RGD Reference Report - Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma. - Rat Genome Database

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Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma.

Authors: Tantisira, K  Klimecki, WT  Lazarus, R  Palmer, LJ  Raby, BA  Kwiatkowski, DJ  Silverman, E  Vercelli, D  Martinez, FD  Weiss, ST 
Citation: Tantisira K, etal., Genes Immun. 2004 Aug;5(5):343-6.
RGD ID: 4889538
Pubmed: PMID:15266299   (View Abstract at PubMed)
DOI: DOI:10.1038/sj.gene.6364096   (Journal Full-text)

Toll-like receptor 6 (TLR6) is one of a series of highly conserved innate immune receptors. We resequenced TLR6 in DNA samples from 24 African Americans, 23 European Americans, and 24 Hispanic Americans, identifying 53 SNPs, 22 with an allele frequency >5%. Significant differences in SNP frequencies among the three populations were noted. In all, 11 SNPs caused amino-acid changes, including one with a frequency >5% in all three populations. Utilizing this SNP (Ser249Pro), we performed exploratory nested case-control disease-association studies, including one involving 56 African Americans with asthma and 93 African American controls. The minor allele of this SNP was associated with decreased risk for asthma (odds ratio 0.38, 95% CI 0.16-0.87, P=0.01), an effect consistent with the known biology of the toll-like receptors. Although replication of this finding in other, larger samples is needed, variation in TLR6 may have relevance to the pathogenesis of immunologically mediated diseases.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
asthma susceptibilityIAGP 4889538DNA:SNP: :p.S249P (human)RGD 
asthma susceptibilityISOTLR6 (Homo sapiens)4889538; 4889538DNA:SNP: :p.S249P (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tlr6  (toll-like receptor 6)

Genes (Mus musculus)
Tlr6  (toll-like receptor 6)

Genes (Homo sapiens)
TLR6  (toll like receptor 6)

Objects referenced in this article
Gene Tlr10 toll-like receptor 10 Rattus norvegicus

Additional Information