Pgam2 (phosphoglycerate mutase 2) - Rat Genome Database

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Gene: Pgam2 (phosphoglycerate mutase 2) Mus musculus
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Symbol: Pgam2
Name: phosphoglycerate mutase 2
RGD ID: 732778
MGI Page MGI
Description: Enables phosphoglycerate mutase activity. Involved in canonical glycolysis. Acts upstream of or within Notch signaling pathway and glycolytic process. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb mesenchyme; and sensory organ. Human ortholog(s) of this gene implicated in myoglobinuria. Orthologous to human PGAM2 (phosphoglycerate mutase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BPG-dependent PGAM 2; muscle-specific phosphoglycerate mutase; PGAM-M; phosphoglycerate mutase isozyme M; phosphoglycerate mutase muscle-specific subunit
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm18298   Gm4042  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39115,751,637 - 5,753,796 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl115,751,640 - 5,753,733 (-)EnsemblGRCm39 Ensembl
GRCm38115,801,637 - 5,803,796 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl115,801,640 - 5,803,733 (-)EnsemblGRCm38mm10GRCm38
MGSCv37115,701,640 - 5,703,799 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36115,701,647 - 5,703,736 (-)NCBIMGSCv36mm8
Celera116,291,798 - 6,293,956 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.87NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IDA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. The histidine phosphatase superfamily: structure and function. Rigden DJ Biochem J. 2008 Jan 15;409(2):333-48.
9. Monochloroacetic acid inhibits liver gluconeogenesis by inactivating glyceraldehyde-3-phosphate dehydrogenase. Sakai A, etal., Chem Res Toxicol. 2005 Feb;18(2):277-82.
10. The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency. Tsujino S, etal., Am J Hum Genet. 1993 Mar;52(3):472-7.
Additional References at PubMed
PMID:2824255   PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11250083   PMID:12466851   PMID:12477932   PMID:14610273   PMID:14681479   PMID:15242968  
PMID:15489334   PMID:15499029   PMID:15665293   PMID:15728386   PMID:16141072   PMID:16141073   PMID:17626619   PMID:18554416   PMID:21267068   PMID:21884692   PMID:22496890   PMID:22673621  
PMID:23117660   PMID:23446454   PMID:23665500   PMID:23951293   PMID:24567357   PMID:24786789   PMID:25195573   PMID:26416771   PMID:27215380   PMID:27760309   PMID:28245920   PMID:30333037  
PMID:31786787   PMID:31847788   PMID:32035422   PMID:32325033   PMID:32634742   PMID:33914812   PMID:37677999  


Genomics

Comparative Map Data
Pgam2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39115,751,637 - 5,753,796 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl115,751,640 - 5,753,733 (-)EnsemblGRCm39 Ensembl
GRCm38115,801,637 - 5,803,796 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl115,801,640 - 5,803,733 (-)EnsemblGRCm38mm10GRCm38
MGSCv37115,701,640 - 5,703,799 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36115,701,647 - 5,703,736 (-)NCBIMGSCv36mm8
Celera116,291,798 - 6,293,956 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.87NCBI
PGAM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38744,062,727 - 44,065,567 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl744,062,727 - 44,065,567 (-)EnsemblGRCh38hg38GRCh38
GRCh37744,102,326 - 44,105,166 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36744,068,851 - 44,071,688 (-)NCBINCBI36Build 36hg18NCBI36
Build 34743,875,566 - 43,878,403NCBI
Celera744,200,271 - 44,203,131 (-)NCBICelera
Cytogenetic Map7p13NCBI
HuRef743,987,609 - 43,990,469 (-)NCBIHuRef
CHM1_1744,106,200 - 44,109,060 (-)NCBICHM1_1
T2T-CHM13v2.0744,221,224 - 44,224,064 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2744,141,816 - 44,144,674 (-)NCBI
Pgam2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81484,895,763 - 84,897,874 (-)NCBIGRCr8
mRatBN7.21480,681,796 - 80,683,907 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1480,681,776 - 80,683,940 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1485,084,326 - 85,086,436 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01486,324,429 - 86,326,539 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01482,773,751 - 82,775,861 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01486,045,005 - 86,047,116 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1486,044,969 - 86,047,162 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01486,736,814 - 86,738,925 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41486,466,055 - 86,468,166 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11486,485,199 - 86,487,311 (-)NCBI
Celera1479,566,749 - 79,568,860 (-)NCBICelera
Cytogenetic Map14q21NCBI
Pgam2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554567,909,891 - 7,912,116 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554567,909,891 - 7,912,116 (+)NCBIChiLan1.0ChiLan1.0
PGAM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2648,973,896 - 48,983,253 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1797,297,291 - 97,301,591 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0744,776,722 - 44,780,248 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1744,843,067 - 44,846,274 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl744,843,067 - 44,845,984 (-)Ensemblpanpan1.1panPan2
PGAM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha162,007,972 - 2,010,428 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01614,851,571 - 14,854,027 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1614,851,574 - 14,854,031 (+)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.01614,482,753 - 14,485,209 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01614,463,237 - 14,465,693 (+)NCBIUU_Cfam_GSD_1.0
Pgam2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511899,810,197 - 99,812,642 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647819,020,048 - 19,024,394 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647819,021,928 - 19,026,110 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PGAM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1848,710,347 - 48,713,862 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11848,693,832 - 48,712,787 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21853,423,580 - 53,425,838 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PGAM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12114,604,127 - 14,609,196 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2114,606,401 - 14,609,158 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660627,905,467 - 7,908,316 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pgam2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247407,947,742 - 7,950,956 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247407,947,738 - 7,949,900 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pgam2
53 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:156
Count of miRNA genes:142
Interacting mature miRNAs:149
Transcripts:ENSMUST00000020768
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
27095914Pglq16_mpelvic girdle length QTL 16, 16 week (mouse)11325000018150000Mouse
27095919Pglq10_mpelvic girdle length QTL 10, 10 week (mouse)11325000018450000Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11325000019750000Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
10053676Eae44a_mexperimental allergic encephalomyelitis susceptibility 44a (mouse)Not determined11450789621379532Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
27226735Metcl16_mmetatarsal-calcaneal length 16, 16 week (mouse)11525000035090827Mouse

Markers in Region
Pgam2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37115,703,392 - 5,703,724UniSTSGRCm37
Celera116,293,549 - 6,293,881UniSTS
Cytogenetic Map11A1UniSTS
cM Map11 UniSTS
Pgam2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38115,803,389 - 5,803,721UniSTSGRCm38
MGSCv37115,703,392 - 5,703,724UniSTSGRCm37
Celera116,293,549 - 6,293,881UniSTS
Cytogenetic Map11A1UniSTS
cM Map11 UniSTS
Pgam2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A1UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000020768   ⟹   ENSMUSP00000020768
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl115,751,640 - 5,753,733 (-)Ensembl
GRCm38.p6 Ensembl115,801,640 - 5,803,733 (-)Ensembl
RefSeq Acc Id: NM_018870   ⟹   NP_061358
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39115,751,637 - 5,753,796 (-)NCBI
GRCm38115,801,637 - 5,803,796 (-)ENTREZGENE
MGSCv37115,701,640 - 5,703,799 (-)RGD
Celera116,291,798 - 6,293,956 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_061358   ⟸   NM_018870
- UniProtKB: O70250 (UniProtKB/Swiss-Prot),   Q5NCI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000020768   ⟸   ENSMUST00000020768

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70250-F1-model_v2 AlphaFold O70250 1-253 view protein structure

Promoters
RGD ID:6821534
Promoter ID:MM_KWN:6315
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_018870
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36115,703,281 - 5,704,627 (-)MPROMDB
RGD ID:8673862
Promoter ID:EPDNEW_M14961
Type:initiation region
Name:Pgam2_1
Description:Mus musculus phosphoglycerate mutase 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38115,803,719 - 5,803,779EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1933118 AgrOrtholog
Ensembl Genes ENSMUSG00000020475 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000020768 ENTREZGENE
  ENSMUST00000020768.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1240 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro His_Pase_superF_clade-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_PPase_superfam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PG/BPGM_mutase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phosphogly_mut1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:56012 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1933118 ENTREZGENE
NCBI Gene 56012 ENTREZGENE
PANTHER PHOSPHOGLYCERATE MUTASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11931 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam His_Phos_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pgam2 PhenoGen
PIRSF 6PFK_2-Ptase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PG_MUTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PGAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53254 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt O70250 ENTREZGENE, UniProtKB/Swiss-Prot
  Q5NCI4 ENTREZGENE, UniProtKB/TrEMBL