Hus1 (HUS1 checkpoint clamp component) - Rat Genome Database

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Gene: Hus1 (HUS1 checkpoint clamp component) Rattus norvegicus
Analyze
Symbol: Hus1
Name: HUS1 checkpoint clamp component
RGD ID: 1591976
Description: Predicted to be involved in several processes, including DNA integrity checkpoint signaling; DNA metabolic process; and cellular response to ionizing radiation. Predicted to act upstream of or within DNA damage checkpoint signaling; protein phosphorylation; and response to UV. Predicted to be located in nucleus. Predicted to be part of checkpoint clamp complex. Predicted to be active in site of double-strand break. Orthologous to human HUS1 (HUS1 checkpoint clamp component); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; bisphenol A; flutamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: checkpoint protein HUS1; HUS1 checkpoint homolog; HUS1 checkpoint homolog (S. pombe); Hus1 homolog; LOC498411; similar to Hus1 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21483,688,702 - 83,703,466 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1483,688,708 - 83,703,442 (-)Ensembl
Rnor_6.01489,194,086 - 89,208,825 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1489,194,092 - 89,208,825 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01488,991,462 - 89,006,201 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41489,527,997 - 89,542,730 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1482,724,930 - 82,739,682 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10846170   PMID:11790307   PMID:12529385   PMID:12676962   PMID:15919177   PMID:16278671   PMID:21659603  


Genomics

Comparative Map Data
Hus1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21483,688,702 - 83,703,466 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1483,688,708 - 83,703,442 (-)Ensembl
Rnor_6.01489,194,086 - 89,208,825 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1489,194,092 - 89,208,825 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01488,991,462 - 89,006,201 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41489,527,997 - 89,542,730 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1482,724,930 - 82,739,682 (-)NCBICelera
Cytogenetic Map14q21NCBI
HUS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38747,963,288 - 47,979,615 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl747,963,288 - 47,979,615 (-)EnsemblGRCh38hg38GRCh38
GRCh37748,002,885 - 48,019,212 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36747,970,308 - 47,985,771 (-)NCBINCBI36hg18NCBI36
Build 34747,777,022 - 47,792,486NCBI
Celera748,103,051 - 48,118,524 (-)NCBI
Cytogenetic Map7p12.3NCBI
HuRef747,888,421 - 47,904,763 (-)NCBIHuRef
CHM1_1748,006,647 - 48,022,950 (-)NCBICHM1_1
T2T-CHM13v2.0748,125,574 - 48,141,862 (-)NCBI
CRA_TCAGchr7v2748,042,830 - 48,059,174 (-)NCBI
Hus1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39118,943,137 - 8,961,240 (-)NCBIGRCm39mm39
GRCm39 Ensembl118,943,137 - 8,961,191 (-)Ensembl
GRCm38118,993,137 - 9,011,236 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl118,993,137 - 9,011,191 (-)EnsemblGRCm38mm10GRCm38
MGSCv37118,893,145 - 8,911,140 (-)NCBIGRCm37mm9NCBIm37
MGSCv36118,893,145 - 8,911,140 (-)NCBImm8
Celera119,425,958 - 9,443,972 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map115.74NCBI
Hus1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554565,465,182 - 5,474,303 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554565,465,180 - 5,476,380 (+)NCBIChiLan1.0ChiLan1.0
HUS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1748,714,028 - 48,731,038 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl748,714,668 - 48,731,005 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0748,606,848 - 48,622,194 (-)NCBIMhudiblu_PPA_v0panPan3
HUS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11693,596 - 104,908 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1693,626 - 125,597 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha16865,769 - 879,528 (+)NCBI
ROS_Cfam_1.01671,091 - 84,888 (+)NCBI
UMICH_Zoey_3.11665,830 - 79,607 (+)NCBI
UNSW_CanFamBas_1.016811 - 14,587 (+)NCBI
Hus1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118103,172,833 - 103,202,691 (-)NCBI
SpeTri2.0NW_00493647822,393,952 - 22,414,349 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HUS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1848,522,998 - 48,534,682 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11848,522,914 - 48,539,267 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HUS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12110,826,799 - 10,841,579 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2110,826,846 - 10,841,382 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606211,380,792 - 11,397,402 (-)NCBIVero_WHO_p1.0
Hus1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247405,606,129 - 5,618,092 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247405,606,828 - 5,617,848 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AF076845  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21483,692,336 - 83,692,430 (+)MAPPERmRatBN7.2
Rnor_6.01489,197,721 - 89,197,814NCBIRnor6.0
Rnor_5.01488,995,097 - 88,995,190UniSTSRnor5.0
RGSC_v3.41489,531,626 - 89,531,719UniSTSRGSC3.4
Celera1482,728,559 - 82,728,652UniSTS
Cytogenetic Map14q21UniSTS
RH130096  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21483,688,753 - 83,688,934 (+)MAPPERmRatBN7.2
Rnor_6.01489,194,138 - 89,194,318NCBIRnor6.0
Rnor_5.01488,991,514 - 88,991,694UniSTSRnor5.0
RGSC_v3.41489,528,043 - 89,528,223UniSTSRGSC3.4
Celera1482,724,976 - 82,725,156UniSTS
RH 3.4 Map14620.5UniSTS
Cytogenetic Map14q21UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat
4889951Bss92Bone structure and strength QTL 923.9tibia area (VT:1000281)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)148205747195876975Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:485
Count of miRNA genes:259
Interacting mature miRNAs:336
Transcripts:ENSRNOT00000006852
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 12 20 14 13 14 54 35 36 11
Low 31 37 27 6 27 8 11 20 5 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006852   ⟹   ENSRNOP00000006852
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1483,688,708 - 83,703,442 (-)Ensembl
Rnor_6.0 Ensembl1489,194,092 - 89,208,825 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091671   ⟹   ENSRNOP00000072823
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1489,194,113 - 89,208,813 (-)Ensembl
RefSeq Acc Id: NM_001109092   ⟹   NP_001102562
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21483,688,708 - 83,703,442 (-)NCBI
Rnor_6.01489,194,092 - 89,208,825 (-)NCBI
Rnor_5.01488,991,462 - 89,006,201 (-)NCBI
RGSC_v3.41489,527,997 - 89,542,730 (-)RGD
Celera1482,724,930 - 82,739,682 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251468   ⟹   XP_006251530
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21483,688,702 - 83,703,466 (-)NCBI
Rnor_6.01489,194,086 - 89,208,820 (-)NCBI
Rnor_5.01488,991,462 - 89,006,201 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251469   ⟹   XP_006251531
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21483,688,702 - 83,703,283 (-)NCBI
Rnor_6.01489,194,086 - 89,208,686 (-)NCBI
Rnor_5.01488,991,462 - 89,006,201 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092298   ⟹   XP_038948226
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21483,688,702 - 83,703,466 (-)NCBI
RefSeq Acc Id: XM_039092299   ⟹   XP_038948227
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21483,688,702 - 83,703,466 (-)NCBI
RefSeq Acc Id: XM_039092300   ⟹   XP_038948228
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21483,694,845 - 83,703,466 (-)NCBI
RefSeq Acc Id: XR_005493002
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21483,694,111 - 83,703,466 (-)NCBI
RefSeq Acc Id: XR_005493003
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21483,694,845 - 83,703,466 (-)NCBI
RefSeq Acc Id: XR_005493004
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21483,694,111 - 83,703,466 (-)NCBI
RefSeq Acc Id: XR_005493005
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21483,694,111 - 83,703,466 (-)NCBI
RefSeq Acc Id: XR_005493006
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21483,694,845 - 83,703,466 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001102562   ⟸   NM_001109092
- UniProtKB: D3ZNA8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251530   ⟸   XM_006251468
- Peptide Label: isoform X1
- UniProtKB: D3ZNA8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251531   ⟸   XM_006251469
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000006852   ⟸   ENSRNOT00000006852
RefSeq Acc Id: ENSRNOP00000072823   ⟸   ENSRNOT00000091671
RefSeq Acc Id: XP_038948227   ⟸   XM_039092299
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038948226   ⟸   XM_039092298
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038948228   ⟸   XM_039092300
- Peptide Label: isoform X5

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZNA8-F1-model_v2 AlphaFold D3ZNA8 1-280 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699492
Promoter ID:EPDNEW_R10011
Type:multiple initiation site
Name:Hus1_1
Description:HUS1 checkpoint clamp component
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01489,208,762 - 89,208,822EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
14 89199864 89199865 C T snv MR/N (MCW), LE/Stm (RGD), LEXF10A/StmMcwi (2020), MR/N (2020), LE/Stm (2019)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1591976 AgrOrtholog
BioCyc Gene G2FUF-15024 BioCyc
Ensembl Genes ENSRNOG00000005141 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000006852 ENTREZGENE
  ENSRNOP00000006852.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006852 ENTREZGENE
  ENSRNOT00000006852.8 UniProtKB/TrEMBL
InterPro Cell_cycle_HUS1 UniProtKB/TrEMBL
  Hus1 UniProtKB/TrEMBL
KEGG Report rno:498411 UniProtKB/TrEMBL
NCBI Gene 498411 ENTREZGENE
Pfam Hus1 UniProtKB/TrEMBL
PhenoGen Hus1 PhenoGen
PIRSF Cell_cycle_HUS1 UniProtKB/TrEMBL
UniProt D3ZNA8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-01 Hus1  HUS1 checkpoint clamp component  Hus1  HUS1 checkpoint homolog (S. pombe)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Hus1  HUS1 checkpoint homolog (S. pombe)  LOC498411  similar to Hus1 homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC498411  similar to Hus1 homolog      Symbol and Name status set to provisional 70820 PROVISIONAL