Gene: Grk4 (G protein-coupled receptor kinase 4) Rattus norvegicus
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Symbol: Grk4
Name: G protein-coupled receptor kinase 4
Description: ENCODES a protein that exhibits rhodopsin kinase activity; INVOLVED IN desensitization of G protein-coupled receptor signaling pathway; G protein-coupled receptor internalization; protein phosphorylation; PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; kinin signaling pathway; chemokine mediated signaling pathway; ASSOCIATED WITH Diabetic Nephropathies; Chemical and Drug Induced Liver Injury (ortholog); essential hypertension (ortholog); FOUND IN cytosol; dendrite; neuronal cell body; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A
AGR Description: Exhibits rhodopsin kinase activity; involved in G protein-coupled receptor internalization and protein phosphorylation; localizes to the cytosol, dendrite, and neuronal cell body; orthologous to human GRK4 (G protein-coupled receptor kinase 4).
Merged Description: Exhibits rhodopsin kinase activity; involved in G protein-coupled receptor internalization and protein phosphorylation; localizes to the cytosol, dendrite, and neuronal cell body; orthologous to human GRK4 (G protein-coupled receptor kinase 4); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; kinin signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: G protein-coupled receptor kinase 2, groucho gene related; G protein-coupled receptor kinase 2, groucho gene related (Drosophila); g protein-coupled receptor kinase GRK4; Gprk2l
Orthologs:
Homo sapiens (human) : GRK4 (G protein-coupled receptor kinase 4)  HGNC  Alliance
Mus musculus (house mouse) : Grk4 (G protein-coupled receptor kinase 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grk4 (G protein-coupled receptor kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK4 (G protein-coupled receptor kinase 4)
Canis lupus familiaris (dog) : GRK4 (G protein-coupled receptor kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk4 (G protein-coupled receptor kinase 4)
Sus scrofa (pig) : GRK4 (G protein-coupled receptor kinase 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01481,261,708 - 81,339,516 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01481,953,108 - 82,026,972 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,648,003 - 81,722,480 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11481,650,393 - 81,724,871 (-)NCBI
Celera1474,930,817 - 75,005,219 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Grk4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 61858
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.