Nf2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor) - Rat Genome Database

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Gene: Nf2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor) Rattus norvegicus
Analyze
Symbol: Nf2
Name: NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor (Ensembl:neurofibromin 2)
RGD ID: 3169
Description: Enables beta-catenin binding activity; integrin binding activity; and protein domain specific binding activity. Involved in animal organ development and negative regulation of cell growth. Located in several cellular components, including membrane raft; perinuclear region of cytoplasm; and synapse. Part of protein-containing complex. Biomarker of epilepsy. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); malignant pleural mesothelioma; meningioma (multiple); neurilemmoma (multiple); and neurofibromatosis 2. Orthologous to human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: merlin; moesin-ezrin-radixin-like protein; neurofibromatosis 2; neurofibromin 2; neurofibromin 2 (merlin); neurofibromin-2; schwannomin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21479,627,399 - 79,710,709 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1479,627,399 - 79,710,667 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1484,057,988 - 84,141,291 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01485,298,058 - 85,381,369 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01481,747,732 - 81,831,027 (-)NCBIRnor_WKY
Rnor_6.01484,996,905 - 85,088,547 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,996,905 - 85,088,523 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,673,149 - 85,766,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41485,415,142 - 85,508,807 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11485,436,559 - 85,527,546 (-)NCBI
Celera1478,532,232 - 78,615,355 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A mouse model recapitulating molecular features of human mesothelioma. Altomare DA, etal., Cancer Res. 2005 Sep 15;65(18):8090-5. doi: 10.1158/0008-5472.CAN-05-2312.
2. Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice. Badhai J, etal., J Exp Med. 2020 Jun 1;217(6). pii: 151644. doi: 10.1084/jem.20191257.
3. Lipid raft localization of ErbB2 in vestibular schwannoma and schwann cells. Brown KD and Hansen MR, Otol Neurotol. 2008 Jan;29(1):79-85.
4. Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations. Bueno R, etal., Nat Genet. 2016 Apr;48(4):407-16. doi: 10.1038/ng.3520. Epub 2016 Feb 29.
5. A mosaic pattern of INI1/SMARCB1 protein expression distinguishes Schwannomatosis and NF2-associated peripheral schwannomas from solitary peripheral schwannomas and NF2-associated vestibular schwannomas. Caltabiano R, etal., Childs Nerv Syst. 2017 Jun;33(6):933-940. doi: 10.1007/s00381-017-3340-2. Epub 2017 Apr 1.
6. Loss of NF2/Merlin expression in advanced sporadic colorectal cancer. Cačev T, etal., Cell Oncol (Dordr). 2014 Feb;37(1):69-77. doi: 10.1007/s13402-013-0164-2. Epub 2013 Dec 10.
7. Merlin, the product of NF2 gene, is associated with aromatase expression and estrogen formation in human liver tissues and liver cancer cells. Cocciadiferro L, etal., J Steroid Biochem Mol Biol. 2017 Sep;172:222-230. doi: 10.1016/j.jsbmb.2016.05.023. Epub 2016 Jun 8.
8. Allelic loss of 14q and 22q, NF2 mutation, and genetic instability occur independently of c-kit mutation in gastrointestinal stromal tumor. Fukasawa T, etal., Jpn J Cancer Res. 2000 Dec;91(12):1241-9. doi: 10.1111/j.1349-7006.2000.tb00910.x.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Characterization of the NF2 protein merlin and the ERM protein ezrin in human, rat, and mouse central nervous system. Gronholm M, etal., Mol Cell Neurosci. 2005 Apr;28(4):683-93.
12. Expression of the neurofibromatosis 2 (NF2) gene isoforms during rat embryonic development. Gutmann DH, etal., Hum Mol Genet 1995 Mar;4(3):471-8.
13. [Expression of Merlin protein in non-small cell lung carcinoma and the clinical significance]. Hu J, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Jun;36(6):565-9. doi: 10.3969/j.issn.1672-7347.2011.06.015.
14. Characterization of the rat neurofibromatosis 2 gene and its involvement in asbestos-induced mesothelioma. Kleymenova EV, etal., Mol Carcinog 1997 Jan;18(1):54-60.
15. p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis. Laine H, etal., J Neurosci. 2007 Feb 7;27(6):1434-44.
16. Targeted next-generation sequencing for differential diagnosis of neurofibromatosis type 2, schwannomatosis, and meningiomatosis. Louvrier C, etal., Neuro Oncol. 2018 Jun 18;20(7):917-929. doi: 10.1093/neuonc/noy009.
17. A splicing variant of Merlin promotes metastasis in hepatocellular carcinoma. Luo ZL, etal., Nat Commun. 2015 Oct 7;6:8457. doi: 10.1038/ncomms9457.
18. Endothelial Cdkn1a (p21) overexpression and accelerated senescence in a mouse model of Fuchs endothelial corneal dystrophy. Matthaei M, etal., Invest Ophthalmol Vis Sci. 2012 Sep 28;53(10):6718-27.
19. Low Merlin expression and high Survivin labeling index are indicators for poor prognosis in patients with malignant pleural mesothelioma. Meerang M, etal., Mol Oncol. 2016 Oct;10(8):1255-65. doi: 10.1016/j.molonc.2016.06.005. Epub 2016 Jun 25.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Aberrant epithelial morphology and persistent epidermal growth factor receptor signaling in a mouse model of renal carcinoma. Morris ZS and McClatchey AI, Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9767-72. Epub 2009 Jun 1.
22. The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44. Morrison H, etal., Genes Dev. 2001 Apr 15;15(8):968-80.
23. Predominant occurrence of somatic mutations of the NF2 gene in meningiomas and schwannomas. Mérel P, etal., Genes Chromosomes Cancer. 1995 Jul;13(3):211-6. doi: 10.1002/gcc.2870130311.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Merlin, the neurofibromatosis type 2 gene product, and beta1 integrin associate in isolated and differentiating Schwann cells. Obremski VJ, etal., J Neurobiol. 1998 Dec;37(4):487-501.
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. Molecular genetics of meningiomas. Ragel BT and Jensen RL, Neurosurg Focus. 2005 Nov 15;19(5):E9.
28. Erbin regulates mitogen-activated protein (MAP) kinase activation and MAP kinase-dependent interactions between Merlin and adherens junction protein complexes in Schwann cells. Rangwala R, etal., J Biol Chem. 2005 Mar 25;280(12):11790-7. Epub 2005 Jan 19.
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. The prognostic significance of BAP1, NF2, and CDKN2A in malignant peritoneal mesothelioma. Singhi AD, etal., Mod Pathol. 2016 Jan;29(1):14-24. doi: 10.1038/modpathol.2015.121. Epub 2015 Oct 23.
33. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition Wang Q, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2006 Jan;37(1):115-7.
34. Involvement of p21 (waf1) in merlin deficient sporadic vestibular schwannomas. Wu H, etal., Neuroscience. 2010 Sep 29;170(1):149-55. doi: 10.1016/j.neuroscience.2010.06.051. Epub 2010 Jul 1.
35. A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions. Yi C, etal., Cancer Cell. 2011 Apr 12;19(4):527-40. doi: 10.1016/j.ccr.2011.02.017.
36. Molecular alterations of the NF2 gene in hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Zhang N, etal., Oncol Rep. 2017 Dec;38(6):3650-3658. doi: 10.3892/or.2017.6055. Epub 2017 Oct 24.
Additional References at PubMed
PMID:8547603   PMID:8889548   PMID:9171370   PMID:9537418   PMID:9553042   PMID:9563848   PMID:9631655   PMID:10401006   PMID:10861283   PMID:10887156   PMID:12118253   PMID:12444102  
PMID:12695331   PMID:14580336   PMID:14991710   PMID:15133494   PMID:15467741   PMID:15598747   PMID:16405865   PMID:16571745   PMID:16885985   PMID:17210637   PMID:17353411   PMID:17891137  
PMID:19946888   PMID:20159598   PMID:20178741   PMID:20181838   PMID:21167305   PMID:21182951   PMID:23863479   PMID:25433207   PMID:29709009  


Genomics

Comparative Map Data
Nf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21479,627,399 - 79,710,709 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1479,627,399 - 79,710,667 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1484,057,988 - 84,141,291 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01485,298,058 - 85,381,369 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01481,747,732 - 81,831,027 (-)NCBIRnor_WKY
Rnor_6.01484,996,905 - 85,088,547 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,996,905 - 85,088,523 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,673,149 - 85,766,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41485,415,142 - 85,508,807 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11485,436,559 - 85,527,546 (-)NCBI
Celera1478,532,232 - 78,615,355 (-)NCBICelera
Cytogenetic Map14q21NCBI
NF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382229,603,556 - 29,698,600 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2229,603,556 - 29,698,598 (+)EnsemblGRCh38hg38GRCh38
GRCh372229,999,545 - 30,094,589 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362228,329,565 - 28,424,587 (+)NCBINCBI36Build 36hg18NCBI36
Build 342228,324,118 - 28,419,137NCBI
Celera2213,799,281 - 13,894,313 (+)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2212,962,966 - 13,057,866 (+)NCBIHuRef
CHM1_12229,958,840 - 30,053,867 (+)NCBICHM1_1
T2T-CHM13v2.02230,066,918 - 30,161,963 (+)NCBIT2T-CHM13v2.0
Nf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,715,845 - 4,799,544 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl114,715,845 - 4,799,536 (-)EnsemblGRCm39 Ensembl
GRCm38114,757,639 - 4,849,544 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,765,845 - 4,849,536 (-)EnsemblGRCm38mm10GRCm38
MGSCv37114,665,851 - 4,749,530 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36114,667,997 - 4,749,553 (-)NCBIMGSCv36mm8
Celera115,266,247 - 5,349,954 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.0NCBI
Nf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554553,862,347 - 3,951,891 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554553,862,804 - 3,950,669 (+)NCBIChiLan1.0ChiLan1.0
NF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12228,454,119 - 28,544,013 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2228,454,119 - 28,544,013 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02210,648,022 - 10,738,167 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12622,816,869 - 22,896,103 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2622,816,551 - 22,894,196 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2622,688,278 - 22,767,181 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02623,190,481 - 23,269,695 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2623,190,429 - 23,269,692 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12622,900,555 - 22,979,936 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02623,163,349 - 23,242,535 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02623,223,162 - 23,302,265 (+)NCBIUU_Cfam_GSD_1.0
Nf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118112,250,596 - 112,334,448 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366573,536,141 - 3,623,821 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366573,536,212 - 3,622,999 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1446,653,900 - 46,731,999 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11446,653,869 - 46,726,421 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21449,688,078 - 49,760,671 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11912,474,479 - 12,572,144 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1912,474,468 - 12,572,250 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045113,569,107 - 113,665,600 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247475,923,834 - 6,011,939 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247475,923,827 - 6,011,276 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nf2
147 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:412
Count of miRNA genes:216
Interacting mature miRNAs:265
Transcripts:ENSRNOT00000010690
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat

Markers in Region
RH130158  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21479,627,425 - 79,627,636 (+)MAPPERmRatBN7.2
Rnor_6.01484,996,932 - 84,997,142NCBIRnor6.0
Rnor_5.01485,673,176 - 85,673,386UniSTSRnor5.0
RGSC_v3.41485,415,169 - 85,415,379UniSTSRGSC3.4
Celera1478,532,259 - 78,532,469UniSTS
RH 3.4 Map14555.1UniSTS
Cytogenetic Map14q21UniSTS
RH134074  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21479,664,298 - 79,664,478 (+)MAPPERmRatBN7.2
Rnor_6.01485,042,171 - 85,042,350NCBIRnor6.0
Rnor_5.01485,719,978 - 85,720,157UniSTSRnor5.0
RGSC_v3.41485,453,237 - 85,453,416UniSTSRGSC3.4
Celera1478,569,038 - 78,569,217UniSTS
RH 3.4 Map14551.79UniSTS
Cytogenetic Map14q21UniSTS
RH94846  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21479,643,232 - 79,643,385 (+)MAPPERmRatBN7.2
Rnor_6.01485,012,815 - 85,012,967NCBIRnor6.0
Rnor_5.01485,689,059 - 85,689,211UniSTSRnor5.0
RGSC_v3.41485,431,087 - 85,431,239UniSTSRGSC3.4
Celera1478,548,060 - 78,548,212UniSTS
Cytogenetic Map14q21UniSTS
RH94847  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21479,643,222 - 79,643,375 (+)MAPPERmRatBN7.2
Rnor_6.01485,012,805 - 85,012,957NCBIRnor6.0
Rnor_5.01485,689,049 - 85,689,201UniSTSRnor5.0
RGSC_v3.41485,431,077 - 85,431,229UniSTSRGSC3.4
Celera1478,548,050 - 78,548,202UniSTS
Cytogenetic Map14q21UniSTS
BF399446  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21479,684,625 - 79,684,832 (+)MAPPERmRatBN7.2
Rnor_6.01485,062,486 - 85,062,692NCBIRnor6.0
Rnor_5.01485,740,263 - 85,740,469UniSTSRnor5.0
RGSC_v3.41485,482,723 - 85,482,929UniSTSRGSC3.4
Celera1478,589,312 - 78,589,518UniSTS
RH 3.4 Map14552.39UniSTS
Cytogenetic Map14q21UniSTS
GDB:373416  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21479,645,804 - 79,645,922 (+)MAPPERmRatBN7.2
Rnor_6.01485,024,417 - 85,024,534NCBIRnor6.0
Rnor_5.01485,702,224 - 85,702,341UniSTSRnor5.0
RGSC_v3.41485,433,893 - 85,434,010UniSTSRGSC3.4
Celera1478,550,428 - 78,550,545UniSTS
Cytogenetic Map14q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 45 29 19 29 4 7 74 35 41 11 4
Low 12 12 12 4 4 4
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA955327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF558742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP499772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ201846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA511825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB578019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB787451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB814077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK364860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO387057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO573762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR467414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U17266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U61772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000010690   ⟹   ENSRNOP00000010690
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1479,627,399 - 79,710,667 (-)Ensembl
Rnor_6.0 Ensembl1484,996,905 - 85,088,523 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105938   ⟹   ENSRNOP00000087785
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1479,627,417 - 79,710,666 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115516   ⟹   ENSRNOP00000089056
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1479,642,208 - 79,710,667 (-)Ensembl
RefSeq Acc Id: NM_013193   ⟹   NP_037325
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21479,627,399 - 79,710,667 (-)NCBI
Rnor_6.01484,996,905 - 85,088,523 (-)NCBI
Rnor_5.01485,673,149 - 85,766,360 (-)NCBI
RGSC_v3.41485,415,142 - 85,508,807 (-)RGD
Celera1478,532,232 - 78,615,355 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251188   ⟹   XP_006251250
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21479,627,400 - 79,710,709 (-)NCBI
Rnor_6.01484,996,907 - 85,088,545 (-)NCBI
Rnor_5.01485,673,149 - 85,766,360 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251191   ⟹   XP_006251253
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21479,645,797 - 79,710,709 (-)NCBI
Rnor_6.01485,026,561 - 85,088,547 (-)NCBI
Rnor_5.01485,673,149 - 85,766,360 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039091641   ⟹   XP_038947569
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21479,627,400 - 79,710,709 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_037325   ⟸   NM_013193
- UniProtKB: Q63648 (UniProtKB/Swiss-Prot),   G3V717 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251250   ⟸   XM_006251188
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A8G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251253   ⟸   XM_006251191
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000010690   ⟸   ENSRNOT00000010690
RefSeq Acc Id: XP_038947569   ⟸   XM_039091641
- Peptide Label: isoform X2
- UniProtKB: G3V717 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000087785   ⟸   ENSRNOT00000105938
RefSeq Acc Id: ENSRNOP00000089056   ⟸   ENSRNOT00000115516
Protein Domains
ERM_C   FERM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63648-F1-model_v2 AlphaFold Q63648 1-586 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699448
Promoter ID:EPDNEW_R9972
Type:initiation region
Name:Nf2_1
Description:neurofibromin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01485,088,565 - 85,088,625EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3169 AgrOrtholog
BioCyc Gene G2FUF-15168 BioCyc
Ensembl Genes ENSRNOG00000007948 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000010690 ENTREZGENE
  ENSRNOP00000010690.5 UniProtKB/TrEMBL
  ENSRNOP00000087785 ENTREZGENE
  ENSRNOP00000087785.1 UniProtKB/TrEMBL
  ENSRNOP00000089056.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010690 ENTREZGENE
  ENSRNOT00000010690.6 UniProtKB/TrEMBL
  ENSRNOT00000105938 ENTREZGENE
  ENSRNOT00000105938.1 UniProtKB/TrEMBL
  ENSRNOT00000115516.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.360.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERM_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERM_FERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERM_helical UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ez/rad/moesin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_central UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_PH-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Moesin_tail_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25744 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25744 ENTREZGENE
PANTHER PTHR23281 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERM_helical UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nf2 PhenoGen
PIRSF ERM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS BAND41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERMFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FERM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART B41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47031 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48678 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A8G0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GHR3_RAT UniProtKB/TrEMBL
  G3V717 ENTREZGENE, UniProtKB/TrEMBL
  MERL_RAT UniProtKB/Swiss-Prot
  Q62723_RAT UniProtKB/TrEMBL
  Q63648 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-10-22 Nf2  NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor  Nf2  neurofibromin 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-07-13 Nf2  neurofibromin 2  Nf2  neurofibromin 2 (merlin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Nf2  neurofibromin 2 (merlin)  Nf2  neurofibromatosis 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Nf2  neurofibromatosis 2    Neurofibromatosis 2  Name updated 625702 APPROVED
2002-06-10 Nf2  Neurofibromatosis 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript alternative splice isoform type 1 merlin is missing exon 16 sequence contained in type 2 merlin 633510