NF2 (neurofibromin 2) - Rat Genome Database

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Gene: NF2 (neurofibromin 2) Sus scrofa
Analyze
Symbol: NF2
Name: neurofibromin 2
RGD ID: 13914960
Description: ENCODES a protein that exhibits beta-catenin binding (ortholog); integrin binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN brain development (ortholog); cell-cell junction organization (ortholog); ectoderm development (ortholog); ASSOCIATED WITH acoustic neuroma (ortholog); breast cancer (ortholog); Breast Cancer, Familial (ortholog); FOUND IN cytoplasm (ortholog); membrane raft (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: merlin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1446,653,902 - 46,731,999 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11446,653,869 - 46,726,421 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21449,688,078 - 49,760,671 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
NF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1446,653,902 - 46,731,999 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11446,653,869 - 46,726,421 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21449,688,078 - 49,760,671 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2229,603,556 - 29,698,598 (+)EnsemblGRCh38hg38GRCh38
GRCh382229,603,556 - 29,698,600 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372229,999,545 - 30,094,589 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362228,329,565 - 28,424,587 (+)NCBINCBI36hg18NCBI36
Build 342228,324,118 - 28,419,137NCBI
Celera2213,799,281 - 13,894,313 (+)NCBI
Cytogenetic Map22q12.2NCBI
HuRef2212,962,966 - 13,057,866 (+)NCBIHuRef
CHM1_12229,958,840 - 30,053,867 (+)NCBICHM1_1
Nf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,715,845 - 4,799,544 (-)NCBIGRCm39mm39
GRCm39 Ensembl114,715,845 - 4,799,536 (-)Ensembl
GRCm38114,757,639 - 4,849,544 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,765,845 - 4,849,536 (-)EnsemblGRCm38mm10GRCm38
MGSCv37114,665,851 - 4,749,530 (-)NCBIGRCm37mm9NCBIm37
MGSCv36114,667,997 - 4,749,553 (-)NCBImm8
Celera115,266,247 - 5,349,954 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.0NCBI
Nf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21479,627,399 - 79,710,709 (-)NCBI
Rnor_6.0 Ensembl1484,996,905 - 85,088,523 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01484,996,905 - 85,088,547 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01485,673,149 - 85,766,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41485,415,142 - 85,508,807 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11485,436,559 - 85,527,546 (-)NCBI
Celera1478,532,232 - 78,615,355 (-)NCBICelera
Cytogenetic Map14q21NCBI
Nf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554553,862,347 - 3,951,891 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554553,862,804 - 3,950,669 (+)NCBIChiLan1.0ChiLan1.0
NF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12228,454,119 - 28,544,013 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2228,454,119 - 28,544,013 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02210,648,022 - 10,738,167 (+)NCBIMhudiblu_PPA_v0panPan3
NF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12622,816,869 - 22,896,103 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2622,816,551 - 22,894,196 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2622,688,278 - 22,767,181 (+)NCBI
ROS_Cfam_1.02623,190,481 - 23,269,695 (+)NCBI
UMICH_Zoey_3.12622,900,555 - 22,979,936 (+)NCBI
UNSW_CanFamBas_1.02623,163,349 - 23,242,535 (+)NCBI
UU_Cfam_GSD_1.02623,223,162 - 23,302,265 (+)NCBI
Nf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118112,250,596 - 112,334,448 (-)NCBI
SpeTri2.0NW_0049366573,536,212 - 3,622,999 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NF2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11912,474,479 - 12,572,144 (+)NCBI
ChlSab1.1 Ensembl1912,474,468 - 12,572,250 (+)Ensembl
Vero_WHO_p1.0NW_023666045113,569,107 - 113,665,600 (-)NCBI
Nf2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247475,923,827 - 6,011,276 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 3 2 1 19 1 2
Low 7 4 3 1 4 1 1 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000010943   ⟹   ENSSSCP00000010658
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1446,653,915 - 46,731,999 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000044057   ⟹   ENSSSCP00000055242
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1446,653,902 - 46,726,420 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000045337   ⟹   ENSSSCP00000038782
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1446,653,980 - 46,726,417 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000065472   ⟹   ENSSSCP00000054922
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1446,654,181 - 46,726,419 (+)Ensembl
RefSeq Acc Id: XM_003483446   ⟹   XP_003483494
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11446,653,869 - 46,726,421 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005670787   ⟹   XP_005670844
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11446,653,870 - 46,725,191 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013983029   ⟹   XP_013838483
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11446,653,906 - 46,725,191 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013983030   ⟹   XP_013838484
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11446,653,878 - 46,725,191 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003483494 (Get FASTA)   NCBI Sequence Viewer  
  XP_005670844 (Get FASTA)   NCBI Sequence Viewer  
  XP_013838483 (Get FASTA)   NCBI Sequence Viewer  
  XP_013838484 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003483494   ⟸   XM_003483446
- Peptide Label: isoform X1
- UniProtKB: A0A287BF19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005670844   ⟸   XM_005670787
- Peptide Label: isoform X2
- UniProtKB: A0A287A495 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013838484   ⟸   XM_013983030
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013838483   ⟸   XM_013983029
- Peptide Label: isoform X2
- UniProtKB: A0A287A495 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000055242   ⟸   ENSSSCT00000044057
RefSeq Acc Id: ENSSSCP00000010658   ⟸   ENSSSCT00000010943
RefSeq Acc Id: ENSSSCP00000054922   ⟸   ENSSSCT00000065472
RefSeq Acc Id: ENSSSCP00000038782   ⟸   ENSSSCT00000045337
Protein Domains
FERM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000028707 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070023366 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000010658 UniProtKB/TrEMBL
  ENSSSCP00000038782 UniProtKB/TrEMBL
  ENSSSCP00000054922 UniProtKB/TrEMBL
  ENSSSCP00000055242 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070039321 UniProtKB/TrEMBL
  ENSSSCP00070039332 UniProtKB/TrEMBL
  ENSSSCP00070039341 UniProtKB/TrEMBL
  ENSSSCP00070039348 UniProtKB/TrEMBL
  ENSSSCP00070039361 UniProtKB/TrEMBL
  ENSSSCP00070039363 UniProtKB/TrEMBL
  ENSSSCP00070039371 UniProtKB/TrEMBL
  ENSSSCP00070039377 UniProtKB/TrEMBL
  ENSSSCP00070039381 UniProtKB/TrEMBL
  ENSSSCP00070039382 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000010943 UniProtKB/TrEMBL
  ENSSSCT00000044057 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000045337 UniProtKB/TrEMBL
  ENSSSCT00000065472 UniProtKB/TrEMBL
  ENSSSCT00070046599 UniProtKB/TrEMBL
  ENSSSCT00070046617 UniProtKB/TrEMBL
  ENSSSCT00070046630 UniProtKB/TrEMBL
  ENSSSCT00070046642 UniProtKB/TrEMBL
  ENSSSCT00070046655 UniProtKB/TrEMBL
  ENSSSCT00070046657 UniProtKB/TrEMBL
  ENSSSCT00070046665 UniProtKB/TrEMBL
  ENSSSCT00070046677 UniProtKB/TrEMBL
  ENSSSCT00070046683 UniProtKB/TrEMBL
  ENSSSCT00070046687 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/TrEMBL
  1.25.40.1020 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  ERM UniProtKB/TrEMBL
  ERM_C_dom UniProtKB/TrEMBL
  ERM_FERM_C UniProtKB/TrEMBL
  Ez/rad/moesin-like UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_CS UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
  FERM_PH-like_C UniProtKB/TrEMBL
  Moesin_tail_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
KEGG Report ssc:100520699 UniProtKB/TrEMBL
NCBI Gene NF2 ENTREZGENE
Pfam ERM UniProtKB/TrEMBL
  FERM_C UniProtKB/TrEMBL
  FERM_M UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
PIRSF ERM UniProtKB/TrEMBL
PRINTS BAND41 UniProtKB/TrEMBL
  ERMFAMILY UniProtKB/TrEMBL
PROSITE FERM_1 UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_3 UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  FERM_C UniProtKB/TrEMBL
Superfamily-SCOP SSF47031 UniProtKB/TrEMBL
  SSF48678 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A287A495 ENTREZGENE, UniProtKB/TrEMBL
  A0A287BF19 ENTREZGENE, UniProtKB/TrEMBL
  A0A287BFX6_PIG UniProtKB/TrEMBL
  A0A480KT19_PIG UniProtKB/TrEMBL
  A0A4X1V8X9_PIG UniProtKB/TrEMBL
  A0A4X1V8Y9_PIG UniProtKB/TrEMBL
  A0A4X1VCC2_PIG UniProtKB/TrEMBL
  A0A4X1VDB9_PIG UniProtKB/TrEMBL
  A0A4X1VDD5_PIG UniProtKB/TrEMBL
  A0A4X1VDD9_PIG UniProtKB/TrEMBL
  A0A4X1VF16_PIG UniProtKB/TrEMBL
  A0A4X1VF20_PIG UniProtKB/TrEMBL
  A0A4X1VF26_PIG UniProtKB/TrEMBL
  F1RFG6_PIG UniProtKB/TrEMBL
UniProt Secondary F1RFF4 UniProtKB/TrEMBL
  I6L689 UniProtKB/TrEMBL
VGNC ID VGNC:90705 ENTREZGENE