Pla2g3 (phospholipase A2, group III) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Pla2g3 (phospholipase A2, group III) Rattus norvegicus
Analyze
Symbol: Pla2g3
Name: phospholipase A2, group III
RGD ID: 1305323
Description: Predicted to enable calcium-dependent phospholipase A2 activity. Acts upstream of or within negative regulation of gene expression. Predicted to be located in centriole and recycling endosome. Orthologous to human PLA2G3 (phospholipase A2 group III); PARTICIPATES IN alpha-linolenic acid metabolic pathway; arachidonic acid metabolic pathway; ether lipid metabolic pathway; INTERACTS WITH 4-nitro-m-cresol; 6-propyl-2-thiouracil; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: group 3 secretory phospholipase A2; LOC289733
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81482,589,908 - 82,597,542 (+)NCBIGRCr8
mRatBN7.21478,367,625 - 78,373,913 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1478,368,105 - 78,373,913 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1482,809,429 - 82,815,114 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01484,049,536 - 84,055,220 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01480,495,298 - 80,500,983 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01483,724,828 - 83,730,614 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1483,724,933 - 83,730,614 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01484,412,999 - 84,418,680 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,119,872 - 84,125,552 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11484,130,645 - 84,143,800 (+)NCBI
Celera1477,281,569 - 77,287,249 (+)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Enhanced Phospholipase A2 Group 3 Expression by Oxidative Stress Decreases the Insulin-Degrading Enzyme. Yui D, etal., PLoS One. 2015 Dec 4;10(12):e0143518. doi: 10.1371/journal.pone.0143518. eCollection 2015.
Additional References at PubMed
PMID:14519523   PMID:20393563   PMID:20424323   PMID:23371482   PMID:23624557  


Genomics

Comparative Map Data
Pla2g3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81482,589,908 - 82,597,542 (+)NCBIGRCr8
mRatBN7.21478,367,625 - 78,373,913 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1478,368,105 - 78,373,913 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1482,809,429 - 82,815,114 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01484,049,536 - 84,055,220 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01480,495,298 - 80,500,983 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01483,724,828 - 83,730,614 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1483,724,933 - 83,730,614 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01484,412,999 - 84,418,680 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,119,872 - 84,125,552 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11484,130,645 - 84,143,800 (+)NCBI
Celera1477,281,569 - 77,287,249 (+)NCBICelera
Cytogenetic Map14q21NCBI
PLA2G3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382231,134,807 - 31,140,508 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2231,134,807 - 31,140,508 (-)EnsemblGRCh38hg38GRCh38
GRCh372231,530,793 - 31,536,494 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,860,793 - 29,866,469 (-)NCBINCBI36Build 36hg18NCBI36
Build 342229,855,346 - 29,861,023NCBI
Celera2215,330,868 - 15,336,544 (-)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2214,492,451 - 14,498,127 (-)NCBIHuRef
CHM1_12231,490,658 - 31,496,334 (-)NCBICHM1_1
T2T-CHM13v2.02231,598,311 - 31,604,012 (-)NCBIT2T-CHM13v2.0
Pla2g3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,438,158 - 3,449,346 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl113,438,284 - 3,449,350 (+)EnsemblGRCm39 Ensembl
GRCm38113,488,158 - 3,499,346 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,488,284 - 3,499,350 (+)EnsemblGRCm38mm10GRCm38
MGSCv37113,388,230 - 3,394,169 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36113,388,302 - 3,399,353 (+)NCBIMGSCv36mm8
Celera113,979,003 - 3,985,078 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.45NCBI
Pla2g3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554555,315,450 - 5,320,053 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554555,314,520 - 5,320,151 (-)NCBIChiLan1.0ChiLan1.0
PLA2G3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22341,090,380 - 41,100,730 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12243,788,928 - 43,799,272 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02212,158,589 - 12,164,441 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12229,995,364 - 30,001,160 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2229,995,364 - 30,001,160 (-)Ensemblpanpan1.1panPan2
PLA2G3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12624,127,074 - 24,132,508 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2624,128,005 - 24,132,508 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,994,204 - 24,002,589 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02624,506,855 - 24,515,226 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2624,510,739 - 24,515,226 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12624,210,260 - 24,218,645 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02624,472,253 - 24,480,619 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02624,533,532 - 24,541,902 (-)NCBIUU_Cfam_GSD_1.0
Pla2g3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118117,049,648 - 117,058,557 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936755306,313 - 312,683 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936755307,166 - 312,683 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLA2G3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,923,954 - 47,928,810 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,923,005 - 47,928,762 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21451,034,721 - 51,040,254 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLA2G3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11914,025,373 - 14,033,214 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1914,025,742 - 14,030,643 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045112,087,770 - 112,093,291 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pla2g3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247477,603,277 - 7,607,753 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247477,602,848 - 7,607,872 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pla2g3
21 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:457
Count of miRNA genes:237
Interacting mature miRNAs:280
Transcripts:ENSRNOT00000029848
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat

Markers in Region
RH132258  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21478,374,195 - 78,374,375 (+)MAPPERmRatBN7.2
Rnor_6.01483,730,897 - 83,731,076NCBIRnor6.0
Rnor_5.01484,418,963 - 84,419,142UniSTSRnor5.0
RGSC_v3.41484,125,835 - 84,126,014UniSTSRGSC3.4
Celera1477,287,532 - 77,287,711UniSTS
RH 3.4 Map14520.7UniSTS
Cytogenetic Map14q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4
Low 2 2 4 2 2 48 17 25 5
Below cutoff 1 33 18 5 7 5 1 1 22 15 5 6 1

Sequence


RefSeq Acc Id: ENSRNOT00000029848   ⟹   ENSRNOP00000031579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1478,368,105 - 78,373,913 (+)Ensembl
Rnor_6.0 Ensembl1483,724,933 - 83,730,614 (+)Ensembl
RefSeq Acc Id: NM_001106015   ⟹   NP_001099485
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81482,591,862 - 82,597,542 (+)NCBI
mRatBN7.21478,368,233 - 78,373,913 (+)NCBI
Rnor_6.01483,724,933 - 83,730,614 (+)NCBI
Rnor_5.01484,412,999 - 84,418,680 (+)NCBI
RGSC_v3.41484,119,872 - 84,125,552 (+)RGD
Celera1477,281,569 - 77,287,249 (+)RGD
Sequence:
RefSeq Acc Id: XM_017599119   ⟹   XP_017454608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81482,589,908 - 82,597,541 (+)NCBI
mRatBN7.21478,367,625 - 78,373,891 (+)NCBI
Rnor_6.01483,724,828 - 83,730,592 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001099485 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454608 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM00178 (Get FASTA)   NCBI Sequence Viewer  
  EDM00179 (Get FASTA)   NCBI Sequence Viewer  
  EDM00180 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000031579
  ENSRNOP00000031579.4
RefSeq Acc Id: NP_001099485   ⟸   NM_001106015
- Peptide Label: precursor
- UniProtKB: A6IKB4 (UniProtKB/TrEMBL),   A6IKB3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454608   ⟸   XM_017599119
- Peptide Label: isoform X1
- UniProtKB: A6IKB3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000031579   ⟸   ENSRNOT00000029848
Protein Domains
Phospholipase A2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZGN6-F1-model_v2 AlphaFold D3ZGN6 1-506 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305323 AgrOrtholog
BioCyc Gene G2FUF-15226 BioCyc
Ensembl Genes ENSRNOG00000025121 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029848 ENTREZGENE
  ENSRNOT00000029848.4 UniProtKB/TrEMBL
Gene3D-CATH 1.20.90.10 UniProtKB/TrEMBL
InterPro Phospholipase_A2 UniProtKB/TrEMBL
  PLipase_A2_dom_sf UniProtKB/TrEMBL
  PLipase_A2_His_AS UniProtKB/TrEMBL
KEGG Report rno:289733 UniProtKB/TrEMBL
NCBI Gene 289733 ENTREZGENE
PANTHER GROUP 3 SECRETORY PHOSPHOLIPASE A2 UniProtKB/TrEMBL
  RH14732P UniProtKB/TrEMBL
Pfam Phospholip_A2_2 UniProtKB/TrEMBL
PhenoGen Pla2g3 PhenoGen
PROSITE PA2_HIS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025121 RatGTEx
Superfamily-SCOP PhospholipaseA2 UniProtKB/TrEMBL
UniProt A6IKB3 ENTREZGENE, UniProtKB/TrEMBL
  A6IKB4 ENTREZGENE, UniProtKB/TrEMBL
  D3ZGN6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Pla2g3  phospholipase A2, group III   Pla2g3_predicted  phospholipase A2, group III (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pla2g3_predicted  phospholipase A2, group III (predicted)      Symbol and Name status set to approved 70820 APPROVED