Exhibits NAD+ nucleosidase activity. Involved in several processes, including blood vessel diameter maintenance; long-term synaptic depression; and negative regulation of bone resorption. Localizes to basolateral plasma membrane; nucleus; and secretory granule membrane. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human CD38 (CD38 molecule); PARTICIPATES IN ADP-ribosylation pathway, cyclic ribosylation; calcium/calcium-mediated signaling pathway; monoterpenoid biosynthetic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
2-2-amino-3-methoxyphenyl-4H-1-benzopyran-4-one inhibits the reaction [Am 580 results in increased expression of CD38 protein], [Ro 25-6603 co-treated with Am 580] results in increased expression of CD38 protein
Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of CD38 mRNA], periodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of CD38 mRNA]]
CD38 gene mutant form inhibits the reaction [FASL protein affects the localization of Calcium], CD38 protein inhibits the reaction [CD38 gene mutant form inhibits the reaction [FASL protein affects the localization of Calcium]]
CD38 gene mutant form inhibits the reaction [FASL protein affects the localization of Calcium], CD38 protein inhibits the reaction [CD38 gene mutant form inhibits the reaction [FASL protein affects the localization of Calcium]]
CD38 gene mutant form promotes the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with CDH3 protein]], CD38 gene mutant form promotes the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with TJP1 protein]]
diphenyleneiodonium inhibits the reaction [VAV2 protein affects the localization of CD38 protein], diphenyleneiodonium inhibits the reaction [VAV2 protein results in increased expression of and results in increased activity of CD38 protein]
Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of CD38 mRNA], periodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of CD38 mRNA]]
2-4-morpholinyl-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased activity of CD38 protein], 2-4-morpholinyl-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of CD38 mRNA]
CD38 gene mutant form inhibits the reaction [NADP promotes the reaction [FASL protein results in increased abundance of NAADP]], CD38 gene mutant form promotes the reaction [Niacinamide inhibits the reaction [NADP promotes the reaction [FASL protein results in increased abundance of NAADP]]]
CD38 gene mutant form inhibits the reaction [NADP promotes the reaction [FASL protein results in increased abundance of NAADP]], CD38 gene mutant form promotes the reaction [Niacinamide inhibits the reaction [NADP promotes the reaction [FASL protein results in increased abundance of NAADP]]]
CD38 gene mutant form promotes the reaction [Niacinamide inhibits the reaction [NADP promotes the reaction [FASL protein results in increased abundance of NAADP]]]
rottlerin inhibits the reaction [Tretinoin results in increased expression of CD38 mRNA], rottlerin inhibits the reaction [Tretinoin results in increased expression of CD38 protein]
CD38 gene mutant form promotes the reaction [Sirolimus results in increased expression of MAP1LC3B protein], CD38 mutant form inhibits the reaction [Sirolimus results in decreased expression of SQSTM1 protein]
CD38 gene mutant form promotes the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with CDH3 protein]], CD38 gene mutant form promotes the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with TJP1 protein]]
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
