Nf2 (neurofibromin 2) - Rat Genome Database
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Gene: Nf2 (neurofibromin 2) Rattus norvegicus
Analyze
Symbol: Nf2
Name: neurofibromin 2
RGD ID: 3169
Description: Exhibits beta-catenin binding activity; integrin binding activity; and protein domain specific binding activity. Involved in negative regulation of cell growth. Localizes to several cellular components, including membrane raft; perinuclear region of cytoplasm; and synapse. Biomarker of epilepsy. Human ortholog(s) of this gene implicated in familial meningioma; neurilemmomatosis; and neurofibromatosis 2. Orthologous to human NF2 (neurofibromin 2); INTERACTS WITH ammonium chloride; bisphenol A; decabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: merlin; moesin-ezrin-radixin-like protein; neurofibromatosis 2; neurofibromin 2 (merlin); neurofibromin-2; schwannomin
Orthologs:
Homo sapiens (human) : NF2 (neurofibromin 2)  HGNC  Alliance
Mus musculus (house mouse) : Nf2 (neurofibromin 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nf2 (neurofibromin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NF2 (neurofibromin 2)
Canis lupus familiaris (dog) : NF2 (neurofibromin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nf2 (neurofibromin 2)
Sus scrofa (pig) : NF2 (neurofibromin 2)
Chlorocebus sabaeus (African green monkey) : NF2 (neurofibromin 2)
Heterocephalus glaber (naked mole-rat) : Nf2 (neurofibromin 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01484,996,905 - 85,088,547 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,996,905 - 85,088,523 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,673,149 - 85,766,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41485,415,142 - 85,508,807 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11485,436,559 - 85,527,546 (-)NCBI
Celera1478,532,232 - 78,615,355 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
adherens junction  (IEA,ISO)
apical part of cell  (IEA,ISO)
cell body  (IEA,ISO)
cleavage furrow  (IEA,ISO)
cortical actin cytoskeleton  (IEA,ISO)
cytoplasm  (IDA,ISO)
cytoskeleton  (ISO)
cytosol  (IEA,ISO)
early endosome  (IEA,ISO)
filopodium  (IEA,ISO)
lamellipodium  (IEA,ISO)
membrane raft  (IDA)
neuron projection  (IEA,ISO)
nucleolus  (IEA,ISO)
nucleus  (ISO)
perinuclear region of cytoplasm  (IDA,IEA,ISO)
plasma membrane  (IDA,ISO)
protein-containing complex  (IDA)
ruffle  (IEA,ISO)
synapse  (IDA)

Molecular Function

References

Additional References at PubMed
PMID:8547603   PMID:8889548   PMID:9171370   PMID:9537418   PMID:9553042   PMID:9563848   PMID:9631655   PMID:10401006   PMID:10861283   PMID:10887156   PMID:12118253   PMID:12444102  
PMID:12695331   PMID:14580336   PMID:14991710   PMID:15133494   PMID:15467741   PMID:15598747   PMID:16405865   PMID:16571745   PMID:16885985   PMID:17210637   PMID:17353411   PMID:17891137  
PMID:19946888   PMID:20159598   PMID:20178741   PMID:20181838   PMID:21167305   PMID:21182951   PMID:23863479   PMID:25433207   PMID:29709009  


Genomics

Comparative Map Data
Nf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01484,996,905 - 85,088,547 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,996,905 - 85,088,523 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,673,149 - 85,766,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41485,415,142 - 85,508,807 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11485,436,559 - 85,527,546 (-)NCBI
Celera1478,532,232 - 78,615,355 (-)NCBICelera
Cytogenetic Map14q21NCBI
NF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2229,603,556 - 29,698,598 (+)EnsemblGRCh38hg38GRCh38
GRCh382229,603,556 - 29,698,600 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372229,999,545 - 30,094,589 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362228,329,565 - 28,424,587 (+)NCBINCBI36hg18NCBI36
Build 342228,324,118 - 28,419,137NCBI
Celera2213,799,281 - 13,894,313 (+)NCBI
Cytogenetic Map22q12.2NCBI
HuRef2212,962,966 - 13,057,866 (+)NCBIHuRef
CHM1_12229,958,840 - 30,053,867 (+)NCBICHM1_1
Nf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,715,845 - 4,799,544 (-)NCBI
GRCm38114,757,639 - 4,849,544 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,765,845 - 4,849,536 (-)EnsemblGRCm38mm10GRCm38
MGSCv37114,665,851 - 4,749,530 (-)NCBIGRCm37mm9NCBIm37
MGSCv36114,667,997 - 4,749,553 (-)NCBImm8
Celera115,266,247 - 5,349,954 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.0NCBI
Nf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554553,862,347 - 3,951,891 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554553,862,804 - 3,950,669 (+)NCBIChiLan1.0ChiLan1.0
NF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12228,454,119 - 28,544,013 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2228,454,119 - 28,544,013 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02210,648,022 - 10,738,167 (+)NCBIMhudiblu_PPA_v0panPan3
NF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2622,816,551 - 22,894,196 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12622,816,869 - 22,896,103 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Nf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366573,536,212 - 3,622,999 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1446,653,902 - 46,731,999 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11446,653,869 - 46,726,421 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21449,688,078 - 49,760,671 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NF2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1912,474,468 - 12,572,250 (+)Ensembl
ChlSab1.11912,474,479 - 12,572,144 (+)NCBI
Nf2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247475,923,827 - 6,011,276 (+)NCBI

Position Markers
RH130158  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01484,996,932 - 84,997,142NCBIRnor6.0
Rnor_5.01485,673,176 - 85,673,386UniSTSRnor5.0
RGSC_v3.41485,415,169 - 85,415,379UniSTSRGSC3.4
Celera1478,532,259 - 78,532,469UniSTS
Cytogenetic Map14q21UniSTS
RH 3.4 Map14555.1UniSTS
RH134074  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01485,042,171 - 85,042,350NCBIRnor6.0
Rnor_5.01485,719,978 - 85,720,157UniSTSRnor5.0
RGSC_v3.41485,453,237 - 85,453,416UniSTSRGSC3.4
Celera1478,569,038 - 78,569,217UniSTS
Cytogenetic Map14q21UniSTS
RH 3.4 Map14551.79UniSTS
RH94846  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01485,012,815 - 85,012,967NCBIRnor6.0
Rnor_5.01485,689,059 - 85,689,211UniSTSRnor5.0
RGSC_v3.41485,431,087 - 85,431,239UniSTSRGSC3.4
Celera1478,548,060 - 78,548,212UniSTS
Cytogenetic Map14q21UniSTS
RH94847  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01485,012,805 - 85,012,957NCBIRnor6.0
Rnor_5.01485,689,049 - 85,689,201UniSTSRnor5.0
RGSC_v3.41485,431,077 - 85,431,229UniSTSRGSC3.4
Celera1478,548,050 - 78,548,202UniSTS
Cytogenetic Map14q21UniSTS
BF399446  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01485,062,486 - 85,062,692NCBIRnor6.0
Rnor_5.01485,740,263 - 85,740,469UniSTSRnor5.0
RGSC_v3.41485,482,723 - 85,482,929UniSTSRGSC3.4
Celera1478,589,312 - 78,589,518UniSTS
Cytogenetic Map14q21UniSTS
RH 3.4 Map14552.39UniSTS
GDB:373416  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01485,024,417 - 85,024,534NCBIRnor6.0
Rnor_5.01485,702,224 - 85,702,341UniSTSRnor5.0
RGSC_v3.41485,433,893 - 85,434,010UniSTSRGSC3.4
Celera1478,550,428 - 78,550,545UniSTS
Cytogenetic Map14q21UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1412680424106641756Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143259392686191589Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)144031561085315610Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)144031561085315610Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)144031561085315610Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)144031561085315610Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1442442731108833671Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1443910761105074364Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1451818462105074364Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1460980905105980905Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1460980905105980905Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)146187332388870994Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1461993178106993178Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1463548095108548095Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147339146788870994Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1478172765102549388Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)1478172765102549388Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1478172765102549388Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1478172765102549388Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1478172765106641756Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1478446303110402569Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1480049285115493446Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1480049285115493446Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:412
Count of miRNA genes:216
Interacting mature miRNAs:265
Transcripts:ENSRNOT00000010690
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 45 29 19 29 4 7 74 35 41 11 4
Low 12 12 12 4 4 4
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA955327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07015900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07015901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01080857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01080858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01080859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF558742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP499772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ201846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA511825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB578019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB787451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB814077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK364860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO387057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO573762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR467414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U17266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U61772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000010690   ⟹   ENSRNOP00000010690
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1484,996,905 - 85,088,523 (-)Ensembl
RefSeq Acc Id: NM_013193   ⟹   NP_037325
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01484,996,905 - 85,088,523 (-)NCBI
Rnor_5.01485,673,149 - 85,766,360 (-)NCBI
RGSC_v3.41485,415,142 - 85,508,807 (-)RGD
Celera1478,532,232 - 78,615,355 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251188   ⟹   XP_006251250
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01484,996,907 - 85,088,545 (-)NCBI
Rnor_5.01485,673,149 - 85,766,360 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251191   ⟹   XP_006251253
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01485,026,561 - 85,088,547 (-)NCBI
Rnor_5.01485,673,149 - 85,766,360 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037325   ⟸   NM_013193
- UniProtKB: Q63648 (UniProtKB/Swiss-Prot),   G3V717 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251250   ⟸   XM_006251188
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006251253   ⟸   XM_006251191
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000010690   ⟸   ENSRNOT00000010690
Protein Domains
ERM   FERM

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699448
Promoter ID:EPDNEW_R9972
Type:initiation region
Name:Nf2_1
Description:neurofibromin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01485,088,565 - 85,088,625EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3169 AgrOrtholog
Ensembl Genes ENSRNOG00000007948 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000010690 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010690 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.1020 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERM_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERM_FERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ez/rad/moesin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_central UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_PH-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Moesin_tail_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25744 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25744 ENTREZGENE
Pfam ERM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nf2 PhenoGen
PIRSF ERM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS BAND41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERMFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FERM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART B41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47031 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48678 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Rn.46695 ENTREZGENE
UniProt G3V717 ENTREZGENE, UniProtKB/TrEMBL
  MERL_RAT UniProtKB/Swiss-Prot
  Q62723_RAT UniProtKB/TrEMBL
  Q63648 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-13 Nf2  neurofibromin 2  Nf2  neurofibromin 2 (merlin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Nf2  neurofibromin 2 (merlin)  Nf2  neurofibromatosis 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Nf2  neurofibromatosis 2    Neurofibromatosis 2  Name updated 625702 APPROVED
2002-06-10 Nf2  Neurofibromatosis 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript alternative splice isoform type 1 merlin is missing exon 16 sequence contained in type 2 merlin 633510