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Gene: ADD1 (adducin 1) Homo sapiens
Symbol: ADD1
Name: adducin 1
Description: Exhibits cytoskeletal protein binding activity; protein dimerization activity; and transcription factor binding activity. Involved in several processes, including barbed-end actin filament capping; positive regulation of adherens junction organization; and positive regulation of establishment of endothelial barrier. Localizes to several cellular components, including the F-actin capping protein complex; cell-cell adherens junction; and nuclear body. Implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; and gastroschisis. Biomarker of pre-eclampsia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADDA; adducin 1 (alpha); adducin 1, alpha; alpha-adducin; erythrocyte adducin alpha subunit; erythrocyte adducin subunit alpha; MGC3339; MGC44427
Mus musculus (house mouse) : Add1 (adducin 1 (alpha))  MGI  Alliance
Rattus norvegicus (Norway rat) : Add1 (adducin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Add1 (adducin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ADD1 (adducin 1)
Canis lupus familiaris (dog) : ADD1 (adducin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Add1 (adducin 1)
Sus scrofa (pig) : ADD1 (adducin 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl42,843,857 - 2,930,076 (+)Ensembl
GRCh3842,843,844 - 2,930,076 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3742,845,454 - 2,931,803 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3642,815,382 - 2,901,587 (+)NCBINCBI36hg18NCBI36
Build 3442,882,589 - 2,968,794NCBI
Celera42,756,785 - 2,842,980 (+)NCBI
Cytogenetic Map4p16.3NCBI
HuRef42,784,038 - 2,870,206 (+)NCBIHuRef
CHM1_142,843,557 - 2,929,744 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ADD1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733925
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.