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Gene: Nsd2 (nuclear receptor binding SET domain protein 2) Rattus norvegicus
Symbol: Nsd2
Name: nuclear receptor binding SET domain protein 2
Description: Predicted to have chromatin binding activity; histone methyltransferase activity (H3-K36 specific); and sequence-specific DNA binding activity. Predicted to be involved in several processes, including cardiac septum morphogenesis; histone lysine methylation; and regulation of nucleobase-containing compound metabolic process. Predicted to localize to the chromatin and nucleus. Human ortholog(s) of this gene implicated in Wolf-Hirschhorn syndrome. Orthologous to human NSD2 (nuclear receptor binding SET domain protein 2); PARTICIPATES IN lysine degradation pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
Also known as: histone-lysine N-methyltransferase NSD2; LOC305456; LOC680537; probable histone-lysine N-methyltransferase NSD2; RGD1565590; similar to Wolf-Hirschhorn syndrome candidate 1 protein isoform 1; Whsc1; Wolf-Hirschhorn syndrome candidate 1; Wolf-Hirschhorn syndrome candidate 1 (human)
Homo sapiens (human) : NSD2 (nuclear receptor binding SET domain protein 2)  HGNC  Alliance
Mus musculus (house mouse) : Nsd2 (nuclear receptor binding SET domain protein 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nsd2 (nuclear receptor binding SET domain protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NSD2 (nuclear receptor binding SET domain protein 2)
Canis lupus familiaris (dog) : NSD2 (nuclear receptor binding SET domain protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nsd2 (nuclear receptor binding SET domain protein 2)
Sus scrofa (pig) : NSD2 (nuclear receptor binding SET domain protein 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01482,119,210 - 82,196,501 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01482,803,450 - 82,885,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41482,528,213 - 82,580,192NCBIRGSC3.4rn4RGSC3.4
Celera1475,757,842 - 75,809,420 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Nsd2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1307955
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.