Ctnnb1 (catenin beta 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ctnnb1 (catenin beta 1) Rattus norvegicus
Analyze
Symbol: Ctnnb1
Name: catenin beta 1
RGD ID: 70487
Description: Enables several functions, including alpha-catenin binding activity; delta-catenin binding activity; and ionotropic glutamate receptor binding activity. Involved in several processes, including cellular response to insulin-like growth factor stimulus; cellular response to lithium ion; and cellular response to mechanical stimulus. Located in several cellular components, including dendritic shaft; intercalated disc; and lateral plasma membrane. Part of protein-containing complex. Used to study colon adenocarcinoma and lung carcinoma. Biomarker of Alzheimer's disease and colorectal cancer. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant intellectual developmental disorder 19; exudative vitreoretinopathy 7; hepatocellular carcinoma (multiple); reproductive organ cancer (multiple); and urinary system cancer (multiple). Orthologous to human CTNNB1 (catenin beta 1); PARTICIPATES IN Wnt signaling, canonical pathway; altered Wnt signaling, canonical pathway; colorectal cancer pathway; INTERACTS WITH (+)-pilocarpine; (-)-epigallocatechin 3-gallate; (R)-adrenaline.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: beta-catenin; catenin (cadherin associated protein), beta 1; catenin (cadherin associated protein), beta 1, 88kDa; catenin beta; catenin beta-1; Catnb
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88129,517,576 - 129,544,661 (+)NCBIGRCr8
mRatBN7.28120,640,008 - 120,667,110 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8120,639,995 - 120,667,111 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8126,248,801 - 126,258,310 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08124,447,834 - 124,457,343 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08122,278,384 - 122,287,893 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08129,601,511 - 129,628,378 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8129,617,812 - 129,627,372 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08128,798,888 - 128,825,828 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48125,978,161 - 125,987,670 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18125,997,897 - 126,007,407 (+)NCBI
Celera8119,795,816 - 119,805,325 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (ISO)
adenocarcinoma  (ISO)
adenoma  (ISO)
Adrenal Gland Neoplasms  (ISO)
adrenocortical carcinoma  (ISO)
Aggressive Fibromatosis  (ISO)
Alazami Syndrome  (ISO)
Alzheimer's disease  (IEP,ISO)
angiosarcoma  (ISO)
Animal Disease Models  (ISO)
atherosclerosis  (ISO)
autism spectrum disorder  (ISS)
autosomal dominant intellectual developmental disorder 19  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
calcinosis  (ISO)
Cecal Neoplasms  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
colon adenocarcinoma  (IAGP)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (IEP,ISO)
Colorectal Neoplasms  (ISO)
congenital muscular dystrophy-dystroglycanopathy type A8  (ISO)
Craniofacial Abnormalities  (ISO)
craniopharyngioma  (ISO)
desmoid tumor  (ISO)
Developmental Disabilities  (ISO)
Developmental Disease  (ISO)
Diabetic Cardiomyopathies  (IEP)
dilated cardiomyopathy  (ISO)
disease  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
endodermal sinus tumor  (ISO)
Endometrial Intraepithelial Neoplasia  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
esophageal carcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
exudative vitreoretinopathy  (ISS)
exudative vitreoretinopathy 1  (ISO)
exudative vitreoretinopathy 7  (ISO)
fibrolamellar carcinoma  (ISO)
Fibrosis  (ISO)
gallbladder cancer  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
granulosa cell tumor  (ISO,ISS)
head and neck squamous cell carcinoma  (ISO)
hepatitis B  (ISO)
hepatoblastoma  (ISO)
hepatocellular adenoma  (ISO)
hepatocellular carcinoma  (ISO)
hereditary desmoid disease  (ISO)
hypertrophic cardiomyopathy  (ISO)
imperforate anus  (ISO)
in situ carcinoma  (ISO)
intellectual disability  (ISO)
Intestinal Neoplasms  (ISO)
invasive lobular carcinoma  (ISO)
Knee Osteoarthritis  (IEP)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (IAGP)
Lung Neoplasms  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
malignant mesothelioma  (ISO)
Mandibular Neoplasms  (IEP)
mantle cell lymphoma  (ISO)
medulloblastoma  (ISO)
melanoma  (ISO)
Metaplasia  (ISO)
Multiple Abnormalities  (ISO)
muscular atrophy  (ISO)
Myocardial Ischemia  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (ISO)
Nerve Degeneration  (ISO)
Nervous System Malformations  (ISO)
Neurodevelopmental Disorders  (ISO)
No-Reflow Phenomenon  (ISO)
ovarian cancer  (ISO,ISS)
Ovarian Neoplasms  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
Parathyroid Neoplasms  (ISO)
Peritoneal Neoplasms  (ISO)
Phyllodes Tumor  (ISO)
pilomatrixoma  (ISO)
polycystic liver disease  (ISO)
Polycystic Liver Disease 1  (ISO)
progressive osseous heteroplasia  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO,ISS)
Prostatic Neoplasms  (ISO)
Recurrence  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
Stevens-Johnson syndrome  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
teratoma  (ISO)
thyroid gland papillary carcinoma  (ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO,ISS)
Urinary Bladder Neoplasm  (ISO)
uterine cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Uterine Neoplasms  (ISO)
Vascular Calcification  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Remodeling  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-sesamin  (ISO)
(-)-Arctigenin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-matairesinol  (ISO)
(1->4)-beta-D-glucan  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-adrenaline  (EXP)
(R)-lipoic acid  (EXP)
(S)-naringenin  (EXP)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3,7,9-tetramethyluric acid  (EXP)
1,3-dinitrobenzene  (EXP)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-nitrotoluene  (ISO)
26-hydroxycholesterol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-aminobenzamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (EXP)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-methylthio-2-oxobutanoic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-formyltetrahydrofolic acid  (EXP)
5-methoxypsoralen  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
[6]-Shogaol  (ISO)
acetamide  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
adenosine  (ISO)
Aeroplysinin 1  (ISO)
aflatoxin B1  (ISO)
AH23848  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-D-galactose  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonia  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
andrographolide  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
artesunate  (EXP)
atazanavir sulfate  (ISO)
atropine  (ISO)
auraptene  (EXP)
azithromycin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
berberine  (ISO)
beta-naphthoflavone  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
boric acid  (ISO)
bortezomib  (ISO)
bosutinib  (ISO)
brazilein  (ISO)
bromocriptine  (ISO)
bruceine D  (ISO)
bucladesine  (EXP)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
calyculin a  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carboxy-PTIO  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
CGS-21680  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (EXP,ISO)
chitosan  (EXP)
chlordecone  (ISO)
chlorohydrocarbon  (ISO)
chloroquine  (EXP)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
chrysin 5,7-dimethyl ether  (EXP)
cisplatin  (EXP,ISO)
clofibric acid  (EXP)
clozapine  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
coenzyme Q10  (ISO)
cordycepin  (ISO)
corosolic acid  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cryptotanshinone  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
DDT  (ISO)
deguelin  (ISO)
delta-tocotrienol  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazoxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethyl sulfoxide  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
dioxygen  (ISO)
disodium cromoglycate  (EXP)
diuron  (EXP)
dizocilpine maleate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
eckol  (ISO)
endosulfan  (EXP,ISO)
erlotinib hydrochloride  (ISO)
Estradiol dipropionate  (ISO)
ethanol  (EXP,ISO)
ethosuximide  (EXP,ISO)
etoposide  (ISO)
eugenol  (ISO)
famotidine  (ISO)
febuxostat  (EXP)
fipronil  (EXP)
fisetin  (EXP,ISO)
flavonoids  (EXP)
fluoxetine  (EXP)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
fumonisin B1  (ISO)
galactose  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (EXP)
gentamycin  (EXP)
Gentiopicrin  (ISO)
geraniol  (EXP)
gingerol  (ISO)
glucose  (EXP,ISO)
glyburide  (EXP)
glycerol 2-phosphate  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (EXP,ISO)
GSK690693  (ISO)
haloperidol  (EXP,ISO)
heparin  (EXP)
heptachlor  (ISO)
hexachlorophene  (ISO)
hexadecanoic acid  (EXP)
Honokiol  (ISO)
hyaluronic acid  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hydroxyflutamide  (ISO)
ibuprofen  (ISO)
Icaritin  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
isoorientin  (ISO)
isopimaric acid  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
juglone  (ISO)
kaempferol  (EXP,ISO)
kenpaullone  (ISO)
ketamine  (EXP)
ketanserin  (EXP)
ketoconazole  (EXP)
L-ascorbic acid  (EXP)
L-ascorbic acid 2-phosphate  (ISO)
lactacystin  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
leupeptin  (EXP)
LGK974  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (EXP,ISO)
lithium chloride  (EXP,ISO)
lithium hydride  (EXP,ISO)
lithocholic acid  (ISO)
loliolide  (ISO)
losartan  (ISO)
lovastatin  (EXP,ISO)
lupeol  (ISO)
luteolin  (ISO)
LY-2157299  (ISO)
LY294002  (EXP,ISO)
Magnolol  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
MeIQ  (ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methotrexate  (EXP,ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
methylmercury(1+)  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (ISO)
MK-2206  (ISO)
ML-7  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (EXP,ISO)
monocrotaline  (EXP)
Morroniside  (EXP)
myricetin  (ISO)
N(6),N(6)-dimethyladenine  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
naproxen  (EXP)
naringin  (ISO)
niclosamide  (EXP,ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitroglycerin  (ISO)
NMN zwitterion  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
Ophiopogonin D  (ISO)
oxazepam  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
parecoxib  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pevonedistat  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenol red  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pinostrobin  (ISO)
pinosylvin  (ISO)
pioglitazone  (ISO)
piperine  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
pluronic P-123  (EXP)
Poloxamer  (EXP)
potassium iodide  (EXP)
pravastatin  (EXP)
proanthocyanidin  (ISO)
progesterone  (EXP,ISO)
prostaglandin E2  (ISO)
puromycin  (ISO)
pyocyanine  (ISO)
pyrithione  (EXP)
pyrvinium  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinacrine  (ISO)
rac-lactic acid  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (EXP,ISO)
ramipril  (EXP)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
risperidone  (EXP)
rotenone  (EXP)
Salinomycin  (ISO)
SB 203580  (ISO)
SB 415286  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
sodium sulfide (anhydrous)  (ISO)
sorafenib  (ISO)
sporidesmin A  (ISO)
staurosporine  (EXP)
streptozocin  (ISO)
SU6656  (ISO)
sulfasalazine  (EXP,ISO)
sulindac  (EXP,ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sumatriptan  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tadalafil  (ISO)
taiwanin C  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (ISO)
theaflavin  (ISO)
thioacetamide  (EXP)
thymoquinone  (EXP,ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (ISO)
trametinib  (ISO)
trans-pinosylvin  (ISO)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tyrphostin AG 1478  (ISO)
uranium atom  (EXP)
ursolic acid  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vincristine  (ISO)
vinyl carbamate  (ISO)
vitamin E  (EXP,ISO)
vorinostat  (ISO)
warfarin  (EXP,ISO)
wogonin  (EXP,ISO)
wortmannin  (ISO)
xanthohumol  (EXP)
XAV939  (EXP,ISO)
zearalenone  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acinar cell differentiation  (IEA,ISO)
adherens junction assembly  (IEA,ISO,ISS)
adherens junction organization  (ISO)
animal organ development  (ISO)
anterior/posterior axis specification  (IEA,ISO)
apoptotic signaling pathway  (IEA,ISO)
astrocyte-dopaminergic neuron signaling  (IEA,ISO)
bicellular tight junction assembly  (ISO)
bone remodeling  (IEP)
bone resorption  (IEA,ISO)
branching involved in blood vessel morphogenesis  (IEA,ISO)
branching involved in ureteric bud morphogenesis  (IEA,ISO)
canonical Wnt signaling pathway  (IBA,IEA,ISO,ISS)
canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation  (IEA,ISO)
cell adhesion  (ISO,ISS,NAS)
cell differentiation  (ISO)
cell fate specification  (IEA,ISO)
cell maturation  (IEA,ISO)
cell morphogenesis  (ISO)
cell population proliferation  (ISO)
cell-cell adhesion  (IBA,IDA,IEA,ISO,ISS,TAS)
cell-matrix adhesion  (IEA,ISO)
cellular response to fibroblast growth factor stimulus  (IEP)
cellular response to growth factor stimulus  (ISO,ISS)
cellular response to indole-3-methanol  (IEA,ISO,ISS)
cellular response to insulin-like growth factor stimulus  (IEP,IMP)
cellular response to lithium ion  (IEP)
cellular response to mechanical stimulus  (IDA)
cellular response to zinc ion starvation  (IEP)
central nervous system vasculogenesis  (IEA,ISO)
chemical synaptic transmission  (IEA,ISO)
chondrocyte differentiation  (IEA,ISO)
cranial ganglion development  (IEA,ISO)
cranial skeletal system development  (IEA,ISO)
DNA-templated transcription  (ISO)
dorsal root ganglion development  (IEA,ISO)
dorsal/ventral axis specification  (IEA,ISO)
dorsal/ventral pattern formation  (ISO)
ectoderm development  (IEA,ISO)
embryonic axis specification  (IEA,ISO)
embryonic brain development  (IEA,ISO)
embryonic digit morphogenesis  (IEA,ISO)
embryonic foregut morphogenesis  (IEA,ISO)
embryonic forelimb morphogenesis  (IEA,ISO)
embryonic heart tube development  (IEA,ISO)
embryonic hindlimb morphogenesis  (IEA,ISO)
embryonic organ development  (ISO)
embryonic skeletal limb joint morphogenesis  (IEA,ISO)
endoderm formation  (ISO)
endodermal cell fate commitment  (IEA,ISO)
endothelial tube morphogenesis  (IEA,ISO,ISS)
epididymis development  (IEP)
epithelial cell differentiation involved in prostate gland development  (IEA,ISO)
epithelial cell proliferation involved in prostate gland development  (IEA,ISO)
epithelial tube branching involved in lung morphogenesis  (IEA,ISO)
establishment of blood-brain barrier  (IEA,ISO)
establishment of blood-retinal barrier  (IEA,ISO)
fibroblast growth factor receptor signaling pathway  (IEA,ISO)
forebrain development  (ISO)
fungiform papilla formation  (IEA,ISO)
gastrulation with mouth forming second  (IEA,ISO)
gene expression  (ISO)
genitalia morphogenesis  (IEA,ISO)
glandular epithelial cell differentiation  (ISO)
glial cell fate determination  (IEA,ISO)
hair cycle process  (ISO)
hair follicle morphogenesis  (IEA,ISO)
hair follicle placode formation  (IEA,ISO)
heart development  (ISO)
hemopoiesis  (ISO)
hindbrain development  (IEA,ISO)
hypothalamus development  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
kidney development  (ISO)
layer formation in cerebral cortex  (IEA,ISO)
lens morphogenesis in camera-type eye  (IEA,ISO)
limb development  (ISO)
liver development  (IEP)
lung cell differentiation  (ISO)
lung development  (ISO)
lung epithelial cell differentiation  (IEA,ISO)
lung induction  (IEA,ISO)
lung-associated mesenchyme development  (IEA,ISO)
male genitalia development  (IEA,ISO)
MAPK cascade  (IEA,ISO)
mesenchymal cell proliferation  (ISO)
mesenchymal cell proliferation involved in lung development  (IEA,ISO)
mesenchymal stem cell differentiation  (ISO)
metanephros morphogenesis  (IEA,ISO)
midbrain development  (ISO)
midbrain dopaminergic neuron differentiation  (IEA,ISO)
midgut development  (IEP)
morphogenesis of embryonic epithelium  (ISO)
myoblast differentiation  (IEP)
myoblast proliferation  (IEA,ISO)
negative regulation of angiogenesis  (IEA,ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of cell population proliferation  (IEA,ISO,ISS)
negative regulation of chondrocyte differentiation  (IEA,ISO)
negative regulation of DNA-templated transcription  (ISO,ISS)
negative regulation of gene expression  (IEA,IMP,ISO)
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  (IEA,ISO)
negative regulation of mitotic cell cycle, embryonic  (IEA,ISO,ISS)
negative regulation of neurogenesis  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of oligodendrocyte differentiation  (IEA,ISO)
negative regulation of osteoclast differentiation  (IEA,ISO)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of protein sumoylation  (IEA,ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
nephron tubule formation  (IEA,ISO)
neural plate development  (IEA,ISO)
neuroblast proliferation  (IEA,ISO)
neuron differentiation  (ISO)
neuron fate determination  (IEA,ISO)
neuron migration  (IEA,ISO)
neuron projection extension  (IEA,ISO,ISS)
odontogenesis of dentin-containing tooth  (IEA,IEP,ISO)
oligodendrocyte differentiation  (IEA,ISO)
oocyte development  (IEA,ISO)
osteoblast differentiation  (IEA,ISO)
osteoclast differentiation  (IEA,ISO)
outflow tract morphogenesis  (IEA,ISO)
oviduct development  (IEA,ISO)
pancreas development  (IEA,ISO)
positive regulation of apoptotic process  (ISO,ISS)
positive regulation of branching involved in lung morphogenesis  (IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of determination of dorsal identity  (IEA,ISO)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of endothelial cell differentiation  (IEA,ISO)
positive regulation of epithelial cell differentiation  (ISO)
positive regulation of epithelial cell proliferation involved in prostate gland development  (IEA,ISO)
positive regulation of epithelial to mesenchymal transition  (IEA,ISO)
positive regulation of fibroblast growth factor receptor signaling pathway  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of heparan sulfate proteoglycan biosynthetic process  (IEA,ISO,ISS)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of mesenchymal cell proliferation  (IEA,ISO)
positive regulation of myoblast proliferation  (IEA,ISO)
positive regulation of neural precursor cell proliferation  (ISO)
positive regulation of neuroblast proliferation  (IEA,ISO,ISS)
positive regulation of neuron apoptotic process  (IEA,ISO)
positive regulation of odontoblast differentiation  (IEA,ISO)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of skeletal muscle tissue development  (IEA,ISO)
positive regulation of stem cell proliferation  (IEA,ISO)
positive regulation of telomere maintenance via telomerase  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,ISO,ISS)
positive regulation of transcription elongation by RNA polymerase II  (IEA,ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA,ISO)
protein localization  (ISO)
protein localization to cell surface  (IEA,ISO,ISS)
protein polyubiquitination  (IEA,ISO)
proximal/distal pattern formation  (IEA,ISO)
regulation of apoptotic process  (ISO)
regulation of calcium ion import  (IEA,ISO,ISS)
regulation of cell differentiation  (ISO)
regulation of cell population proliferation  (ISO)
regulation of centriole-centriole cohesion  (IEA,ISO,ISS)
regulation of centromeric sister chromatid cohesion  (IEA,ISO,ISS)
regulation of epithelial cell differentiation  (ISO)
regulation of gene expression  (ISO)
regulation of myelination  (IEA,ISO)
regulation of nephron tubule epithelial cell differentiation  (IEA,ISO)
regulation of osteoblast differentiation  (ISO)
regulation of osteoclast differentiation  (ISO)
regulation of protein localization to cell surface  (IEA,ISO,ISS)
regulation of protein ubiquitination  (IEA,ISO)
regulation of secondary heart field cardioblast proliferation  (IEA,ISO)
regulation of smooth muscle cell proliferation  (IEA,ISO,ISS)
regulation of synapse assembly  (IEA,ISO)
regulation of T cell proliferation  (IEA,ISO)
regulation of timing of anagen  (IEA,ISO)
regulation of transcription by RNA polymerase II  (ISO)
renal inner medulla development  (IEA,ISO)
renal outer medulla development  (IEA,ISO)
renal vesicle formation  (IEA,ISO)
response to activity  (IEP)
response to cadmium ion  (IEP)
response to cytokine  (IDA)
response to estradiol  (IEA,IEP,ISO,ISS)
response to estrogen  (IDA)
response to hormone  (IEP)
response to organic cyclic compound  (IEP)
response to xenobiotic stimulus  (IEA,ISO)
Schwann cell proliferation  (IMP)
skeletal system development  (ISO)
skin development  (ISO)
smooth muscle cell differentiation  (IEA,ISO)
stem cell proliferation  (IEA,ISO)
sympathetic ganglion development  (IEA,ISO,ISS)
synapse organization  (IEA,ISO)
synaptic vesicle clustering  (IEA,ISO)
synaptic vesicle transport  (IEA,ISO)
T cell differentiation  (ISO)
T cell differentiation in thymus  (IEA,ISO)
thymus development  (IEA,ISO)
tissue homeostasis  (ISO)
trachea formation  (IEA,ISO)
trachea morphogenesis  (ISO)
transcription by RNA polymerase II  (IEA,ISO)
vasculature development  (ISO)
vasculogenesis  (ISO)

Cellular Component
adherens junction  (IBA,IDA,IEA,ISO)
apical junction complex  (ISO)
apical part of cell  (IEA,ISO)
apical plasma membrane  (IDA)
apicolateral plasma membrane  (IEA,ISO)
basolateral plasma membrane  (IEA,ISO)
beta-catenin destruction complex  (IEA,ISO,ISS)
beta-catenin-ICAT complex  (IEA,ISO)
beta-catenin-TCF complex  (ISO)
beta-catenin-TCF7L2 complex  (IEA,ISO,ISS)
bicellular tight junction  (IEA,ISO)
catenin complex  (IBA,IEA,ISO,ISS)
cell cortex  (ISO,ISS)
cell junction  (ISO,ISS)
cell periphery  (ISO,ISS)
cell projection membrane  (ISO)
cell-cell junction  (ISO,ISS)
centrosome  (IEA,ISO,ISS)
cytoplasm  (IBA,IDA,IEA,ISO,ISS)
cytosol  (IEA,ISO)
dendritic shaft  (IDA)
euchromatin  (IEA,ISO)
exocytic vesicle  (ISO)
fascia adherens  (IEA,ISO)
flotillin complex  (IEA,ISO)
glutamatergic synapse  (IEA,ISO)
intercalated disc  (IDA,ISO)
lamellipodium  (IEA,ISO)
lateral plasma membrane  (IDA,IEA,ISO)
membrane  (IDA,ISO)
microvillus membrane  (IEA,ISO)
nuclear membrane  (IDA)
nucleus  (IBA,IDA,IEA,ISO)
perinuclear region of cytoplasm  (IDA,IEA,ISO,ISS)
plasma membrane  (IDA,ISO,ISS)
postsynaptic density, intracellular component  (IEA,ISO)
postsynaptic membrane  (IEA,ISO)
presynaptic active zone cytoplasmic component  (IEA,ISO)
presynaptic membrane  (IEA,ISO)
protein-containing complex  (IDA,ISO)
protein-DNA complex  (ISO,ISS)
RNA polymerase II transcription regulator complex  (ISO)
Schaffer collateral - CA1 synapse  (IEA,ISO)
Scrib-APC-beta-catenin complex  (IEA,ISO)
spindle pole  (IEA)
synapse  (ISO)
tight junction  (IDA)
transcription regulator complex  (ISO,ISS)
Wnt signalosome  (IEA,ISO)
Z disc  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. The expression and prognostic value of alpha-, beta- and gamma-catenins in renal cell carcinoma. Aaltomaa S, etal., Anticancer Res. 2004 Jul-Aug;24(4):2407-13.
2. Differential expression of E-cadherin and beta catenin in primary and metastatic Wilms's tumours. Alami J, etal., Mol Pathol. 2003 Aug;56(4):218-25.
3. Regulation of dishevelled and beta-catenin in rat skeletal muscle: an alternative exercise-induced GSK-3beta signaling pathway. Aschenbach WG, etal., Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E152-8. Epub 2006 Feb 14.
4. The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies. Bansal N, etal., Cancer Control. 2009 Jan;16(1):8-13.
5. A novel pretherapeutic gene expression-based risk score for treatment guidance in gastric cancer. Bauer L, etal., Ann Oncol. 2018 Jan 1;29(1):127-132. doi: 10.1093/annonc/mdx685.
6. Expression and colocalization of beta-catenin and lymphoid enhancing factor-1 in prostate cancer progression. Bauman TM, etal., Hum Pathol. 2016 May;51:124-33. doi: 10.1016/j.humpath.2015.12.024. Epub 2016 Jan 19.
7. Identification and prognostic significance of an epithelial-mesenchymal transition expression profile in human bladder tumors. Baumgart E, etal., Clin Cancer Res. 2007 Mar 15;13(6):1685-94.
8. Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun. Blum CA, etal., Mol Carcinog 2003 Apr;36(4):195-203.
9. Beta-catenin accumulation and mutation of the CTNNB1 gene in hepatoblastoma. Bläker H, etal., Genes Chromosomes Cancer. 1999 Aug;25(4):399-402.
10. Dominant-stable beta-catenin expression causes cell fate alterations and Wnt signaling antagonist expression in a murine granulosa cell tumor model. Boerboom D, etal., Cancer Res. 2006 Feb 15;66(4):1964-73.
11. Islet-1 is a dual regulator of fibrogenic epithelial-to-mesenchymal transition in epicardial mesothelial cells. Brønnum H, etal., Exp Cell Res. 2013 Feb 15;319(4):424-35. doi: 10.1016/j.yexcr.2012.12.019. Epub 2012 Dec 24.
12. Treadmill training regulates beta-catenin signaling through phosphorylation of GSK-3beta in lumbar vertebrae of ovariectomized rats. Bu S, etal., Eur J Appl Physiol. 2012 Sep;112(9):3295-304. doi: 10.1007/s00421-011-2306-4. Epub 2012 Jan 18.
13. Activation of beta-catenin in the stem cell region of crypts during growth of the small intestine in infant rats. Camac KS, etal., Dig Dis Sci. 2007 May;52(5):1242-6. Epub 2007 Mar 14.
14. Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells. Caruso A, etal., J Neurochem. 2006 Jul;98(2):364-71.
15. The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Chen HJ, etal., Genes Dev. 2006 Jul 15;20(14):1933-45. Epub 2006 Jun 30.
16. Study on the formation of specialized inter-Sertoli cell junctions in vitro. Chung SS, etal., J Cell Physiol 1999 Nov;181(2):258-72.
17. Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene. Cieply B, etal., Hepatology. 2009 Mar;49(3):821-31. doi: 10.1002/hep.22695.
18. The spectrum of morphomolecular abnormalities of the E-cadherin/catenin complex in pleomorphic lobular carcinoma of the breast. Dabbs DJ, etal., Appl Immunohistochem Mol Morphol. 2007 Sep;15(3):260-6.
19. High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat. Dashwood RH, etal., Cancer Res 1998 Mar 15;58(6):1127-9.
20. Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils. De Ferrari GV, etal., Mol Psychiatry. 2003 Feb;8(2):195-208.
21. Simultaneous loss of E-cadherin and catenins in invasive lobular breast cancer and lobular carcinoma in situ. De Leeuw WJ, etal., J Pathol. 1997 Dec;183(4):404-11.
22. Catenins in the rat epididymis: their expression and regulation in adulthood and during postnatal development. DeBellefeuille S, etal., Endocrinology. 2003 Nov;144(11):5040-9. doi: 10.1210/en.2002-0139. Epub 2003 Aug 13.
23. Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19Arf/p53 pathway lesions but not p16 Ink4a loss. Debies MT, etal., J Clin Invest. 2008 Jan;118(1):51-63.
24. Quantitative in situ analysis of beta-catenin expression in breast cancer shows decreased expression is associated with poor outcome. Dolled-Filhart M, etal., Cancer Res. 2006 May 15;66(10):5487-94.
25. WNT10A/ß-catenin pathway in tumorigenesis of papillary thyroid carcinoma. Dong T, etal., Oncol Rep. 2017 Aug;38(2):1287-1294. doi: 10.3892/or.2017.5777. Epub 2017 Jul 3.
26. LINC00689 participates in proliferation, chemoresistance and metastasis via miR-31-5p/YAP/β-catenin axis in colorectal cancer. Du YL, etal., Exp Cell Res. 2020 Oct 1;395(1):112176. doi: 10.1016/j.yexcr.2020.112176. Epub 2020 Jul 16.
27. Loss of beta-catenin is associated with poor survival in ovarian carcinomas. Faleiro-Rodrigues C, etal., Int J Gynecol Pathol. 2004 Oct;23(4):337-46.
28. [Expression of beta-catenin in articular cartilage of knee primary osteoarthritis]. Fang X, etal., Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2012 May;26(5):532-5.
29. Differential regulation of cadherins and catenins during axonal reorganization in the adult rat CNS. Fasen K, etal., J Neuropathol Exp Neurol 2002 Oct;61(10):903-13.
30. Activation of Wnt/beta-catenin signaling in distinct histologic subtypes of human germ cell tumors. Fritsch MK, etal., Pediatr Dev Pathol. 2006 Mar-Apr;9(2):115-31. Epub 2006 Jun 16.
31. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
32. Inhibition of N-cadherin and beta-catenin function reduces axon-induced Schwann cell proliferation. Gess B, etal., J Neurosci Res. 2007 Oct 16;86(4):797-812.
33. Phospho-beta-catenin accumulation in Alzheimer's disease and in aggresomes attributable to proteasome dysfunction. Ghanevati M and Miller CA, J Mol Neurosci. 2005;25(1):79-94.
34. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
35. Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells. Gorski JA, etal., Mol Biol Cell. 2005 Aug;16(8):3574-90. Epub 2005 Jun 1.
36. Fibroblast growth factor 1 regulates signaling via the glycogen synthase kinase-3beta pathway. Implications for neuroprotection. Hashimoto M, etal., J Biol Chem 2002 Sep 6;277(36):32985-91.
37. Secreted frizzled-related protein 2 (SFRP2) expression promotes lesion proliferation via canonical WNT signaling and indicates lesion borders in extraovarian endometriosis. Heinosalo T, etal., Hum Reprod. 2018 May 1;33(5):817-831. doi: 10.1093/humrep/dey026.
38. N-cadherin in adult rat cardiomyocytes in culture. II. Spatio-temporal appearance of proteins involved in cell-cell contact and communication. Formation of two distinct N-cadherin/catenin complexes. Hertig CM, etal., J Cell Sci. 1996 Jan;109 ( Pt 1):11-20.
39. Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK. Hie M, etal., Bone. 2011 Dec;49(6):1152-9. doi: 10.1016/j.bone.2011.08.019. Epub 2011 Aug 26.
40. Stabilised beta-catenin in postnatal ventricular myocardium leads to dilated cardiomyopathy and premature death. Hirschy A, etal., Basic Res Cardiol. 2010 Sep;105(5):597-608. doi: 10.1007/s00395-010-0101-8. Epub 2010 Apr 8.
41. The Fat1 cadherin integrates vascular smooth muscle cell growth and migration signals. Hou R, etal., J Cell Biol. 2006 May 8;173(3):417-29.
42. Down-regulation of β-catenin and the associated migration ability by Taiwanin C in arecoline and 4-NQO-induced oral cancer cells via GSK-3β activation. Hsieh CH, etal., Mol Carcinog. 2017 Mar;56(3):1055-1067. doi: 10.1002/mc.22570. Epub 2016 Oct 4.
43. Host Wnt/beta-catenin pathway triggered by Helicobacter pylori correlates with regression of gastric intestinal metaplasia after H. pylori eradication. Hung KH, etal., J Med Microbiol. 2009 May;58(Pt 5):567-576. doi: 10.1099/jmm.0.007310-0.
44. Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin. Ide N, etal., Biochem Biophys Res Commun. 1999 Mar 24;256(3):456-61.
45. Involvement of mutation-based inhibition of beta-catenin phosphorylation at Ser33 in the malignant progression of lung (pre)neoplastic lesions induced by N-nitrosobis(2-hydroxypropyl)amine in male Fischer 344 rats. Igarashi M, etal., Lung. 2007 Sep-Oct;185(5):271-8. Epub 2007 Jul 18.
46. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. Ikeda S, etal., EMBO J 1998 Mar 2;17(5):1371-84.
47. Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling. Karasawa T, etal., J Biol Chem 2002 Oct 4;277(40):37479-86.
48. The prognostic value of E-cadherin, alpha-, beta-, and gamma-catenin in urothelial cancer of the upper urinary tract. Kashibuchi K, etal., Eur Urol. 2006 May;49(5):839-45; discussion 845. Epub 2006 Jan 6.
49. Genetic polymorphisms in the Wnt/β-catenin pathway genes as predictors of tumor development and survival in patients with hepatitis B virus-associated hepatocellular carcinoma. Kim SS, etal., Clin Biochem. 2016 Jul;49(10-11):792-801. doi: 10.1016/j.clinbiochem.2016.01.025. Epub 2016 Mar 9.
50. The expression of molecular mediators in the idiopathic cutaneous calcification and ossification. Kim SY, etal., J Cutan Pathol. 2008 Sep;35(9):826-31. doi: 10.1111/j.1600-0560.2007.00904.x. Epub 2008 Apr 18.
51. Overexpression of ß-Catenin and Cyclin D1 is Associated with Poor Overall Survival in Patients with Stage IA-IIA Squamous Cell Lung Cancer Irrespective of Adjuvant Chemotherapy. Kim Y, etal., J Thorac Oncol. 2016 Dec;11(12):2193-2201. doi: 10.1016/j.jtho.2016.07.021. Epub 2016 Aug 4.
52. Reduced expression level of mgmt mRNA and beta-catenin gene mutation in rat colon tumors. Kinjo T, etal., Anticancer Res. 2006 Jul-Aug;26(4B):2829-32.
53. DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability. Kishida S, etal., Mol Cell Biol. 1999 Jun;19(6):4414-22.
54. Wnt signalling and its impact on development and cancer. Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98.
55. Mechanism of Action of l-CDB-4022, a Potential Nonhormonal Male Contraceptive, in the Seminiferous Epithelium of the Rat Testis. Koduri S, etal., Endocrinology. 2008 Jan 3;.
56. ENHANCED BETA-CATENIN EXPRESSION IS ASSOCIATED WITH RECURRENCE OF PAPILLARY THYROID CARCINOMA. Kordestani Z, etal., Endocr Pract. 2018 May;24(5):411-418. doi: 10.4158/EP171983.OR. Epub 2018 Mar 2.
57. Human chorionic gonadotropin (hCG) up-regulates wnt5b and wnt7b in the mammary gland, and hCGbeta transgenic female mice present with mammary Gland tumors exhibiting characteristics of the Wnt/beta-catenin pathway activation. Kuorelahti A, etal., Endocrinology. 2007 Aug;148(8):3694-703. Epub 2007 May 17.
58. Codon 45 of the beta-catenin gene, a specific mutational target site of Wilms' tumor. Kusafuka T, etal., Int J Mol Med. 2002 Oct;10(4):395-9.
59. Granulocyte colony-stimulating factor activates Wnt signal to sustain gap junction function through recruitment of beta-catenin and cadherin. Kuwabara M, etal., FEBS Lett. 2007 Oct 16;581(25):4821-30. Epub 2007 Sep 14.
60. Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase. Kwon YT, etal., Curr Biol. 2000 Apr 6;10(7):363-72.
61. Is the cadherin/catenin complex a functional unit of cell-cell actin-based adherens junctions in the rat testis? Lee NP, etal., Biol Reprod. 2003 Feb;68(2):489-508.
62. Regulation of Sertoli-germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/beta-catenin (CATNB) signaling pathway: an in vitro and in vivo study. Lee NP, etal., Biol Reprod. 2005 Sep;73(3):458-71. Epub 2005 Apr 27.
63. Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity. Legoix P, etal., Oncogene 1999 Jul 8;18(27):4044-6.
64. Chinese Herbal Formulas Miao-Yi-Ai-Tang Inhibits the Proliferation and Migration of Lung Cancer Cells through Targeting β-Catenin/AXIN and Presents Synergistic Effect with Cisplatin Suppressing Lung Cancer. Li B, etal., Biomed Res Int. 2020 Jan 16;2020:2761850. doi: 10.1155/2020/2761850. eCollection 2020.
65. Influence of polymorphisms in the Wnt/β-catenin pathway genes on hepatocellular carcinoma risk in a Chinese Han population. Li QM, etal., Medicine (Baltimore). 2017 Mar;96(12):e6127. doi: 10.1097/MD.0000000000006127.
66. Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes. Li TF, etal., J Biol Chem. 2006 Jul 28;281(30):21296-304. doi: 10.1074/jbc.M600514200. Epub 2006 May 10.
67. Activation of glycogen synthase kinase-3 beta is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. Li YC, etal., J Neurosci. 2009 Dec 9;29(49):15551-63.
68. [Beta-catenin expression in intestinal mucosa of rats with severe abdominal infection] Liu JF and Wu CT, Nan Fang Yi Ke Da Xue Xue Bao. 2006 Dec;26(12):1733-5.
69. Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. Lucas JJ, etal., EMBO J 2001 Jan 15;20(1-2):27-39.
70. Tension force-induced bone formation in orthodontic tooth movement via modulation of the GSK-3ß/ß-catenin signaling pathway. Mao Y, etal., J Mol Histol. 2018 Feb;49(1):75-84. doi: 10.1007/s10735-017-9748-x. Epub 2017 Dec 9.
71. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
72. Silencing of Wnt signaling and activation of multiple metabolic pathways in response to thyroid hormone-stimulated cell proliferation. Miller LD, etal., Mol Cell Biol 2001 Oct;21(19):6626-39.
73. [Prognostic value of E-cadherina, beta catenin, Ki-67 antigen and p53 protein in the superficial bladder tumors] Moyano Calvo JL, etal., Actas Urol Esp. 2006 Oct;30(9):871-8.
74. Depolarization drives beta-Catenin into neuronal spines promoting changes in synaptic structure and function. Murase S, etal., Neuron 2002 Jul 3;35(1):91-105.
75. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
76. Interaction of synaptic scaffolding molecule and Beta -catenin. Nishimura W, etal., J Neurosci 2002 Feb 1;22(3):757-65.
77. Immunohistochemical expression of PTEN and beta-catenin for endometrial intraepithelial neoplasia in Japanese women. Norimatsu Y, etal., Ann Diagn Pathol. 2007 Apr;11(2):103-8.
78. Epicardial-myocardial signaling directing coronary vasculogenesis. Olivey HE and Svensson EC, Circ Res. 2010 Mar 19;106(5):818-32. doi: 10.1161/CIRCRESAHA.109.209197.
79. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
80. Expression pattern of adhesion molecules (E-cadherin, alpha-, beta-, gamma-catenin and claudin-7), their influence on survival in primary breast carcinoma, and their corresponding axillary lymph node metastasis. Park D, etal., APMIS. 2007 Jan;115(1):52-65.
81. Tumor specific mutations in TERT promoter and CTNNB1 gene in hepatitis B and hepatitis C related hepatocellular carcinoma. Pezzuto F, etal., Oncotarget. 2016 Aug 23;7(34):54253-54262. doi: 10.18632/oncotarget.9801.
82. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
83. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
84. Erbin regulates mitogen-activated protein (MAP) kinase activation and MAP kinase-dependent interactions between Merlin and adherens junction protein complexes in Schwann cells. Rangwala R, etal., J Biol Chem. 2005 Mar 25;280(12):11790-7. Epub 2005 Jan 19.
85. GOA pipeline RGD automated data pipeline
86. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
87. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
88. Progesterone initiates Wnt-beta-catenin signaling but estradiol is required for nuclear activation and synchronous proliferation of rat uterine stromal cells. Rider V, etal., J Endocrinol. 2006 Dec;191(3):537-48.
89. Abnormal distribution of E-cadherin and beta-catenin in different histologic types of cancer of the uterine cervix. Rodriguez-Sastre MA, etal., Gynecol Oncol. 2005 May;97(2):330-6.
90. Overexpression of E-cadherin and beta-catenin proteins in metastatic prostate cancer cells in bone. Saha B, etal., Prostate. 2008 Jan 1;68(1):78-84.
91. Beta-catenin abnormalities and associated insulin-like growth factor overexpression are important in phyllodes tumours and fibroadenomas of the breast. Sawyer EJ, etal., J Pathol. 2003 Aug;200(5):627-32.
92. Combined E-cadherin, alpha-catenin, and beta-catenin expression is a favorable prognostic factor in endometrial carcinoma. Scholten AN, etal., Int J Gynecol Cancer. 2006 May-Jun;16(3):1379-85.
93. Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP mice. Shukla S, etal., Cancer Res. 2007 Jul 15;67(14):6925-35.
94. Comparative expression patterns of T-, N-, E-cadherins, beta-catenin, and polysialic acid neural cell adhesion molecule in rat cochlea during development: implications for the nature of Kolliker's organ. Simonneau L, etal., J Comp Neurol 2003 Apr 28;459(2):113-26.
95. The cadherin-catenin complex is expressed alternately with the adenomatous polyposis coli protein during rat incisor amelogenesis. Sorkin BC, etal., J Histochem Cytochem. 2000 Mar;48(3):397-406.
96. Development of leiomyosarcoma of the uterus in MMTV-CR-1 transgenic mice. Strizzi L, etal., J Pathol. 2007 Jan;211(1):36-44.
97. Wnt/beta-catenin signaling pathway in hepatocellular carcinomas cases from Colombia. Suarez M I, etal., Ann Hepatol. 2015 Jan-Feb;14(1):64-74.
98. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling. Sunters A, etal., J Biol Chem. 2010 Mar 19;285(12):8743-58. doi: 10.1074/jbc.M109.027086. Epub 2009 Dec 30.
99. Different mutation status of the beta-catenin gene in carcinogen-induced colon, brain, and oral tumors in rats. Suzui M, etal., Mol Carcinog 2001 Dec;32(4):206-12.
100. beta-Catenin associates with the actin-bundling protein fascin in a noncadherin complex. Tao YS, etal., J Cell Biol. 1996 Sep;134(5):1271-81.
101. Cadmium induces nuclear translocation of beta-catenin and increases expression of c-myc and Abcb1a in kidney proximal tubule cells. Thevenod F, etal., Biometals. 2006 Nov 29;.
102. Aldosterone, through novel signaling proteins, is a fundamental molecular bridge between the genetic defect and the cardiac phenotype of hypertrophic cardiomyopathy. Tsybouleva N, etal., Circulation. 2004 Mar 16;109(10):1284-91. Epub 2004 Mar 1.
103. Neurite outgrowth involves adenomatous polyposis coli protein and beta-catenin. Votin V, etal., J Cell Sci. 2005 Dec 15;118(Pt 24):5699-708. Epub 2005 Nov 22.
104. Thyroid hormone interacts with the Wnt/beta-catenin signaling pathway in the terminal differentiation of growth plate chondrocytes. Wang L, etal., J Bone Miner Res. 2007 Dec;22(12):1988-95.
105. [The role of beta-catenin in rat embryonic development and tumorigenesis] Wang QM, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2006 Nov;37(6):872-5.
106. M-cadherin and beta-catenin participate in differentiation of rat satellite cells. Wrobel E, etal., Eur J Cell Biol. 2007 Feb;86(2):99-109. Epub 2007 Jan 11.
107. Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways. Wu R, etal., Cancer Cell. 2007 Apr;11(4):321-33.
108. Activation of Wnt/ß-catenin/GSK3ß signaling during the development of diabetic cardiomyopathy. Xi XH, etal., Cardiovasc Pathol. 2015 May-Jun;24(3):179-86. doi: 10.1016/j.carpath.2014.12.002. Epub 2014 Dec 16.
109. Differential interactions between transforming growth factor-beta3/TbetaR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion. Xia W, etal., J Biol Chem. 2006 Jun 16;281(24):16799-813. Epub 2006 Apr 13.
110. Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis. Xia X, etal., Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10863-8. Epub 2001 Aug 21.
111. Green tea polyphenols inhibit colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats. Xiao H, etal., Carcinogenesis. 2008 Jan;29(1):113-9. Epub 2007 Sep 24.
112. Knockdown of lncRNA H19 alleviates ox-LDL-induced HCAECs inflammation and injury by mediating miR-20a-5p/HDAC4 axis. Yang Y, etal., Inflamm Res. 2022 Sep;71(9):1109-1121. doi: 10.1007/s00011-022-01604-z. Epub 2022 Jul 19.
113. [Beta-catenin and its mRNA in renal cell carcinoma] Zang T, etal., Zhonghua Wai Ke Za Zhi. 2000 Jan;38(1):37-9.
114. Hypothermia blocks beta-catenin degradation after focal ischemia in rats. Zhang H, etal., Brain Res. 2008 Jan 14;.
115. Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes. Zhang M, etal., J Biol Chem. 2010 Mar 19;285(12):8703-10. doi: 10.1074/jbc.M109.093526. Epub 2010 Jan 22.
116. Expression of E-cadherin, beta-catenin, cathepsin D, gelatinases and their inhibitors in invasive ductal breast carcinomas. Zhang YG, etal., Chin Med J (Engl). 2007 Sep 20;120(18):1597-605.
Additional References at PubMed
PMID:7650039   PMID:7806582   PMID:7890674   PMID:8582267   PMID:8636221   PMID:8638126   PMID:8663237   PMID:8821035   PMID:8853988   PMID:8909549   PMID:9065401   PMID:9065402  
PMID:9230313   PMID:9488439   PMID:9566905   PMID:9707618   PMID:9950951   PMID:10318824   PMID:10403777   PMID:10631168   PMID:10644691   PMID:10662781   PMID:10773885   PMID:10825188  
PMID:10868478   PMID:10873669   PMID:10921920   PMID:10980594   PMID:11113207   PMID:11121423   PMID:11262227   PMID:11371349   PMID:11533658   PMID:11731229   PMID:11731231   PMID:11731265  
PMID:11751639   PMID:11793365   PMID:11867232   PMID:11872843   PMID:11955446   PMID:12040017   PMID:12055200   PMID:12072559   PMID:12154096   PMID:12181493   PMID:12194849   PMID:12203715  
PMID:12235125   PMID:12432063   PMID:12464179   PMID:12511557   PMID:12538353   PMID:12551949   PMID:12569130   PMID:12611902   PMID:12651860   PMID:12668767   PMID:12686140   PMID:12695331  
PMID:12717450   PMID:12734196   PMID:12799378   PMID:12812787   PMID:12813461   PMID:12861022   PMID:12874278   PMID:12885771   PMID:12923052   PMID:12937339   PMID:12949260   PMID:12970740  
PMID:12975353   PMID:14551262   PMID:14597196   PMID:14608382   PMID:14622577   PMID:14625387   PMID:14641328   PMID:14657280   PMID:14660579   PMID:14662019   PMID:14687547   PMID:14706452  
PMID:14758363   PMID:14981260   PMID:14985333   PMID:15023525   PMID:15024079   PMID:15037549   PMID:15040835   PMID:15057752   PMID:15063782   PMID:15064718   PMID:15117735   PMID:15131783  
PMID:15148305   PMID:15226261   PMID:15292239   PMID:15304487   PMID:15314168   PMID:15371327   PMID:15371442   PMID:15389538   PMID:15458849   PMID:15492040   PMID:15525667   PMID:15574752  
PMID:15576404   PMID:15592430   PMID:15645444   PMID:15668231   PMID:15673614   PMID:15708565   PMID:15729346   PMID:15750591   PMID:15775979   PMID:15778706   PMID:15781477   PMID:15802266  
PMID:15843474   PMID:15853773   PMID:15866163   PMID:15866165   PMID:15893845   PMID:15905404   PMID:15907834   PMID:15987773   PMID:16025118   PMID:16040629   PMID:16102745   PMID:16160859  
PMID:16188939   PMID:16192304   PMID:16199027   PMID:16249236   PMID:16364283   PMID:16396499   PMID:16418220   PMID:16439479   PMID:16478791   PMID:16481290   PMID:16481394   PMID:16489008  
PMID:16510873   PMID:16574648   PMID:16581771   PMID:16611247   PMID:16621792   PMID:16678101   PMID:16678815   PMID:16717102   PMID:16733663   PMID:16740478   PMID:16761624   PMID:16776666  
PMID:16806007   PMID:16818445   PMID:16831887   PMID:16858399   PMID:16858403   PMID:16892058   PMID:16920707   PMID:16936075   PMID:16940239   PMID:16962386   PMID:16973135   PMID:16989802  
PMID:17055474   PMID:17072303   PMID:17122440   PMID:17128274   PMID:17130295   PMID:17331723   PMID:17404573   PMID:17510083   PMID:17532316   PMID:17535849   PMID:17537789   PMID:17544522  
PMID:17560206   PMID:17560563   PMID:17596282   PMID:17615359   PMID:17666436   PMID:17670980   PMID:17671182   PMID:17679699   PMID:17693601   PMID:17706960   PMID:17767158   PMID:17976063  
PMID:18004065   PMID:18038450   PMID:18055543   PMID:18086858   PMID:18193033   PMID:18231602   PMID:18287330   PMID:18291362   PMID:18316368   PMID:18343708   PMID:18353896   PMID:18356165  
PMID:18387957   PMID:18407748   PMID:18463494   PMID:18467435   PMID:18490442   PMID:18504258   PMID:18533146   PMID:18579517   PMID:18593713   PMID:18624906   PMID:18635608   PMID:18664491  
PMID:18692041   PMID:18756595   PMID:18787224   PMID:18816447   PMID:18936100   PMID:18978355   PMID:19023080   PMID:19038973   PMID:19047464   PMID:19056892   PMID:19060336   PMID:19094982  
PMID:19095296   PMID:19101069   PMID:19112489   PMID:19122665   PMID:19129494   PMID:19151727   PMID:19154719   PMID:19187541   PMID:19199708   PMID:19204372   PMID:19213727   PMID:19282366  
PMID:19306293   PMID:19328798   PMID:19348510   PMID:19443654   PMID:19473345   PMID:19493659   PMID:19497282   PMID:19503085   PMID:19515974   PMID:19546590   PMID:19591802   PMID:19619491  
PMID:19620969   PMID:19653274   PMID:19661059   PMID:19676129   PMID:19686689   PMID:19690384   PMID:19703901   PMID:19718027   PMID:19726620   PMID:19796622   PMID:19799869   PMID:19805073  
PMID:19805295   PMID:19830702   PMID:19850029   PMID:19864575   PMID:19883644   PMID:19920216   PMID:19933277   PMID:19966784   PMID:19996314   PMID:20016102   PMID:20041157   PMID:20043884  
PMID:20086044   PMID:20089884   PMID:20123964   PMID:20159597   PMID:20200966   PMID:20200986   PMID:20235220   PMID:20300119   PMID:20302655   PMID:20369282   PMID:20371816   PMID:20412773  
PMID:20454446   PMID:20499363   PMID:20503375   PMID:20576499   PMID:20623542   PMID:20627076   PMID:20886368   PMID:20931782   PMID:20945354   PMID:21262216   PMID:21325504   PMID:21350016  
PMID:21377456   PMID:21393547   PMID:21404708   PMID:21414924   PMID:21423176   PMID:21443457   PMID:21468580   PMID:21512031   PMID:21602191   PMID:21695899   PMID:21712954   PMID:21718540  
PMID:21724833   PMID:21750544   PMID:21752258   PMID:21757747   PMID:21762377   PMID:21911068   PMID:21928230   PMID:21935365   PMID:21937711   PMID:21991325   PMID:21991385   PMID:22034513  
PMID:22083958   PMID:22089197   PMID:22102609   PMID:22114281   PMID:22139371   PMID:22152883   PMID:22155184   PMID:22190524   PMID:22211239   PMID:22230368   PMID:22240259   PMID:22406377  
PMID:22467863   PMID:22472057   PMID:22475393   PMID:22477723   PMID:22517624   PMID:22521772   PMID:22645310   PMID:22665494   PMID:22706027   PMID:22723415   PMID:22855531   PMID:22898837  
