Grk4 (G protein-coupled receptor kinase 4) - Rat Genome Database

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Gene: Grk4 (G protein-coupled receptor kinase 4) Rattus norvegicus
Analyze
Symbol: Grk4
Name: G protein-coupled receptor kinase 4
RGD ID: 61858
Description: Enables rhodopsin kinase activity. Involved in G protein-coupled receptor internalization and protein phosphorylation. Located in cytosol; dendrite; and neuronal cell body. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to human GRK4 (G protein-coupled receptor kinase 4); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; kinin signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G protein-coupled receptor kinase 2, groucho gene related; G protein-coupled receptor kinase 2, groucho gene related (Drosophila); g protein-coupled receptor kinase GRK4; Gprk2l
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21475,998,554 - 76,080,808 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,006,218 - 76,080,693 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1480,458,931 - 80,533,471 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01481,699,586 - 81,774,124 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01478,144,821 - 78,219,352 (-)NCBIRnor_WKY
Rnor_6.01481,261,708 - 81,339,516 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1481,265,672 - 81,339,526 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01481,953,108 - 82,026,972 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,648,003 - 81,722,480 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11481,650,393 - 81,724,871 (-)NCBI
Celera1474,930,817 - 75,005,219 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Involvement of G protein-coupled receptor kinase 4 and 6 in rapid desensitization of dopamine D1 receptor in rat IEC-6 intestinal epithelial cells. Fraga S, etal., Am J Physiol Regul Integr Comp Physiol. 2004 Oct;287(4):R772-9. Epub 2004 May 27.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Role of G protein-coupled receptor kinase 4 and beta-arrestin 1 in agonist-stimulated metabotropic glutamate receptor 1 internalization and activation of mitogen-activated protein kinases. Iacovelli L, etal., J Biol Chem 2003 Apr 4;278(14):12433-42. Epub 2003 Jan 07.
4. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Leeb-Lundberg LM, etal., Pharmacol Rev. 2005 Mar;57(1):27-77.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
8. Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. Pi M, etal., Mol Endocrinol. 2005 Apr;19(4):1078-87. Epub 2005 Jan 6.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation. Premont RT, etal., J Biol Chem 1999 Oct 8;274(41):29381-9.
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. The G-protein-coupled receptor kinase GRK4 mediates homologous desensitization of metabotropic glutamate receptor 1. Sallese M, etal., FASEB J. 2000 Dec;14(15):2569-80.
14. Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension. Speirs HJ, etal., J Hypertens. 2004 May;22(5):931-6.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16. Rat G protein-coupled receptor kinase GRK4: identification, functional expression, and differential tissue distribution of two splice variants. Virlon B, etal., Endocrinology 1998 Jun;139(6):2784-95.
17. Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats. Wang FL, etal., Mol Biol Rep. 2013 Mar;40(3):2405-18. doi: 10.1007/s11033-012-2321-5. Epub 2012 Nov 30.
Additional References at PubMed
PMID:16636192   PMID:18957817   PMID:20074556   PMID:23839509   PMID:32687659   PMID:32940654  


Genomics

Comparative Map Data
Grk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21475,998,554 - 76,080,808 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,006,218 - 76,080,693 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1480,458,931 - 80,533,471 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01481,699,586 - 81,774,124 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01478,144,821 - 78,219,352 (-)NCBIRnor_WKY
Rnor_6.01481,261,708 - 81,339,516 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1481,265,672 - 81,339,526 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01481,953,108 - 82,026,972 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,648,003 - 81,722,480 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11481,650,393 - 81,724,871 (-)NCBI
Celera1474,930,817 - 75,005,219 (-)NCBICelera
Cytogenetic Map14q21NCBI
GRK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3842,963,571 - 3,040,760 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl42,963,571 - 3,040,760 (+)EnsemblGRCh38hg38GRCh38
GRCh3742,965,298 - 3,042,487 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3642,935,141 - 3,012,272 (+)NCBINCBI36Build 36hg18NCBI36
Celera42,876,244 - 2,953,687 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef42,903,673 - 2,980,923 (+)NCBIHuRef
CHM1_142,963,374 - 3,040,591 (+)NCBICHM1_1
T2T-CHM13v2.042,962,247 - 3,039,448 (+)NCBIT2T-CHM13v2.0
Grk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39534,817,641 - 34,912,649 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl534,817,723 - 34,912,649 (+)EnsemblGRCm39 Ensembl
GRCm38534,660,250 - 34,755,305 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl534,660,379 - 34,755,305 (+)EnsemblGRCm38mm10GRCm38
MGSCv37535,003,028 - 35,097,952 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36534,977,810 - 35,072,160 (+)NCBIMGSCv36mm8
Celera532,133,988 - 32,229,425 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.91NCBI
Grk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555141,837,141 - 1,895,785 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555141,837,141 - 1,895,785 (+)NCBIChiLan1.0ChiLan1.0
GRK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.143,007,989 - 3,083,215 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl43,008,126 - 3,083,094 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v043,106,064 - 3,181,270 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GRK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1361,233,066 - 61,331,094 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl361,079,904 - 61,330,290 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha363,816,745 - 63,913,652 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0361,708,736 - 61,805,626 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl361,708,837 - 61,805,819 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1361,200,173 - 61,297,184 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0361,404,752 - 61,501,823 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0361,764,513 - 61,861,425 (-)NCBIUU_Cfam_GSD_1.0
GRK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl81,738,333 - 1,792,374 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.181,737,960 - 1,792,390 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.281,370,315 - 1,444,424 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12745,691,936 - 45,765,334 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660512,054,185 - 2,131,243 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475524,742,073 - 24,830,314 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475524,741,985 - 24,789,972 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grk4
225 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:126
Count of miRNA genes:81
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000015894, ENSRNOT00000016153
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat

Markers in Region
Gprk2l  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21476,048,124 - 76,048,527 (+)MAPPERmRatBN7.2
Rnor_6.01481,306,941 - 81,307,343NCBIRnor6.0
Rnor_5.01481,994,397 - 81,994,799UniSTSRnor5.0
RGSC_v3.41481,689,906 - 81,690,308UniSTSRGSC3.4
Celera1474,972,650 - 74,973,052UniSTS
Cytogenetic Map14q21UniSTS
RH138943  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21476,080,793 - 76,080,920 (+)MAPPERmRatBN7.2
Rnor_6.01481,339,617 - 81,339,743NCBIRnor6.0
Rnor_5.01482,027,073 - 82,027,199UniSTSRnor5.0
RGSC_v3.41481,722,581 - 81,722,707UniSTSRGSC3.4
Celera1475,005,320 - 75,005,446UniSTS
Cytogenetic Map14q21UniSTS
AU049804  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21476,008,922 - 76,009,082 (+)MAPPERmRatBN7.2
Rnor_6.01481,268,488 - 81,268,647NCBIRnor6.0
Rnor_5.01481,955,944 - 81,956,103UniSTSRnor5.0
RGSC_v3.41481,650,704 - 81,650,863UniSTSRGSC3.4
Celera1474,933,512 - 74,933,671UniSTS
Cytogenetic Map14q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 16 23 8
Low 3 43 57 41 19 41 8 11 58 35 18 3 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005493008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000015894   ⟹   ENSRNOP00000015894
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,006,218 - 76,080,693 (-)Ensembl
Rnor_6.0 Ensembl1481,265,672 - 81,339,526 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094171   ⟹   ENSRNOP00000088283
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,006,218 - 76,080,693 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098753   ⟹   ENSRNOP00000083618
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,006,218 - 76,080,693 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103702   ⟹   ENSRNOP00000086910
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,007,902 - 76,075,325 (-)Ensembl
RefSeq Acc Id: NM_022928   ⟹   NP_075217
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,006,218 - 76,080,693 (-)NCBI
Rnor_6.01481,265,784 - 81,339,516 (-)NCBI
Rnor_5.01481,953,108 - 82,026,972 (-)NCBI
RGSC_v3.41481,648,003 - 81,722,480 (-)RGD
Celera1474,930,817 - 75,005,219 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251359   ⟹   XP_006251421
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,006,101 - 76,080,808 (-)NCBI
Rnor_6.01481,261,708 - 81,339,359 (-)NCBI
Rnor_5.01481,953,108 - 82,026,972 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251360   ⟹   XP_006251422
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,006,188 - 76,080,808 (-)NCBI
Rnor_6.01481,261,708 - 81,339,359 (-)NCBI
Rnor_5.01481,953,108 - 82,026,972 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599346   ⟹   XP_017454835
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,006,101 - 76,080,808 (-)NCBI
Rnor_6.01481,261,708 - 81,339,359 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599347   ⟹   XP_017454836
