Fam114a1 (family with sequence similarity 114, member A1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Fam114a1 (family with sequence similarity 114, member A1) Rattus norvegicus
Analyze
Symbol: Fam114a1
Name: family with sequence similarity 114, member A1
RGD ID: 1560201
Description: Predicted to act upstream of or within several processes, including angiotensin-activated signaling pathway; fibroblast activation; and fibroblast migration. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Orthologous to human FAM114A1 (family with sequence similarity 114 member A1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC498366; RGD1560201; similar to RIKEN cDNA 9130005N14
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81443,629,349 - 43,699,800 (-)NCBIGRCr8
mRatBN7.21443,275,693 - 43,346,154 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1443,275,701 - 43,346,174 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1443,633,193 - 43,703,714 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01444,933,150 - 45,003,667 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01443,413,332 - 43,483,844 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01444,941,705 - 45,012,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1444,943,172 - 45,002,719 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01444,754,796 - 44,824,690 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41445,978,345 - 46,072,588 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1442,420,406 - 42,489,825 (-)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-bromohexadecanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
glafenine  (EXP)
glyphosate  (EXP)
indole-3-methanol  (EXP)
ivermectin  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:25002582  


Genomics

Comparative Map Data
Fam114a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81443,629,349 - 43,699,800 (-)NCBIGRCr8
mRatBN7.21443,275,693 - 43,346,154 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1443,275,701 - 43,346,174 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1443,633,193 - 43,703,714 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01444,933,150 - 45,003,667 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01443,413,332 - 43,483,844 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01444,941,705 - 45,012,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1444,943,172 - 45,002,719 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01444,754,796 - 44,824,690 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41445,978,345 - 46,072,588 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1442,420,406 - 42,489,825 (-)NCBICelera
Cytogenetic Map14p11NCBI
FAM114A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38438,867,806 - 38,945,739 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl438,867,677 - 38,945,739 (+)EnsemblGRCh38hg38GRCh38
GRCh37438,869,427 - 38,947,360 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36438,545,832 - 38,621,823 (+)NCBINCBI36Build 36hg18NCBI36
Celera439,307,544 - 39,385,485 (+)NCBICelera
Cytogenetic Map4p14NCBI
HuRef438,193,845 - 38,272,234 (+)NCBIHuRef
CHM1_1438,868,932 - 38,946,925 (+)NCBICHM1_1
T2T-CHM13v2.0438,837,934 - 38,915,794 (+)NCBIT2T-CHM13v2.0
Fam114a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39565,127,459 - 65,199,217 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl565,127,414 - 65,199,229 (+)EnsemblGRCm39 Ensembl
GRCm38564,970,075 - 65,041,901 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl564,970,071 - 65,041,886 (+)EnsemblGRCm38mm10GRCm38
MGSCv37565,361,314 - 65,433,140 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36565,249,247 - 65,321,009 (+)NCBIMGSCv36mm8
Celera562,242,915 - 62,316,310 (+)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map533.55NCBI
Fam114a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554438,319,205 - 8,394,889 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554438,315,839 - 8,399,751 (-)NCBIChiLan1.0ChiLan1.0
FAM114A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2339,055,978 - 39,134,147 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1439,248,529 - 39,326,753 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0433,195,907 - 33,274,081 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1439,049,619 - 39,127,656 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl439,049,619 - 39,127,656 (+)Ensemblpanpan1.1panPan2
FAM114A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1373,424,277 - 73,494,419 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl373,427,758 - 73,495,256 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha375,971,409 - 76,041,555 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0374,205,111 - 74,275,265 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl374,206,254 - 74,275,205 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1373,471,287 - 73,541,467 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0373,617,682 - 73,687,818 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0373,997,690 - 74,067,875 (-)NCBIUU_Cfam_GSD_1.0
Fam114a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528539,609,175 - 39,659,781 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364826,638,411 - 6,690,318 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364826,638,457 - 6,689,498 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAM114A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl830,114,635 - 30,274,164 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1830,191,950 - 30,274,167 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2831,672,139 - 31,764,523 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FAM114A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12711,349,732 - 11,428,582 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2711,349,718 - 11,418,007 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604757,763,745 - 57,842,732 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam114a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248407,352,539 - 7,423,520 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248407,352,552 - 7,423,520 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:77
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000002883
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143802371083023710Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143900944484009444Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143123808072970315Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143802371083023710Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143802371083023710Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143802371083023710Rat

