Cnrip1 (cannabinoid receptor interacting protein 1) - Rat Genome Database

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Gene: Cnrip1 (cannabinoid receptor interacting protein 1) Rattus norvegicus
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Symbol: Cnrip1
Name: cannabinoid receptor interacting protein 1
RGD ID: 1308373
Description: Enables type 1 cannabinoid receptor binding activity. Predicted to be involved in negative regulation of signaling receptor activity. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human CNRIP1 (cannabinoid receptor interacting protein 1); INTERACTS WITH all-trans-retinoic acid; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CB1 cannabinoid receptor interacting; CB1 cannabinoid receptor-interacting protein 1; CRIP-1; Crip1a; LOC364208; RGD1308373; similar to DKFZP566K1924 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21491,463,046 - 91,492,736 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1491,462,647 - 91,492,735 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1495,775,359 - 95,802,450 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01497,019,686 - 97,046,778 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01493,484,748 - 93,511,843 (+)NCBIRnor_WKY
Rnor_6.014100,217,547 - 100,247,235 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14100,217,289 - 100,247,235 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014100,291,061 - 100,320,330 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41497,908,407 - 97,937,729 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11497,927,551 - 97,956,872 (+)NCBI
Celera1490,510,990 - 90,539,802 (+)NCBICelera
Cytogenetic Map14q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
plasma membrane  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a. Niehaus JL, etal., Mol Pharmacol. 2007 Dec;72(6):1557-66. Epub 2007 Sep 25.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:17634366   PMID:18308297   PMID:18782338   PMID:22079489   PMID:22871113   PMID:23286559   PMID:25657338   PMID:27895162   PMID:29476059  


Genomics

Comparative Map Data
Cnrip1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21491,463,046 - 91,492,736 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1491,462,647 - 91,492,735 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1495,775,359 - 95,802,450 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01497,019,686 - 97,046,778 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01493,484,748 - 93,511,843 (+)NCBIRnor_WKY
Rnor_6.014100,217,547 - 100,247,235 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14100,217,289 - 100,247,235 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014100,291,061 - 100,320,330 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41497,908,407 - 97,937,729 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11497,927,551 - 97,956,872 (+)NCBI
Celera1490,510,990 - 90,539,802 (+)NCBICelera
Cytogenetic Map14q22NCBI
CNRIP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38268,284,171 - 68,319,949 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl268,284,171 - 68,320,051 (-)EnsemblGRCh38hg38GRCh38
GRCh37268,511,303 - 68,547,081 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36268,373,646 - 68,400,347 (-)NCBINCBI36Build 36hg18NCBI36
Build 34268,431,793 - 68,458,494NCBI
Celera268,360,897 - 68,396,770 (-)NCBICelera
Cytogenetic Map2p14NCBI
HuRef268,248,683 - 68,284,582 (-)NCBIHuRef
CHM1_1268,442,098 - 68,477,947 (-)NCBICHM1_1
T2T-CHM13v2.0268,294,742 - 68,330,519 (-)NCBIT2T-CHM13v2.0
Cnrip1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391117,001,859 - 17,029,372 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1117,001,586 - 17,029,371 (+)EnsemblGRCm39 Ensembl
GRCm381117,051,859 - 17,079,372 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1117,051,586 - 17,079,371 (+)EnsemblGRCm38mm10GRCm38
MGSCv371116,951,937 - 16,979,375 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361116,951,937 - 16,979,375 (+)NCBIMGSCv36mm8
Celera1117,425,098 - 17,450,009 (+)NCBICelera
Cytogenetic Map11A2NCBI
Cnrip1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542416,563,499 - 16,588,711 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542416,563,499 - 16,588,711 (+)NCBIChiLan1.0ChiLan1.0
CNRIP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A69,465,496 - 69,492,148 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A69,456,924 - 69,492,716 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A68,332,179 - 68,368,033 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CNRIP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11067,340,452 - 67,358,927 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1067,340,604 - 67,357,360 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1067,230,395 - 67,246,774 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01068,360,141 - 68,376,535 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1068,360,293 - 68,376,514 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11068,043,382 - 68,059,580 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01068,341,262 - 68,357,739 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01068,636,647 - 68,653,120 (-)NCBIUU_Cfam_GSD_1.0
CNRIP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl373,939,481 - 73,943,131 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1373,939,486 - 73,963,735 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2377,470,781 - 77,495,083 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CNRIP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11438,768,496 - 38,792,368 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1438,769,105 - 38,792,412 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604573,174,652 - 73,207,864 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnrip1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247625,029,753 - 5,054,197 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247625,030,278 - 5,051,504 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cnrip1
384 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:131
Count of miRNA genes:97
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000007104
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat
4889951Bss92Bone structure and strength QTL 923.9tibia area (VT:1000281)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)148205747195876975Rat

Markers in Region
RH129001  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21491,492,384 - 91,492,593 (+)MAPPERmRatBN7.2
Rnor_6.014100,246,884 - 100,247,092NCBIRnor6.0
Rnor_5.014100,291,204 - 100,291,412UniSTSRnor5.0
RGSC_v3.41497,937,378 - 97,937,586UniSTSRGSC3.4
Celera1490,539,451 - 90,539,659UniSTS
RH 3.4 Map14675.1UniSTS
Cytogenetic Map14q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10 6 6 3 6 74 20 29 7
Low 3 33 51 35 16 35 8 11 15 11 4 8
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007104   ⟹   ENSRNOP00000007104
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1491,463,046 - 91,492,735 (+)Ensembl
Rnor_6.0 Ensembl14100,217,393 - 100,247,235 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077171   ⟹   ENSRNOP00000071855
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1491,462,647 - 91,492,735 (+)Ensembl
Rnor_6.0 Ensembl14100,217,289 - 100,246,555 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118949   ⟹   ENSRNOP00000095876
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1491,463,421 - 91,492,735 (+)Ensembl
RefSeq Acc Id: NM_001014232   ⟹   NP_001014254
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21491,463,046 - 91,492,736 (+)NCBI
Rnor_6.014100,217,547 - 100,247,235 (+)NCBI
Rnor_5.014100,291,061 - 100,320,330 (-)NCBI
RGSC_v3.41497,908,407 - 97,937,729 (+)RGD
Celera1490,510,990 - 90,539,802 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001014254   ⟸   NM_001014232
- UniProtKB: A2RQR5 (UniProtKB/Swiss-Prot),   Q5M7A7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071855   ⟸   ENSRNOT00000077171
RefSeq Acc Id: ENSRNOP00000007104   ⟸   ENSRNOT00000007104
RefSeq Acc Id: ENSRNOP00000095876   ⟸   ENSRNOT00000118949

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5M7A7-F1-model_v2 AlphaFold Q5M7A7 1-164 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699509
Promoter ID:EPDNEW_R10024
Type:initiation region
Name:Cnrip1_1
Description:cannabinoid receptor interacting protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.014100,217,314 - 100,217,374EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308373 AgrOrtholog
BioCyc Gene G2FUF-14936 BioCyc
Ensembl Genes ENSRNOG00000005326 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000007104 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000071855.2 UniProtKB/TrEMBL
  ENSRNOP00000095876.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007104 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000077171.2 UniProtKB/TrEMBL
  ENSRNOT00000118949.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7319918 IMAGE-MGC_LOAD
InterPro CNRIP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:364208 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105778 IMAGE-MGC_LOAD
NCBI Gene 364208 ENTREZGENE
PANTHER PTHR31952 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CNRIP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cnrip1 PhenoGen
UniProt A0A0G2K1I5_RAT UniProtKB/TrEMBL
  A0A8I6APM5_RAT UniProtKB/TrEMBL
  A2RQR5 ENTREZGENE
  CNRP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2RQR5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-31 Cnrip1  cannabinoid receptor interacting protein 1  RGD1308373  similar to DKFZP566K1924 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1308373  similar to DKFZP566K1924 protein  RGD1308373_predicted  similar to DKFZP566K1924 protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1308373_predicted  similar to DKFZP566K1924 protein (predicted)  LOC364208_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC364208_predicted  similar to DKFZP566K1924 protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL