Qdpr (quinoid dihydropteridine reductase) - Rat Genome Database

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Gene: Qdpr (quinoid dihydropteridine reductase) Rattus norvegicus
Analyze
Symbol: Qdpr
Name: quinoid dihydropteridine reductase
RGD ID: 619915
Description: Enables 6,7-dihydropteridine reductase activity; adenyl nucleotide binding activity; and identical protein binding activity. Involved in several processes, including L-phenylalanine catabolic process; response to glucagon; and tetrahydrobiopterin biosynthetic process. Predicted to be active in cytoplasm. Biomarker of hypertension and status epilepticus. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia C and phenylketonuria. Orthologous to human QDPR (quinoid dihydropteridine reductase); PARTICIPATES IN dopa responsive dystonia pathway; dopamine biosynthetic pathway; epinephrine biosynthetic pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dihydropteridine reductase; HDHPR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81469,882,776 - 69,896,378 (+)NCBIGRCr8
mRatBN7.21465,670,251 - 65,683,853 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1465,670,131 - 65,683,854 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1470,063,070 - 70,076,654 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01471,350,269 - 71,363,871 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01467,773,459 - 67,787,043 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01470,164,682 - 70,178,284 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1470,164,650 - 70,178,284 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01470,207,866 - 70,221,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41470,741,998 - 70,755,600 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11470,744,388 - 70,757,991 (+)NCBI
Celera1464,651,352 - 64,664,952 (+)NCBICelera
RH 3.4 Map14474.3RGD
Cytogenetic Map14q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
acetamide  (EXP)
aconitine  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alachlor  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
clozapine  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
folpet  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
miconazole  (ISO)
N-nitrosodiethylamine  (EXP)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Effect of glucagon on phenylalanine metabolism and phenylalanine-degrading enzymes in the rat. Brand LM and Harper AE, Biochem J. 1974 Aug;142(2):231-45.
2. Regional and subcellular distribution and some factors in the regulation of reduced pterins in rat brain. Bullard WP, etal., J Pharmacol Exp Ther. 1978 Jul;206(1):4-20.
3. The effect of lead and aluminium on rat dihydropteridine reductase. Cutler P and Blair JA, Arch Toxicol Suppl. 1987;11:227-30.
4. The effect of lead on tetrahydrobiopterin metabolism. A possible mechanism for neurotoxicity. Eggar C, etal., Clin Chim Acta. 1986 Nov 30;161(1):103-9.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Proteome changes associated with hippocampal MRI abnormalities in the lithium pilocarpine-induced model of convulsive status epilepticus. Greene ND, etal., Proteomics. 2007 Apr;7(8):1336-44.
8. Characterization and nucleotide binding properties of a mutant dihydropteridine reductase containing an aspartate 37-isoleucine replacement. Grimshaw CE, etal., J Biol Chem. 1992 Aug 5;267(22):15334-9.
9. Tetrahydrobiopterin metabolism in the streptozotocin induced diabetic state in rats. Hamon CG, etal., Clin Chim Acta. 1989 May 31;181(3):249-53.
10. Insertion of an extra codon for threonine is a cause of dihydropteridine reductase deficiency. Howells DW, etal., Am J Hum Genet. 1990 Aug;47(2):279-85.
11. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
12. The comparative interaction of quinonoid (6R)-dihydrobiopterin and an alternative dihydropterin substrate with wild-type and mutant rat dihydropteridine reductases. Kiefer PM, etal., Biochemistry. 1997 Aug 5;36(31):9438-45.
13. Altered structural and mechanistic properties of mutant dihydropteridine reductases. Kiefer PM, etal., J Biol Chem. 1996 Feb 16;271(7):3437-44.
14. Catecholaminergic systems in stress: structural and molecular genetic approaches. Kvetnansky R, etal., Physiol Rev. 2009 Apr;89(2):535-606.
15. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
16. Diminished expression of dihydropteridine reductase is a potent biomarker for hypertensive vessels. Lee CK, etal., Proteomics. 2009 Nov;9(21):4851-8.
17. Effect of chronic lead exposure on biopterin metabolism in the rat neostriatum. Martinez-Fong D, etal., J Neurosci Res. 1990 May;26(1):112-4.
18. Role of aspartate-37 in determining cofactor specificity and binding in rat liver dihydropteridine reductase. Matthews DA, etal., Arch Biochem Biophys. 1991 Jun;287(2):234-9.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Comprehensive gene review and curation RGD comprehensive gene curation
28. Dihydropteridine reductase activity of adult, fetal and neoplastic tissues. Sanchez-Urretia L, etal., Enzyme. 1978;23(5):346-52.
29. Structural studies and isolation of cDNA clones providing the complete sequence of rat liver dihydropteridine reductase. Shahbaz M, etal., J Biol Chem 1987 Dec 5;262(34):16412-6.
30. Regulation of GTP cyclohydrolase I and dihydropteridine reductase in rat pheochromocytoma PC 12 cells. Shen RS, etal., J Enzyme Inhib. 1989;3(2):119-26.
31. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
32. The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue. Su Y, etal., J Biol Chem. 1993 Dec 25;268(36):26836-41.
33. Crystal structure of rat liver dihydropteridine reductase. Varughese KI, etal., Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6080-4.
Additional References at PubMed
PMID:3033643   PMID:3566737   PMID:7744010   PMID:8304094   PMID:15489334   PMID:18614015   PMID:19056867   PMID:20643204   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Qdpr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81469,882,776 - 69,896,378 (+)NCBIGRCr8
mRatBN7.21465,670,251 - 65,683,853 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1465,670,131 - 65,683,854 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1470,063,070 - 70,076,654 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01471,350,269 - 71,363,871 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01467,773,459 - 67,787,043 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01470,164,682 - 70,178,284 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1470,164,650 - 70,178,284 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01470,207,866 - 70,221,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41470,741,998 - 70,755,600 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11470,744,388 - 70,757,991 (+)NCBI
Celera1464,651,352 - 64,664,952 (+)NCBICelera
RH 3.4 Map14474.3RGD
Cytogenetic Map14q11NCBI
QDPR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38417,486,395 - 17,512,090 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl417,460,261 - 17,512,206 (-)EnsemblGRCh38hg38GRCh38
GRCh37417,488,018 - 17,513,713 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36417,097,121 - 17,154,822 (-)NCBINCBI36Build 36hg18NCBI36
Build 34417,164,291 - 17,189,982NCBI
Celera417,953,005 - 17,978,851 (-)NCBICelera
Cytogenetic Map4p15.32NCBI
HuRef416,842,683 - 16,868,527 (-)NCBIHuRef
CHM1_1417,485,950 - 17,511,774 (-)NCBICHM1_1
T2T-CHM13v2.0417,468,141 - 17,493,839 (-)NCBIT2T-CHM13v2.0
Qdpr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39545,591,374 - 45,607,571 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl545,591,363 - 45,607,578 (-)EnsemblGRCm39 Ensembl
GRCm38545,434,032 - 45,450,229 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl545,434,021 - 45,450,236 (-)EnsemblGRCm38mm10GRCm38
MGSCv37545,825,271 - 45,841,468 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36545,722,303 - 45,738,405 (-)NCBIMGSCv36mm8
Celera542,859,912 - 42,876,126 (-)NCBICelera
Cytogenetic Map5B3NCBI
cM Map524.9NCBI
Qdpr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554806,646,088 - 6,669,526 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554806,646,088 - 6,666,866 (+)NCBIChiLan1.0ChiLan1.0
QDPR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2317,748,236 - 17,773,952 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1417,945,618 - 17,971,298 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0411,906,439 - 11,932,311 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1417,199,772 - 17,225,667 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl417,199,772 - 17,225,667 (-)Ensemblpanpan1.1panPan2
QDPR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1362,970,850 - 62,987,512 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl362,970,121 - 63,028,395 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha365,486,672 - 65,503,339 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0363,445,733 - 63,462,419 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl363,444,950 - 63,462,417 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1362,936,851 - 62,953,518 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0363,140,819 - 63,157,481 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0363,500,293 - 63,516,958 (+)NCBIUU_Cfam_GSD_1.0
Qdpr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528556,985,664 - 57,006,322 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647710,687,276 - 10,708,031 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647710,687,328 - 10,708,015 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
QDPR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl812,529,512 - 12,549,603 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1812,529,500 - 12,549,471 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2812,332,191 - 12,351,742 (-)NCBISscrofa10.2Sscrofa10.2susScr3
QDPR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12732,697,582 - 32,723,616 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2732,697,599 - 32,723,016 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604779,429,420 - 79,455,598 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Qdpr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475514,333,235 - 14,357,159 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475514,333,308 - 14,353,949 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Qdpr
53 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:87
Count of miRNA genes:66
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000004385
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143999825175582726Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat

Markers in Region
RH142413  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21465,683,444 - 65,683,655 (+)MAPPERmRatBN7.2
Rnor_6.01470,177,876 - 70,178,086NCBIRnor6.0
Rnor_5.01470,221,060 - 70,221,270UniSTSRnor5.0
RGSC_v3.41470,755,192 - 70,755,402UniSTSRGSC3.4
Celera1464,664,544 - 64,664,754UniSTS
RH 3.4 Map14474.3UniSTS
Cytogenetic Map14q21UniSTS
RH127087  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21465,683,640 - 65,683,847 (+)MAPPERmRatBN7.2
mRatBN7.28819,421 - 819,628 (+)MAPPERmRatBN7.2
Rnor_6.08833,086 - 833,292NCBIRnor6.0
Rnor_6.01470,178,072 - 70,178,278NCBIRnor6.0
Rnor_5.01470,221,256 - 70,221,462UniSTSRnor5.0
Rnor_5.08836,484 - 836,690UniSTSRnor5.0
RGSC_v3.41470,755,388 - 70,755,594UniSTSRGSC3.4
RGSC_v3.48190,903 - 191,109UniSTSRGSC3.4
Celera8704,176 - 704,382UniSTS
Celera1464,664,740 - 64,664,946UniSTS
Cytogenetic Map8q11UniSTS
Cytogenetic Map14q21UniSTS
RH140863  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21465,683,591 - 65,683,788 (+)MAPPERmRatBN7.2
Rnor_6.01470,178,023 - 70,178,219NCBIRnor6.0
Rnor_5.01470,221,207 - 70,221,403UniSTSRnor5.0
RGSC_v3.41470,755,339 - 70,755,535UniSTSRGSC3.4
Celera1464,664,691 - 64,664,887UniSTS
RH 3.4 Map14459.47UniSTS
Cytogenetic Map14q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 55 41 12 41 3 74 35 37 5
Low 8 2 7 8 8 4 6 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000004385   ⟹   ENSRNOP00000004385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1465,670,131 - 65,683,854 (+)Ensembl
Rnor_6.0 Ensembl1470,164,650 - 70,178,284 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115352   ⟹   ENSRNOP00000097613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1465,670,169 - 65,683,331 (+)Ensembl
RefSeq Acc Id: NM_022390   ⟹   NP_071785
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81469,882,776 - 69,896,378 (+)NCBI
mRatBN7.21465,670,251 - 65,683,853 (+)NCBI
Rnor_6.01470,164,682 - 70,178,284 (+)NCBI
Rnor_5.01470,207,866 - 70,221,468 (+)NCBI
RGSC_v3.41470,741,998 - 70,755,600 (+)RGD
Celera1464,651,352 - 64,664,952 (+)RGD
Sequence:
RefSeq Acc Id: NP_071785   ⟸   NM_022390
- UniProtKB: P11348 (UniProtKB/Swiss-Prot),   A0A8I6ARI8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004385   ⟸   ENSRNOT00000004385
RefSeq Acc Id: ENSRNOP00000097613   ⟸   ENSRNOT00000115352

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11348-F1-model_v2 AlphaFold P11348 1-241 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699350
Promoter ID:EPDNEW_R9874
Type:initiation region
Name:Qdpr_1
Description:quinoid dihydropteridine reductase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01470,164,650 - 70,164,710EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619915 AgrOrtholog
BioCyc Gene G2FUF-15536 BioCyc
BioCyc Pathway PWY-8099 [tetrahydropteridine recycling] BioCyc
BioCyc Pathway Image PWY-8099 BioCyc
Ensembl Genes ENSRNOG00000003253 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004385 ENTREZGENE
  ENSRNOT00000004385.5 UniProtKB/TrEMBL
  ENSRNOT00000115352.1 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7103182 IMAGE-MGC_LOAD
InterPro NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64192 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91693 IMAGE-MGC_LOAD
NCBI Gene 64192 ENTREZGENE
PANTHER DIHYDROPTERIDINE REDUCTASE UniProtKB/Swiss-Prot
  DIHYDROPTERIDINE REDUCTASE UniProtKB/Swiss-Prot
  DIHYDROPTERIDINE REDUCTASE UniProtKB/TrEMBL
  DIHYDROPTERIDINE REDUCTASE UniProtKB/TrEMBL
Pfam adh_short UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Qdpr PhenoGen
PROSITE ADH_SHORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003253 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ARI8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q0Z9_RAT UniProtKB/TrEMBL
  A6IJL7_RAT UniProtKB/TrEMBL
  A6IJL8_RAT UniProtKB/TrEMBL
  A6IJL9_RAT UniProtKB/TrEMBL
  A6IJM0_RAT UniProtKB/TrEMBL
  A6IJM1_RAT UniProtKB/TrEMBL
  DHPR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Qdpr  quinoid dihydropteridine reductase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Qdpr  quinoid dihydropteridine reductase      Symbol and Name status set to provisional 70820 PROVISIONAL