Pgam2 (phosphoglycerate mutase 2) - Rat Genome Database

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Gene: Pgam2 (phosphoglycerate mutase 2) Rattus norvegicus
Analyze
Symbol: Pgam2
Name: phosphoglycerate mutase 2
RGD ID: 3313
Description: Enables phosphoglycerate mutase activity. Involved in gluconeogenesis; response to mercury ion; and spermatogenesis. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in myoglobinuria. Orthologous to human PGAM2 (phosphoglycerate mutase 2); PARTICIPATES IN gluconeogenesis pathway; Fanconi syndrome pathway; fructose-1,6-bisphosphatase deficiency pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BPG-dependent PGAM 2; D14Mgh1; isozyme MM; muscle-specific phosphoglycerate mutase; PGAM-M; Pgmut; phosphoglycerate mutase 2 (muscle); phosphoglycerate mutase isozyme M; type MM phosphoglycerate mutase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81484,895,763 - 84,897,874 (-)NCBIGRCr8
mRatBN7.21480,681,796 - 80,683,907 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1480,681,776 - 80,683,940 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1485,084,326 - 85,086,436 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01486,324,429 - 86,326,539 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01482,773,751 - 82,775,861 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01486,045,005 - 86,047,116 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01486,736,814 - 86,738,925 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41486,466,055 - 86,468,166 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11486,485,199 - 86,487,311 (-)NCBI
Celera1479,566,749 - 79,568,860 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
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Evidence
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Original Reference(s)
Pgam2Ratmyoglobinuria  ISOPGAM2 (Homo sapiens)1599129 RGD 
Object Symbol
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Original Reference(s)
Pgam2RatDimauro Disease  ISOPGAM2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10545043 more ...
Pgam2Ratgenetic disease  ISOPGAM2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Pgam2Ratpleomorphic xanthoastrocytoma  ISOPGAM2 (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358
Pgam2RatRhabdomyolysis  ISOPGAM2 (Homo sapiens)8554872ClinVar Annotator: match by term: RhabdomyolysisClinVarPMID:28779239
Object Symbol
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Original Reference(s)
Pgam2RatDimauro Disease  ISOPGAM2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Pgam2RatProstatic Neoplasms  ISOPGAM2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17013881
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Original Reference(s)
Pgam2RatDimauro Disease  ISOPGAM2 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Pgam2Rat1,1-dichloroethene decreases expressionISOPgam2 (Mus musculus)6480464vinylidene chloride results in decreased expression of PGAM2 mRNACTDPMID:26682919
Pgam2Rat17alpha-ethynylestradiol multiple interactionsISOPgam2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PGAM2 mRNACTDPMID:17942748
Pgam2Rat17beta-estradiol decreases expressionISOPgam2 (Mus musculus)6480464Estradiol results in decreased expression of PGAM2 mRNACTDPMID:19484750
Pgam2Rat17beta-estradiol increases expressionISOPgam2 (Mus musculus)6480464Estradiol results in increased expression of PGAM2 mRNACTDPMID:39298647
Pgam2Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of PGAM2 mRNACTDPMID:32145629
Pgam2Rat17beta-estradiol multiple interactionsISOPGAM2 (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of PGAM2 mRNACTDPMID:30165855
Pgam2Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOPgam2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PGAM2 mRNACTDPMID:17942748
Pgam2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PGAM2 mRNACTDPMID:32109520 and PMID:33387578
Pgam2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOPgam2 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of PGAM2 mRNACTDPMID:21354282
Pgam2Rat2,4-diaminotoluene increases expressionISOPgam2 (Mus musculus)64804642 and 4-diaminotoluene results in increased expression of PGAM2 mRNACTDPMID:22016648
Pgam2Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOPgam2 (Mus musculus)64804642 more ...CTDPMID:38648751
Pgam2Rat2-hydroxypropanoic acid affects expressionISOPGAM2 (Homo sapiens)6480464Lactic Acid affects the expression of PGAM2 mRNACTDPMID:30851411
Pgam2Rat3-chloropropane-1,2-diol decreases expressionEXP 6480464alpha-Chlorohydrin results in decreased expression of PGAM2 mRNACTDPMID:20409345
Pgam2Rat3H-1,2-dithiole-3-thione increases expressionEXP 64804641 and 2-dithiol-3-thione results in increased expression of PGAM2 mRNACTDPMID:19162173
Pgam2Rat4,4'-sulfonyldiphenol increases expressionISOPgam2 (Mus musculus)6480464bisphenol S results in increased expression of PGAM2 mRNACTDPMID:30951980
Pgam2Ratacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of PGAM2 mRNACTDPMID:28606764
Pgam2Ratalpha-Zearalanol multiple interactionsEXP 6480464[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of PGAM2 mRNACTDPMID:35163327
Pgam2Ratalpha-Zearalanol decreases expressionEXP 6480464Zeranol results in decreased expression of PGAM2 mRNACTDPMID:35163327
Pgam2Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of PGAM2 mRNACTDPMID:16483693
Pgam2Rataristolochic acids increases expressionEXP 6480464Aristolochic Acids results in increased expression of PGAM2 mRNACTDPMID:19717638

