Ascc2 (activating signal cointegrator 1 complex subunit 2)

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Gene: Ascc2 (activating signal cointegrator 1 complex subunit 2) Rattus norvegicus

Analyze

Symbol:

Ascc2

Name:

activating signal cointegrator 1 complex subunit 2

RGD ID:

1561422

Description:

Predicted to enable ubiquitin binding activity. Predicted to be involved in regulation of DNA-templated transcription; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be part of DNA repair complex and activating signal cointegrator 1 complex. Orthologous to human ASCC2 (activating signal cointegrator 1 complex subunit 2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC498402; RGD1561422; similar to ASC-1 complex subunit P100

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	79,503,449 - 79,547,801 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	79,503,517 - 79,545,494 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	83,934,172 - 83,976,128 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	14	85,174,233 - 85,216,197 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	14	81,623,865 - 81,665,862 (+)	NCBI	Rnor_WKY
Rnor_6.0	14	84,873,507 - 84,913,923 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	84,876,781 - 84,913,617 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	85,550,450 - 85,592,750 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	85,277,839 - 85,320,029 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	14	78,409,997 - 78,452,215 (+)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Cancer, Familial (ISO)

genetic disease (ISO)

neurofibromatosis 2 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

aristolochic acid A (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

CGP 52608 (ISO)

chlordecone (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dicrotophos (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

folic acid (ISO)

fulvestrant (ISO)

gentamycin (EXP)

glycidol (EXP)

ivermectin (ISO)

lead(0) (ISO)

lead(2+) (ISO)

leflunomide (ISO)

methidathion (ISO)

methyl methanesulfonate (ISO)

paracetamol (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

Soman (EXP)

tamoxifen (ISO)

tetrachloromethane (EXP,ISO)

trimellitic anhydride (ISO)

triptonide (ISO)

tunicamycin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

regulation of DNA-templated transcription (IBA,ISO)

rescue of stalled ribosome (ISO)

ribosome disassembly (ISO)

ribosome-associated ubiquitin-dependent protein catabolic process (ISO)

Cellular Component

activating signal cointegrator 1 complex (ISO)

cytosolic ribosome (ISO)

DNA repair complex (ISO)

nucleus (ISO)

Molecular Function

enzyme activator activity (ISO)

K63-linked polyubiquitin modification-dependent protein binding (ISO)

nucleoside-triphosphatase regulator activity (ISO)

protein binding (ISO)

ubiquitin binding (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12077347	PMID:26924529

Genomics

Comparative Map Data

Ascc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	79,503,449 - 79,547,801 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	79,503,517 - 79,545,494 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	83,934,172 - 83,976,128 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	14	85,174,233 - 85,216,197 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	14	81,623,865 - 81,665,862 (+)	NCBI	Rnor_WKY
Rnor_6.0	14	84,873,507 - 84,913,923 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	84,876,781 - 84,913,617 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	85,550,450 - 85,592,750 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	85,277,839 - 85,320,029 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	14	78,409,997 - 78,452,215 (+)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

ASCC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	29,788,611 - 29,838,274 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	22	29,788,609 - 29,838,304 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	30,184,600 - 30,234,263 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	28,514,600 - 28,564,254 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	28,509,155 - 28,558,808	NCBI
Celera	22	13,984,318 - 14,033,974 (-)	NCBI		Celera
Cytogenetic Map	22	q12.2	NCBI
HuRef	22	13,146,838 - 13,196,327 (-)	NCBI		HuRef
CHM1_1	22	30,143,775 - 30,193,418 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	30,251,982 - 30,301,644 (-)	NCBI		T2T-CHM13v2.0

Ascc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	4,587,698 - 4,635,699 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	4,587,747 - 4,635,699 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	4,637,696 - 4,685,699 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	4,637,747 - 4,685,699 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	4,537,796 - 4,583,388 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	4,537,796 - 4,583,388 (+)	NCBI		MGSCv36	mm8
Celera	11	5,138,813 - 5,181,677 (+)	NCBI		Celera
Cytogenetic Map	11	A1	NCBI

Ascc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	4,032,194 - 4,077,953 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955455	4,032,357 - 4,077,900 (-)	NCBI	ChiLan1.0	ChiLan1.0

ASCC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	22	28,637,041 - 28,686,019 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	28,637,041 - 28,686,003 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	22	10,832,102 - 10,881,987 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

ASCC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	22,967,880 - 23,009,600 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	22,970,222 - 23,004,731 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	22,838,835 - 22,880,563 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	23,341,402 - 23,383,094 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	23,341,404 - 23,383,009 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	23,051,584 - 23,093,413 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	23,314,145 - 23,355,874 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	23,373,924 - 23,415,658 (-)	NCBI		UU_Cfam_GSD_1.0

Ascc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	112,118,251 - 112,161,111 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936657	3,707,721 - 3,752,499 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936657	3,709,578 - 3,752,377 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ASCC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	46,797,317 - 46,842,459 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	46,797,307 - 46,842,479 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	49,832,165 - 49,879,613 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ASCC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	12,673,642 - 12,725,268 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	12,673,064 - 12,725,233 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	113,421,058 - 113,472,673 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ascc2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	6,105,753 - 6,149,987 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	6,103,219 - 6,150,011 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ascc2
211 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	61
Count of miRNA genes:	54
Interacting mature miRNAs:	58
Transcripts:	ENSRNOT00000065188
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	95876975	Rat
70187	Pancm5	Pancreatic morphology QTL 5	16.7		pancreas mass (VT:0010144)	pancreas weight to body weight ratio (CMO:0000630)	14	30320092	80829842	Rat
2313048	Bss84	Bone structure and strength QTL 84	3.1	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	14	37669719	82669719	Rat
2313084	Bss83	Bone structure and strength QTL 83	2.9	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	14	37669719	82669719	Rat
2313089	Bss81	Bone structure and strength QTL 81	3.4	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	14	37669719	82669719	Rat
2313100	Bss82	Bone structure and strength QTL 82	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	14	37669719	82669719	Rat
738037	Hcas6	Hepatocarcinoma susceptibility QTL 6	2.93		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	14	39057237	83368335	Rat
631523	Pia13	Pristane induced arthritis QTL 13	3.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	40793460	98037301	Rat
1300136	Rf22	Renal function QTL 22	3.9		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	14	42262529	95023211	Rat
1549834	Scl45	Serum cholesterol level QTL 45	5.8		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	50023211	95023211	Rat
2300197	Scl59	Serum cholesterol level QTL 59			blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	55147478	100147478	Rat
9590294	Uminl4	Urine mineral level QTL 4	5.66	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	14	55624247	100624247	Rat
9589034	Epfw11	Epididymal fat weight QTL 11	6	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	14	55624247	100624247	Rat
2317879	Alcrsp27	Alcohol response QTL 27	3.3	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	14	56631369	101631369	Rat
634328	Hc5	Hypercalciuria QTL 5	2.3		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	14	58184885	103184885	Rat
70153	Bp59	Blood pressure QTL 59	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	14	68757796	83368335	Rat
1582259	Gluco23	Glucose level QTL 23	3.1	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	70053989	104886043	Rat
1641900	Alcrsp11	Alcohol response QTL 11			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	14	70053989	104886043	Rat
1582197	Gluco27	Glucose level QTL 27	3.4	0.0006	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	73415323	92554092	Rat
1582209	Gluco20	Glucose level QTL 20	3.8	0.0005	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	73415323	92554092	Rat
1582236	Gluco22	Glucose level QTL 22	3.3	0.0164	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	73415323	92554092	Rat
1582255	Gluco29	Glucose level QTL 29	3.1	0.0025	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	14	73415323	92554092	Rat
1582250	Gluco26	Glucose level QTL 26	3.3	0.0009	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	73415323	95876975	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	34	39	24	18	24			66	31	41	11
Low		9	18	17	1	17	8	11	8	4			8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109091	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092295	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092296	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000254	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000065188 ⟹ ENSRNOP00000060720

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	79,503,536 - 79,545,494 (+)	Ensembl
Rnor_6.0 Ensembl	14	84,876,781 - 84,913,617 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000109658 ⟹ ENSRNOP00000090694

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	79,503,536 - 79,545,494 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000115226 ⟹ ENSRNOP00000077053

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	79,503,536 - 79,545,494 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000117747 ⟹ ENSRNOP00000083909

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	79,503,517 - 79,545,494 (+)	Ensembl

RefSeq Acc Id:

NM_001109091 ⟹ NP_001102561

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	79,503,536 - 79,545,494 (+)	NCBI
Rnor_6.0	14	84,873,507 - 84,913,923 (+)	NCBI
Rnor_5.0	14	85,550,450 - 85,592,750 (+)	NCBI
RGSC_v3.4	14	85,277,839 - 85,320,029 (+)	RGD
Celera	14	78,409,997 - 78,452,215 (+)	RGD

Sequence:

show sequence

GGAAGCTGTCGCGGTGAATTGCGGCTGAACATCACGGGTGTGGAGCCGGGGAGGAGGGTCACGC
AGCACAATGCCAGCTCTGCCCCTGGACCAACTCCAGATCACCCACAAAGACCCGAAGACAGGCA
AGCTGAGGACTTCAGCAGCGCTGCACCCTGAGCAGAAGGCAGACCGGTATTTTGTGTTGTACAA
ACCACCCCCTAAAGACAACATTCCTGCCCTGGTGGAGGAGTACCTGGAGCGTGCCAACTTCGTA
GCCAATGACCTCGACTGGCTCCTGGCCTTGCCTCACGATAAATTCTGGTGCCAGGTCATCTTTG
ATGAGAGCCTGCAGAAGTGCCTGGACTCCTACCTGCACTATGTGCCCCGAAAATTTGATGAGTG
GGTGGCCCCAACCCCTGAGGTTGCTGACATGCAGAAGCACCTGCACCGAAGTGTTTTCCTCACC
TTCCTTCGAATGTCCACTCACAAGGAATCCAAAGACCACTTCATTTCTCCATCCGCATTTGGAG
AAATCCTCTACAATAACTTCCTCTTTGACATCCCAAAGATCCTGGACCTCTGTGTGCTCTTTGG
GAAAGGCAACTCACCACTGCTCCAGAAAATGATAGGAAACATATTTACCCAGCAGCCAAGTTAC
TATAATGACCTGGACGAAACCATTCCCACCATACTTCAGGTCTTCAGCAATATCCTCCAGCACT
GTGGTTTGCAAGGGGATGGAATAAACACCATACCCCAGAAACTCGGGGAGAGGCCTCGGTTGAC
GCCCAGTGACATGCCTCTCTTGGAATTAAAGGACATTGTTCTCTACCTGTGTGACACCTCCACC
ACACTCTGGGCCTTTCTGGACATCTTCCCTTTGGCCTGCCAAACCTTCCAGAAACATGACTTTT
GTTACAGACTAGCTTCCTTTTATGAGATGGCGATTCCGGAAATAGAGTCTGCAATTAAGAAGAG
GAGGCTTGAAGACAGCAAGCTCCTGGGTGACATGTGGCAGAGGCTCTCCCATTCCAAGAAGAAG
CTAATGGAGGTGTTTCACACCATCCTGAACCAGATCTGCCTCCTTCCCATTCTAGAGAGCAGCT
GTGACAACATTCAAGGCTTCATTGAAGAATTCCTTCAAATCTTTAGCTCTTTGCTGCAGGAGAA
GAGATTCCTCCGAGACTATGACTCATTCTTCCCTGTAGCTGAAGACATCAGCTTGCTGCAGCAG
GCTTCATCAGCATTGGATGAAACCCGGACTACCTACATCCTACAGGCTGTGGAAGGTGCATGGG
AAGGGGTGGACAGACAGAAAATCAAGGACATTAAAGACCCATCAAGAGCCAAGGATTCTAATAA
CGGAGTCACAATGACAGCAGAGCCAGTCAGTGAAATGCCATCACAGCTGGAGAATTCGGAAGAC
GATGAGGAGTGCATGGGTGCAGCAGCTGCCGTGGGCCCCGCCGTGAGCGGTGTGGAACTGGACT
CACTCATCTCCCAAGTGAAGGACCTGCTGCCAGACCTCGGGGAGGGCTTTATTCTGGCCTGCCT
GGAGCACTACAGCTATGATTCAGAGCGGGTTATCAACAACATCCTGGAGGATCGGCTGGCCCCT
GAGCTCAGTCAGCTGGACCGAAGCCTAGAAAGACAAGTAAAGCCGGACCCCACACCCCTGTTGT
CATCGCGTCACAACGTCTTCCAGAACGATGAGTTCGATGTGTTCAGCAGGGACTCAGTAGACCT
GAGCCGAGTGCACAAGGGCAGGAGGAAGGAGGAGACCGTGAGGAGCCTGGTGAATGACAAGCAG
GCTGTGGTGGCACAGTGGCAGCGCTACCAGAAGTACAGTGTGATAGTGGAGGAGGTCCCACTGC
AGCCAGGAGAATACCAGGCTGATGACTATGAGGACGAGTATGATGACACATACGATGGCAACCA
GGTGGGCGCCAATGATGCTGACTCTGATGACGAGCTCATCAGCCGCAGGCCCTTCACCATCCCT
CAGGTGCTGAGAACCAAAATGCCTGTGGAAGGGCAGGAGGAGGAGTGTGATGAAGAGGATGAGG
TTGAAGAGGAGGCCCCCAAGCCAGACCATTTCATTCAGGATCCTGCAGTGCTGAGGGAAAAGGC
TGAAGCTAGGCGCATAGCCTTCCTCGCCAGGAAAGGGTATCGACCTGAGAACTCCACTGCAGTG
ACAGGTGGACCCCGGGGCCATGGGCAAAGCCGAGAAACAACCCAGGAGCGCAGGAAGAAAGAGG
CCAACAAGGCAGCCAGAGCCAACCACAGCCGTAGAACCATGGCTGACCGAAAGAGAAACAAAGG
CATGATCCCATCCTGAGGCCACAAGCTGCCTGGACCAGGGAGGCCCCTCAAGACCACCATCACA
CCTCACCTACCAGCCAGCCGTGAGCGCCTTCTTGTCAAACACACAGTGCCTTATCCCTTGGTGC
GGGAACCCAGTGCCATCGAGCAGGCTCTCTCCCAGCTGTGCTGGTGGGAAGGATGGGGCTGCAG
AACCAAAGTGTCTCTCATCTCGGGCAGCAAGGCACCACCTCCAGAAGTCCTGGATGGCAGGAGA
CCTGTATATTCAGAAGCAACGAAAGGCCCATGAATAAAGTTTCTGACCTTCCAACAGTGCTCCC
TG

hide sequence

RefSeq Acc Id:

XM_039092295 ⟹ XP_038948223

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	79,503,563 - 79,547,801 (+)	NCBI

RefSeq Acc Id:

XM_039092296 ⟹ XP_038948224

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	79,503,449 - 79,547,801 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102561	(Get FASTA)	NCBI Sequence Viewer
	XP_038948223	(Get FASTA)	NCBI Sequence Viewer
	XP_038948224	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM00235	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001102561 ⟸ NM_001109091

- UniProtKB:

A0A8I6ANY1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPALPLDQLQITHKDPKTGKLRTSAALHPEQKADRYFVLYKPPPKDNIPALVEEYLERANFVAN
DLDWLLALPHDKFWCQVIFDESLQKCLDSYLHYVPRKFDEWVAPTPEVADMQKHLHRSVFLTFL
RMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMIGNIFTQQPSYYN
DLDETIPTILQVFSNILQHCGLQGDGINTIPQKLGERPRLTPSDMPLLELKDIVLYLCDTSTTL
WAFLDIFPLACQTFQKHDFCYRLASFYEMAIPEIESAIKKRRLEDSKLLGDMWQRLSHSKKKLM
EVFHTILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQEKRFLRDYDSFFPVAEDISLLQQAS
SALDETRTTYILQAVEGAWEGVDRQKIKDIKDPSRAKDSNNGVTMTAEPVSEMPSQLENSEDDE
ECMGAAAAVGPAVSGVELDSLISQVKDLLPDLGEGFILACLEHYSYDSERVINNILEDRLAPEL
SQLDRSLERQVKPDPTPLLSSRHNVFQNDEFDVFSRDSVDLSRVHKGRRKEETVRSLVNDKQAV
VAQWQRYQKYSVIVEEVPLQPGEYQADDYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQV
LRTKMPVEGQEEECDEEDEVEEEAPKPDHFIQDPAVLREKAEARRIAFLARKGYRPENSTAVTG
GPRGHGQSRETTQERRKKEANKAARANHSRRTMADRKRNKGMIPS

hide sequence

RefSeq Acc Id:

ENSRNOP00000060720 ⟸ ENSRNOT00000065188

RefSeq Acc Id:	XP_038948224 ⟸ XM_039092296
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038948223 ⟸ XM_039092295
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A067 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000083909 ⟸ ENSRNOT00000117747

RefSeq Acc Id:

ENSRNOP00000090694 ⟸ ENSRNOT00000109658

RefSeq Acc Id:

ENSRNOP00000077053 ⟸ ENSRNOT00000115226

Protein Domains

CUE

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZPJ9-F1-model_v2	AlphaFold	D3ZPJ9	1-749	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561422	AgrOrtholog
BioCyc Gene	G2FUF-15173	BioCyc
Ensembl Genes	ENSRNOG00000007349	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000060720.4	UniProtKB/TrEMBL
	ENSRNOP00000077053.1	UniProtKB/TrEMBL
	ENSRNOP00000083909	ENTREZGENE
	ENSRNOP00000083909.1	UniProtKB/TrEMBL
	ENSRNOP00000090694	ENTREZGENE
	ENSRNOP00000090694.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000065188.4	UniProtKB/TrEMBL
	ENSRNOT00000109658	ENTREZGENE
	ENSRNOT00000109658.1	UniProtKB/TrEMBL
	ENSRNOT00000115226.1	UniProtKB/TrEMBL
	ENSRNOT00000117747	ENTREZGENE
	ENSRNOT00000117747.1	UniProtKB/TrEMBL
Gene3D-CATH	DNA helicase RuvA subunit, C-terminal domain	UniProtKB/TrEMBL
InterPro	ASCC2_CUE	UniProtKB/TrEMBL
	CUE	UniProtKB/TrEMBL
	UBA-like	UniProtKB/TrEMBL
NCBI Gene	498402	ENTREZGENE
PANTHER	ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2	UniProtKB/TrEMBL
	ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100	UniProtKB/TrEMBL
Pfam	CUE	UniProtKB/TrEMBL
PhenoGen	Ascc2	PhenoGen
PROSITE	CUE	UniProtKB/TrEMBL
SMART	CUE	UniProtKB/TrEMBL
Superfamily-SCOP	UBA_like	UniProtKB/TrEMBL
UniProt	A0A8I5ZK78_RAT	UniProtKB/TrEMBL
	A0A8I6A067	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ANY1	ENTREZGENE, UniProtKB/TrEMBL
	D3ZPJ9_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-29	Ascc2	activating signal cointegrator 1 complex subunit 2	RGD1561422_predicted	similar to ASC-1 complex subunit P100 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1561422_predicted	similar to ASC-1 complex subunit P100 (predicted)	LOC498402	similar to ASC-1 complex subunit P100	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC498402	similar to ASC-1 complex subunit P100			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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