Upp1 (uridine phosphorylase 1) - Rat Genome Database

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Gene: Upp1 (uridine phosphorylase 1) Rattus norvegicus
Analyze
Symbol: Upp1
Name: uridine phosphorylase 1
RGD ID: 1305566
Description: Predicted to enable identical protein binding activity and pyrimidine-nucleoside phosphorylase activity. Involved in cellular response to glucose starvation. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Biomarker of middle cerebral artery infarction. Orthologous to human UPP1 (uridine phosphorylase 1); PARTICIPATES IN pyrimidine metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC289801; MGC124655
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81488,023,155 - 88,043,036 (+)NCBIGRCr8
mRatBN7.21483,809,495 - 83,829,299 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1483,809,960 - 83,829,462 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1488,205,103 - 88,223,414 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01489,445,021 - 89,463,332 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01485,912,157 - 85,930,471 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01489,314,234 - 89,334,060 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1489,314,176 - 89,334,276 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01489,112,302 - 89,132,102 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41489,651,264 - 89,669,630 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11489,669,068 - 89,688,775 (+)NCBI
Celera1482,846,265 - 82,864,631 (+)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-benzyl-1-(2-hydroxyethoxymethyl)uracil  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aconitine  (EXP)
adenosine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
calyculin a  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlordecone  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cytidine  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
formaldehyde  (ISO)
guanosine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indometacin  (EXP,ISO)
ivermectin  (ISO)
Licochalcone B  (ISO)
manganese(II) chloride  (EXP)
menadione  (ISO)
mercury dichloride  (EXP)
methamphetamine  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
Monobutylphthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (EXP,ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
obeticholic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentobarbital  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
pyrimidine  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
tert-butyl hydroperoxide  (ISO)
thalidomide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
uridine  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,ISO)
nucleoplasm  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Uridine protects cortical neurons from glucose deprivation-induced death: possible role of uridine phosphorylase. Choi JW, etal., J Neurotrauma. 2008 Jun;25(6):695-707.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7488099   PMID:7744869   PMID:12477932   PMID:15772079   PMID:19291308   PMID:20856879   PMID:23355744  


Genomics

Comparative Map Data
Upp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81488,023,155 - 88,043,036 (+)NCBIGRCr8
mRatBN7.21483,809,495 - 83,829,299 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1483,809,960 - 83,829,462 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1488,205,103 - 88,223,414 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01489,445,021 - 89,463,332 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01485,912,157 - 85,930,471 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01489,314,234 - 89,334,060 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1489,314,176 - 89,334,276 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01489,112,302 - 89,132,102 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41489,651,264 - 89,669,630 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11489,669,068 - 89,688,775 (+)NCBI
Celera1482,846,265 - 82,864,631 (+)NCBICelera
Cytogenetic Map14q21NCBI
UPP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38748,088,704 - 48,108,736 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl748,088,628 - 48,108,736 (+)EnsemblGRCh38hg38GRCh38
GRCh37748,128,301 - 48,148,333 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36748,094,880 - 48,114,855 (+)NCBINCBI36Build 36hg18NCBI36
Celera748,227,538 - 48,247,515 (+)NCBICelera
Cytogenetic Map7p12.3NCBI
HuRef748,013,948 - 48,033,924 (+)NCBIHuRef
CHM1_1748,132,055 - 48,152,030 (+)NCBICHM1_1
T2T-CHM13v2.0748,250,938 - 48,270,970 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2748,168,224 - 48,188,201 (+)NCBI
Upp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39119,068,008 - 9,086,170 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl119,068,103 - 9,086,170 (+)EnsemblGRCm39 Ensembl
GRCm38119,118,008 - 9,136,170 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl119,118,103 - 9,136,170 (+)EnsemblGRCm38mm10GRCm38
MGSCv37119,018,011 - 9,036,173 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36119,018,106 - 9,036,167 (+)NCBIMGSCv36mm8
Celera119,551,715 - 9,569,878 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map116.13NCBI
Upp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554565,365,877 - 5,385,336 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554565,365,912 - 5,385,336 (-)NCBIChiLan1.0ChiLan1.0
UPP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2652,964,340 - 52,983,714 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17101,288,443 - 101,308,447 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0748,729,975 - 48,749,598 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1748,838,901 - 48,858,189 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl748,838,893 - 48,858,185 (+)Ensemblpanpan1.1panPan2
UPP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.118108,215 - 120,213 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1867,812 - 89,151 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.018133,593 - 154,855 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl18133,673 - 164,752 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.118108,433 - 129,715 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.018111,361 - 132,570 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.018246,479 - 267,730 (+)NCBIUU_Cfam_GSD_1.0
Upp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118103,296,840 - 103,319,396 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647822,508,559 - 22,531,898 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647822,508,602 - 22,531,604 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UPP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1848,418,385 - 48,440,736 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11848,418,385 - 48,440,414 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
UPP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12110,686,600 - 10,707,181 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2110,686,093 - 10,706,347 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606211,525,130 - 11,545,495 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Upp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247405,517,387 - 5,531,594 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Upp1
246 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:71
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000006765
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
4889951Bss92Bone structure and strength QTL 923.9tibia area (VT:1000281)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)148205747195876975Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat

Markers in Region
RH131849  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21483,829,092 - 83,829,280 (+)MAPPERmRatBN7.2
Rnor_6.01489,333,857 - 89,334,044NCBIRnor6.0
Rnor_5.01489,131,899 - 89,132,086UniSTSRnor5.0
RGSC_v3.41489,669,431 - 89,669,618UniSTSRGSC3.4
Celera1482,864,432 - 82,864,619UniSTS
RH 3.4 Map14617.2UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001030025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC099752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000006765   ⟹   ENSRNOP00000006765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1483,809,960 - 83,829,462 (+)Ensembl
Rnor_6.0 Ensembl1489,314,176 - 89,334,276 (+)Ensembl
RefSeq Acc Id: NM_001030025   ⟹   NP_001025196
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81488,024,670 - 88,043,036 (+)NCBI
mRatBN7.21483,810,924 - 83,829,292 (+)NCBI
Rnor_6.01489,315,690 - 89,334,056 (+)NCBI
Rnor_5.01489,112,302 - 89,132,102 (+)NCBI
RGSC_v3.41489,651,264 - 89,669,630 (+)RGD
Celera1482,846,265 - 82,864,631 (+)RGD
Sequence:
RefSeq Acc Id: XM_006251483   ⟹   XP_006251545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81488,023,206 - 88,043,036 (+)NCBI
mRatBN7.21483,809,830 - 83,829,299 (+)NCBI
Rnor_6.01489,314,520 - 89,334,060 (+)NCBI
Rnor_5.01489,112,302 - 89,132,102 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006251484   ⟹   XP_006251546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81488,023,155 - 88,043,036 (+)NCBI
mRatBN7.21483,809,584 - 83,829,299 (+)NCBI
Rnor_6.01489,314,234 - 89,334,060 (+)NCBI
Rnor_5.01489,112,302 - 89,132,102 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006251485   ⟹   XP_006251547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81488,023,291 - 88,043,036 (+)NCBI
mRatBN7.21483,809,552 - 83,829,299 (+)NCBI
Rnor_6.01489,314,234 - 89,334,060 (+)NCBI
Rnor_5.01489,112,302 - 89,132,102 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006251487   ⟹   XP_006251549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81488,023,557 - 88,043,036 (+)NCBI
mRatBN7.21483,809,817 - 83,829,299 (+)NCBI
Rnor_6.01489,314,520 - 89,334,060 (+)NCBI
Rnor_5.01489,112,302 - 89,132,102 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039091760   ⟹   XP_038947688
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81488,023,193 - 88,043,036 (+)NCBI
mRatBN7.21483,809,495 - 83,829,299 (+)NCBI
RefSeq Acc Id: XM_039091762   ⟹   XP_038947690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81488,023,265 - 88,043,036 (+)NCBI
mRatBN7.21483,809,595 - 83,829,299 (+)NCBI
RefSeq Acc Id: XM_039091763   ⟹   XP_038947691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81488,023,560 - 88,043,036 (+)NCBI
mRatBN7.21483,809,820 - 83,829,299 (+)NCBI
RefSeq Acc Id: XM_039091764   ⟹   XP_038947692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81488,023,288 - 88,043,036 (+)NCBI
mRatBN7.21483,809,550 - 83,829,299 (+)NCBI
RefSeq Acc Id: XM_063272975   ⟹   XP_063129045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81488,023,566 - 88,043,036 (+)NCBI
RefSeq Acc Id: XM_063272976   ⟹   XP_063129046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81488,023,919 - 88,043,036 (+)NCBI
RefSeq Acc Id: XM_063272977   ⟹   XP_063129047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81488,023,233 - 88,043,036 (+)NCBI
RefSeq Acc Id: XM_063272978   ⟹   XP_063129048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81488,023,232 - 88,043,036 (+)NCBI
RefSeq Acc Id: XM_063272979   ⟹   XP_063129049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81488,023,913 - 88,043,036 (+)NCBI
RefSeq Acc Id: NP_001025196   ⟸   NM_001030025
- UniProtKB: Q499V1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251546   ⟸   XM_006251484
- Peptide Label: isoform X1
- UniProtKB: Q499V1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251547   ⟸   XM_006251485
- Peptide Label: isoform X1
- UniProtKB: Q499V1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251549   ⟸   XM_006251487
- Peptide Label: isoform X2
- UniProtKB: F7F0D5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251545   ⟸   XM_006251483
- Peptide Label: isoform X1
- UniProtKB: Q499V1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006765   ⟸   ENSRNOT00000006765
RefSeq Acc Id: XP_038947688   ⟸   XM_039091760
- Peptide Label: isoform X1
- UniProtKB: Q499V1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947692   ⟸   XM_039091764
- Peptide Label: isoform X1
- UniProtKB: Q499V1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947690   ⟸   XM_039091762
- Peptide Label: isoform X1
- UniProtKB: Q499V1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947691   ⟸   XM_039091763
- Peptide Label: isoform X1
- UniProtKB: Q499V1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129048   ⟸   XM_063272978
- Peptide Label: isoform X2
- UniProtKB: F7F0D5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129047   ⟸   XM_063272977
- Peptide Label: isoform X2
- UniProtKB: F7F0D5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129045   ⟸   XM_063272975
- Peptide Label: isoform X1
- UniProtKB: Q499V1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129049   ⟸   XM_063272979
- Peptide Label: isoform X2
- UniProtKB: F7F0D5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129046   ⟸   XM_063272976
- Peptide Label: isoform X1
- UniProtKB: Q499V1 (UniProtKB/TrEMBL)
Protein Domains
Nucleoside phosphorylase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q499V1-F1-model_v2 AlphaFold Q499V1 1-312 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699490
Promoter ID:EPDNEW_R10013
Type:single initiation site
Name:Upp1_2
Description:uridine phosphorylase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10014  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01489,314,249 - 89,314,309EPDNEW
RGD ID:13699491
Promoter ID:EPDNEW_R10014
Type:multiple initiation site
Name:Upp1_1
Description:uridine phosphorylase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10013  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01489,314,861 - 89,314,921EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305566 AgrOrtholog
BioCyc Gene G2FUF-15021 BioCyc
BioCyc Pathway PWY-7181 [pyrimidine deoxyribonucleosides degradation] BioCyc
  PWY0-1295 [pyrimidine ribonucleosides degradation] BioCyc
BioCyc Pathway Image PWY-7181 BioCyc
  PWY0-1295 BioCyc
Ensembl Genes ENSRNOG00000004972 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006765.8 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1580 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623209 IMAGE-MGC_LOAD
InterPro Nucleoside_phosphorylase UniProtKB/TrEMBL
  Nucleoside_phosphorylase_CS UniProtKB/TrEMBL
  Nucleoside_phosphorylase_sf UniProtKB/TrEMBL
  Uridine_phosphorylase_euk UniProtKB/TrEMBL
KEGG Report rno:289801 UniProtKB/TrEMBL
MGC_CLONE MGC:124655 IMAGE-MGC_LOAD
NCBI Gene 289801 ENTREZGENE
PANTHER URIDINE PHOSPHORYLASE UniProtKB/TrEMBL
  URIDINE PHOSPHORYLASE 1 UniProtKB/TrEMBL
Pfam PNP_UDP_1 UniProtKB/TrEMBL
PharmGKB UPP1 RGD
PhenoGen Upp1 PhenoGen
PROSITE PNP_UDP_1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004972 RatGTEx
Superfamily-SCOP SSF53167 UniProtKB/TrEMBL
UniProt F7F0D5 ENTREZGENE, UniProtKB/TrEMBL
  Q499V1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Upp1  uridine phosphorylase 1  Upp1_predicted  uridine phosphorylase 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Upp1_predicted  uridine phosphorylase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED