Tug1 (taurine up-regulated 1) - Rat Genome Database

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Gene: Tug1 (taurine up-regulated 1) Rattus norvegicus
Analyze
Symbol: Tug1
Name: taurine up-regulated 1
RGD ID: 9685395
Description: Predicted to enable cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of regulatory T cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human TUG1 (taurine up-regulated 1); PARTICIPATES IN Huntington's disease pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: ncrna (Ensembl: protein-coding)
RefSeq Status: VALIDATED
Previously known as: taurine up-regulated 1 (non-protein coding)
RGD Orthologs
Human
Mouse
Bonobo
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81482,743,501 - 82,750,534 (-)NCBIGRCr8
mRatBN7.21478,519,894 - 78,526,927 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1478,522,506 - 78,526,927 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1482,961,035 - 82,968,068 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01484,201,125 - 84,208,158 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01480,646,916 - 80,653,949 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01483,878,757 - 83,885,791 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1483,878,295 - 83,887,584 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01484,563,854 - 84,570,784 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1477,432,155 - 77,439,189 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
nucleus  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Zhenbao Pill reduces Treg cell proportion in acute spinal cord injury rats by regulating TUG1/miR-214/HSP27 axis. He Y, etal., Biosci Rep. 2018 Nov 7;38(6). pii: BSR20180895. doi: 10.1042/BSR20180895. Print 2018 Dec 21.
2. Long non-coding RNAs in Huntington's disease neurodegeneration. Johnson R Neurobiol Dis. 2012 May;46(2):245-54. doi: 10.1016/j.nbd.2011.12.006. Epub 2011 Dec 14.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. LncRNA TUG1 Promotes Apoptosis, Invasion, and Angiogenesis of Retinal Endothelial Cells in Retinopathy of Prematurity via MiR-145-5p. Wang Y, etal., Front Med (Lausanne). 2022 Apr 4;9:803214. doi: 10.3389/fmed.2022.803214. eCollection 2022.
Additional References at PubMed
PMID:12477932   PMID:15797018   PMID:26034286   PMID:26048247   PMID:28202414   PMID:28344045   PMID:29758198   PMID:30715406   PMID:31210284   PMID:31539141   PMID:31935381   PMID:32206944  
PMID:32599321   PMID:32833900   PMID:33225366   PMID:34163467   PMID:34341870   PMID:34517787   PMID:34553456   PMID:34821094   PMID:35599572   PMID:36148952   PMID:36330459   PMID:37721002  


Genomics

Comparative Map Data
Tug1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81482,743,501 - 82,750,534 (-)NCBIGRCr8
mRatBN7.21478,519,894 - 78,526,927 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1478,522,506 - 78,526,927 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1482,961,035 - 82,968,068 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01484,201,125 - 84,208,158 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01480,646,916 - 80,653,949 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01483,878,757 - 83,885,791 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1483,878,295 - 83,887,584 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01484,563,854 - 84,570,784 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1477,432,155 - 77,439,189 (-)NCBICelera
Cytogenetic Map14q21NCBI
TUG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382230,969,265 - 30,979,395 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2230,969,245 - 30,979,395 (+)EnsemblGRCh38hg38GRCh38
GRCh372231,365,251 - 31,375,381 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,695,634 - 29,705,381 (+)NCBINCBI36Build 36hg18NCBI36
Celera2215,165,777 - 15,175,526 (+)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2214,327,854 - 14,337,603 (+)NCBIHuRef
CHM1_12231,325,458 - 31,335,205 (+)NCBICHM1_1
T2T-CHM13v2.02231,432,823 - 31,442,955 (+)NCBIT2T-CHM13v2.0
Tug1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,589,313 - 3,599,021 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl113,589,785 - 3,599,673 (-)EnsemblGRCm39 Ensembl
GRCm38113,639,785 - 3,648,814 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,639,785 - 3,649,673 (-)EnsemblGRCm38mm10GRCm38
MGSCv37113,539,797 - 3,548,811 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36113,539,797 - 3,548,811 (-)NCBIMGSCv36mm8
Celera114,130,991 - 4,140,005 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.56NCBI
TUG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22340,927,474 - 40,929,508 (+)NCBINHGRI_mPanPan1-v2

Variants

.
Variants in Tug1
15 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 40 51 35 19 35 2 2 74 35 41 11 2
Low 3 6 6 6 6 9 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000076420
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1483,878,295 - 83,887,584 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1478,522,506 - 78,526,927 (-)Ensembl
Rnor_6.0 Ensembl1483,881,371 - 83,885,791 (-)Ensembl
RefSeq Acc Id: NR_130147
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81482,743,501 - 82,750,534 (-)NCBI
mRatBN7.21478,519,894 - 78,526,927 (-)NCBI
Rnor_6.01483,878,757 - 83,885,791 (-)NCBI
Celera1477,432,155 - 77,439,189 (-)NCBI
Sequence:
Protein Sequences
GenBank Protein AAH89106 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000078782.1
Reference Protein Sequences

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:9685395 AgrOrtholog
BioCyc Gene G2FUF-15217 BioCyc
Ensembl Genes ENSRNOG00000051135 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000089742.2 UniProtKB/TrEMBL
NCBI Gene Tug1 ENTREZGENE
PhenoGen Tug1 PhenoGen
RatGTEx ENSRNOG00000051135 RatGTEx
RNAcentral URS00007E3A25 RNACentral
  URS00021EDA49 RNACentral
UniProt Q5HZA8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-25 Tug1  taurine up-regulated 1  Tug1  taurine up-regulated 1 (non-protein coding)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-06 Tug1  taurine up-regulated 1 (non-protein coding)      Symbol and Name status set to provisional 70820 PROVISIONAL