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Gene: Wfs1 (wolframin ER transmembrane glycoprotein) Rattus norvegicus
Symbol: Wfs1
Name: wolframin ER transmembrane glycoprotein
RGD ID: 68954
Description: Exhibits several functions, including calmodulin binding activity; proteasome binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of ATF6-mediated unfolded protein response; protein stabilization; and regulation of transcription, DNA-templated. Localizes to integral component of synaptic vesicle membrane. Biomarker of post-traumatic stress disorder and visual epilepsy. Human ortholog(s) of this gene implicated in Wolfram syndrome (multiple); auditory system disease (multiple); cataract 41; diabetes mellitus (multiple); and optic atrophy (multiple). Orthologous to human WFS1 (wolframin ER transmembrane glycoprotein); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
Also known as: Wolfram syndrome 1; Wolfram syndrome 1 (wolframin); Wolfram syndrome 1 homolog; Wolfram syndrome 1 homolog (human); wolframin
Homo sapiens (human) : WFS1 (wolframin ER transmembrane glycoprotein)  HGNC  Alliance
Mus musculus (house mouse) : Wfs1 (wolframin ER transmembrane glycoprotein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Wfs1 (wolframin ER transmembrane glycoprotein)
Pan paniscus (bonobo/pygmy chimpanzee) : WFS1 (wolframin ER transmembrane glycoprotein)
Canis lupus familiaris (dog) : WFS1 (wolframin ER transmembrane glycoprotein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Wfs1 (wolframin ER transmembrane glycoprotein)
Sus scrofa (pig) : WFS1 (wolframin ER transmembrane glycoprotein)
Chlorocebus sabaeus (African green monkey) : WFS1 (wolframin ER transmembrane glycoprotein)
Heterocephalus glaber (naked mole-rat) : Wfs1 (wolframin ER transmembrane glycoprotein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01478,640,707 - 78,665,224 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1478,640,620 - 78,665,966 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01478,606,172 - 78,630,689 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41479,379,680 - 79,404,003 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11479,389,637 - 79,406,394 (+)NCBI
Celera1472,756,725 - 72,781,236 (+)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Wfs1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68954
Created: 2001-11-06
Species: Rattus norvegicus
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.