProtKB/Swiss-Prot
  GOLD_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:67815 UniProtKB/Swiss-Prot
MGD MGI:1915065 ENTREZGENE
NCBI Gene 67815 ENTREZGENE
PANTHER SEC14 RELATED PROTEIN UniProtKB/Swiss-Prot
  SEC14-LIKE PROTEIN 2 UniProtKB/Swiss-Prot
Pfam CRAL_TRIO UniProtKB/Swiss-Prot
  CRAL_TRIO_N UniProtKB/Swiss-Prot
PhenoGen Sec14l2 PhenoGen
PRINTS CRETINALDHBP UniProtKB/Swiss-Prot
PROSITE CRAL_TRIO UniProtKB/Swiss-Prot
  GOLD UniProtKB/Swiss-Prot
SMART CRAL_TRIO_N UniProtKB/Swiss-Prot
  SEC14 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF101576 UniProtKB/Swiss-Prot
  SSF46938 UniProtKB/Swiss-Prot
  SSF52087 UniProtKB/Swiss-Prot
UniProt Q99J08 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-10-06 Sec14l2  SEC14-like lipid binding 2    SEC14-like 2 (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED