Tlr10 (toll-like receptor 10) - Rat Genome Database

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Gene: Tlr10 (toll-like receptor 10) Rattus norvegicus
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Symbol: Tlr10
Name: toll-like receptor 10
RGD ID: 1311569
Description: Predicted to enable several functions, including Toll-like receptor 2 binding activity; identical protein binding activity; and lipopeptide binding activity. Predicted to be involved in cellular response to bacterial lipopeptide; inflammatory response; and toll-like receptor signaling pathway. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human TLR10 (toll like receptor 10); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC305355
RGD Orthologs
Human
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81443,758,940 - 43,768,352 (+)NCBIGRCr8
mRatBN7.21443,400,843 - 43,414,056 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1443,406,217 - 43,413,917 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1443,771,023 - 43,773,458 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01445,070,977 - 45,073,412 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01443,551,149 - 43,553,584 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01445,073,652 - 45,082,242 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01444,883,732 - 44,891,494 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41446,139,461 - 46,141,896 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11446,136,620 - 46,144,401 (+)NCBI
Celera1442,555,440 - 42,557,875 (+)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. Toll-like receptor heterodimer variants protect from childhood asthma. Kormann MS, etal., J Allergy Clin Immunol. 2008 Jul;122(1):86-92, 92.e1-8. Epub 2008 Jun 10.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma. Tantisira K, etal., Genes Immun. 2004 Aug;5(5):343-6.
Additional References at PubMed
PMID:15728506   PMID:21873635   PMID:23155421  


Genomics

Comparative Map Data
Tlr10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81443,758,940 - 43,768,352 (+)NCBIGRCr8
mRatBN7.21443,400,843 - 43,414,056 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1443,406,217 - 43,413,917 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1443,771,023 - 43,773,458 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01445,070,977 - 45,073,412 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01443,551,149 - 43,553,584 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01445,073,652 - 45,082,242 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01444,883,732 - 44,891,494 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41446,139,461 - 46,141,896 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11446,136,620 - 46,144,401 (+)NCBI
Celera1442,555,440 - 42,557,875 (+)NCBICelera
Cytogenetic Map14p11NCBI
TLR10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38438,772,238 - 38,782,990 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl438,772,238 - 38,782,990 (-)EnsemblGRCh38hg38GRCh38
GRCh37438,773,859 - 38,784,611 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36438,450,629 - 38,460,984 (-)NCBINCBI36Build 36hg18NCBI36
Build 34438,597,261 - 38,600,531NCBI
Celera439,213,490 - 39,223,937 (-)NCBICelera
Cytogenetic Map4p14NCBI
HuRef438,098,227 - 38,108,978 (-)NCBIHuRef
CHM1_1438,773,441 - 38,784,192 (-)NCBICHM1_1
T2T-CHM13v2.0438,742,654 - 38,753,390 (-)NCBIT2T-CHM13v2.0
Tlr10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554438,462,852 - 8,469,812 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554438,442,439 - 8,468,966 (+)NCBIChiLan1.0ChiLan1.0
TLR10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2338,960,655 - 38,972,144 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1439,153,165 - 39,164,652 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0433,100,588 - 33,111,750 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1438,954,748 - 38,965,479 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl438,955,660 - 38,958,095 (-)Ensemblpanpan1.1panPan2
TLR10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1373,561,596 - 73,589,286 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl373,568,321 - 73,570,744 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha376,115,404 - 76,117,827 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0374,341,903 - 74,394,720 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1373,614,824 - 73,617,247 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0373,760,286 - 73,762,709 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0374,141,129 - 74,143,552 (+)NCBIUU_Cfam_GSD_1.0
Tlr10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528539,733,232 - 39,735,878 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364826,562,396 - 6,565,003 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl830,124,895 - 30,134,854 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1830,124,895 - 30,134,854 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2831,604,659 - 31,615,420 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLR10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12711,486,273 - 11,515,841 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2711,512,239 - 11,514,671 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604757,927,128 - 57,931,071 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlr10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248407,269,628 - 7,273,316 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tlr10
78 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:131
Count of miRNA genes:117
Interacting mature miRNAs:124
Transcripts:ENSRNOT00000059124
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143999825175582726Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
7387267Uae42Urinary albumin excretion QTL 420.61urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)142216796767167967Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000111600   ⟹   ENSRNOP00000088063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1443,406,737 - 43,413,917 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112127   ⟹   ENSRNOP00000091458
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1443,406,217 - 43,413,917 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113226   ⟹   ENSRNOP00000096056
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1443,406,217 - 43,413,917 (+)Ensembl
RefSeq Acc Id: NM_001146035   ⟹   NP_001139507
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81443,765,022 - 43,767,457 (+)NCBI
mRatBN7.21443,411,386 - 43,413,821 (+)NCBI
Rnor_6.01445,079,655 - 45,082,090 (+)NCBI
Rnor_5.01444,883,732 - 44,891,494 (+)NCBI
RGSC_v3.41446,139,461 - 46,141,896 (+)RGD
Celera1442,555,440 - 42,557,875 (+)RGD
Sequence:
RefSeq Acc Id: XM_006251002   ⟹   XP_006251064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81443,758,940 - 43,768,352 (+)NCBI
mRatBN7.21443,400,843 - 43,414,056 (+)NCBI
Rnor_6.01445,073,652 - 45,082,242 (+)NCBI
Rnor_5.01444,883,732 - 44,891,494 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001139507 (Get FASTA)   NCBI Sequence Viewer  
  XP_006251064 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ACN78428 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000088063.1
  ENSRNOP00000091458.1
  ENSRNOP00000096056.1
RefSeq Acc Id: NP_001139507   ⟸   NM_001146035
- UniProtKB: C0LSK8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251064   ⟸   XM_006251002
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AFM9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000088063   ⟸   ENSRNOT00000111600
Ensembl Acc Id: ENSRNOP00000096056   ⟸   ENSRNOT00000113226
Ensembl Acc Id: ENSRNOP00000091458   ⟸   ENSRNOT00000112127
Protein Domains
TIR

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311569 AgrOrtholog
BioCyc Gene G2FUF-15725 BioCyc
Ensembl Genes ENSRNOG00000067138 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000111600.1 UniProtKB/TrEMBL
  ENSRNOT00000112127.1 UniProtKB/TrEMBL
  ENSRNOT00000113226.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  Toll-Interleukin_rcpt UniProtKB/TrEMBL
  Toll-like_receptor UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
KEGG Report rno:305355 UniProtKB/TrEMBL
NCBI Gene 305355 ENTREZGENE
PANTHER PTHR24365 UniProtKB/TrEMBL
  PTHR24365:SF23 UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
PhenoGen Tlr10 PhenoGen
PIRSF Toll-like_receptor UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000067138 RatGTEx
SMART LRR_TYP UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
UniProt A0A8I6AFM9 ENTREZGENE, UniProtKB/TrEMBL
  C0LSK8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Tlr10  toll-like receptor 10   Tlr10_predicted  toll-like receptor 10 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tlr10_predicted  toll-like receptor 10 (predicted)      Symbol and Name status set to approved 70820 APPROVED