Cd38 (CD38 molecule) - Rat Genome Database

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Gene: Cd38 (CD38 molecule) Rattus norvegicus
Analyze
Symbol: Cd38
Name: CD38 molecule
RGD ID: 2303
Description: Enables NAD+ nucleotidase, cyclic ADP-ribose generating. Involved in several processes, including blood vessel diameter maintenance; long-term synaptic depression; and negative regulation of bone resorption. Located in basolateral plasma membrane and nuclear membrane. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human CD38 (CD38 molecule); PARTICIPATES IN ADP-ribosylation pathway, cyclic ribosylation; calcium/calcium-mediated signaling pathway; monoterpenoid biosynthetic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADPRC 1; cADPr hydrolase 1; CD38 antigen; CD38 antigen (ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase); CD38H; cyclic ADP-ribose hydrolase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81471,384,532 - 71,424,794 (-)NCBIGRCr8
mRatBN7.21467,172,062 - 67,212,328 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1467,172,063 - 67,211,986 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1471,579,124 - 71,618,344 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01472,852,696 - 72,892,105 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01469,289,563 - 69,328,779 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01471,714,768 - 71,754,990 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1471,715,269 - 71,754,672 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01471,745,754 - 71,786,080 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41472,320,479 - 72,360,329 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11472,322,869 - 72,362,720 (-)NCBI
Celera1466,130,278 - 66,169,650 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7-ketocholesterol  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benomyl  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
cyclic ADP-beta-D-ribose  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
D-penicillamine  (EXP)
dacarbazine  (ISO)
DDE  (EXP)
Deoxycorticosterone acetate  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (ISO)
Dibutyl phosphate  (ISO)
dichloromethane  (EXP)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
ethanol  (ISO)
ethylbenzene  (EXP)
fenvalerate  (EXP)
flavonoids  (EXP)
flutamide  (EXP,ISO)
fonofos  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
hydroxychloroquine  (ISO)
indole-3-methanol  (EXP)
iron dichloride  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ketamine  (EXP)
lipopolysaccharide  (ISO)
LY294002  (ISO)
methotrexate  (ISO)
methyl beta-cyclodextrin  (ISO)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nickel atom  (ISO)
nicotinamide  (ISO)
nicotinic acid-adenine dinucleotide phosphate  (ISO)
NMN zwitterion  (ISO)
novobiocin  (ISO)
omacetaxine mepesuccinate  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
parathion  (ISO)
PCB138  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
progesterone  (EXP,ISO)
protein kinase inhibitor  (ISO)
quercitrin  (ISO)
resveratrol  (ISO)
Ro 31-8220  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium chloride  (ISO)
Soman  (EXP)
sulfasalazine  (ISO)
superoxide  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Autoimmunity to CD38 and GAD in Type I and Type II diabetes: CD38 and HLA genotypes and clinical phenotypes. Antonelli A, etal., Diabetologia. 2002 Sep;45(9):1298-306. Epub 2002 Jul 24.
2. CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice. Chen YG, etal., J Immunol. 2006 Sep 1;177(5):2939-47.
3. CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues. Chini EN, etal., Biochem J 2002 Feb 15;362(Pt 1):125-30.
4. Retinoic acid and triiodothyronine stimulate ADP-ribosyl cyclase activity in rat vascular smooth muscle cells. de Toledo FG, etal., Biochem Biophys Res Commun. 1997 Sep 29;238(3):847-50.
5. Changes in CD38 expression and ADP-ribosyl cyclase activity in rat myometrium during pregnancy: influence of sex steroid hormones. Dogan S, etal., Biol Reprod. 2004 Jul;71(1):97-103. Epub 2004 Mar 3.
6. Design, synthesis and biological characterization of novel inhibitors of CD38. Dong M, etal., Org Biomol Chem. 2011 May 7;9(9):3246-57. doi: 10.1039/c0ob00768d. Epub 2011 Mar 23.
7. Altered CD38 expression in thioacetamide-induced rat model of liver cirrhosis. Gan BH, etal., Liver Int. 2005 Dec;25(6):1233-42.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Myocardial ischemia and reperfusion reduce the levels of cyclic ADP-ribose in rat myocardium. Ge ZD, etal., Basic Res Cardiol. 2002 Jul;97(4):312-9.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Inhibition of ADP-ribosyl cyclase attenuates angiotensin II-induced cardiac hypertrophy. Gul R, etal., Cardiovasc Res. 2009 Feb 15;81(3):582-91. Epub 2008 Aug 21.
12. Autoantibodies against CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) that impair glucose-induced insulin secretion in noninsulin- dependent diabetes patients. Ikehata F, etal., J Clin Invest. 1998 Jul 15;102(2):395-401.
13. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
14. Identification and characterization of nuclear CD38 in the rat spleen. Khoo KM and Chang CF, Int J Biochem Cell Biol 2002 Jan;34(1):43-54.
15. Role of kidney ADP-ribosyl cyclase in diabetic nephropathy. Kim SY, etal., Am J Physiol Renal Physiol. 2009 Feb;296(2):F291-7. Epub 2008 Dec 10.
16. Anti-CD38 autoantibodies: characterisation in new-onset type I diabetes and latent autoimmune diabetes of the adult (LADA) and comparison with other islet autoantibodies. Mallone R, etal., Diabetologia. 2002 Dec;45(12):1667-77. Epub 2002 Oct 24.
17. Identification and functional characterization of the hepatic stellate cell CD38 cell surface molecule. March S, etal., Am J Pathol. 2007 Jan;170(1):176-87.
18. CD38/ADP-ribosyl cyclase in the rat sublingual gland: subcellular localization under resting and saliva-secreting conditions. Masuda W and Jimi E, Arch Biochem Biophys. 2011 Sep 15;513(2):131-9. doi: 10.1016/j.abb.2011.07.006. Epub 2011 Jul 19.
19. Expression of CD38 gene, but not of mitochondrial glycerol-3-phosphate dehydrogenase gene, is impaired in pancreatic islets of GK rats. Matsuoka T, etal., Biochem Biophys Res Commun. 1995 Sep 5;214(1):239-46.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Decreased ADP-ribosyl cyclase activity in peripheral blood mononuclear cells from diabetic patients with nephropathy. Ohtsuji M, etal., Exp Diabetes Res. 2008;2008:897508. Epub 2009 Mar 17.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. Anti-CD38 autoimmunity in children with newly diagnosed type 1 diabetes mellitus. Pupilli C, etal., J Pediatr Endocrinol Metab. 2005 Dec;18(12):1417-23.
25. CD38 and CD157: a long journey from activation markers to multifunctional molecules. Quarona V, etal., Cytometry B Clin Cytom. 2013 Jul-Aug;84(4):207-17. doi: 10.1002/cyto.b.21092. Epub 2013 Apr 10.
26. Evidence of a role for cyclic ADP-ribose in long-term synaptic depression in hippocampus. Reyes-Harde M, etal., Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4061-6.
27. GOA pipeline RGD automated data pipeline
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. CD38/ADP-ribosyl cyclase: A new role in the regulation of osteoclastic bone resorption. Sun L, etal., J Cell Biol. 1999 Sep 6;146(5):1161-72.
30. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
31. ADP-ribosyl cyclase and ryanodine receptors mediate endothelin ETA and ETB receptor-induced renal vasoconstriction in vivo. Thai TL and Arendshorst WJ, Am J Physiol Renal Physiol. 2008 Aug;295(2):F360-8. Epub 2008 Jun 4.
32. Increase of intracellular Ca(2+) during ischemia/reperfusion injury of heart is mediated by cyclic ADP-ribose. Xie GH, etal., Biochem Biophys Res Commun. 2003 Aug 1;307(3):713-8.
33. A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro. Yagui K, etal., Diabetologia. 1998 Sep;41(9):1024-8.
34. CD38/cADPR/Ca2+ pathway promotes cell proliferation and delays nerve growth factor-induced differentiation in PC12 cells. Yue J, etal., J Biol Chem. 2009 Oct 23;284(43):29335-42. doi: 10.1074/jbc.M109.049767. Epub 2009 Aug 20.
35. cADP-ribose/ryanodine channel/Ca2+-release signal transduction pathway in mesangial cells. Yusufi AN, etal., Am J Physiol Renal Physiol. 2001 Jul;281(1):F91-F102.
Additional References at PubMed
PMID:8037769   PMID:8061050   PMID:8666928   PMID:9324354   PMID:12403647   PMID:12807891   PMID:16493007   PMID:17652368   PMID:17875758   PMID:18456728   PMID:19513369   PMID:20870729  
PMID:22154909   PMID:22863568   PMID:23533145   PMID:26297248   PMID:27547294   PMID:28295574   PMID:28296029   PMID:29187364   PMID:32507768   PMID:34364851   PMID:36490326  


Genomics

Comparative Map Data
Cd38
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81471,384,532 - 71,424,794 (-)NCBIGRCr8
mRatBN7.21467,172,062 - 67,212,328 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1467,172,063 - 67,211,986 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1471,579,124 - 71,618,344 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01472,852,696 - 72,892,105 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01469,289,563 - 69,328,779 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01471,714,768 - 71,754,990 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1471,715,269 - 71,754,672 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01471,745,754 - 71,786,080 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41472,320,479 - 72,360,329 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11472,322,869 - 72,362,720 (-)NCBI
Celera1466,130,278 - 66,169,650 (-)NCBICelera
Cytogenetic Map14q21NCBI
CD38
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38415,778,328 - 15,853,232 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl415,778,275 - 15,853,232 (+)EnsemblGRCh38hg38GRCh38
GRCh37415,779,951 - 15,854,855 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36415,389,029 - 15,459,806 (+)NCBINCBI36Build 36hg18NCBI36
Build 34415,456,199 - 15,526,975NCBI
Celera416,244,567 - 16,315,338 (+)NCBICelera
Cytogenetic Map4p15.32NCBI
HuRef415,130,537 - 15,200,389 (+)NCBIHuRef
CHM1_1415,777,961 - 15,848,763 (+)NCBICHM1_1
T2T-CHM13v2.0415,760,485 - 15,834,815 (+)NCBIT2T-CHM13v2.0
Cd38
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39544,026,153 - 44,069,714 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl544,025,895 - 44,069,717 (+)EnsemblGRCm39 Ensembl
GRCm38543,868,809 - 43,912,374 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl543,868,553 - 43,912,375 (+)EnsemblGRCm38mm10GRCm38
MGSCv37544,260,066 - 44,303,613 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36544,157,098 - 44,200,622 (+)NCBIMGSCv36mm8
Celera541,298,320 - 41,341,871 (+)NCBICelera
Cytogenetic Map5B3NCBI
cM Map523.85NCBI
Cd38
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554808,178,473 - 8,217,643 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554808,177,178 - 8,218,483 (-)NCBIChiLan1.0ChiLan1.0
CD38
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2316,068,255 - 16,136,264 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1416,266,125 - 16,337,568 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0410,228,803 - 10,295,129 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1415,525,835 - 15,587,677 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl415,525,835 - 15,587,677 (+)Ensemblpanpan1.1panPan2
CD38
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1364,529,129 - 64,577,755 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl364,529,721 - 64,578,099 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha367,047,105 - 67,094,978 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0365,007,240 - 65,055,632 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl365,004,679 - 65,056,133 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1364,496,819 - 64,544,484 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0364,701,068 - 64,748,707 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0365,061,119 - 65,108,887 (-)NCBIUU_Cfam_GSD_1.0
Cd38
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528558,407,127 - 58,454,437 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647712,108,742 - 12,156,248 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647712,109,761 - 12,156,037 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD38
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl811,083,682 - 11,130,756 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1811,083,682 - 11,130,783 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2810,731,289 - 10,781,193 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CD38
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12734,375,859 - 34,449,131 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2734,376,271 - 34,449,425 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604781,109,026 - 81,183,145 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd38
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475516,034,771 - 16,093,866 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475516,035,412 - 16,093,610 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cd38
286 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:443
Count of miRNA genes:238
Interacting mature miRNAs:289
Transcripts:ENSRNOT00000004121
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143999825175582726Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat

Markers in Region
RH133845  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21467,173,293 - 67,173,498 (+)MAPPERmRatBN7.2
Rnor_6.01471,716,000 - 71,716,204NCBIRnor6.0
Rnor_5.01471,746,986 - 71,747,190UniSTSRnor5.0
RGSC_v3.41472,321,210 - 72,321,414UniSTSRGSC3.4
Celera1466,131,009 - 66,131,213UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000004121   ⟹   ENSRNOP00000004121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1467,172,063 - 67,211,986 (-)Ensembl
Rnor_6.0 Ensembl1471,715,269 - 71,754,672 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111519   ⟹   ENSRNOP00000082585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1467,172,063 - 67,211,986 (-)Ensembl
RefSeq Acc Id: NM_013127   ⟹   NP_037259
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81471,384,532 - 71,424,505 (-)NCBI
mRatBN7.21467,172,062 - 67,212,035 (-)NCBI
Rnor_6.01471,715,269 - 71,754,672 (-)NCBI
Rnor_5.01471,745,754 - 71,786,080 (-)NCBI
RGSC_v3.41472,320,479 - 72,360,329 (-)RGD
Celera1466,130,278 - 66,169,650 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251072   ⟹   XP_006251134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81471,384,532 - 71,424,794 (-)NCBI
mRatBN7.21467,172,062 - 67,212,328 (-)NCBI
Rnor_6.01471,714,768 - 71,754,990 (-)NCBI
Rnor_5.01471,745,754 - 71,786,080 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063272880   ⟹   XP_063128950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81471,388,448 - 71,424,787 (-)NCBI
RefSeq Acc Id: NP_037259   ⟸   NM_013127
- UniProtKB: Q64244 (UniProtKB/Swiss-Prot),   A6IJN9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251134   ⟸   XM_006251072
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZXC3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004121   ⟸   ENSRNOT00000004121
Ensembl Acc Id: ENSRNOP00000082585   ⟸   ENSRNOT00000111519
RefSeq Acc Id: XP_063128950   ⟸   XM_063272880
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64244-F1-model_v2 AlphaFold Q64244 1-303 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699353
Promoter ID:EPDNEW_R9877
Type:initiation region
Name:Cd38_1
Description:CD38 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01471,754,678 - 71,754,738EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2303 AgrOrtholog
BioCyc Gene G2FUF-15511 BioCyc
Ensembl Genes ENSRNOG00000003069 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055015136 UniProtKB/Swiss-Prot
  ENSRNOG00060019019 UniProtKB/Swiss-Prot
  ENSRNOG00065005575 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004121.5 UniProtKB/Swiss-Prot
  ENSRNOT00000111519.1 UniProtKB/TrEMBL
  ENSRNOT00055025910 UniProtKB/Swiss-Prot
  ENSRNOT00060032921 UniProtKB/Swiss-Prot
  ENSRNOT00065008260 UniProtKB/Swiss-Prot
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADP-ribosyl_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25668 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25668 ENTREZGENE
PANTHER PTHR10912 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10912:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Rib_hydrolayse UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd38 PhenoGen
RatGTEx ENSRNOG00000003069 RatGTEx
  ENSRNOG00055015136 RatGTEx
  ENSRNOG00060019019 RatGTEx
  ENSRNOG00065005575 RatGTEx
Superfamily-SCOP N-(deoxy)ribosyltransferase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC220739
UniProt A0A8I5ZXC3 ENTREZGENE, UniProtKB/TrEMBL
  A6IJN9 ENTREZGENE, UniProtKB/TrEMBL
  CD38_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-06-27 Cd38  CD38 molecule  Cd38  CD38 antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Cd38  CD38 antigen    CD38 antigen (ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase)  Name updated 625702 APPROVED
2002-06-10 Cd38  CD38 antigen (ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in nucleus of hepatocytes and splenocytes in marginal zone and red pulp but not in splenic germinal centers 1299847
gene_function exhibits nuclear ADP-ribosyl cyclase activity 1299847
gene_process enzyme involved in synthesis of the Ca(2+)-releasing nucleotide nicotinic acid-adenine dinucleotide phosphate 631312