Add1 (adducin 1) - Rat Genome Database

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Gene: Add1 (adducin 1) Rattus norvegicus
Analyze
Symbol: Add1
Name: adducin 1
RGD ID: 2041
Description: Enables T cell receptor binding activity. Involved in several processes, including cellular response to retinoic acid; negative regulation of actin filament polymerization; and positive regulation of angiogenesis. Located in dendritic spine; perinuclear region of cytoplasm; and postsynaptic density. Used to study hypertension. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; and gastroschisis. Orthologous to human ADD1 (adducin 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: adducin 1 (alpha); adducin 1, alpha; alpha-ADD; alpha-adducin; erythrocyte adducin subunit alpha; MGC124621
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   MHS/N  
QTLs:   Bp59  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21476,108,643 - 76,167,267 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1476,108,654 - 76,167,182 (-)Ensembl
Rnor_6.01481,367,466 - 81,426,610 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1481,367,468 - 81,426,496 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,054,922 - 82,114,066 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,750,430 - 81,808,919 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11481,754,353 - 81,784,555 (-)NCBI
Celera1475,033,169 - 75,091,638 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2. Beeks E, etal., Am J Hypertens. 2001 Dec;14(12):1185-90.
3. Bianchi MG, etal., Neuroscience. 2010 Aug 25;169(2):584-95. Epub 2010 May 20.
4. Bunker-Wiersma HE, etal., Pediatr Crit Care Med. 2008 Sep;9(5):517-23.
5. Cappuzzello C, etal., Cardiovasc Res. 2007 Aug 1;75(3):608-17. Epub 2007 May 4.
6. Cusi D, etal., Lancet. 1997 May 10;349(9062):1353-7.
7. Dong L, etal., J Biol Chem 1995 Oct 27;270(43):25534-40.
8. Farina A, etal., Prenat Diagn. 2009 Nov;29(11):1038-44.
9. Ferrandi M, etal., J Mol Med (Berl). 2010 Feb;88(2):203-17. Epub 2009 Oct 17.
10. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. GOA data from the GO Consortium
12. Lu Q, etal., Mol Immunol. 2004 Jun;41(4):435-47.
13. MGD data from the GO Consortium
14. NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline
16. RGD automated import pipeline for gene-chemical interactions
17. Seidel B, etal., Brain Res. 1995 Nov 27;700(1-2):13-24.
18. Shaw GM, etal., Am J Med Genet A. 2005 Sep 15;138(1):21-6.
19. Torfs CP, etal., Birth Defects Res A Clin Mol Teratol. 2006 Oct;76(10):723-30.
20. Torielli L, etal., Am J Physiol Renal Physiol. 2008 Aug;295(2):F478-87. Epub 2008 Jun 4.
21. Tripodi G, etal., Biochem Biophys Res Commun 2004 Nov 12;324(2):562-8.
22. Tripodi G, etal., Gene 1995 Dec 12;166(2):307-11.
23. Tripodi G, etal., J Clin Invest. 1996 Jun 15;97(12):2815-22.
24. van Rijn MJ, etal., Stroke. 2006 Dec;37(12):2930-4. Epub 2006 Nov 2.
25. Wyneken U, etal., Neuroscience. 2001;102(1):65-74.
26. Zee RY, etal., J Thromb Haemost. 2006 Feb;4(2):341-8.
Additional References at PubMed
PMID:3693401   PMID:7642559   PMID:8626479   PMID:10485892   PMID:12477932   PMID:16289097   PMID:16641100   PMID:18723693   PMID:21423176   PMID:21451595   PMID:22658674   PMID:25468996  
PMID:25978380   PMID:29476059  


Genomics

Candidate Gene Status
Add1 is a candidate Gene for QTL Bp59
Comparative Map Data
Add1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21476,108,643 - 76,167,267 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1476,108,654 - 76,167,182 (-)Ensembl
Rnor_6.01481,367,466 - 81,426,610 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1481,367,468 - 81,426,496 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,054,922 - 82,114,066 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,750,430 - 81,808,919 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11481,754,353 - 81,784,555 (-)NCBI
Celera1475,033,169 - 75,091,638 (-)NCBICelera
Cytogenetic Map14q21NCBI
ADD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl42,843,844 - 2,930,076 (+)EnsemblGRCh38hg38GRCh38
GRCh3842,843,844 - 2,930,065 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3742,845,571 - 2,931,789 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3642,815,382 - 2,901,587 (+)NCBINCBI36hg18NCBI36
Build 3442,882,589 - 2,968,794NCBI
Celera42,756,785 - 2,842,980 (+)NCBI
Cytogenetic Map4p16.3NCBI
HuRef42,784,038 - 2,870,206 (+)NCBIHuRef
CHM1_142,843,557 - 2,929,744 (+)NCBICHM1_1
Add1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39534,731,008 - 34,789,652 (+)NCBIGRCm39mm39
GRCm39 Ensembl534,731,008 - 34,789,652 (+)Ensembl
GRCm38534,573,664 - 34,632,308 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl534,573,664 - 34,632,308 (+)EnsemblGRCm38mm10GRCm38
MGSCv37534,916,363 - 34,974,954 (+)NCBIGRCm37mm9NCBIm37
MGSCv36534,890,669 - 34,949,165 (+)NCBImm8
Celera532,044,658 - 32,103,240 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.9NCBI
Add1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555141,783,814 - 1,815,917 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555141,784,302 - 1,812,845 (+)NCBIChiLan1.0ChiLan1.0
ADD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.142,889,073 - 2,975,012 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl42,920,781 - 2,975,012 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v042,986,301 - 3,072,590 (+)NCBIMhudiblu_PPA_v0panPan3
ADD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1361,356,643 - 61,443,851 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl361,358,162 - 61,474,830 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha363,940,255 - 64,027,099 (-)NCBI
ROS_Cfam_1.0361,832,145 - 61,919,366 (-)NCBI
UMICH_Zoey_3.1361,323,682 - 61,410,615 (-)NCBI
UNSW_CanFamBas_1.0361,528,369 - 61,615,629 (-)NCBI
UU_Cfam_GSD_1.0361,887,972 - 61,975,241 (-)NCBI
Add1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528566,993,417 - 67,064,321 (-)NCBI
SpeTri2.0NW_00493647720,695,109 - 20,766,053 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl81,627,177 - 1,710,661 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.181,627,146 - 1,710,653 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.281,208,520 - 1,292,568 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12745,811,611 - 45,901,277 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2745,813,496 - 45,900,778 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660512,167,948 - 2,256,880 (-)NCBIVero_WHO_p1.0
Add1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475524,854,742 - 24,927,912 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH127695  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21476,108,737 - 76,108,918 (+)MAPPERmRatBN7.2
Rnor_6.01481,367,561 - 81,367,741NCBIRnor6.0
Rnor_5.01482,055,017 - 82,055,197UniSTSRnor5.0
RGSC_v3.41481,750,525 - 81,750,705UniSTSRGSC3.4
Celera1475,033,264 - 75,033,444UniSTS
RH 3.4 Map14489.48UniSTS
Cytogenetic Map14q21UniSTS
BF397471  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21476,158,943 - 76,159,087 (+)MAPPERmRatBN7.2
Rnor_6.01481,418,008 - 81,418,151NCBIRnor6.0
Rnor_5.01482,105,464 - 82,105,607UniSTSRnor5.0
RGSC_v3.41481,800,722 - 81,800,865UniSTSRGSC3.4
Celera1475,083,447 - 75,083,590UniSTS
RH 3.4 Map14483.48UniSTS
Cytogenetic Map14q21UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat


Related Rat Strains
The following Strains have been annotated to Add1

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:608
Count of miRNA genes:255
Interacting mature miRNAs:320
Transcripts:ENSRNOT00000018073, ENSRNOT00000018340
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_016990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC107657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X83715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z49081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z49082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000018073   ⟹   ENSRNOP00000018072
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,108,656 - 76,167,172 (-)Ensembl
Rnor_6.0 Ensembl1481,367,468 - 81,426,496 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000018340   ⟹   ENSRNOP00000018340
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,108,663 - 76,140,405 (-)Ensembl
Rnor_6.0 Ensembl1481,369,146 - 81,399,353 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098266   ⟹   ENSRNOP00000094525
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,108,654 - 76,167,182 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100756   ⟹   ENSRNOP00000077285
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,108,654 - 76,167,182 (-)Ensembl
RefSeq Acc Id: NM_016990   ⟹   NP_058686
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,108,643 - 76,167,141 (-)NCBI
Rnor_6.01481,367,466 - 81,426,496 (-)NCBI
Rnor_5.01482,054,922 - 82,114,066 (-)NCBI
RGSC_v3.41481,750,430 - 81,808,919 (-)RGD
Celera1475,033,169 - 75,091,638 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251159   ⟹   XP_006251221
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,108,643 - 76,167,267 (-)NCBI
Rnor_6.01481,367,466 - 81,426,610 (-)NCBI
Rnor_5.01482,054,922 - 82,114,066 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251160   ⟹   XP_006251222
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,108,660 - 76,167,266 (-)NCBI
Rnor_6.01481,368,854 - 81,426,610 (-)NCBI
Rnor_5.01482,054,922 - 82,114,066 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251161   ⟹   XP_006251223
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,108,643 - 76,167,266 (-)NCBI
Rnor_6.01481,367,466 - 81,426,610 (-)NCBI
Rnor_5.01482,054,922 - 82,114,066 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251165   ⟹   XP_006251227
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,110,504 - 76,167,266 (-)NCBI
Rnor_6.01481,369,065 - 81,426,610 (-)NCBI
Rnor_5.01482,054,922 - 82,114,066 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251167   ⟹   XP_006251229
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,111,780 - 76,167,266 (-)NCBI
Rnor_6.01481,370,603 - 81,426,610 (-)NCBI
Rnor_5.01482,054,922 - 82,114,066 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599064   ⟹   XP_017454553
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,108,643 - 76,167,267 (-)NCBI
Rnor_6.01481,367,466 - 81,426,610 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599065   ⟹   XP_017454554
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,110,504 - 76,167,267 (-)NCBI
Rnor_6.01481,369,065 - 81,426,610 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599066   ⟹   XP_017454555
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,110,382 - 76,167,267 (-)NCBI
Rnor_6.01481,369,256 - 81,426,610 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039091605   ⟹   XP_038947533
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,111,780 - 76,167,267 (-)NCBI
RefSeq Acc Id: XM_039091606   ⟹   XP_038947534
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,111,780 - 76,167,267 (-)NCBI
RefSeq Acc Id: XM_039091607   ⟹   XP_038947535
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,111,780 - 76,140,383 (-)NCBI
RefSeq Acc Id: XM_039091609   ⟹   XP_038947537
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,111,780 - 76,167,266 (-)NCBI
RefSeq Acc Id: XM_039091610   ⟹   XP_038947538
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,111,780 - 76,140,383 (-)NCBI
RefSeq Acc Id: XM_039091611   ⟹   XP_038947539
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,108,652 - 76,167,179 (-)NCBI
RefSeq Acc Id: XM_039091612   ⟹   XP_038947540
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,111,780 - 76,140,383 (-)NCBI
RefSeq Acc Id: XM_039091613   ⟹   XP_038947541
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,111,780 - 76,140,383 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_058686   ⟸   NM_016990
- UniProtKB: Q63028 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006251223   ⟸   XM_006251161
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006251221   ⟸   XM_006251159
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006251222   ⟸   XM_006251160
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006251227   ⟸   XM_006251165
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_006251229   ⟸   XM_006251167
- Peptide Label: isoform X13
- Sequence:
RefSeq Acc Id: XP_017454553   ⟸   XM_017599064
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017454554   ⟸   XM_017599065
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017454555   ⟸   XM_017599066
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: ENSRNOP00000018340   ⟸   ENSRNOT00000018340
RefSeq Acc Id: ENSRNOP00000018072   ⟸   ENSRNOT00000018073
RefSeq Acc Id: XP_038947539   ⟸   XM_039091611
- Peptide Label: isoform X14
RefSeq Acc Id: XP_038947534   ⟸   XM_039091606
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038947533   ⟸   XM_039091605
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038947537   ⟸   XM_039091609
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038947541   ⟸   XM_039091613
- Peptide Label: isoform X16
RefSeq Acc Id: XP_038947540   ⟸   XM_039091612
- Peptide Label: isoform X15
RefSeq Acc Id: XP_038947538   ⟸   XM_039091610
- Peptide Label: isoform X12
RefSeq Acc Id: XP_038947535   ⟸   XM_039091607
- Peptide Label: isoform X10
RefSeq Acc Id: ENSRNOP00000094525   ⟸   ENSRNOT00000098266
RefSeq Acc Id: ENSRNOP00000077285   ⟸   ENSRNOT00000100756
Protein Domains
Aldolase_II

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699398
Promoter ID:EPDNEW_R9923
Type:initiation region
Name:Add1_1
Description:adducin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01481,426,518 - 81,426,578EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BUF/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
DA/OlaHsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
F344/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FXLE16/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/FarMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
HXB10/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEXF10A/StmMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
M520/NRrrcMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MWF/Hsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/OlalpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/RijCrl (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2041 AgrOrtholog
Ensembl Genes ENSRNOG00000013039 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000018072 UniProtKB/TrEMBL
  ENSRNOP00000018340 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018073 UniProtKB/TrEMBL
  ENSRNOT00000018340 UniProtKB/TrEMBL
Gene3D-CATH 3.40.225.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7935564 IMAGE-MGC_LOAD
InterPro ADD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldolase_II/adducin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldolase_II/adducin_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24170 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124621 IMAGE-MGC_LOAD
NCBI Gene 24170 ENTREZGENE
PANTHER PTHR10672:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldolase_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ADD1 RGD
PhenoGen Add1 PhenoGen
SMART Aldolase_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53639 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSM7_RAT UniProtKB/TrEMBL
  ADDA_RAT UniProtKB/Swiss-Prot
  D3ZZ99_RAT UniProtKB/TrEMBL
  Q63028 ENTREZGENE
UniProt Secondary Q3B7D4 UniProtKB/Swiss-Prot
  Q64722 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Add1  adducin 1  Add1  adducin 1 (alpha)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Add1  adducin 1 (alpha)    adducin 1, alpha  Name updated 1299863 APPROVED
2002-11-06 Add1  adducin 1, alpha    Adducin 1, alpha  Name updated 625702 APPROVED
2002-06-10 Add1  Adducin 1, alpha      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the cytoskeleton 631736
gene_disease variation in the heteromeric ADD protein is associated with blood pressure variation in the Milan hypertensive strain (MHS) 631736
gene_expression expressed in spleen and kidney 631736
gene_function interacts with other proteins of the membrane cytoskeleton 631736
gene_homology has 91% amino acid identity with human ADD1 631736
gene_physical_interaction forms a heterodimer with beta adducin (Add2) 631736
gene_process does not appear to affect heart rate 1302895
gene_process association with blood pressure strongly indicated by fine mapping of reciprocal congenic strains derived from MNS (hypertensicve) and MHS (normnotensive) rats 1302895
gene_process may play a role in ion transport and signal transduction 631736
gene_protein contains 735 amino acid sequence 631736
gene_transcript has splice variants containing alternatively spliced exons 631736