Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Genetic Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: ADD1 (adducin 1) Homo sapiens
Analyze
Symbol: ADD1
Name: adducin 1
Description: Exhibits cytoskeletal protein binding activity; protein dimerization activity; and transcription factor binding activity. Involved in several processes, including barbed-end actin filament capping; positive regulation of adherens junction organization; and positive regulation of establishment of endothelial barrier. Localizes to several cellular components, including the F-actin capping protein complex; cell-cell adherens junction; and nuclear body. Implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; and gastroschisis. Biomarker of pre-eclampsia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADDA; adducin 1 (alpha); adducin 1, alpha; alpha-adducin; erythrocyte adducin alpha subunit; erythrocyte adducin subunit alpha; MGC3339; MGC44427
Orthologs:
Mus musculus (house mouse) : Add1 (adducin 1 (alpha))  MGI  Alliance
Rattus norvegicus (Norway rat) : Add1 (adducin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Add1 (adducin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ADD1 (adducin 1)
Canis lupus familiaris (dog) : ADD1 (adducin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Add1 (adducin 1)
Sus scrofa (pig) : ADD1 (adducin 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl42,843,857 - 2,930,076 (+)Ensembl
GRCh3842,843,844 - 2,930,076 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3742,845,454 - 2,931,803 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3642,815,382 - 2,901,587 (+)NCBINCBI36hg18NCBI36
Build 3442,882,589 - 2,968,794NCBI
Celera42,756,785 - 2,842,980 (+)NCBI
Cytogenetic Map4p16.3NCBI
HuRef42,784,038 - 2,870,206 (+)NCBIHuRef
CHM1_142,843,557 - 2,929,744 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model

Annotation    (Toggle Annotation Detail/Summary View)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
  
More on ADD1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733925
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



Contact Us |  About Us |  License CC BY 4.0 |  Legal Disclaimer |  © Medical College of Wisconsin
NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.