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Biological Process
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Original Reference(s)
Pgam2Ratcanonical glycolysis involved_inIEAUniProtKB:O70250 and ensembl:ENSMUSP000000207681600115GO_REF:0000107EnsemblGO_REF:0000107
Pgam2Ratcanonical glycolysis involved_inISOPgam2 (Mus musculus)1624291 PMID:23951293RGDPMID:23951293
Pgam2Ratgluconeogenesis  IDA 2302795 RGD 
Pgam2Ratglycolytic process involved_inISOPGAM2 (Homo sapiens)1624291 PMID:6262916RGDPMID:6262916
Pgam2Ratglycolytic process involved_inIEAInterPro:IPR0059521600115GO_REF:0000002InterProGO_REF:0000002
Pgam2Ratglycolytic process acts_upstream_of_or_withinISOPgam2 (Mus musculus)1624291 PMID:15665293RGDPMID:15665293
Pgam2Ratglycolytic process involved_inIEAUniProtKB:P15259 and ensembl:ENSP000002972831600115GO_REF:0000107EnsemblGO_REF:0000107
Pgam2Ratglycolytic process involved_inIEAUniProtKB-KW:KW-03241600115GO_REF:0000043UniProtGO_REF:0000043
Pgam2Ratglycolytic process acts_upstream_of_or_withinIEAUniProtKB:O70250 and ensembl:ENSMUSP000000207681600115GO_REF:0000107EnsemblGO_REF:0000107
Pgam2RatNotch signaling pathway acts_upstream_of_or_withinIEAUniProtKB:O70250 and ensembl:ENSMUSP000000207681600115GO_REF:0000107EnsemblGO_REF:0000107
Pgam2RatNotch signaling pathway acts_upstream_of_or_withinISOPgam2 (Mus musculus)1624291 PMID:23117660RGDPMID:23117660
Pgam2Ratresponse to mercury ion  IMP 1598712 RGD 
Pgam2Ratspermatogenesis  IEP 2302062 RGD 
Pgam2Ratstriated muscle contraction involved_inISOPGAM2 (Homo sapiens)1624291 PMID:6262916RGDPMID:6262916
Pgam2Ratstriated muscle contraction involved_inIEAUniProtKB:P15259 and ensembl:ENSP000002972831600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component

  
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Original Reference(s)
Pgam2Ratcytosol is_active_inISOPgam2 (Mus musculus)1624291 PMID:32035422RGDPMID:32035422
Pgam2Ratcytosol is_active_inIEAUniProtKB:O70250 and ensembl:ENSMUSP000000207681600115GO_REF:0000107EnsemblGO_REF:0000107

Molecular Function
1 to 20 of 20 rows

  
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Original Reference(s)
Pgam2Ratbisphosphoglycerate mutase activity enablesIEARHEA:177651600115GO_REF:0000116RHEAGO_REF:0000116
Pgam2Ratbisphosphoglycerate mutase activity enablesIEAEC:5.4.2.41600115GO_REF:0000003UniProtGO_REF:0000003
Pgam2Ratcatalytic activity enablesIEAInterPro:IPR0013451600115GO_REF:0000002InterProGO_REF:0000002
Pgam2Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Pgam2Ratidentical protein binding enablesISOPGAM2 (Homo sapiens)1624291UniProtKB:P15259 and PMID:32296183RGDPMID:32296183
Pgam2Ratidentical protein binding enablesIEAUniProtKB:P15259 and ensembl:ENSP000002972831600115GO_REF:0000107EnsemblGO_REF:0000107
Pgam2Ratintramolecular phosphotransferase activity enablesIEAARBA:ARBA000269591600115GO_REF:0000117UniProtGO_REF:0000117
Pgam2Ratintramolecular phosphotransferase activity enablesIEAInterPro:IPR0059521600115GO_REF:0000002InterProGO_REF:0000002
Pgam2Ratisomerase activity enablesIEAUniProtKB-KW:KW-04131600115GO_REF:0000043UniProtGO_REF:0000043
Pgam2Ratphosphoglycerate mutase activity  IDA 1598712 RGD 
Pgam2Ratphosphoglycerate mutase activity  IDA 2302786 RGD 
Pgam2Ratphosphoglycerate mutase activity enablesIEARHEA:159011600115GO_REF:0000116RHEAGO_REF:0000116
Pgam2Ratphosphoglycerate mutase activity enablesIEAUniProtKB:O70250 and ensembl:ENSMUSP000000207681600115GO_REF:0000107EnsemblGO_REF:0000107
Pgam2Ratphosphoglycerate mutase activity enablesISOPgam2 (Mus musculus)1624291 PMID:11250083 more ...RGDPMID:11250083 more ...
Pgam2Ratphosphoglycerate mutase activity enablesIEAEC:5.4.2.111600115GO_REF:0000003UniProtGO_REF:0000003
Pgam2Ratphosphoglycerate mutase activity enablesIEAUniProtKB:P15259 and ensembl:ENSP000002972831600115GO_REF:0000107EnsemblGO_REF:0000107
Pgam2Ratphosphoglycerate mutase activity enablesISOPGAM2 (Homo sapiens)1624291 PMID:4827367 and PMID:6262916RGDPMID:4827367 and PMID:6262916
Pgam2Ratphosphoglycerate mutase activity  IDA 2302795 RGD 
Pgam2Ratprotein binding enablesISOPGAM2 (Homo sapiens)1624291UniProtKB:P07738 more ...RGDPMID:28514442 more ...
Pgam2Ratprotein binding enablesISOPgam2 (Mus musculus)1624291UniProtKB:Q5FW97 and PMID:23446454RGDPMID:23446454
1 to 20 of 20 rows

RGD Manual Annotations


  
Object Symbol
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Original Reference(s)
Pgam2Ratgluconeogenesis pathway   IDA 2302795 RGD 
Pgam2Ratgluconeogenesis pathway   ISOPGAM2 (Homo sapiens)2302794 RGD 
Pgam2Ratglycolysis pathway   ISOPGAM2 (Homo sapiens)2302794 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Pgam2Ratgluconeogenesis pathway   IEA 6907045 KEGGrno:00010
Pgam2Ratglycolysis pathway   IEA 6907045 KEGGrno:00010
Pgam2Ratglycolysis/gluconeogenesis pathway  IEA 6907045 KEGGrno:00010

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#
Reference Title
Reference Citation
1. The muscle-specific phosphoglycerate mutase gene is specifically expressed in testis during spermatogenesis. Broceno C, etal., Eur J Biochem. 1995 Feb 1;227(3):629-35.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Inactivation of type MM phosphoglycerate mutase by sulfhydryl group reagents during facial embryogenesis. Granstrom G and Mangs H, Acta Odontol Scand. 1988 Oct;46(5):273-9.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. The histidine phosphatase superfamily: structure and function. Rigden DJ Biochem J. 2008 Jan 15;409(2):333-48.
13. The gene encoding rat phosphoglycerate mutase subunit M: cloning and promoter analysis in skeletal muscle cells. Ruiz-Lozano P, etal., Gene 1994 Sep 30;147(2):243-8.
14. Monochloroacetic acid inhibits liver gluconeogenesis by inactivating glyceraldehyde-3-phosphate dehydrogenase. Sakai A, etal., Chem Res Toxicol. 2005 Feb;18(2):277-82.
15. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
16. The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency. Tsujino S, etal., Am J Hum Genet. 1993 Mar;52(3):472-7.
17. Location of phosphoglycerate mutase in rat skeletal muscle. An immunocytochemical and biochemical study. Urena JM, etal., Eur J Cell Biol. 1990 Feb;51(1):151-6.
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PMID:2558656   PMID:2824255   PMID:4827367   PMID:6262916   PMID:11250083   PMID:15665293   PMID:21630459   PMID:23117660   PMID:23533145   PMID:29476059  



Pgam2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81484,895,763 - 84,897,874 (-)NCBIGRCr8
mRatBN7.21480,681,796 - 80,683,907 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1480,681,776 - 80,683,940 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1485,084,326 - 85,086,436 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01486,324,429 - 86,326,539 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01482,773,751 - 82,775,861 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01486,045,005 - 86,047,116 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01486,736,814 - 86,738,925 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41486,466,055 - 86,468,166 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11486,485,199 - 86,487,311 (-)NCBI
Celera1479,566,749 - 79,568,860 (-)NCBICelera
Cytogenetic Map14q21NCBI
PGAM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38744,062,727 - 44,065,567 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl744,062,727 - 44,065,567 (-)EnsemblGRCh38hg38GRCh38
GRCh37744,102,326 - 44,105,166 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36744,068,851 - 44,071,688 (-)NCBINCBI36Build 36hg18NCBI36
Build 34743,875,566 - 43,878,403NCBI
Celera744,200,271 - 44,203,131 (-)NCBICelera
Cytogenetic Map7p13NCBI
HuRef743,987,609 - 43,990,469 (-)NCBIHuRef
CHM1_1744,106,200 - 44,109,060 (-)NCBICHM1_1
T2T-CHM13v2.0744,221,224 - 44,224,064 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2744,141,816 - 44,144,674 (-)NCBI
Pgam2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39115,751,637 - 5,753,796 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl115,751,640 - 5,753,733 (-)EnsemblGRCm39 Ensembl
GRCm38115,801,637 - 5,803,796 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl115,801,640 - 5,803,733 (-)EnsemblGRCm38mm10GRCm38
MGSCv37115,701,640 - 5,703,799 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36115,701,647 - 5,703,736 (-)NCBIMGSCv36mm8
Celera116,291,798 - 6,293,956 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.87NCBI
Pgam2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554567,909,891 - 7,912,116 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554567,909,891 - 7,912,116 (+)NCBIChiLan1.0ChiLan1.0
PGAM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2648,973,896 - 48,983,253 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1797,297,291 - 97,301,591 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0744,776,722 - 44,780,248 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1744,843,067 - 44,846,274 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl744,843,067 - 44,845,984 (-)Ensemblpanpan1.1panPan2
PGAM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha162,007,972 - 2,010,428 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01614,851,571 - 14,854,027 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1614,851,574 - 14,854,031 (+)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.01614,482,753 - 14,485,209 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01614,463,237 - 14,465,693 (+)NCBIUU_Cfam_GSD_1.0
Pgam2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511899,810,197 - 99,812,642 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647819,020,048 - 19,024,394 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647819,021,928 - 19,026,110 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PGAM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1848,710,347 - 48,713,862 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11848,693,832 - 48,712,787 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21853,423,580 - 53,425,838 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PGAM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12114,604,127 - 14,609,196 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2114,606,401 - 14,609,158 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660627,905,467 - 7,908,316 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pgam2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247407,947,742 - 7,950,956 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247407,947,738 - 7,949,900 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Pgam2
7 total Variants


Assembly: mRatBN7.2
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
14 80681842 80681843 T C snv MWF/Hsd (2019), MWF/SimwMcwi (2019), MWF/SimwMcwi (2019NG) View more Information


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
14 86045051 86045052 T C snv MWF/Hsd (2019) View more Information

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:42
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000018227
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 24 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat

1 to 10 of 24 rows
D14Mgh1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81484,898,800 - 84,898,905 (+)Marker Load Pipeline
mRatBN7.21480,684,833 - 80,684,938 (+)MAPPERmRatBN7.2
Rnor_6.01486,048,043 - 86,048,147NCBIRnor6.0
Rnor_5.01486,739,852 - 86,739,956UniSTSRnor5.0
RGSC_v3.41486,469,093 - 86,469,197UniSTSRGSC3.4
Celera1479,569,638 - 79,569,742UniSTS
RH 3.4 Map14571.5RGD
RH 3.4 Map14571.5UniSTS
RH 2.0 Map14702.9RGD
SHRSP x BN Map1444.8999RGD
Cytogenetic Map14q21UniSTS
Cytogenetic Map14q21-q22UniSTS
D14Rat19  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81484,898,287 - 84,898,449 (+)Marker Load Pipeline
mRatBN7.21480,684,320 - 80,684,482 (+)MAPPERmRatBN7.2
Rnor_6.01486,047,530 - 86,047,691NCBIRnor6.0
Rnor_5.01486,739,339 - 86,739,500UniSTSRnor5.0
RGSC_v3.41486,468,580 - 86,468,741UniSTSRGSC3.4
RGSC_v3.41486,468,542 - 86,468,937RGDRGSC3.4
RGSC_v3.11486,487,725 - 86,487,886RGD
RH 3.4 Map14571.5RGD
RH 3.4 Map14571.5UniSTS
RH 2.0 Map14702.7RGD
SHRSP x BN Map1445.38RGD
Cytogenetic Map14q21UniSTS
Cytogenetic Map14q21-q22UniSTS
AW527377  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21480,682,949 - 80,683,113 (+)MAPPERmRatBN7.2
Rnor_6.01486,046,159 - 86,046,322NCBIRnor6.0
Rnor_5.01486,737,968 - 86,738,131UniSTSRnor5.0
RGSC_v3.41486,467,209 - 86,467,372UniSTSRGSC3.4
Celera1479,567,903 - 79,568,066UniSTS
RH 3.4 Map14571.5UniSTS
Cytogenetic Map14q21UniSTS
Cytogenetic Map14q21-q22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 60 66 65 34 25 34 6 193 97 40 45 55 31


