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Gene: Add1 (adducin 1) Rattus norvegicus
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Symbol: Add1
Name: adducin 1
Description: Exhibits T cell receptor binding activity. Involved in several processes, including cellular response to retinoic acid; negative regulation of actin filament polymerization; and positive regulation of angiogenesis. Localizes to the dendritic spine; perinuclear region of cytoplasm; and postsynaptic density. Used to study hypertension. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; and gastroschisis. Orthologous to human ADD1 (adducin 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: adducin 1 (alpha); adducin 1, alpha; alpha-ADD; alpha-adducin; erythrocyte adducin subunit alpha; MGC124621
Orthologs:
Homo sapiens (human) : ADD1 (adducin 1)  HGNC  Alliance
Mus musculus (house mouse) : Add1 (adducin 1 (alpha))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Add1 (adducin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ADD1 (adducin 1)
Canis lupus familiaris (dog) : ADD1 (adducin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Add1 (adducin 1)
Sus scrofa (pig) : ADD1 (adducin 1)
more info ...
Is Marker For: Strains:   MHS/N  
QTLs:   Bp59  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01481,367,466 - 81,426,610 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1481,367,468 - 81,426,496 (-)Ensembl
Rnor_5.01482,054,922 - 82,114,066 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,750,430 - 81,808,919 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11481,754,353 - 81,784,555 (-)NCBI
Celera1475,033,169 - 75,091,638 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Add1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2041
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.