Markers in Region
RH133990  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21443,276,211 - 43,276,405 (+)MAPPERmRatBN7.2
mRatBN7.29111,656,866 - 111,657,060 (+)MAPPERmRatBN7.2
Rnor_6.09120,098,372 - 120,098,565NCBIRnor6.0
Rnor_6.01444,942,195 - 44,942,388NCBIRnor6.0
Rnor_5.01444,755,300 - 44,755,493UniSTSRnor5.0
Rnor_5.09119,554,109 - 119,554,302UniSTSRnor5.0
RGSC_v3.49110,988,666 - 110,988,859UniSTSRGSC3.4
RGSC_v3.41445,977,887 - 45,978,080UniSTSRGSC3.4
Celera1442,420,896 - 42,421,089UniSTS
Celera9108,768,406 - 108,768,599UniSTS
Cytogenetic Map14p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000002883   ⟹   ENSRNOP00000002883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1443,275,701 - 43,346,174 (-)Ensembl
Rnor_6.0 Ensembl1444,943,172 - 45,002,719 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097519   ⟹   ENSRNOP00000087727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1443,275,701 - 43,337,005 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105967   ⟹   ENSRNOP00000082523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1443,275,701 - 43,339,384 (-)Ensembl
RefSeq Acc Id: NM_001399036   ⟹   NP_001385965
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81443,629,365 - 43,699,800 (-)NCBI
mRatBN7.21443,275,717 - 43,346,154 (-)NCBI
RefSeq Acc Id: XM_039092749   ⟹   XP_038948677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81443,629,349 - 43,699,457 (-)NCBI
mRatBN7.21443,275,693 - 43,345,806 (-)NCBI
RefSeq Acc Id: XM_039092750   ⟹   XP_038948678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81443,629,349 - 43,699,800 (-)NCBI
mRatBN7.21443,275,693 - 43,346,032 (-)NCBI
RefSeq Acc Id: XM_039092751   ⟹   XP_038948679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81443,629,349 - 43,675,874 (-)NCBI
mRatBN7.21443,275,693 - 43,322,228 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001385965 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948677 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948678 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948679 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002883.6
  ENSRNOP00000082523.1
  ENSRNOP00000087727.1
Ensembl Acc Id: ENSRNOP00000002883   ⟸   ENSRNOT00000002883
RefSeq Acc Id: XP_038948678   ⟸   XM_039092750
- Peptide Label: isoform X1
- UniProtKB: D4A777 (UniProtKB/TrEMBL),   A0A8I6GGB2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948677   ⟸   XM_039092749
- Peptide Label: isoform X1
- UniProtKB: D4A777 (UniProtKB/TrEMBL),   A0A8I6GGB2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948679   ⟸   XM_039092751
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000087727   ⟸   ENSRNOT00000097519
Ensembl Acc Id: ENSRNOP00000082523   ⟸   ENSRNOT00000105967
RefSeq Acc Id: NP_001385965   ⟸   NM_001399036
- UniProtKB: A0A8I6GGB2 (UniProtKB/TrEMBL),   D4A777 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A777-F1-model_v2 AlphaFold D4A777 1-567 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560201 AgrOrtholog
BioCyc Gene G2FUF-15730 BioCyc
Ensembl Genes ENSRNOG00000026504 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002883.7 UniProtKB/TrEMBL
  ENSRNOT00000097519.1 UniProtKB/TrEMBL
  ENSRNOT00000105967.1 UniProtKB/TrEMBL
InterPro DUF719 UniProtKB/TrEMBL
NCBI Gene 498366 ENTREZGENE
PANTHER DUF719 UniProtKB/TrEMBL
  PROTEIN NOXP20 UniProtKB/TrEMBL
Pfam DUF719 UniProtKB/TrEMBL
PhenoGen Fam114a1 PhenoGen
RatGTEx ENSRNOG00000026504 RatGTEx
UniProt A0A8I5ZXD6_RAT UniProtKB/TrEMBL
  A0A8I6GGB2 ENTREZGENE, UniProtKB/TrEMBL
  D4A777 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Fam114a1  family with sequence similarity 114, member A1  RGD1560201_predicted  similar to RIKEN cDNA 9130005N14 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560201_predicted  similar to RIKEN cDNA 9130005N14 (predicted)  LOC498366  similar to RIKEN cDNA 9130005N14  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498366  similar to RIKEN cDNA 9130005N14      Symbol and Name status set to provisional 70820 PROVISIONAL