1 to 17 of 17 rows
RefSeq Transcripts NM_017328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC128636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HH770049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HH770393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z17319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 17 of 17 rows

Ensembl Acc Id: ENSRNOT00000018227   ⟹   ENSRNOP00000018227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1480,681,776 - 80,683,940 (-)Ensembl
Rnor_6.0 Ensembl1486,044,969 - 86,047,162 (-)Ensembl
RefSeq Acc Id: NM_017328   ⟹   NP_059024
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,895,763 - 84,897,874 (-)NCBI
mRatBN7.21480,681,796 - 80,683,907 (-)NCBI
Rnor_6.01486,045,005 - 86,047,116 (-)NCBI
Rnor_5.01486,736,814 - 86,738,925 (-)NCBI
RGSC_v3.41486,466,055 - 86,468,166 (-)RGD
Celera1479,566,749 - 79,568,860 (-)RGD
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_059024 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41835 (Get FASTA)   NCBI Sequence Viewer  
  CAA78967 (Get FASTA)   NCBI Sequence Viewer  
  CBX85742 (Get FASTA)   NCBI Sequence Viewer  
  CBX85914 (Get FASTA)   NCBI Sequence Viewer  
  EDM00310 (Get FASTA)   NCBI Sequence Viewer  
  EDM00311 (Get FASTA)   NCBI Sequence Viewer  
  EDM00312 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018227
  ENSRNOP00000018227.4
GenBank Protein P16290 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_059024   ⟸   NM_017328
- UniProtKB: P16290 (UniProtKB/Swiss-Prot),   A6IKP7 (UniProtKB/TrEMBL),   A6IKP6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018227   ⟸   ENSRNOT00000018227

Name Modeler Protein Id AA Range Protein Structure
AF-P16290-F1-model_v2 AlphaFold P16290 1-253 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699462
Promoter ID:EPDNEW_R9986
Type:initiation region
Name:Pgam2_1
Description:phosphoglycerate mutase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01486,047,132 - 86,047,192EPDNEW


1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-15126 BioCyc
BioCyc Pathway ANAGLYCOLYSIS-PWY [glycolysis III (from glucose)] BioCyc
  PWY-6405 [Rapoport-Luebering glycolytic shunt] BioCyc
  PWY66-399 [gluconeogenesis III] BioCyc
BioCyc Pathway Image ANAGLYCOLYSIS-PWY BioCyc
  PWY-6405 BioCyc
  PWY66-399 BioCyc
Ensembl Genes ENSRNOG00000013532 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018227 ENTREZGENE
  ENSRNOT00000018227.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1240 UniProtKB/Swiss-Prot
InterPro His_Pase_superF_clade-1 UniProtKB/Swiss-Prot
  His_PPase_superfam UniProtKB/Swiss-Prot
  PG/BPGM_mutase_AS UniProtKB/Swiss-Prot
  Phosphogly_mut1 UniProtKB/Swiss-Prot
KEGG Report rno:24959 UniProtKB/Swiss-Prot
NCBI Gene 24959 ENTREZGENE
PANTHER PTHR11931 UniProtKB/Swiss-Prot
Pfam His_Phos_1 UniProtKB/Swiss-Prot
PhenoGen Pgam2 PhenoGen
PIRSF 6PFK_2-Ptase UniProtKB/Swiss-Prot
PROSITE PG_MUTASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013532 RatGTEx
SMART PGAM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53254 UniProtKB/Swiss-Prot
UniProt A6IKP6 ENTREZGENE, UniProtKB/TrEMBL
  A6IKP7 ENTREZGENE, UniProtKB/TrEMBL
  A6IKP8_RAT UniProtKB/TrEMBL
  P16290 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Pgam2  phosphoglycerate mutase 2  Pgam2  phosphoglycerate mutase 2 (muscle)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-17 Pgam2  phosphoglycerate mutase 2 (muscle)  Pgam2  phosphoglycerate mutase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pgam2  phosphoglycerate mutase 2      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_function interconverts 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction