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Gene: Nf2 (neurofibromin 2) Mus musculus
Symbol: Nf2
Name: neurofibromin 2
Description: Predicted to have beta-catenin binding activity; integrin binding activity; and protein domain specific binding activity. Involved in several processes, including animal organ development; ectoderm development; and negative regulation of protein phosphorylation. Localizes to several cellular components, including adherens junction; cleavage furrow; and ruffle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study familial meningioma; neurofibromatosis; otitis media; and renal cell carcinoma. Human ortholog(s) of this gene implicated in familial meningioma; neurilemmomatosis; and neurofibromatosis 2. Orthologous to human NF2 (neurofibromin 2); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: merlin; moesin-ezrin-radixin-like protein; neurofibromatosis 2; neurofibromin-2; schwannomin
Homo sapiens (human) : NF2 (neurofibromin 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nf2 (neurofibromin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nf2 (neurofibromin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NF2 (neurofibromin 2)
Canis lupus familiaris (dog) : NF2 (neurofibromin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nf2 (neurofibromin 2)
Sus scrofa (pig) : NF2 (neurofibromin 2)
Chlorocebus sabaeus (African green monkey) : NF2 (neurofibromin 2)
Heterocephalus glaber (naked mole-rat) : Nf2 (neurofibromin 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl114,765,845 - 4,849,536 (-)EnsemblGRCm38mm10GRCm38
GRCm38114,757,639 - 4,849,544 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37114,665,851 - 4,749,530 (-)NCBIGRCm37mm9NCBIm37
MGSCv36114,667,997 - 4,749,553 (-)NCBImm8
Celera115,266,247 - 5,349,954 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.0NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Nf2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731859
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-07-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.