PMID:22899650   PMID:22956852   PMID:23080431   PMID:23124852   PMID:23136403   PMID:23157480   PMID:23198873   PMID:23266329   PMID:23271279   PMID:23374535   PMID:23460868   PMID:23466459  
PMID:23536073   PMID:23591738   PMID:23610556   PMID:23619006   PMID:23740243   PMID:23824574   PMID:23843312   PMID:23856522   PMID:23863479   PMID:23983127   PMID:24046456   PMID:24122933  
PMID:24139451   PMID:24191021   PMID:24248537   PMID:24300170   PMID:24309208   PMID:24338362   PMID:24520423   PMID:24617038   PMID:24625528   PMID:24645679   PMID:24657339   PMID:24681597  
PMID:24691545   PMID:24691643   PMID:24743739   PMID:24817933   PMID:24839947   PMID:24862762   PMID:25009587   PMID:25232112   PMID:25265211   PMID:25337654   PMID:25468996   PMID:25535395  
PMID:25550365   PMID:25556568   PMID:25634106   PMID:25661318   PMID:25674206   PMID:25724365   PMID:25867402   PMID:25931508   PMID:25945342   PMID:25961718   PMID:25979161   PMID:26135564  
PMID:26287173   PMID:26371318   PMID:26429533   PMID:26474975   PMID:26541456   PMID:26739494   PMID:26781174   PMID:26787558   PMID:26833564   PMID:26947974   PMID:26984496   PMID:27097102  
PMID:27328456   PMID:27573468   PMID:27734460   PMID:27922964   PMID:28051089   PMID:28116168   PMID:28177765   PMID:28244647   PMID:28277542   PMID:28296634   PMID:28298358   PMID:28303247  
PMID:28347817   PMID:28365156   PMID:28424168   PMID:28612507   PMID:28641114   PMID:28760678   PMID:28798257   PMID:28829046   PMID:28830684   PMID:28880264   PMID:28887537   PMID:29174980  
PMID:29367600   PMID:29374064   PMID:29476059   PMID:29581478   PMID:29688389   PMID:29739711   PMID:30176346   PMID:30342431   PMID:30361391   PMID:30478225   PMID:30575922   PMID:30605761  
PMID:30710530   PMID:30710617   PMID:30779853   PMID:30861181   PMID:31001900   PMID:31628816   PMID:31694396   PMID:31883297   PMID:31918279   PMID:32003536   PMID:32068571   PMID:32323740  
PMID:32469229   PMID:32729343   PMID:32929341   PMID:32949181   PMID:33040788   PMID:33236141   PMID:33314748   PMID:33380723   PMID:33450132   PMID:33655338   PMID:33726573   PMID:33924991  
PMID:34107845   PMID:34311444   PMID:34399774   PMID:34431454   PMID:35177206   PMID:35347917   PMID:36050404   PMID:36063391   PMID:37015185   PMID:37179212   PMID:37199660   PMID:37410396  
PMID:37566526   PMID:37567011   PMID:37792794   PMID:37930731  


Genomics

Comparative Map Data
Ctnnb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88129,517,576 - 129,544,661 (+)NCBIGRCr8
mRatBN7.28120,640,008 - 120,667,110 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8120,639,995 - 120,667,111 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8126,248,801 - 126,258,310 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08124,447,834 - 124,457,343 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08122,278,384 - 122,287,893 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08129,601,511 - 129,628,378 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8129,617,812 - 129,627,372 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08128,798,888 - 128,825,828 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48125,978,161 - 125,987,670 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18125,997,897 - 126,007,407 (+)NCBI
Celera8119,795,816 - 119,805,325 (+)NCBICelera
Cytogenetic Map8q32NCBI
CTNNB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38341,199,505 - 41,240,443 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl341,194,741 - 41,260,096 (+)EnsemblGRCh38hg38GRCh38
GRCh37341,240,996 - 41,281,934 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36341,215,946 - 41,256,943 (+)NCBINCBI36Build 36hg18NCBI36
Build 34341,216,015 - 41,256,938NCBI
Celera341,179,363 - 41,220,269 (+)NCBICelera
Cytogenetic Map3p22.1NCBI
HuRef341,285,983 - 41,326,988 (+)NCBIHuRef
CHM1_1341,191,513 - 41,232,505 (+)NCBICHM1_1
T2T-CHM13v2.0341,214,904 - 41,255,840 (+)NCBIT2T-CHM13v2.0
Ctnnb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399120,762,466 - 120,789,573 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9120,758,282 - 120,789,573 (+)EnsemblGRCm39 Ensembl
GRCm389120,933,400 - 120,960,507 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9120,929,216 - 120,960,507 (+)EnsemblGRCm38mm10GRCm38
MGSCv379120,842,518 - 120,869,625 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369120,782,173 - 120,809,205 (+)NCBIMGSCv36mm8
Celera9121,404,098 - 121,431,499 (+)NCBICelera
Cytogenetic Map9F4NCBI
cM Map972.19NCBI
Ctnnb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542029,030,716 - 29,047,449 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542029,030,716 - 29,047,447 (-)NCBIChiLan1.0ChiLan1.0
CTNNB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2241,160,670 - 41,201,708 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1341,165,431 - 41,206,468 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0341,104,940 - 41,145,934 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1341,372,368 - 41,414,030 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl341,373,726 - 41,414,030 (+)Ensemblpanpan1.1panPan2
CTNNB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12310,559,722 - 10,572,933 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2310,559,718 - 10,572,927 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2310,596,271 - 10,609,470 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02310,821,172 - 10,860,317 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2310,821,086 - 10,860,327 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12310,656,868 - 10,670,063 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02310,798,400 - 10,811,602 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02310,790,373 - 10,803,572 (+)NCBIUU_Cfam_GSD_1.0
Ctnnb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118196,856,510 - 196,896,035 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647329,999,562 - 30,038,293 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647329,999,542 - 30,034,610 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTNNB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1325,164,277 - 25,208,311 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11325,163,550 - 25,208,314 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21327,623,189 - 27,667,260 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CTNNB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1222,679,488 - 2,725,034 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl222,684,022 - 2,723,949 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041164,464,011 - 164,505,060 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctnnb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473077,875,257 - 77,887,234 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473077,876,361 - 77,887,228 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ctnnb1
48 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:375
Count of miRNA genes:226
Interacting mature miRNAs:285
Transcripts:ENSRNOT00000026016
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat

Markers in Region
PMC316619P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28120,657,290 - 120,658,063 (+)MAPPERmRatBN7.2
Rnor_6.08129,618,559 - 129,619,331NCBIRnor6.0
Rnor_5.08128,816,009 - 128,816,781UniSTSRnor5.0
RGSC_v3.48125,978,867 - 125,979,639UniSTSRGSC3.4
Celera8119,796,522 - 119,797,294UniSTS
Cytogenetic Map8q32UniSTS
Catnb  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28120,666,150 - 120,666,283 (+)MAPPERmRatBN7.2
Rnor_6.08129,627,419 - 129,627,551NCBIRnor6.0
Rnor_5.08128,824,869 - 128,825,001UniSTSRnor5.0
RGSC_v3.48125,987,727 - 125,987,859UniSTSRGSC3.4
Celera8119,805,382 - 119,805,514UniSTS
Cytogenetic Map8q32UniSTS
RH133995  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28120,666,861 - 120,667,070 (+)MAPPERmRatBN7.2
mRatBN7.21941,591,312 - 41,591,521 (+)MAPPERmRatBN7.2
Rnor_6.01945,912,675 - 45,912,883NCBIRnor6.0
Rnor_6.08129,628,130 - 129,628,338NCBIRnor6.0
Rnor_5.01956,737,456 - 56,737,664UniSTSRnor5.0
Rnor_5.08128,825,580 - 128,825,788UniSTSRnor5.0
RGSC_v3.48125,988,438 - 125,988,646UniSTSRGSC3.4
RGSC_v3.41943,603,592 - 43,603,800UniSTSRGSC3.4
Celera1940,907,382 - 40,907,590UniSTS
Celera8119,806,093 - 119,806,301UniSTS
RH 3.4 Map18574.2UniSTS
Cytogenetic Map19q12UniSTS
Cytogenetic Map8q32UniSTS
RH140639  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28120,656,582 - 120,657,098 (+)MAPPERmRatBN7.2
Rnor_6.08129,617,851 - 129,618,366NCBIRnor6.0
Rnor_5.08128,815,301 - 128,815,816UniSTSRnor5.0
RGSC_v3.48125,978,159 - 125,978,674UniSTSRGSC3.4
Celera8119,795,814 - 119,796,329UniSTS
RH 3.4 Map7606.2UniSTS
Cytogenetic Map8q32UniSTS
Ctnnb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2788,699,496 - 88,699,873 (+)MAPPERmRatBN7.2
Rnor_6.0797,013,193 - 97,013,569NCBIRnor6.0
Rnor_5.0797,629,244 - 97,629,620UniSTSRnor5.0
RGSC_v3.4793,845,171 - 93,845,547UniSTSRGSC3.4
Celera785,477,314 - 85,477,690UniSTS
Cytogenetic Map8q32UniSTS
Cytogenetic Map7q32UniSTS
PMC21165P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28120,663,823 - 120,664,218 (+)MAPPERmRatBN7.2
Rnor_6.08129,625,092 - 129,625,486NCBIRnor6.0
Rnor_5.08128,822,542 - 128,822,936UniSTSRnor5.0
RGSC_v3.48125,985,400 - 125,985,794UniSTSRGSC3.4
Celera8119,803,055 - 119,803,449UniSTS
Cytogenetic Map8q32UniSTS
Ctnnb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28120,665,224 - 120,666,008 (+)MAPPERmRatBN7.2
Rnor_6.08129,626,493 - 129,627,276NCBIRnor6.0
Rnor_5.08128,823,943 - 128,824,726UniSTSRnor5.0
RGSC_v3.48125,986,801 - 125,987,584UniSTSRGSC3.4
Celera8119,804,456 - 119,805,239UniSTS
Cytogenetic Map8q32UniSTS
Ctnnb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28120,665,882 - 120,666,840 (+)MAPPERmRatBN7.2
Rnor_6.08129,627,151 - 129,628,108NCBIRnor6.0
Rnor_5.08128,824,601 - 128,825,558UniSTSRnor5.0
Celera8119,805,114 - 119,806,071UniSTS
Cytogenetic Map8q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF121265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF397179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF486617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ002272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ002273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ002274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000079085   ⟹   ENSRNOP00000068620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8120,640,008 - 120,667,109 (+)Ensembl
Rnor_6.0 Ensembl8129,617,812 - 129,627,372 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101345   ⟹   ENSRNOP00000094665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8120,639,995 - 120,667,111 (+)Ensembl
RefSeq Acc Id: NM_053357   ⟹   NP_445809
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88129,534,137 - 129,543,646 (+)NCBI
mRatBN7.28120,656,585 - 120,666,094 (+)NCBI
Rnor_6.08129,617,853 - 129,627,362 (+)NCBI
Rnor_5.08128,798,888 - 128,825,828 (+)NCBI
RGSC_v3.48125,978,161 - 125,987,670 (+)RGD
Celera8119,795,816 - 119,805,325 (+)RGD
Sequence:
RefSeq Acc Id: XM_039082207   ⟹   XP_038938135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88129,517,580 - 129,544,661 (+)NCBI
mRatBN7.28120,640,029 - 120,667,110 (+)NCBI
RefSeq Acc Id: XM_039082208   ⟹   XP_038938136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88129,517,576 - 129,544,661 (+)NCBI
mRatBN7.28120,640,011 - 120,667,110 (+)NCBI
RefSeq Acc Id: XM_039082209   ⟹   XP_038938137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88129,517,576 - 129,544,661 (+)NCBI
mRatBN7.28120,640,008 - 120,667,103 (+)NCBI
RefSeq Acc Id: XM_063266224   ⟹   XP_063122294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88129,517,580 - 129,544,661 (+)NCBI
RefSeq Acc Id: XM_063266225   ⟹   XP_063122295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88129,517,913 - 129,544,661 (+)NCBI
RefSeq Acc Id: XM_063266226   ⟹   XP_063122296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88129,517,580 - 129,544,661 (+)NCBI
RefSeq Acc Id: XM_063266227   ⟹   XP_063122297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88129,517,580 - 129,544,661 (+)NCBI
RefSeq Acc Id: XM_063266228   ⟹   XP_063122298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88129,517,923 - 129,544,661 (+)NCBI
RefSeq Acc Id: XM_063266229   ⟹   XP_063122299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88129,517,576 - 129,544,661 (+)NCBI
RefSeq Acc Id: NP_445809   ⟸   NM_053357
- UniProtKB: Q9WU82 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068620   ⟸   ENSRNOT00000079085
RefSeq Acc Id: XP_038938137   ⟸   XM_039082209
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JT93 (UniProtKB/TrEMBL),   A6I428 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938136   ⟸   XM_039082208
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JT93 (UniProtKB/TrEMBL),   A6I428 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938135   ⟸   XM_039082207
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JT93 (UniProtKB/TrEMBL),   A6I428 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000094665   ⟸   ENSRNOT00000101345
RefSeq Acc Id: XP_063122299   ⟸   XM_063266229
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063122296   ⟸   XM_063266226
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063122294   ⟸   XM_063266224
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063122297   ⟸   XM_063266227
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063122295   ⟸   XM_063266225
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063122298   ⟸   XM_063266228
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WU82-F1-model_v2 AlphaFold Q9WU82 1-781 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70487 AgrOrtholog
BioCyc Gene G2FUF-28711 BioCyc
Ensembl Genes ENSRNOG00000054172 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079085.2 UniProtKB/TrEMBL
  ENSRNOT00000101345.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Armadillo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Beta-catenin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84353 UniProtKB/Swiss-Prot
NCBI Gene 84353 ENTREZGENE
PANTHER CATENIN BETA-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45976 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arm UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CTNNB1 RGD
PhenoGen Ctnnb1 PhenoGen
PRINTS BCATNINFAMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ARM_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054172 RatGTEx
SMART ARM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JT93 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GKV3_RAT UniProtKB/TrEMBL
  A6I428 ENTREZGENE, UniProtKB/TrEMBL
  A6I429_RAT UniProtKB/TrEMBL
  B6DMG1_RAT UniProtKB/TrEMBL
  CTNB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Ctnnb1  catenin beta 1  Ctnnb1  catenin (cadherin associated protein), beta 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ctnnb1  catenin (cadherin associated protein), beta 1    catenin (cadherin associated protein), beta 1, 88kDa  Name updated 1299863 APPROVED
2005-09-19 Ctnnb1  catenin (cadherin associated protein), beta 1, 88kDa  Catnb  catenin beta  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-01-20 Catnb  catenin beta    beta-catenin  Name updated 1299863 APPROVED
2002-06-10 Catnb  beta-catenin      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease has a role in heterocyclic amine-induced colon tumors development 69506
gene_disease has a role in heterocyclic amine-induced colon tumors development 70260
gene_disease mutations in gene are associated with colon adenomas 1299223
gene_disease gene mutations have been detected in chemically induced colon tumors but were not found in liver tumors 1302224
gene_expression protein level was reduced in thyroid hormone (T3)-induced cell proliferation in GC rat pituitary cell line 69506
gene_expression protein level was reduced in thyroid hormone (T3)-induced cell proliferation in GC rat pituitary cell line 70260
gene_function key signal transducer in Wnt signaling pathway 69506
gene_function key signal transducer in Wnt signaling pathway 70260
gene_process mediates interactions between cadherins and the actin cytoskeleton 1299225
gene_regulation transcriptional activity is regulated by thyroid hormone (T3) 69506