TLR10 (toll like receptor 10) - Rat Genome Database

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Gene: TLR10 (toll like receptor 10) Canis lupus familiaris
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Symbol: TLR10
Name: toll like receptor 10
RGD ID: 12292309
Description: ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN cellular response to bacterial lipopeptide (inferred); immune response (inferred); inflammatory response (inferred); ASSOCIATED WITH asthma (ortholog); genetic disease (ortholog); Hyperglycinemia, Lactic Acidosis, and Seizures (ortholog); FOUND IN receptor complex (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: toll-like receptor 10
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1373,561,596 - 73,589,286 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl373,568,321 - 73,570,744 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha376,115,404 - 76,117,827 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0374,341,903 - 74,394,720 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1373,614,824 - 73,617,247 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0373,760,286 - 73,762,709 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0374,141,129 - 74,143,552 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:22321737   PMID:30032202  


Genomics

Comparative Map Data
TLR10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1373,561,596 - 73,589,286 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl373,568,321 - 73,570,744 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha376,115,404 - 76,117,827 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0374,341,903 - 74,394,720 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1373,614,824 - 73,617,247 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0373,760,286 - 73,762,709 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0374,141,129 - 74,143,552 (+)NCBIUU_Cfam_GSD_1.0
TLR10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38438,772,238 - 38,782,990 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl438,772,238 - 38,782,990 (-)EnsemblGRCh38hg38GRCh38
GRCh37438,773,859 - 38,784,611 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36438,450,629 - 38,460,984 (-)NCBINCBI36Build 36hg18NCBI36
Build 34438,597,261 - 38,600,531NCBI
Celera439,213,490 - 39,223,937 (-)NCBICelera
Cytogenetic Map4p14NCBI
HuRef438,098,227 - 38,108,978 (-)NCBIHuRef
CHM1_1438,773,441 - 38,784,192 (-)NCBICHM1_1
T2T-CHM13v2.0438,742,654 - 38,753,390 (-)NCBIT2T-CHM13v2.0
Tlr10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81443,758,940 - 43,768,352 (+)NCBIGRCr8
mRatBN7.21443,400,843 - 43,414,056 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1443,406,217 - 43,413,917 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1443,771,023 - 43,773,458 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01445,070,977 - 45,073,412 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01443,551,149 - 43,553,584 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01445,073,652 - 45,082,242 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01444,883,732 - 44,891,494 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41446,139,461 - 46,141,896 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11446,136,620 - 46,144,401 (+)NCBI
Celera1442,555,440 - 42,557,875 (+)NCBICelera
Cytogenetic Map14p11NCBI
Tlr10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554438,462,852 - 8,469,812 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554438,442,439 - 8,468,966 (+)NCBIChiLan1.0ChiLan1.0
TLR10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2338,960,655 - 38,972,144 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1439,153,165 - 39,164,652 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0433,100,588 - 33,111,750 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1438,954,748 - 38,965,479 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl438,955,660 - 38,958,095 (-)Ensemblpanpan1.1panPan2
Tlr10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528539,733,232 - 39,735,878 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364826,562,396 - 6,565,003 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl830,124,895 - 30,134,854 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1830,124,895 - 30,134,854 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2831,604,659 - 31,615,420 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLR10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12711,486,273 - 11,515,841 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2711,512,239 - 11,514,671 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604757,927,128 - 57,931,071 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlr10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248407,269,628 - 7,273,316 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TLR10
315 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 2 8 1 6 1 10 5
Below cutoff 3 5 14 5 5 6 6 2 8 5 6

Sequence


RefSeq Acc Id: ENSCAFT00000025668   ⟹   ENSCAFP00000023840
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl373,568,321 - 73,570,744 (+)Ensembl
RefSeq Acc Id: NM_001173127   ⟹   NP_001166598
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1373,568,321 - 73,570,744 (+)NCBI
Dog10K_Boxer_Tasha376,115,404 - 76,117,827 (+)NCBI
ROS_Cfam_1.0374,347,751 - 74,350,174 (+)NCBI
UMICH_Zoey_3.1373,614,824 - 73,617,247 (+)NCBI
UNSW_CanFamBas_1.0373,760,286 - 73,762,709 (+)NCBI
UU_Cfam_GSD_1.0374,141,129 - 74,143,552 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038660409   ⟹   XP_038516337
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0374,341,903 - 74,350,441 (+)NCBI
RefSeq Acc Id: XR_005423840
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0374,341,903 - 74,354,657 (+)NCBI
RefSeq Acc Id: XR_005423841
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0374,341,903 - 74,368,745 (+)NCBI
RefSeq Acc Id: XR_005423842
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0374,341,903 - 74,394,720 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001166598 (Get FASTA)   NCBI Sequence Viewer  
  XP_038516337 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AFA51122 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00030006613.1
  ENSCAFP00040000218.1
RefSeq Acc Id: NP_001166598   ⟸   NM_001173127
- UniProtKB: A0A8C0MAB7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000023840   ⟸   ENSCAFT00000025668
RefSeq Acc Id: XP_038516337   ⟸   XM_038660409
- Peptide Label: isoform X1
- UniProtKB: A0A8C0MAB7 (UniProtKB/TrEMBL)
Protein Domains
TIR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016175 Ensembl
  ENSCAFG00030004096 UniProtKB/TrEMBL
  ENSCAFG00040000186 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030007545.1 UniProtKB/TrEMBL
  ENSCAFT00040000283.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  TIR_dom UniProtKB/TrEMBL
  Toll-like_receptor UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:100379585 UniProtKB/TrEMBL
NCBI Gene TLR10 ENTREZGENE
PANTHER PTHR24365 UniProtKB/TrEMBL
  PTHR24365:SF23 UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
PIRSF Toll-like_receptor UniProtKB/TrEMBL
PRINTS INTRLKN1R1F UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  SSF52200 UniProtKB/TrEMBL
UniProt A0A8C0MAB7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PJX7_CANLF UniProtKB/TrEMBL
  H6BA90_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:53248 ENTREZGENE