Qdpr (quinoid dihydropteridine reductase) - Rat Genome Database

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Gene: Qdpr (quinoid dihydropteridine reductase) Rattus norvegicus
Analyze
Symbol: Qdpr
Name: quinoid dihydropteridine reductase
RGD ID: 619915
Description: Enables 6,7-dihydropteridine reductase activity; identical protein binding activity; and nucleotide binding activity. Involved in several processes, including L-phenylalanine catabolic process; response to glucagon; and tetrahydrobiopterin biosynthetic process. Located in cytosol and neuron projection. Biomarker of hypertension and status epilepticus. Human ortholog(s) of this gene implicated in phenylketonuria. Orthologous to human QDPR (quinoid dihydropteridine reductase); PARTICIPATES IN dopa responsive dystonia pathway; dopamine biosynthetic pathway; epinephrine biosynthetic pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dihydropteridine reductase; HDHPR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21465,670,251 - 65,683,853 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1465,670,131 - 65,683,854 (+)Ensembl
Rnor_6.01470,164,682 - 70,178,284 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1470,164,650 - 70,178,284 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01470,207,866 - 70,221,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41470,741,998 - 70,755,600 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11470,744,388 - 70,757,991 (+)NCBI
Celera1464,651,352 - 64,664,952 (+)NCBICelera
RH 3.4 Map14474.3RGD
Cytogenetic Map14q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IDA)
neuron projection  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Effect of glucagon on phenylalanine metabolism and phenylalanine-degrading enzymes in the rat. Brand LM and Harper AE, Biochem J. 1974 Aug;142(2):231-45.
2. Regional and subcellular distribution and some factors in the regulation of reduced pterins in rat brain. Bullard WP, etal., J Pharmacol Exp Ther. 1978 Jul;206(1):4-20.
3. The effect of lead and aluminium on rat dihydropteridine reductase. Cutler P and Blair JA, Arch Toxicol Suppl. 1987;11:227-30.
4. The effect of lead on tetrahydrobiopterin metabolism. A possible mechanism for neurotoxicity. Eggar C, etal., Clin Chim Acta. 1986 Nov 30;161(1):103-9.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Proteome changes associated with hippocampal MRI abnormalities in the lithium pilocarpine-induced model of convulsive status epilepticus. Greene ND, etal., Proteomics. 2007 Apr;7(8):1336-44.
8. Characterization and nucleotide binding properties of a mutant dihydropteridine reductase containing an aspartate 37-isoleucine replacement. Grimshaw CE, etal., J Biol Chem. 1992 Aug 5;267(22):15334-9.
9. Tetrahydrobiopterin metabolism in the streptozotocin induced diabetic state in rats. Hamon CG, etal., Clin Chim Acta. 1989 May 31;181(3):249-53.
10. Insertion of an extra codon for threonine is a cause of dihydropteridine reductase deficiency. Howells DW, etal., Am J Hum Genet. 1990 Aug;47(2):279-85.
11. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
12. The comparative interaction of quinonoid (6R)-dihydrobiopterin and an alternative dihydropterin substrate with wild-type and mutant rat dihydropteridine reductases. Kiefer PM, etal., Biochemistry. 1997 Aug 5;36(31):9438-45.
13. Altered structural and mechanistic properties of mutant dihydropteridine reductases. Kiefer PM, etal., J Biol Chem. 1996 Feb 16;271(7):3437-44.
14. Catecholaminergic systems in stress: structural and molecular genetic approaches. Kvetnansky R, etal., Physiol Rev. 2009 Apr;89(2):535-606.
15. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
16. Diminished expression of dihydropteridine reductase is a potent biomarker for hypertensive vessels. Lee CK, etal., Proteomics. 2009 Nov;9(21):4851-8.
17. Effect of chronic lead exposure on biopterin metabolism in the rat neostriatum. Martinez-Fong D, etal., J Neurosci Res. 1990 May;26(1):112-4.
18. Role of aspartate-37 in determining cofactor specificity and binding in rat liver dihydropteridine reductase. Matthews DA, etal., Arch Biochem Biophys. 1991 Jun;287(2):234-9.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Comprehensive gene review and curation RGD comprehensive gene curation
28. Dihydropteridine reductase activity of adult, fetal and neoplastic tissues. Sanchez-Urretia L, etal., Enzyme. 1978;23(5):346-52.
29. Structural studies and isolation of cDNA clones providing the complete sequence of rat liver dihydropteridine reductase. Shahbaz M, etal., J Biol Chem 1987 Dec 5;262(34):16412-6.
30. Regulation of GTP cyclohydrolase I and dihydropteridine reductase in rat pheochromocytoma PC 12 cells. Shen RS, etal., J Enzyme Inhib. 1989;3(2):119-26.
31. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
32. The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue. Su Y, etal., J Biol Chem. 1993 Dec 25;268(36):26836-41.
33. Crystal structure of rat liver dihydropteridine reductase. Varughese KI, etal., Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6080-4.
Additional References at PubMed
PMID:3033643   PMID:3566737   PMID:7744010   PMID:8304094   PMID:15489334   PMID:18614015   PMID:19056867   PMID:20643204   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Qdpr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21465,670,251 - 65,683,853 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1465,670,131 - 65,683,854 (+)Ensembl
Rnor_6.01470,164,682 - 70,178,284 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1470,164,650 - 70,178,284 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01470,207,866 - 70,221,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41470,741,998 - 70,755,600 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11470,744,388 - 70,757,991 (+)NCBI
Celera1464,651,352 - 64,664,952 (+)NCBICelera
RH 3.4 Map14474.3RGD
Cytogenetic Map14q11NCBI
QDPR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38417,486,395 - 17,512,090 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl417,460,261 - 17,512,206 (-)EnsemblGRCh38hg38GRCh38
GRCh37417,488,018 - 17,513,713 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36417,097,121 - 17,154,822 (-)NCBINCBI36hg18NCBI36
Build 34417,164,291 - 17,189,982NCBI
Celera417,953,005 - 17,978,851 (-)NCBI
Cytogenetic Map4p15.32NCBI
HuRef416,842,683 - 16,868,527 (-)NCBIHuRef
CHM1_1417,485,950 - 17,511,774 (-)NCBICHM1_1
T2T-CHM13v2.0417,468,141 - 17,493,839 (-)NCBI
Qdpr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39545,591,374 - 45,607,571 (-)NCBIGRCm39mm39
GRCm39 Ensembl545,591,363 - 45,607,578 (-)Ensembl
GRCm38545,434,032 - 45,450,229 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl545,434,021 - 45,450,236 (-)EnsemblGRCm38mm10GRCm38
MGSCv37545,825,271 - 45,841,468 (-)NCBIGRCm37mm9NCBIm37
MGSCv36545,722,303 - 45,738,405 (-)NCBImm8
Celera542,859,912 - 42,876,126 (-)NCBICelera
Cytogenetic Map5B3NCBI
cM Map524.9NCBI
Qdpr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554806,646,088 - 6,669,526 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554806,646,088 - 6,666,866 (+)NCBIChiLan1.0ChiLan1.0
QDPR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1417,199,772 - 17,225,667 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl417,199,772 - 17,225,667 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0411,906,439 - 11,932,311 (-)NCBIMhudiblu_PPA_v0panPan3
QDPR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1362,970,850 - 62,987,512 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl362,970,121 - 63,028,395 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha365,486,672 - 65,503,339 (+)NCBI
ROS_Cfam_1.0363,445,733 - 63,462,419 (+)NCBI
ROS_Cfam_1.0 Ensembl363,444,950 - 63,462,417 (+)Ensembl
UMICH_Zoey_3.1362,936,851 - 62,953,518 (+)NCBI
UNSW_CanFamBas_1.0363,140,819 - 63,157,481 (+)NCBI
UU_Cfam_GSD_1.0363,500,293 - 63,516,958 (+)NCBI
Qdpr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528556,985,664 - 57,006,322 (+)NCBI
SpeTri2.0NW_00493647710,687,328 - 10,708,015 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
QDPR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl812,335,252 - 12,549,603 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1812,529,500 - 12,549,471 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2812,332,191 - 12,351,742 (-)NCBISscrofa10.2Sscrofa10.2susScr3
QDPR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12732,697,582 - 32,723,616 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2732,697,599 - 32,723,016 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604779,429,420 - 79,455,598 (+)NCBIVero_WHO_p1.0
Qdpr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475514,333,235 - 14,357,159 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462475514,333,308 - 14,353,949 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH142413  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21465,683,444 - 65,683,655 (+)MAPPERmRatBN7.2
Rnor_6.01470,177,876 - 70,178,086NCBIRnor6.0
Rnor_5.01470,221,060 - 70,221,270UniSTSRnor5.0
RGSC_v3.41470,755,192 - 70,755,402UniSTSRGSC3.4
Celera1464,664,544 - 64,664,754UniSTS
RH 3.4 Map14474.3UniSTS
Cytogenetic Map14q21UniSTS
RH127087  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21465,683,640 - 65,683,847 (+)MAPPERmRatBN7.2
mRatBN7.28819,421 - 819,628 (+)MAPPERmRatBN7.2
Rnor_6.08833,086 - 833,292NCBIRnor6.0
Rnor_6.01470,178,072 - 70,178,278NCBIRnor6.0
Rnor_5.01470,221,256 - 70,221,462UniSTSRnor5.0
Rnor_5.08836,484 - 836,690UniSTSRnor5.0
RGSC_v3.41470,755,388 - 70,755,594UniSTSRGSC3.4
RGSC_v3.48190,903 - 191,109UniSTSRGSC3.4
Celera8704,176 - 704,382UniSTS
Celera1464,664,740 - 64,664,946UniSTS
Cytogenetic Map8q11UniSTS
Cytogenetic Map14q21UniSTS
RH140863  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21465,683,591 - 65,683,788 (+)MAPPERmRatBN7.2
Rnor_6.01470,178,023 - 70,178,219NCBIRnor6.0
Rnor_5.01470,221,207 - 70,221,403UniSTSRnor5.0
RGSC_v3.41470,755,339 - 70,755,535UniSTSRGSC3.4
Celera1464,664,691 - 64,664,887UniSTS
RH 3.4 Map14459.47UniSTS
Cytogenetic Map14q21UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143999825175582726Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:87
Count of miRNA genes:66
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000004385
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 55 41 12 41 3 74 35 37 5
Low 8 2 7 8 8 4 6 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004385   ⟹   ENSRNOP00000004385
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1465,670,131 - 65,683,854 (+)Ensembl
Rnor_6.0 Ensembl1470,164,650 - 70,178,284 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115352   ⟹   ENSRNOP00000097613
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1465,670,169 - 65,683,331 (+)Ensembl
RefSeq Acc Id: NM_022390   ⟹   NP_071785
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21465,670,251 - 65,683,853 (+)NCBI
Rnor_6.01470,164,682 - 70,178,284 (+)NCBI
Rnor_5.01470,207,866 - 70,221,468 (+)NCBI
RGSC_v3.41470,741,998 - 70,755,600 (+)RGD
Celera1464,651,352 - 64,664,952 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_071785   ⟸   NM_022390
- UniProtKB: P11348 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004385   ⟸   ENSRNOT00000004385
RefSeq Acc Id: ENSRNOP00000097613   ⟸   ENSRNOT00000115352

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11348-F1-model_v2 AlphaFold P11348 1-241 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699350
Promoter ID:EPDNEW_R9874
Type:initiation region
Name:Qdpr_1
Description:quinoid dihydropteridine reductase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01470,164,650 - 70,164,710EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
14 70169287 70169288 A C snv FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), SBN/Ygl (MCW), WKY/N (MCW), FHH/EurMcwi (RGD), WKY/N (2020), SBN/Ygl (RGD), WKY/NCrl (RGD), WKY/NHsd (RGD), FHH/EurMcwi (2019), WKY/NCrl (2019), FHL/EurMcwi (RGD)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
14 70212471 70212472 A C snv FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), SBN/Ygl (MCW), FHH/EurMcwi (KNAW), FHL/EurMcwi (KNAW), IS-Tlk/Kyo (KyushuU), WKY/N (KNAW), WKY/NCrl (KNAW), WKY/NHsd (KNAW), Crl:SD (UDEL), IS/Kyo (KyushuU), SBN/Ygl (KNAW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
14 70746603 70746604 A C snv FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), FHH/EurMcwi (MDC), WKY/N (KNAW), WKY/NHsd (ICL), FHL/EurMcwi (ICL), SBN/Ygl (ICL), WKY/NCrl (ICL), FHH/EurMcwi (ICL)


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
14 65674856 65674857 A C snv FHH/EurMcwi (2019), WKY/N (2020), WKY/NCrl (2019)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619915 AgrOrtholog
BioCyc Gene G2FUF-15536 BioCyc
BioCyc Pathway PWY-8099 [tetrahydropteridine recycling] BioCyc
Ensembl Genes ENSRNOG00000003253 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000004385 ENTREZGENE
  ENSRNOP00000097613.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004385 ENTREZGENE
  ENSRNOT00000115352.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7103182 IMAGE-MGC_LOAD
InterPro NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot
  SDR_fam UniProtKB/Swiss-Prot
KEGG Report rno:64192 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91693 IMAGE-MGC_LOAD
NCBI Gene 64192 ENTREZGENE
Pfam adh_short UniProtKB/Swiss-Prot
PhenoGen Qdpr PhenoGen
PROSITE ADH_SHORT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
UniProt A0A8I6ARI8_RAT UniProtKB/TrEMBL
  DHPR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Qdpr  quinoid dihydropteridine reductase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Qdpr  quinoid dihydropteridine reductase      Symbol and Name status set to provisional 70820 PROVISIONAL