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,006,101 - 76,080,808 (-)NCBI
Rnor_6.01481,261,708 - 81,339,359 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092349   ⟹   XP_038948277
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21475,998,554 - 76,080,808 (-)NCBI
RefSeq Acc Id: XM_039092350   ⟹   XP_038948278
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,006,101 - 76,080,808 (-)NCBI
RefSeq Acc Id: XM_039092351   ⟹   XP_038948279
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,006,101 - 76,080,808 (-)NCBI
RefSeq Acc Id: XM_039092352   ⟹   XP_038948280
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,006,101 - 76,080,808 (-)NCBI
RefSeq Acc Id: XM_039092353   ⟹   XP_038948281
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,006,101 - 76,080,808 (-)NCBI
RefSeq Acc Id: XM_039092355   ⟹   XP_038948283
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,006,101 - 76,080,808 (-)NCBI
RefSeq Acc Id: XM_039092356   ⟹   XP_038948284
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,021,400 - 76,080,808 (-)NCBI
RefSeq Acc Id: XM_039092357   ⟹   XP_038948285
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,033,910 - 76,080,808 (-)NCBI
RefSeq Acc Id: XM_039092358   ⟹   XP_038948286
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,033,754 - 76,080,808 (-)NCBI
RefSeq Acc Id: XM_039092359   ⟹   XP_038948287
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,001,670 - 76,036,320 (-)NCBI
RefSeq Acc Id: XM_039092360   ⟹   XP_038948288
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,021,292 - 76,080,808 (-)NCBI
RefSeq Acc Id: XR_005493008
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,011,062 - 76,080,808 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_075217   ⟸   NM_022928
- UniProtKB: P70508 (UniProtKB/Swiss-Prot),   P70507 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006251421   ⟸   XM_006251359
- Peptide Label: isoform X6
- UniProtKB: P70507 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006251422   ⟸   XM_006251360
- Peptide Label: isoform X9
- UniProtKB: A0A8I5ZVP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454836   ⟸   XM_017599347
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_017454835   ⟸   XM_017599346
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000015894   ⟸   ENSRNOT00000015894
RefSeq Acc Id: XP_038948277   ⟸   XM_039092349
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038948287   ⟸   XM_039092359
- Peptide Label: isoform X14
RefSeq Acc Id: XP_038948283   ⟸   XM_039092355
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038948279   ⟸   XM_039092351
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038948281   ⟸   XM_039092353
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038948278   ⟸   XM_039092350
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038948280   ⟸   XM_039092352
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038948288   ⟸   XM_039092360
- Peptide Label: isoform X15
RefSeq Acc Id: XP_038948284   ⟸   XM_039092356
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038948286   ⟸   XM_039092358
- Peptide Label: isoform X13
RefSeq Acc Id: XP_038948285   ⟸   XM_039092357
- Peptide Label: isoform X12
RefSeq Acc Id: ENSRNOP00000086910   ⟸   ENSRNOT00000103702
RefSeq Acc Id: ENSRNOP00000083618   ⟸   ENSRNOT00000098753
RefSeq Acc Id: ENSRNOP00000088283   ⟸   ENSRNOT00000094171
Protein Domains
AGC-kinase C-terminal   Protein kinase   RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70507-F1-model_v2 AlphaFold P70507 1-575 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61858 AgrOrtholog
BioCyc Gene G2FUF-15300 BioCyc
Ensembl Genes ENSRNOG00000011847 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000015894 ENTREZGENE
  ENSRNOP00000015894.2 UniProtKB/Swiss-Prot
  ENSRNOP00000083618 ENTREZGENE
  ENSRNOP00000083618.1 UniProtKB/TrEMBL
  ENSRNOP00000086910.1 UniProtKB/TrEMBL
  ENSRNOP00000088283 ENTREZGENE
  ENSRNOP00000088283.1 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015894 ENTREZGENE
  ENSRNOT00000015894.5 UniProtKB/Swiss-Prot
  ENSRNOT00000094171 ENTREZGENE
  ENSRNOT00000094171.1 UniProtKB/Swiss-Prot
  ENSRNOT00000098753 ENTREZGENE
  ENSRNOT00000098753.1 UniProtKB/TrEMBL
  ENSRNOT00000103702.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59077 UniProtKB/Swiss-Prot
NCBI Gene 59077 ENTREZGENE
PANTHER G PROTEIN-COUPLED RECEPTOR KINASE 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grk4 PhenoGen
PRINTS GPCRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC219373
UniProt A0A8I5ZVP3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A4S4_RAT UniProtKB/TrEMBL
  GRK4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P70508 ENTREZGENE
UniProt Secondary P70508 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-18 Grk4  G protein-coupled receptor kinase 4  Gprk2l  G protein-coupled receptor kinase 2, groucho gene related (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gprk2l  G protein-coupled receptor kinase 2, groucho gene related (Drosophila)      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript has two splicing variants, one which has a 31-amino acid deletion in the N-terminal domain 61617