Tnip2 (TNFAIP3 interacting protein 2) - Rat Genome Database

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Gene: Tnip2 (TNFAIP3 interacting protein 2) Rattus norvegicus
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Symbol: Tnip2
Name: TNFAIP3 interacting protein 2
RGD ID: 1307717
Description: Predicted to enable polyubiquitin modification-dependent protein binding activity and protein kinase binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; pattern recognition receptor signaling pathway; and positive regulation of leukocyte activation. Predicted to act upstream of or within I-kappaB kinase/NF-kappaB signaling. Predicted to be located in cytosol and nucleoplasm. Orthologous to human TNIP2 (TNFAIP3 interacting protein 2); INTERACTS WITH 2,4-dinitrotoluene; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC305451; TNFAIP3-interacting protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21476,228,283 - 76,246,609 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,228,371 - 76,275,265 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1480,680,797 - 80,698,114 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01481,921,444 - 81,938,761 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01478,366,692 - 78,384,009 (+)NCBIRnor_WKY
Rnor_6.01481,487,934 - 81,505,889 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1481,488,008 - 81,504,686 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,175,144 - 82,192,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,870,935 - 81,888,169 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11481,873,325 - 81,890,560 (+)NCBI
Celera1475,152,826 - 75,170,060 (+)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11390377   PMID:12477932   PMID:12753905   PMID:12933576   PMID:16633345   PMID:18212736   PMID:21784860   PMID:30720079  


Genomics

Comparative Map Data
Tnip2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21476,228,283 - 76,246,609 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,228,371 - 76,275,265 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1480,680,797 - 80,698,114 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01481,921,444 - 81,938,761 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01478,366,692 - 78,384,009 (+)NCBIRnor_WKY
Rnor_6.01481,487,934 - 81,505,889 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1481,488,008 - 81,504,686 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,175,144 - 82,192,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,870,935 - 81,888,169 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11481,873,325 - 81,890,560 (+)NCBI
Celera1475,152,826 - 75,170,060 (+)NCBICelera
Cytogenetic Map14q21NCBI
TNIP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3842,741,648 - 2,756,336 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl42,741,648 - 2,756,342 (-)EnsemblGRCh38hg38GRCh38
GRCh3742,743,375 - 2,758,063 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3642,713,185 - 2,727,859 (-)NCBINCBI36Build 36hg18NCBI36
Build 3442,780,592 - 2,795,267NCBI
Celera42,654,688 - 2,669,415 (-)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef42,682,483 - 2,696,862 (-)NCBIHuRef
CHM1_142,741,351 - 2,756,073 (-)NCBICHM1_1
T2T-CHM13v2.042,740,398 - 2,755,095 (-)NCBIT2T-CHM13v2.0
Tnip2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39534,653,440 - 34,671,323 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl534,653,431 - 34,671,335 (-)EnsemblGRCm39 Ensembl
GRCm38534,496,096 - 34,513,979 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl534,496,087 - 34,513,991 (-)EnsemblGRCm38mm10GRCm38
MGSCv37534,838,745 - 34,856,628 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36534,812,953 - 34,830,836 (-)NCBIMGSCv36mm8
Celera531,967,000 - 31,984,842 (-)NCBICelera
Cytogenetic Map5B2NCBI
Tnip2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555141,682,641 - 1,687,881 (-)NCBIChiLan1.0ChiLan1.0
TNIP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.142,787,594 - 2,793,893 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v042,884,265 - 2,899,160 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TNIP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1361,511,676 - 61,535,480 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha364,094,717 - 64,118,689 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0361,987,047 - 62,011,284 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl361,987,047 - 62,012,472 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1361,478,352 - 61,502,338 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0361,683,311 - 61,707,304 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0362,042,935 - 62,067,151 (+)NCBIUU_Cfam_GSD_1.0
Tnip2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528567,105,267 - 67,139,845 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647720,834,849 - 20,841,535 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647720,810,188 - 20,841,537 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNIP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl81,533,429 - 1,554,683 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.181,530,534 - 1,554,677 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.281,115,215 - 1,136,000 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNIP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12746,001,814 - 46,017,676 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2746,001,872 - 46,018,494 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660512,366,620 - 2,381,224 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnip2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475524,976,361 - 25,001,397 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475524,976,375 - 24,995,150 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tnip2
37 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:180
Count of miRNA genes:123
Interacting mature miRNAs:154
Transcripts:ENSRNOT00000018477
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat

Markers in Region
RH134898  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21476,245,222 - 76,245,429 (+)MAPPERmRatBN7.2
Rnor_6.01481,504,688 - 81,504,894NCBIRnor6.0
Rnor_5.01482,192,172 - 82,192,378UniSTSRnor5.0
RGSC_v3.41481,887,848 - 81,888,054UniSTSRGSC3.4
Celera1475,169,739 - 75,169,945UniSTS
Cytogenetic Map14q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 13 4 19 4 4 21 11
Low 1 41 44 37 37 8 11 74 31 20 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018477   ⟹   ENSRNOP00000018477
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,228,371 - 76,275,265 (+)Ensembl
Rnor_6.0 Ensembl1481,488,008 - 81,504,686 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108907   ⟹   ENSRNOP00000084407
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,228,371 - 76,275,265 (+)Ensembl
RefSeq Acc Id: NM_001024771   ⟹   NP_001019942
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,228,312 - 76,245,544 (+)NCBI
Rnor_6.01481,488,012 - 81,505,009 (+)NCBI
Rnor_5.01482,175,144 - 82,192,502 (+)NCBI
RGSC_v3.41481,870,935 - 81,888,169 (+)RGD
Celera1475,152,826 - 75,170,060 (+)RGD
Sequence:
RefSeq Acc Id: XM_006251255   ⟹   XP_006251317
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,228,283 - 76,246,609 (+)NCBI
Rnor_6.01481,487,934 - 81,505,889 (+)NCBI
Rnor_5.01482,175,144 - 82,192,502 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001019942 (Get FASTA)   NCBI Sequence Viewer  
  NP_001381613 (Get FASTA)   NCBI Sequence Viewer  
  XP_006251317 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97956 (Get FASTA)   NCBI Sequence Viewer  
  EDM00094 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001019942   ⟸   NM_001024771
- Sequence:
RefSeq Acc Id: XP_006251317   ⟸   XM_006251255
- Peptide Label: isoform X1
- UniProtKB: G3V7R6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018477   ⟸   ENSRNOT00000018477
RefSeq Acc Id: ENSRNOP00000084407   ⟸   ENSRNOT00000108907
Protein Domains
CCHC NOA-type   EABR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V7R6-F1-model_v2 AlphaFold G3V7R6 1-430 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699401
Promoter ID:EPDNEW_R9925
Type:multiple initiation site
Name:Tnip2_1
Description:TNFAIP3 interacting protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01481,488,079 - 81,488,139EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307717 AgrOrtholog
BioCyc Gene G2FUF-15292 BioCyc
Ensembl Genes ENSRNOG00000013805 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000018477 ENTREZGENE
  ENSRNOP00000018477.5 UniProtKB/TrEMBL
  ENSRNOP00000084407.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018477 ENTREZGENE
  ENSRNOT00000018477.7 UniProtKB/TrEMBL
  ENSRNOT00000108907.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7098405 IMAGE-MGC_LOAD
  IMAGE:7461734 IMAGE-MGC_LOAD
InterPro EABR UniProtKB/TrEMBL
  ZF_CCHC_NOA UniProtKB/TrEMBL
KEGG Report rno:305451 UniProtKB/TrEMBL
MGC_CLONE MGC:116079 IMAGE-MGC_LOAD
  MGC:94771 IMAGE-MGC_LOAD
NCBI Gene 305451 ENTREZGENE
Pfam EABR UniProtKB/TrEMBL
PhenoGen Tnip2 PhenoGen
PROSITE ZF_CCHC_NOA UniProtKB/TrEMBL
UniProt A0A0G2QC05_RAT UniProtKB/TrEMBL
  A0A8I5ZX56_RAT UniProtKB/TrEMBL
  G3V7R6 ENTREZGENE, UniProtKB/TrEMBL
  Q4V7E7 ENTREZGENE
UniProt Secondary Q4V7E7 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Tnip2  TNFAIP3 interacting protein 2  Tnip2_predicted  TNFAIP3 interacting protein 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Tnip2_predicted  TNFAIP3 interacting protein 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED