RGD Reference Report - Diminished expression of dihydropteridine reductase is a potent biomarker for hypertensive vessels. - Rat Genome Database

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Diminished expression of dihydropteridine reductase is a potent biomarker for hypertensive vessels.

Authors: Lee, CK  Han, JS  Won, KJ  Jung, SH  Park, HJ  Lee, HM  Kim, J  Park, YS  Kim, HJ  Park, PJ  Park, TK  Kim, B 
Citation: Lee CK, etal., Proteomics. 2009 Nov;9(21):4851-8.
RGD ID: 5128580
Pubmed: PMID:19743417   (View Abstract at PubMed)
DOI: DOI:10.1002/pmic.200800973   (Journal Full-text)

To identify the new targets for hypertension, we analyzed the protein expression profiles of aortic smooth muscle in spontaneously hypertensive rats (SHR) of various ages during the development of hypertension, as well as in age-matched normotensive Wistar-Kyoto (WKY) rats, using a proteomic analysis. The expressions of seven proteins were altered in SHR compared with WKY rats. Of these proteins, NADH dehydrogenase 1alpha, GSTomega1, peroxi-redoxin I and transgelin were upregulated in SHR compared with WKY rats. On the other hand, the expression of HSP27 and Ran protein decreased in SHR. The diminution of dihydrobiopterin reductase, an enzyme located in the regeneration pathways of tetrahydrobiopterin (BH4), was also prominent in SHR. The results from a PCR analysis revealed that the expression of BH4 biosynthesis enzymes - GTP cyclohydrolase-1 and sepiapterin reductase - decreased and increased, respectively, in SHR compared with WKY rats. The level of BH4 was less in aortic strips from SHR than from WKY rats. Moreover, treatment with BH4 inhibited aortic smooth muscle contraction induced by serotonin. These results suggest that the deficiency in BH4 regeneration produced by diminished dihydrobiopterin reductase expression is involved in vascular disorders in hypertensive rats.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension  ISOQdpr (Rattus norvegicus)5128580; 5128580protein:decreased expression:aorta smooth muscle (rat)RGD 
hypertension  IEP 5128580protein:decreased expression:aorta smooth muscle (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Qdpr  (quinoid dihydropteridine reductase)

Genes (Mus musculus)
Qdpr  (quinoid dihydropteridine reductase)

Genes (Homo sapiens)
QDPR  (quinoid dihydropteridine reductase)


Additional Information