Nat8l (N-acetyltransferase 8-like)

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Gene: Nat8l (N-acetyltransferase 8-like) Rattus norvegicus

Analyze

Symbol:

Nat8l

Name:

N-acetyltransferase 8-like

RGD ID:

1305719

Description:

Enables aspartate N-acetyltransferase activity. Predicted to be involved in acetate metabolic process; aspartate metabolic process; and positive regulation of dopamine uptake involved in synaptic transmission. Located in mitochondrion. Orthologous to human NAT8L (N-acetyltransferase 8 like); INTERACTS WITH 1,2-dimethylhydrazine; 6-propyl-2-thiouracil; amphetamine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC289727; N-acetylaspartate synthetase; NAA synthetase; RGD1305719; similar to putative N-acetyltransferase Camello 2

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NAT8L (N-acetyltransferase 8 like)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Nat8l (N-acetyltransferase 8-like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nat8l (N-acetyltransferase 8 like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NAT8L (N-acetyltransferase 8 like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NAT8L (N-acetyltransferase 8 like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nat8l (N-acetyltransferase 8 like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NAT8L (N-acetyltransferase 8 like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NAT8L (N-acetyltransferase 8 like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nat8l (N-acetyltransferase 8 like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Nat8l (N-acetyltransferase 8-like)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	NAT8L (N-acetyltransferase 8 like)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nat8l (N-acetyltransferase 8-like)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	nat8l	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	76,756,077 - 76,762,712 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	76,756,077 - 76,763,411 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	81,208,268 - 81,214,903 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	82,448,910 - 82,455,545 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	78,894,162 - 78,900,797 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	82,041,616 - 82,048,251 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	82,041,616 - 82,048,251 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	82,725,856 - 82,732,491 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	82,450,004 - 82,456,639 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	82,452,871 - 82,459,041 (-)	NCBI
Celera	14	75,679,651 - 75,686,286 (-)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cherubism (ISO)

genetic disease (ISO)

microcephaly (ISO)

N-Acetylaspartate Deficiency (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

choline (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

Cuprizon (EXP)

dorsomorphin (ISO)

ethanol (ISO)

folic acid (ISO)

genistein (ISO)

L-methionine (ISO)

lipopolysaccharide (ISO)

manganese(II) chloride (EXP)

methimazole (EXP)

Nor-9-carboxy-delta9-THC (ISO)

ozone (ISO)

paracetamol (EXP)

pentanal (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

propanal (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sulfadimethoxine (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acetate metabolic process (ISO)

aspartate metabolic process (ISO)

positive regulation of dopamine uptake involved in synaptic transmission (ISO)

Cellular Component

cytoplasm (ISO)

endoplasmic reticulum membrane (ISO)

intracellular membrane-bounded organelle (IDA)

mitochondrial matrix (ISO)

mitochondrial membrane (IBA,ISO)

mitochondrion (IDA,ISO)

Molecular Function

aspartate N-acetyltransferase activity (IBA,IDA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	N-acetylaspartate synthesis in the brain: mitochondria vs. microsomes.	Ariyannur PS, etal., Brain Res. 2008 Aug 28;1227:34-41. doi: 10.1016/j.brainres.2008.06.040. Epub 2008 Jun 21.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:19014384	PMID:19524112	PMID:19807691	PMID:20385109	PMID:20643647	PMID:24515258

Genomics

Comparative Map Data

Nat8l
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	76,756,077 - 76,762,712 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	76,756,077 - 76,763,411 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	81,208,268 - 81,214,903 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	82,448,910 - 82,455,545 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	78,894,162 - 78,900,797 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	82,041,616 - 82,048,251 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	82,041,616 - 82,048,251 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	82,725,856 - 82,732,491 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	82,450,004 - 82,456,639 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	82,452,871 - 82,459,041 (-)	NCBI
Celera	14	75,679,651 - 75,686,286 (-)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

NAT8L
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	2,059,327 - 2,069,089 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	2,059,327 - 2,069,089 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	2,061,054 - 2,070,816 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	2,031,385 - 2,037,433 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	4	1,973,294 - 1,982,873 (+)	NCBI		Celera
Cytogenetic Map	4	p16.3	NCBI
HuRef	4	2,002,444 - 2,011,663 (+)	NCBI		HuRef
CHM1_1	4	2,059,837 - 2,069,384 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	2,057,805 - 2,067,569 (+)	NCBI		T2T-CHM13v2.0

Nat8l
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	34,153,328 - 34,163,260 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	34,153,328 - 34,163,260 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	33,995,984 - 34,005,916 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	33,995,984 - 34,005,916 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	34,338,633 - 34,348,565 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	34,312,841 - 34,322,771 (+)	NCBI		MGSCv36	mm8
Celera	5	31,465,700 - 31,475,650 (+)	NCBI		Celera
Cytogenetic Map	5	B2	NCBI
cM Map	5	17.83	NCBI

Nat8l
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955514	1,207,310 - 1,213,732 (+)	NCBI	ChiLan1.0	ChiLan1.0

NAT8L
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	4	2,328,762 - 2,338,464 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	2,201,326 - 2,211,302 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	2,111,100 - 2,114,512 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

NAT8L
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	62,107,060 - 62,113,807 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	62,108,003 - 62,113,737 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	64,625,039 - 64,631,752 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	62,582,678 - 62,589,391 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	62,579,869 - 62,589,356 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	62,075,250 - 62,081,962 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	62,278,911 - 62,285,622 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	62,638,914 - 62,645,627 (-)	NCBI		UU_Cfam_GSD_1.0

Nat8l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	67,696,037 - 67,703,423 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936477	21,397,729 - 21,405,098 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NAT8L
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	1,063,824 - 1,072,189 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	1,063,917 - 1,072,191 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	448,361 - 456,975 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NAT8L
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	46,697,086 - 46,703,494 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	46,698,845 - 46,703,413 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666051	3,064,403 - 3,073,881 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nat8l
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624755	25,468,658 - 25,472,837 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624755	25,465,154 - 25,472,906 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Nat8l
20 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	388
Count of miRNA genes:	200
Interacting mature miRNAs:	258
Transcripts:	ENSRNOT00000074734
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	95876975	Rat
70187	Pancm5	Pancreatic morphology QTL 5	16.7		pancreas mass (VT:0010144)	pancreas weight to body weight ratio (CMO:0000630)	14	30320092	80829842	Rat
2313048	Bss84	Bone structure and strength QTL 84	3.1	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	14	37669719	82669719	Rat
2313084	Bss83	Bone structure and strength QTL 83	2.9	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	14	37669719	82669719	Rat
2313089	Bss81	Bone structure and strength QTL 81	3.4	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	14	37669719	82669719	Rat
2313100	Bss82	Bone structure and strength QTL 82	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	14	37669719	82669719	Rat
738037	Hcas6	Hepatocarcinoma susceptibility QTL 6	2.93		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	14	39057237	83368335	Rat
631523	Pia13	Pristane induced arthritis QTL 13	3.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	40793460	98037301	Rat
1300136	Rf22	Renal function QTL 22	3.9		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	14	42262529	95023211	Rat
1549834	Scl45	Serum cholesterol level QTL 45	5.8		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	50023211	95023211	Rat
2300197	Scl59	Serum cholesterol level QTL 59			blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	55147478	100147478	Rat
9590294	Uminl4	Urine mineral level QTL 4	5.66	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	14	55624247	100624247	Rat
9589034	Epfw11	Epididymal fat weight QTL 11	6	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	14	55624247	100624247	Rat
2317879	Alcrsp27	Alcohol response QTL 27	3.3	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	14	56631369	101631369	Rat
634328	Hc5	Hypercalciuria QTL 5	2.3		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	14	58184885	103184885	Rat
70153	Bp59	Blood pressure QTL 59	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	14	68757796	83368335	Rat
1582259	Gluco23	Glucose level QTL 23	3.1	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	70053989	104886043	Rat
1641900	Alcrsp11	Alcohol response QTL 11			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	14	70053989	104886043	Rat
1582197	Gluco27	Glucose level QTL 27	3.4	0.0006	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	73415323	92554092	Rat
1582209	Gluco20	Glucose level QTL 20	3.8	0.0005	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	73415323	92554092	Rat
1582236	Gluco22	Glucose level QTL 22	3.3	0.0164	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	73415323	92554092	Rat
1582255	Gluco29	Glucose level QTL 29	3.1	0.0025	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	14	73415323	92554092	Rat
1582250	Gluco26	Glucose level QTL 26	3.3	0.0009	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	73415323	95876975	Rat

Markers in Region

RH143045

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	76,756,615 - 76,756,832 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	82,042,155 - 82,042,371	NCBI	Rnor6.0
Rnor_5.0	14	82,726,395 - 82,726,611	UniSTS	Rnor5.0
RGSC_v3.4	14	82,450,543 - 82,450,759	UniSTS	RGSC3.4
Celera	14	75,680,190 - 75,680,406	UniSTS
Cytogenetic Map	14	q21	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			4		2				74		2
Low	2	33	14	2	12	2	3	4		27	39	11	3
Below cutoff	1	10	27	27	5	27	5	7		8			5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191681	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000254	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000074734 ⟹ ENSRNOP00000066413

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	76,756,077 - 76,763,411 (-)	Ensembl
Rnor_6.0 Ensembl	14	82,041,616 - 82,048,251 (-)	Ensembl

RefSeq Acc Id:

NM_001191681 ⟹ NP_001178610

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	76,756,077 - 76,762,712 (-)	NCBI
Rnor_6.0	14	82,041,616 - 82,048,251 (-)	NCBI
Rnor_5.0	14	82,725,856 - 82,732,491 (-)	NCBI
Celera	14	75,679,651 - 75,686,286 (-)	NCBI

Sequence:

show sequence

ATGCATTGTGGGCCTCCCGACATGGTCTGCGAGACGAAGATCGTGGCTACGGAGGACCATGAGG
CACTGCCGGGGGCCAAGAAGGACGCGCTGCTCGCCGCCGCCGGAGCCATGTGGCCCCCGCTGCC
CGCCGCGCCCGGGCCGGCTGCCGCACCCCCACCCGCGGCAGGTCCCCAGCCCCACGGAGGCACC
GGGGGCGCGGGGCCGCCGGAGGGGCGCGGCGTGTGCATCCGCGAGTTCCGCGCAGCCGAGCAGG
AGGCGGCGCGCCGCATCTTCTACGACGGCATCTTGGAGCGCATCCCCAACACGGCTTTCCGAGG
CCTGCGGCAGCACCCGCGCACCCAGCTGCTCTACGCCCTGCTGGCGGCCCTCTGTTTTGCTGTG
ACCCGCTCACTGCTGCTGACATGCCTGGTGCCGGCCGGGCTCCTGGCCCTGCGCTACTACTACA
GTCGCAAGGTGATTCTGGCCTACCTGGAGTGTGCGCTGCACACGGACATGGCTGACATTGAACA
GTACTACATGAAGCCACCTGGTTCCTGTTTCTGGGTGGCTGTGCTGGACGGCAATGTTGTGGGC
ATCGTGGCGGCTCGGGCCCATGAGGAAGACAACACAGTGGAGCTGCTCCGCATGTCCGTGGACT
CGCGCTTCCGCGGCAAAGGCATCGCCAAGGCCCTGGGCAGGAGGGTGTTGGAGTTTGCCATGCT
GCACAACTACTCTGCAGTGGTACTGGGCACCACAGCCGTTAAGGTGGCCGCCCACAAGCTCTAT
GAGTCACTGGGCTTCAGACACATGGGCGCGAGTGATCACTACGTGCTGCCTGGCATGACCCTCT
CGCTGGCCGAGCGCCTCTTCTTCCAGGTCCGCTACCACCGCTACCGCCTGCAGCTGCGCGAGGA
GTGACCACCACCACCTGCCCACCACCCTGTCTGCCCCCGTCCACCTCTGCCCTCCTGCTCGCTG
CCTAGTGCGGCCCTGCTTTCCAATGCTCACCTTGGCGTTTGTTTGGGTTTTCCTTTTTCAGCAT
CCTGCTGGTTCACCACCTGGCTGGTTCTGGAGCCACAGGGTCCCAGTCCAGAGTGCTCAGCAGC
AGCACTCTGGTGGGGTGGATTGTCTGCAGCTATGGCCCTTGCCTCCCCAGCCCATCAGAGTGGC
TCATCATGCCTTGAAGAGTAGCATTGTGGACCATCTGAACTATCCACAAAGCTGCCCAGCCTGC
CTCCATCAGGGAAGGACTAGCTTTGCCCATCAAGCACAGAACCTCTACAACAACCCCCCCAAGG
AGCAGAACCCTGGCCCCAGCCAGGCTAAGGCCCAGCTATTGGCCTCTGGAAGAATGGTCTGCTG
GGCTGGCCAGCCACTGCCCCATGGGAGGCCAAGCTGGCCTCAGGCCCTGCTTTGCCCTGTGCAT
GCTAAGGACATGGCCTGGCTGCAGCATGCCGCATGCCACAGCCCCCTGCCCCGCTGCCCGCCCA
GCCTGGACTTCAGGCCTGAGCTGGTGAGCTCCCTTGTCCTGTCCTGAGCTGGCCTCTGGAGGGC
CTACCTGCCTGACCCTGTCTGCTCTCTGGTGGGGCCTGGCCTGGCCTAACCTGGCTCTATTCAC
TCCTGCTTTGCTTTGAAATCATCTTACCTCTTTCCCTTTTCAGTCCCTGTGCCTCCTTGCTCTG
GCTGACTTGGCTGGTCACCTGGGTCTGGCTCCTGTAGCAATCCACTGCACAGCATGGTGGGGAT
TTCATGGGGAGGGGGAACACCTCCCCCAATACCTGTTAGATCAGGTGGCCACCTCCCAGCTGCC
TGAGGTCCCATGGCCTCATGCTGTCTGTGGGGTCTGCCCTGTGAATGTAACTAGCCCAGGCTGT
TGTTGGCAATGCCTGCCACAGCTTCTCCCAGCCTGAAACAACCCATTCTCTAATAAGTTACGTA
GACAGAATAGCACTCTGCATGACTTTAATTCCTGGGACAAAATGGTAGTTTGAGCCTCCAGACA
CACATCTGTGTGGTGCTAGCATATGCACGGTCTCTGGCCCCATTTGATGGGGGTGGGTGGCCGG
GTAGGTGGAAGATTTCATTTTGAAGTATGGAAGGAGACTCTAATTTAGTGTAAATGCCCCCAAA
GTGCTCTCACAACACAAAGCTTATGAGGCTCAGGCTGCCCCTTGACTCCTTGTGTGCAGGACTG
AGGGGACTGGAGGGTCTGAGAGCCTCATAGGAAGGGCTGGGCACTGCTTTGGGGGCAGGAGCTG
GTGGTTGGGGTAGGTCCAGCCTCCCACTACAGACTACTCTGCTAGGCCATCTCTTCTCCTCGTT
TCTCCTTTTTGAGGTCCAATTTAGAATCCAGCCTAGATGGGGGTGGGGATGGCCTAGGACAGGG
AGAGGCAGTAGCTGGCAGTGTTCATGCGCCAGCTGAAACTTGGACTTAGCTTTAGTGCAGGGGG
TGCATAAAGGCCCATACACACTCTCCTGTGTGGGGCTTGGGGTGAGGAGTGGCAGGCTAGGTAG
ACCATAGAGCTGGGCCCCTGGCACCAAGGCTGCAATGTTAGAAAGGCTCTTTAGAGTTAATGAG
TTGGTGGAGCAAGCCCAGCTTCCTGAGGGGCCTTTTGTCCTGTTAGCAATTGAGGCATTTGCAG
AACACTGTACAGACCCCGCTCTCCCCTGTACATTCCTCCCTGGTGGTGCCCGGTCCCCACTTGG
GGATGGGAGTTTTGTAGACTGTACAGAAATCGGCACCCTATTTTCTTGCAGCTCTCAGATTTTG
TTAATCTGGATTATACAGACAGACGTAAAGTGTTTTAGCAAAATGGAAAACAAACAGTTGTGCC
TTTTTTCTCTTTTCTGTTTGGATTGGTCTCGGCTCGGGGCTAGTTTTAGTTGTTGTGGGGGTGT
AGGGACTGCTGGTGTCTGAGGCCTGGGTGGGCCTAAGTGGGAGCCAGGTCTGCTGGACACCACC
AGCTGCCAAGGCTTCTCTGATCCTGTGCCTTTGGGGCCTGCAGTCTGGGGTTGGAAGGTATGGC
AGAGCACTGGGATCACATGTGCACAGAGCATGGGGACCCTGTAGCCACCCATGTCTCTTTGATA
CTGACCTGGGATGAGCTCATAGTAGATTTCTCCATCCTAGGAACTTGGGGGGAGGTGTGGTCCT
TCTGGCCTCTTGGCACCTATCTGTTCAAGGGGATCTCTTCCCTCTGAACAACCCATGGATAAAG
GGAAGTGCGCTGGGCTCGCGAGTATTCATTGCCTTCTGTTGCTGCCAAGACTTGGTAGAGATTC
CAGGAATGGATGGTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001178610	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	D3ZVU9	(Get FASTA)	NCBI Sequence Viewer
	EDM00108	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000066413

RefSeq Acc Id:

NP_001178610 ⟸ NM_001191681

- UniProtKB:

D3ZVU9 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MHCGPPDMVCETKIVATEDHEALPGAKKDALLAAAGAMWPPLPAAPGPAAAPPPAAGPQPHGGT
GGAGPPEGRGVCIREFRAAEQEAARRIFYDGILERIPNTAFRGLRQHPRTQLLYALLAALCFAV
TRSLLLTCLVPAGLLALRYYYSRKVILAYLECALHTDMADIEQYYMKPPGSCFWVAVLDGNVVG
IVAARAHEEDNTVELLRMSVDSRFRGKGIAKALGRRVLEFAMLHNYSAVVLGTTAVKVAAHKLY
ESLGFRHMGASDHYVLPGMTLSLAERLFFQVRYHRYRLQLREE

hide sequence

RefSeq Acc Id:

ENSRNOP00000066413 ⟸ ENSRNOT00000074734

Protein Domains

N-acetyltransferase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZVU9-F1-model_v2	AlphaFold	D3ZVU9	1-299	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305719	AgrOrtholog
BioCyc Gene	G2FUF-15278	BioCyc
Ensembl Genes	ENSRNOG00000049351	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000074734	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.630.30	UniProtKB/Swiss-Prot
InterPro	Acyl_CoA_acyltransferase	UniProtKB/Swiss-Prot
	GNAT_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:289727	UniProtKB/Swiss-Prot
NCBI Gene	289727	ENTREZGENE
PANTHER	GNAT FAMILY N-ACETYLTRANSFERASE	UniProtKB/Swiss-Prot
	N-ACETYLASPARTATE SYNTHETASE	UniProtKB/Swiss-Prot
Pfam	Acetyltransf_1	UniProtKB/Swiss-Prot
PhenoGen	Nat8l	PhenoGen
PROSITE	GNAT	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000049351	RatGTEx
Superfamily-SCOP	SSF55729	UniProtKB/Swiss-Prot
UniProt	D3ZVU9	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Nat8l	N-acetyltransferase 8-like	Nat8l_predicted	N-acetyltransferase 8-like (predicted)	'predicted' is removed	2292626	APPROVED
2007-12-17	Nat8l_predicted		Nat8l _predicted	N-acetyltransferase 8-like (predicted)	Symbol updated	1299863	APPROVED
2007-03-29	Nat8l _predicted	N-acetyltransferase 8-like (predicted)	RGD1305719_predicted	similar to putative N-acetyltransferase Camello 2 (predicted)	Symbol and Name updated to reflect Human and Mouse nomenclature	1299863	APPROVED
2005-01-20	RGD1305719_predicted	similar to putative N-acetyltransferase Camello 2 (predicted)	LOC289727_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC289727_predicted	similar to putative N-acetyltransferase Camello 2 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM