Ikzf1 (IKAROS family zinc finger 1) - Rat Genome Database

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Gene: Ikzf1 (IKAROS family zinc finger 1) Rattus norvegicus
Analyze
Symbol: Ikzf1
Name: IKAROS family zinc finger 1
RGD ID: 1562979
Description: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and nucleic acid binding activity. Predicted to be involved in erythrocyte differentiation; lymphocyte differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including hematopoietic or lymphoid organ development; lymphocyte differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of pericentric heterochromatin. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; colorectal cancer; and common variable immunodeficiency 13. Orthologous to human IKZF1 (IKAROS family zinc finger 1); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DNA-binding protein Ikaros; LOC305501; RGD1562979; similar to DNA-binding protein Ikaros form 1 - mouse
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81490,468,696 - 90,556,522 (+)NCBIGRCr8
mRatBN7.21486,255,065 - 86,340,839 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1486,255,065 - 86,342,416 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1490,660,495 - 90,746,740 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01491,905,260 - 91,991,074 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01488,372,438 - 88,458,707 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01491,782,281 - 91,867,828 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1491,782,354 - 91,867,424 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01491,567,474 - 91,652,828 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41492,560,200 - 92,657,336 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1485,257,476 - 85,342,328 (+)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
clofibrate  (EXP)
Cuprizon  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
dimethylarsinic acid  (ISO)
diquat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
L-ascorbic acid  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
permethrin  (EXP)
picoxystrobin  (ISO)
pomalidomide  (ISO)
protein kinase inhibitor  (ISO)
pyrimidifen  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
tamibarotene  (ISO)
tebufenpyrad  (ISO)
testosterone  (EXP)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Long-range epigenetic silencing associates with deregulation of Ikaros targets in colorectal cancer cells. Javierre BM, etal., Mol Cancer Res. 2011 Aug;9(8):1139-51. doi: 10.1158/1541-7786.MCR-10-0515. Epub 2011 Jul 7.
3. Methylation and Gene Expression of BCAT1 and IKZF1 in Colorectal Cancer Tissues. Jedi M, etal., Clin Med Insights Oncol. 2018 May 10;12:1179554918775064. doi: 10.1177/1179554918775064. eCollection 2018.
4. Prognostic value of genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia. Krentz S, etal., Leukemia. 2013 Feb;27(2):295-304. doi: 10.1038/leu.2012.155. Epub 2012 Jun 13.
5. Detection of Colorectal Cancer in Circulating Cell-Free DNA by Methylated CpG Tandem Amplification and Sequencing. Li J, etal., Clin Chem. 2019 Jul;65(7):916-926. doi: 10.1373/clinchem.2019.301804. Epub 2019 Apr 22.
6. Disease risk factors identified through shared genetic architecture and electronic medical records. Li L, etal., Sci Transl Med. 2014 Apr 30;6(234):234ra57. doi: 10.1126/scitranslmed.3007191.
7. Relationship between post-surgery detection of methylated circulating tumor DNA with risk of residual disease and recurrence-free survival. Murray DH, etal., J Cancer Res Clin Oncol. 2018 Sep;144(9):1741-1750. doi: 10.1007/s00432-018-2701-x. Epub 2018 Jul 10.
8. Evaluation of Circulating Tumor DNA for Methylated BCAT1 and IKZF1 to Detect Recurrence of Stage II/Stage III Colorectal Cancer (CRC). Musher BL, etal., Cancer Epidemiol Biomarkers Prev. 2020 Dec;29(12):2702-2709. doi: 10.1158/1055-9965.EPI-20-0574. Epub 2020 Sep 21.
9. A two-gene blood test for methylated DNA sensitive for colorectal cancer. Pedersen SK, etal., PLoS One. 2015 Apr 30;10(4):e0125041. doi: 10.1371/journal.pone.0125041. eCollection 2015.
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Evaluation of newly identified Ikaros family zinc finger 1 loci in colorectal cancer. Sharma B, etal., J Cancer Res Ther. 2021 Jan-Mar;17(1):46-50. doi: 10.4103/jcrt.JCRT_844_20.
13. Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases. Sun J, etal., Nat Commun. 2019 Jul 18;10(1):3190. doi: 10.1038/s41467-019-10987-3.
14. Circulating epigenetic biomarkers for detection of recurrent colorectal cancer. Symonds EL, etal., Cancer. 2020 Apr 1;126(7):1460-1469. doi: 10.1002/cncr.32695. Epub 2020 Jan 7.
15. Circulating tumour DNA for monitoring colorectal cancer-a prospective cohort study to assess relationship to tissue methylation, cancer characteristics and surgical resection. Symonds EL, etal., Clin Epigenetics. 2018 May 16;10:63. doi: 10.1186/s13148-018-0500-5. eCollection 2018.
16. A cross-sectional study comparing a blood test for methylated BCAT1 and IKZF1 tumor-derived DNA with CEA for detection of recurrent colorectal cancer. Young GP, etal., Cancer Med. 2016 Oct;5(10):2763-2772. doi: 10.1002/cam4.868. Epub 2016 Oct 11.
17. Evaluation of a panel of tumor-specific differentially-methylated DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of colorectal cancer. Young GP, etal., Clin Epigenetics. 2021 Jan 21;13(1):14. doi: 10.1186/s13148-020-00999-y.
18. Inhibitory effects of transcription factor Ikaros on the expression of liver cancer stem cell marker CD133 in hepatocellular carcinoma. Zhang L, etal., Oncotarget. 2014 Nov 15;5(21):10621-35. doi: 10.18632/oncotarget.2524.
19. Ikaros is heterogeneously expressed in lung adenocarcinoma and is involved in its progression. Zhao W, etal., J Int Med Res. 2020 Aug;48(8):300060520945860. doi: 10.1177/0300060520945860.
Additional References at PubMed
PMID:7923373   PMID:7969165   PMID:9560339   PMID:10218586   PMID:10366784   PMID:11805317   PMID:12406904   PMID:12617992   PMID:15491138   PMID:15767674   PMID:15841184   PMID:16467156  
PMID:17934067   PMID:18804520   PMID:18940586   PMID:21245044   PMID:21548011   PMID:22106042   PMID:22301782   PMID:23071339   PMID:25654255  


Genomics

Comparative Map Data
Ikzf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81490,468,696 - 90,556,522 (+)NCBIGRCr8
mRatBN7.21486,255,065 - 86,340,839 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1486,255,065 - 86,342,416 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1490,660,495 - 90,746,740 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01491,905,260 - 91,991,074 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01488,372,438 - 88,458,707 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01491,782,281 - 91,867,828 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1491,782,354 - 91,867,424 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01491,567,474 - 91,652,828 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41492,560,200 - 92,657,336 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1485,257,476 - 85,342,328 (+)NCBICelera
Cytogenetic Map14q21NCBI
IKZF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38750,303,455 - 50,405,101 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl750,304,068 - 50,405,101 (+)EnsemblGRCh38hg38GRCh38
GRCh37750,343,660 - 50,472,799 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36750,411,725 - 50,440,293 (+)NCBINCBI36Build 36hg18NCBI36
Build 34750,218,438 - 50,244,768NCBI
Celera750,439,276 - 50,537,765 (+)NCBICelera
Cytogenetic Map7p12.2NCBI
HuRef750,294,198 - 50,322,765 (+)NCBIHuRef
HuRef750,224,730 - 50,247,709 (+)NCBIHuRef
CHM1_1750,446,524 - 50,475,092 (+)NCBICHM1_1
CHM1_1750,346,669 - 50,369,648 (+)NCBICHM1_1
T2T-CHM13v2.0750,464,429 - 50,566,317 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2750,381,631 - 50,478,870 (+)NCBI
Ikzf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391111,634,970 - 11,722,930 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1111,634,980 - 11,722,926 (+)EnsemblGRCm39 Ensembl
GRCm381111,684,962 - 11,772,930 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1111,685,003 - 11,772,926 (+)EnsemblGRCm38mm10GRCm38
MGSCv371111,586,216 - 11,672,929 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361111,586,216 - 11,672,929 (+)NCBIMGSCv36mm8
Celera1112,146,027 - 12,232,163 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map117.02NCBI
Ikzf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554563,635,380 - 3,721,791 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554563,617,988 - 3,721,791 (-)NCBIChiLan1.0ChiLan1.0
IKZF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2655,183,057 - 55,284,060 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17103,507,780 - 103,608,783 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0750,946,817 - 51,047,168 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1751,191,691 - 51,291,245 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl751,191,685 - 51,291,245 (+)Ensemblpanpan1.1panPan2
IKZF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1181,661,851 - 1,750,987 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl181,661,690 - 1,770,768 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha181,653,280 - 1,744,958 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0181,719,409 - 1,812,327 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl181,719,944 - 1,812,326 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1181,693,685 - 1,785,344 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0181,690,232 - 1,781,782 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0181,826,862 - 1,918,574 (+)NCBIUU_Cfam_GSD_1.0
Ikzf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118104,966,894 - 105,063,530 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366861,462,145 - 1,556,451 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366861,459,582 - 1,556,478 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IKZF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9136,372,725 - 136,464,940 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19136,372,202 - 136,464,942 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29150,041,447 - 150,045,891 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IKZF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,398,902 - 8,500,431 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl218,402,719 - 8,484,723 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606213,778,793 - 13,883,296 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ikzf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247403,785,209 - 3,875,841 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247403,785,342 - 3,875,892 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ikzf1
373 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:54
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000005902
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
4889951Bss92Bone structure and strength QTL 923.9tibia area (VT:1000281)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)148205747195876975Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat

Markers in Region
D14Uia3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21486,258,403 - 86,258,598 (+)MAPPERmRatBN7.2
Rnor_6.01491,785,693 - 91,785,887NCBIRnor6.0
Rnor_5.01491,570,812 - 91,571,006UniSTSRnor5.0
RGSC_v3.41492,563,538 - 92,563,733RGDRGSC3.4
RGSC_v3.41492,563,539 - 92,563,733UniSTSRGSC3.4
RGSC_v3.11492,582,683 - 92,582,878RGD
Celera1485,260,815 - 85,261,009UniSTS
Cytogenetic Map14q21UniSTS
RH137594  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21486,287,429 - 86,287,625 (+)MAPPERmRatBN7.2
Rnor_6.01491,814,590 - 91,814,785NCBIRnor6.0
Rnor_5.01491,599,505 - 91,599,700UniSTSRnor5.0
RGSC_v3.41492,603,718 - 92,603,913UniSTSRGSC3.4
Celera1485,289,605 - 85,289,800UniSTS
Cytogenetic Map14q21UniSTS
RH139754  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21486,342,476 - 86,342,684 (+)MAPPERmRatBN7.2
Rnor_6.01491,869,464 - 91,869,671NCBIRnor6.0
Rnor_5.01491,654,287 - 91,654,494UniSTSRnor5.0
RGSC_v3.41492,659,376 - 92,659,583UniSTSRGSC3.4
Celera1485,344,368 - 85,344,575UniSTS
RH 3.4 Map14634.49UniSTS
Cytogenetic Map14q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 4 28 20 19 20 9
Low 1 29 29 21 21 8 9 74 35 38 2 8
Below cutoff 10 2 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001107237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC115644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000005902   ⟹   ENSRNOP00000005902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1486,255,065 - 86,340,437 (+)Ensembl
Rnor_6.0 Ensembl1491,782,354 - 91,867,424 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080753   ⟹   ENSRNOP00000069446
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1486,255,625 - 86,340,437 (+)Ensembl
Rnor_6.0 Ensembl1491,783,514 - 91,867,098 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094159   ⟹   ENSRNOP00000082686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1486,262,134 - 86,340,437 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097538   ⟹   ENSRNOP00000086084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1486,255,065 - 86,342,416 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113896   ⟹   ENSRNOP00000088172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1486,256,227 - 86,340,437 (+)Ensembl
RefSeq Acc Id: NM_001107237   ⟹   NP_001100707
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,468,696 - 90,554,061 (+)NCBI
mRatBN7.21486,255,065 - 86,340,437 (+)NCBI
Rnor_6.01491,782,354 - 91,867,424 (+)NCBI
Rnor_5.01491,567,474 - 91,652,828 (+)NCBI
RGSC_v3.41492,560,200 - 92,657,336 (+)RGD
Celera1485,257,476 - 85,342,328 (+)RGD
Sequence:
RefSeq Acc Id: XM_006251491   ⟹   XP_006251553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,469,444 - 90,556,522 (+)NCBI
mRatBN7.21486,255,877 - 86,340,219 (+)NCBI
Rnor_6.01491,783,732 - 91,867,828 (+)NCBI
Rnor_5.01491,567,474 - 91,652,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006251492   ⟹   XP_006251554
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,470,209 - 90,556,522 (+)NCBI
mRatBN7.21486,256,577 - 86,340,839 (+)NCBI
Rnor_6.01491,783,836 - 91,867,828 (+)NCBI
Rnor_5.01491,567,474 - 91,652,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006251494   ⟹   XP_006251556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,469,199 - 90,556,522 (+)NCBI
mRatBN7.21486,255,727 - 86,340,839 (+)NCBI
Rnor_6.01491,783,039 - 91,867,828 (+)NCBI
Rnor_5.01491,567,474 - 91,652,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008770313   ⟹   XP_008768535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,469,299 - 90,556,522 (+)NCBI
mRatBN7.21486,255,726 - 86,340,839 (+)NCBI
Rnor_6.01491,783,038 - 91,867,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008770314   ⟹   XP_008768536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,469,303 - 90,556,522 (+)NCBI
mRatBN7.21486,255,726 - 86,340,839 (+)NCBI
Rnor_6.01491,783,038 - 91,867,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008770315   ⟹   XP_008768537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,469,309 - 90,556,522 (+)NCBI
mRatBN7.21486,255,726 - 86,340,839 (+)NCBI
Rnor_6.01491,783,039 - 91,867,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008770316   ⟹   XP_008768538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,469,296 - 90,556,522 (+)NCBI
mRatBN7.21486,255,726 - 86,340,839 (+)NCBI
Rnor_6.01491,783,038 - 91,867,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008770318   ⟹   XP_008768540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,469,291 - 90,556,522 (+)NCBI
mRatBN7.21486,255,725 - 86,340,839 (+)NCBI
Rnor_6.01491,783,037 - 91,867,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039092062   ⟹   XP_038947990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,469,302 - 90,556,522 (+)NCBI
mRatBN7.21486,255,726 - 86,340,839 (+)NCBI
RefSeq Acc Id: XM_039092063   ⟹   XP_038947991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,469,288 - 90,556,522 (+)NCBI
mRatBN7.21486,255,725 - 86,340,839 (+)NCBI
RefSeq Acc Id: XM_039092065   ⟹   XP_038947993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,469,295 - 90,556,522 (+)NCBI
mRatBN7.21486,255,726 - 86,340,839 (+)NCBI
RefSeq Acc Id: XM_039092066   ⟹   XP_038947994
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,469,252 - 90,556,522 (+)NCBI
mRatBN7.21486,255,725 - 86,340,839 (+)NCBI
RefSeq Acc Id: XM_063273233   ⟹   XP_063129303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,469,295 - 90,556,522 (+)NCBI
RefSeq Acc Id: XM_063273234   ⟹   XP_063129304
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,469,285 - 90,556,522 (+)NCBI
RefSeq Acc Id: NP_001100707   ⟸   NM_001107237
- UniProtKB: A6KJA9 (UniProtKB/TrEMBL),   A0A8I5ZVE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251556   ⟸   XM_006251494
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006251553   ⟸   XM_006251491
- Peptide Label: isoform X5
- UniProtKB: A6KJA7 (UniProtKB/TrEMBL),   D4A9W4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251554   ⟸   XM_006251492
- Peptide Label: isoform X5
- UniProtKB: A6KJA7 (UniProtKB/TrEMBL),   D4A9W4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768536   ⟸   XM_008770314
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008768535   ⟸   XM_008770313
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008768538   ⟸   XM_008770316
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_008768537   ⟸   XM_008770315
- Peptide Label: isoform X7
- UniProtKB: A6KJA9 (UniProtKB/TrEMBL),   A0A8I5ZVE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768540   ⟸   XM_008770318
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: ENSRNOP00000069446   ⟸   ENSRNOT00000080753
RefSeq Acc Id: ENSRNOP00000005902   ⟸   ENSRNOT00000005902
RefSeq Acc Id: XP_038947991   ⟸   XM_039092063
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038947994   ⟸   XM_039092066
- Peptide Label: isoform X12
RefSeq Acc Id: XP_038947990   ⟸   XM_039092062
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038947993   ⟸   XM_039092065
- Peptide Label: isoform X9
RefSeq Acc Id: ENSRNOP00000082686   ⟸   ENSRNOT00000094159
RefSeq Acc Id: ENSRNOP00000088172   ⟸   ENSRNOT00000113896
RefSeq Acc Id: ENSRNOP00000086084   ⟸   ENSRNOT00000097538
RefSeq Acc Id: XP_063129304   ⟸   XM_063273234
- Peptide Label: isoform X13
RefSeq Acc Id: XP_063129303   ⟸   XM_063273233
- Peptide Label: isoform X11
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JVD9-F1-model_v2 AlphaFold A0A0G2JVD9 1-514 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699494
Promoter ID:EPDNEW_R10016
Type:initiation region
Name:Ikzf1_1
Description:IKAROS family zinc finger 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01491,783,570 - 91,783,630EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562979 AgrOrtholog
BioCyc Gene G2FUF-14993 BioCyc
Ensembl Genes ENSRNOG00000004444 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005902.7 UniProtKB/TrEMBL
  ENSRNOT00000080753.2 UniProtKB/TrEMBL
  ENSRNOT00000094159 ENTREZGENE
  ENSRNOT00000094159.1 UniProtKB/TrEMBL
  ENSRNOT00000097538.1 UniProtKB/TrEMBL
  ENSRNOT00000113896.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:305501 UniProtKB/TrEMBL
NCBI Gene 305501 ENTREZGENE
PANTHER DNA-BINDING PROTEIN IKAROS UniProtKB/TrEMBL
  FI03704P-RELATED UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Ikzf1 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004444 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A0G2JVD9_RAT UniProtKB/TrEMBL
  A0A8I5ZVE4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A4M7_RAT UniProtKB/TrEMBL
  A0A8I6A5Y7_RAT UniProtKB/TrEMBL
  A6KJA7 ENTREZGENE, UniProtKB/TrEMBL
  A6KJA9 ENTREZGENE, UniProtKB/TrEMBL
  D4A9W4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-11-06 Ikzf1  IKAROS family zinc finger 1  RGD1562979  similar to DNA-binding protein Ikaros form 1 - mouse   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1562979  similar to DNA-binding protein Ikaros form 1 - mouse   RGD1562979_predicted  similar to DNA-binding protein Ikaros form 1 - mouse (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562979_predicted  similar to DNA-binding protein Ikaros form 1 - mouse (predicted)  LOC305501  similar to DNA-binding protein Ikaros form 1 - mouse  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC305501  similar to DNA-binding protein Ikaros form 1 - mouse      Symbol and Name status set to provisional 70820 PROVISIONAL