Fam193a (family with sequence similarity 193, member A) - Rat Genome Database

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Gene: Fam193a (family with sequence similarity 193, member A) Rattus norvegicus
Analyze
Symbol: Fam193a
Name: family with sequence similarity 193, member A
RGD ID: 1309634
Description: Orthologous to human FAM193A (family with sequence similarity 193 member A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical LOC305452; LOC103690085; LOC305452; protein FAM193A-like; RGD1309634; uncharacterized protein LOC305452
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21476,250,103 - 76,382,525 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,256,161 - 76,382,514 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01481,515,897 - 81,638,919 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1481,516,407 - 81,638,934 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,583,510 - 82,593,446 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01482,203,381 - 82,326,333 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,898,783 - 81,981,572 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11481,901,167 - 81,955,170 (-)NCBI
Celera1475,180,670 - 75,306,206 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Fam193a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21476,250,103 - 76,382,525 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,256,161 - 76,382,514 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01481,515,897 - 81,638,919 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1481,516,407 - 81,638,934 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,583,510 - 82,593,446 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01482,203,381 - 82,326,333 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,898,783 - 81,981,572 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11481,901,167 - 81,955,170 (-)NCBI
Celera1475,180,670 - 75,306,206 (-)NCBICelera
Cytogenetic Map14q21NCBI
FAM193A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3842,535,375 - 2,732,573 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl42,536,647 - 2,732,573 (+)EnsemblGRCh38hg38GRCh38
GRCh3742,537,102 - 2,734,300 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3642,596,957 - 2,704,100 (+)NCBINCBI36Build 36hg18NCBI36
Build 3442,664,364 - 2,771,507NCBI
Celera42,538,459 - 2,645,603 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef42,566,408 - 2,673,398 (+)NCBIHuRef
CHM1_142,625,112 - 2,732,275 (+)NCBICHM1_1
T2T-CHM13v2.042,534,120 - 2,731,332 (+)NCBIT2T-CHM13v2.0
Fam193a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39534,527,295 - 34,643,800 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl534,527,277 - 34,643,800 (+)EnsemblGRCm39 Ensembl
GRCm38534,369,933 - 34,486,458 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl534,369,933 - 34,486,456 (+)EnsemblGRCm38mm10GRCm38
MGSCv37534,763,500 - 34,829,105 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36534,737,708 - 34,803,313 (+)NCBIMGSCv36mm8
Celera531,891,761 - 31,957,359 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.88NCBI
Fam193a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555141,588,894 - 1,672,292 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555141,588,882 - 1,672,292 (+)NCBIChiLan1.0ChiLan1.0
FAM193A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan142,806,017 - 3,004,143 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v042,678,935 - 2,875,203 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.142,584,369 - 2,777,767 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl42,641,979 - 2,777,761 (+)Ensemblpanpan1.1panPan2
FAM193A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1361,543,738 - 61,674,729 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl361,544,354 - 61,644,322 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha364,126,947 - 64,291,419 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0362,019,542 - 62,184,441 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl362,019,542 - 62,089,617 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1361,510,589 - 61,675,269 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0361,715,556 - 61,880,952 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0362,075,411 - 62,240,712 (-)NCBIUU_Cfam_GSD_1.0
Fam193a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528567,173,199 - 67,262,618 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647720,871,241 - 20,964,352 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647720,874,889 - 20,964,328 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAM193A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl81,388,266 - 1,523,928 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.181,388,442 - 1,523,935 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.281,022,753 - 1,106,802 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FAM193A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12746,028,534 - 46,227,991 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2746,028,533 - 46,168,051 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660512,392,353 - 2,530,379 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam193a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475524,996,270 - 25,133,961 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475524,996,262 - 25,133,918 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fam193a
424 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:162
Count of miRNA genes:126
Interacting mature miRNAs:146
Transcripts:ENSRNOT00000018616
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 30 32 16 19 16 1 1 74 33 41 11 1
Low 13 25 25 25 7 10 2 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000018616   ⟹   ENSRNOP00000018616
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,256,161 - 76,382,514 (-)Ensembl
Rnor_6.0 Ensembl1481,516,407 - 81,638,934 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097212   ⟹   ENSRNOP00000095571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,256,161 - 76,382,514 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115786   ⟹   ENSRNOP00000084188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,256,161 - 76,382,514 (-)Ensembl
RefSeq Acc Id: XM_039092825   ⟹   XP_038948753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,250,103 - 76,382,509 (-)NCBI
RefSeq Acc Id: XM_039092826   ⟹   XP_038948754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,279,884 - 76,382,525 (-)NCBI
RefSeq Acc Id: XM_223536   ⟹   XP_223536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,250,103 - 76,381,901 (-)NCBI
Rnor_6.01481,515,897 - 81,638,919 (-)NCBI
Rnor_5.01482,203,381 - 82,326,333 (-)NCBI
RGSC_v3.41481,898,783 - 81,981,572 (-)RGD
Sequence:
RefSeq Acc Id: XP_223536   ⟸   XM_223536
- Peptide Label: isoform X2
- UniProtKB: D3ZIG8 (UniProtKB/TrEMBL),   A6IK31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018616   ⟸   ENSRNOT00000018616
RefSeq Acc Id: XP_038948753   ⟸   XM_039092825
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GBK1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948754   ⟸   XM_039092826
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000095571   ⟸   ENSRNOT00000097212
RefSeq Acc Id: ENSRNOP00000084188   ⟸   ENSRNOT00000115786
Protein Domains
FAM193 C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZIG8-F1-model_v2 AlphaFold D3ZIG8 1-1436 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309634 AgrOrtholog
BioCyc Gene G2FUF-15291 BioCyc
Ensembl Genes ENSRNOG00000013832 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018616 ENTREZGENE
  ENSRNOT00000018616.8 UniProtKB/TrEMBL
  ENSRNOT00000097212.1 UniProtKB/TrEMBL
  ENSRNOT00000115786 ENTREZGENE
  ENSRNOT00000115786.1 UniProtKB/TrEMBL
InterPro FAM193 UniProtKB/TrEMBL
  FAM193_C UniProtKB/TrEMBL
KEGG Report rno:305452 UniProtKB/TrEMBL
NCBI Gene 305452 ENTREZGENE
PANTHER PTHR15109 UniProtKB/TrEMBL
  PTHR15109:SF2 UniProtKB/TrEMBL
Pfam FAM193_C UniProtKB/TrEMBL
PhenoGen Fam193a PhenoGen
RatGTEx ENSRNOG00000013832 RatGTEx
UniProt A0A8I6APE8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GBK1 ENTREZGENE, UniProtKB/TrEMBL
  A6IK31 ENTREZGENE, UniProtKB/TrEMBL
  D3ZIG8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Fam193a  family with sequence similarity 193, member A  LOC103690085  protein FAM193A-like  Data merged from RGD:9197066 737654 PROVISIONAL
2014-08-25 LOC103690085  protein FAM193A-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-04-23 Fam193a  family with sequence similarity 193, member A  RGD1309634  hypothetical LOC305452  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1309634  hypothetical LOC305452   RGD1309634_predicted  hypothetical LOC305452 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1309634_predicted  hypothetical LOC305452 (predicted)  LOC305452_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC305452_predicted  hypothetical LOC305452 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL