Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | ISO | Klf3 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of KLF3 mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of KLF3 mRNA | CTD | PMID:26496021 | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | Klf3 (Mus musculus) | 6480464 | Dihydrotestosterone results in increased expression of KLF3 mRNA | CTD | PMID:17023530 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Klf3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of KLF3 mRNA | CTD | PMID:17035482 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of KLF3 mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KLF3 mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Klf3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to KLF3 promoter] | CTD | PMID:19654925 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of KLF3 mRNA | CTD | PMID:31881176 | aflatoxin B1 | decreases methylation | ISO | KLF3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of KLF3 gene | CTD | PMID:27153756 | all-trans-retinoic acid | increases expression | ISO | KLF3 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of KLF3 mRNA | CTD | PMID:23830798 | amosite asbestos | increases methylation | ISO | KLF3 (Homo sapiens) | 6480464 | Asbestos and Amosite results in increased methylation of KLF3 gene | CTD | PMID:32062310 | aristolochic acid A | decreases expression | ISO | KLF3 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of KLF3 mRNA | CTD | PMID:33212167 | Aroclor 1254 | decreases expression | ISO | Klf3 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of KLF3 mRNA | CTD | PMID:23650126 | arsenite(3-) | multiple interactions | ISO | KLF3 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to KLF3 mRNA] | CTD | PMID:32406909 | arsenous acid | increases expression | ISO | KLF3 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of KLF3 mRNA | CTD | PMID:20458559 | benzo[a]pyrene | increases expression | ISO | Klf3 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of KLF3 mRNA | CTD | PMID:22228805 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of KLF3 mRNA | CTD | PMID:26496021 | bisphenol A | decreases expression | ISO | Klf3 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of KLF3 mRNA | CTD | PMID:33221593 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of KLF3 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | Klf3 (Mus musculus) | 6480464 | bisphenol A results in increased expression of KLF3 mRNA | CTD | PMID:26063408 | cadmium dichloride | increases expression | ISO | KLF3 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of KLF3 mRNA | CTD | PMID:26472689 | caffeine | affects phosphorylation | ISO | KLF3 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of KLF3 protein | CTD | PMID:35688186 | carbon nanotube | increases methylation | ISO | KLF3 (Homo sapiens) | 6480464 | Nanotubes and Carbon results in increased methylation of KLF3 gene | CTD | PMID:32062310 | carbon nanotube | decreases expression | ISO | Klf3 (Mus musculus) | 6480464 | Nanotubes and Carbon results in decreased expression of KLF3 mRNA | CTD | PMID:25554681 | carbon nanotube | increases expression | ISO | Klf3 (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in increased expression of KLF3 mRNA | CTD | PMID:25620056 | cisplatin | increases phosphorylation | ISO | Klf3 (Mus musculus) | 6480464 | Cisplatin results in increased phosphorylation of KLF3 protein | CTD | PMID:22006019 | clofibrate | multiple interactions | ISO | Klf3 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of KLF3 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of KLF3 mRNA] | CTD | PMID:17585979 | clofibrate | decreases expression | ISO | Klf3 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of KLF3 mRNA | CTD | PMID:17585979 | clofibric acid | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of KLF3 mRNA | CTD | PMID:17602206 | cyclosporin A | decreases expression | ISO | KLF3 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of KLF3 mRNA | CTD | PMID:25562108 | diarsenic trioxide | increases expression | ISO | KLF3 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of KLF3 mRNA | CTD | PMID:20458559 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of KLF3 mRNA | CTD | PMID:21266533 | dibutyl phthalate | increases expression | ISO | Klf3 (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of KLF3 mRNA | CTD | PMID:17361019 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of KLF3 mRNA | CTD | PMID:21551480 | dorsomorphin | multiple interactions | ISO | KLF3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLF3 mRNA | CTD | PMID:27188386 | epoxiconazole | decreases expression | ISO | Klf3 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of KLF3 mRNA | CTD | PMID:35436446 | fenamidone | increases expression | ISO | Klf3 (Mus musculus) | 6480464 | fenamidone results in increased expression of KLF3 mRNA | CTD | PMID:27029645 | formaldehyde | decreases expression | ISO | KLF3 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of KLF3 mRNA | CTD | PMID:20655997 | FR900359 | affects phosphorylation | ISO | KLF3 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of KLF3 protein | CTD | PMID:37730182 | furan | decreases expression | EXP | | 6480464 | furan results in decreased expression of KLF3 mRNA | CTD | PMID:26194646 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of KLF3 mRNA | CTD | PMID:22061828 | geraniol | increases expression | ISO | KLF3 (Homo sapiens) | 6480464 | geraniol results in increased expression of KLF3 mRNA | CTD | PMID:27683099 | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of KLF3 mRNA | CTD | PMID:24136188 | isoprenaline | increases expression | ISO | Klf3 (Mus musculus) | 6480464 | Isoproterenol results in increased expression of KLF3 mRNA | CTD | PMID:20003209 | leflunomide | increases expression | ISO | KLF3 (Homo sapiens) | 6480464 | leflunomide results in increased expression of KLF3 mRNA | CTD | PMID:28988120 | lipopolysaccharide | increases expression | ISO | Klf3 (Mus musculus) | 6480464 | Lipopolysaccharides results in increased expression of KLF3 mRNA | CTD | PMID:10975854 and PMID:26582142 | methylmercury chloride | increases expression | ISO | KLF3 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of KLF3 mRNA | CTD | PMID:28001369 | methylmercury chloride | decreases expression | ISO | KLF3 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of KLF3 mRNA | CTD | PMID:28001369 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of KLF3 mRNA | CTD | PMID:17602206 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] affects the expression of KLF3 mRNA | CTD | PMID:25729387 | p-toluidine | decreases expression | EXP | | 6480464 | 4-toluidine results in decreased expression of KLF3 mRNA | CTD | PMID:27638505 | paracetamol | multiple interactions | ISO | Klf3 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of KLF3 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of KLF3 mRNA] | CTD | PMID:17585979 | paracetamol | decreases expression | ISO | KLF3 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of KLF3 mRNA | CTD | PMID:21420995 | paracetamol | affects expression | ISO | Klf3 (Mus musculus) | 6480464 | Acetaminophen affects the expression of KLF3 mRNA | CTD | PMID:17562736 | phenobarbital | affects expression | ISO | Klf3 (Mus musculus) | 6480464 | Phenobarbital affects the expression of KLF3 mRNA | CTD | PMID:23091169 | pirinixic acid | multiple interactions | ISO | KLF3 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of KLF3 mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | ISO | Klf3 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of KLF3 mRNA | CTD | PMID:18445702 | propiconazole | increases expression | ISO | Klf3 (Mus musculus) | 6480464 | propiconazole results in increased expression of KLF3 mRNA | CTD | PMID:21278054 | quercetin | decreases expression | ISO | KLF3 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of KLF3 mRNA | CTD | PMID:21632981 | SB 431542 | multiple interactions | ISO | KLF3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLF3 mRNA | CTD | PMID:27188386 | silicon dioxide | increases expression | ISO | Klf3 (Mus musculus) | 6480464 | Silicon Dioxide results in increased expression of KLF3 mRNA | CTD | PMID:19073995 | silicon dioxide | decreases expression | ISO | KLF3 (Homo sapiens) | 6480464 | Silicon Dioxide results in decreased expression of KLF3 mRNA | CTD | PMID:25351596 | sodium arsenite | affects methylation | ISO | KLF3 (Homo sapiens) | 6480464 | sodium arsenite affects the methylation of KLF3 gene | CTD | PMID:28589171 | sunitinib | increases expression | ISO | KLF3 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of KLF3 mRNA | CTD | PMID:31533062 | testosterone | decreases expression | ISO | KLF3 (Homo sapiens) | 6480464 | Testosterone results in decreased expression of KLF3 mRNA | CTD | PMID:33359661 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of KLF3 mRNA | CTD | PMID:34492290 | titanium dioxide | affects expression | ISO | Klf3 (Mus musculus) | 6480464 | titanium dioxide affects the expression of KLF3 mRNA | CTD | PMID:17656681 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] affects the expression of KLF3 mRNA | CTD | PMID:25729387 | trichloroethene | increases expression | ISO | Klf3 (Mus musculus) | 6480464 | Trichloroethylene results in increased expression of KLF3 mRNA | CTD | PMID:19448997 | triptonide | decreases expression | ISO | Klf3 (Mus musculus) | 6480464 | triptonide results in decreased expression of KLF3 mRNA | CTD | PMID:33045310 | troglitazone | increases expression | ISO | Klf3 (Mus musculus) | 6480464 | troglitazone results in increased expression of KLF3 mRNA | CTD | PMID:28973697 | tungsten | decreases expression | ISO | Klf3 (Mus musculus) | 6480464 | Tungsten results in decreased expression of KLF3 mRNA | CTD | PMID:30912803 | valproic acid | increases methylation | ISO | KLF3 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of KLF3 gene | CTD | PMID:29154799 | valproic acid | increases expression | ISO | KLF3 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of KLF3 mRNA | CTD | PMID:28001369 | valproic acid | multiple interactions | ISO | KLF3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLF3 mRNA | CTD | PMID:27188386 | valproic acid | decreases expression | ISO | KLF3 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of KLF3 mRNA | CTD | PMID:23179753 and PMID:26272509 | valproic acid | affects expression | ISO | KLF3 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of KLF3 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | Klf3 (Mus musculus) | 6480464 | Valproic Acid results in decreased expression of KLF3 mRNA | CTD | PMID:21427059 | zinc atom | multiple interactions | ISO | KLF3 (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of KLF3 mRNA | CTD | PMID:18593933 | zinc(0) | multiple interactions | ISO | KLF3 (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of KLF3 mRNA | CTD | PMID:18593933 | |