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Characterisation and chromosomal localisation of the rat alpha- and beta-adducin-encoding genes.

Authors: Tripodi, G  Casari, G  Tisminetzky, S  Bianchi, G  Devescovi, G  Muro, A  Tuteja, R  Baralle, FE 
Citation: Tripodi G, etal., Gene 1995 Dec 12;166(2):307-11.
Pubmed: (View Article at PubMed) PMID:8543181

A polymorphism in the genes encoding alpha- and beta-adducin (ADD) was described as being associated with blood-pressure variation in a genetically hypertensive strain of rats (MHS). ADD is a cytoskeletal heterodimeric protein which may be involved in cellular signal transduction and interacts with other membrane skeleton proteins which affect ion transport across the cell membrane. The cDNA encoding the alpha subunit of rat ADD was isolated using PCR methods. The cDNA consists of about 3900 bp and encodes a protein of 735 amino acids (aa) which shows 91% aa identity with the human counterpart. In spleen and kidney, three alternative spliced exons were found by PCR amplification and confirmed by RNase protection analysis. 17 inbred rat strains were genotyped for the polymorphism in the alpha- and beta-ADD genes. Chromosomal localisation mapped rat alpha-ADD on chromosome 14 and rat beta-ADD on chromosome 4.


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RGD Object Information
RGD ID: 631736
Created: 2003-08-19
Species: All species
Last Modified: 2003-08-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.