Exhibits glucose:sodium symporter activity. Predicted to be involved in several processes, including alpha-glucoside transport; import across plasma membrane; and transepithelial water transport. Localizes to apical plasma membrane; brush border membrane; and cell-cell junction. Orthologous to human SLC5A1 (solute carrier family 5 member 1); PARTICIPATES IN lactose degradation pathway; sodium-glucose cotransporter mediated glucose transport pathway; trehalose degradation pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; acetamide; aldehydo-D-glucose.
high affinity sodium-glucose cotransporter; MGC93553; Na(+)/glucose cotransporter 1; SGLT1; SGLT1a; sodium/glucose cotransporter 1; solute carrier family 5 (sodium/glucose cotransporter), member 1; Solute carrier family 5 member alpha 1 (Na+/glucose cotransporter); solute carrier family 5, member 1; Solute carrier family 5, member alpha 1 (Na+/glucose cotransporter)
[gentamicin C results in decreased expression of SLC5A1 protein] which results in decreased uptake of Glucose, [Phlorhizin results in decreased activity of SLC5A1 protein] which results in decreased uptake of Glucose
[Cisplatin results in decreased expression of SLC5A1 mRNA] which affects the transport of Glucose, [Gentamicins results in decreased expression of SLC5A1 mRNA] which affects the transport of Glucose
[Cadmium binds to SLC5A1 protein] which affects the folding of SLC5A1 protein, Cadmium inhibits the reaction [SLC5A1 results in increased uptake of methylglucoside]
Cadmium inhibits the reaction [[SP1 protein binds to Zinc] which binds to SLC5A1 promoter], Zinc inhibits the reaction [Cadmium inhibits the reaction [[SP1 protein binds to Zinc] which binds to SLC5A1 promoter]]
[Cisplatin results in decreased expression of HNF1A mRNA] which results in decreased expression of SLC5A1 mRNA, Cisplatin results in decreased expression of SLC5A1 mRNA
[Cisplatin results in decreased expression of SLC5A1 mRNA] which affects the transport of Glucose, [Gentamicins results in decreased expression of SLC5A1 mRNA] which affects the transport of Glucose
[gentamicin C results in decreased expression of SLC5A1 protein] which results in decreased uptake of Glucose, [Phlorhizin results in decreased activity of SLC5A1 protein] which results in decreased uptake of Glucose
[Gentamicins results in decreased expression of HNF1A mRNA] which results in decreased expression of SLC5A1 mRNA, Gentamicins results in decreased expression of SLC5A1 mRNA
[Cisplatin results in decreased expression of SLC5A1 mRNA] which affects the transport of Glucose, [Gentamicins results in decreased expression of SLC5A1 mRNA] which affects the transport of Glucose
[gentamicin C results in decreased expression of SLC5A1 protein] which results in decreased uptake of Glucose, [Phlorhizin results in decreased activity of SLC5A1 protein] which results in decreased uptake of Glucose
Phlorhizin inhibits the reaction [[Sodium co-treated with SLC5A1 protein] results in increased uptake of methylglucoside], Phlorhizin inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside]
Cadmium inhibits the reaction [[SP1 protein binds to Zinc] which binds to SLC5A1 promoter], Zinc inhibits the reaction [Cadmium inhibits the reaction [[SP1 protein binds to Zinc] which binds to SLC5A1 promoter]]
zinc chloride inhibits the reaction [Cadmium Chloride inhibits the reaction [SP1 protein binds to and affects the expression of SLC5A1 promoter]], zinc chloride inhibits the reaction [Cadmium Chloride results in decreased expression of SLC5A1 mRNA]
Cadmium inhibits the reaction [[SP1 protein binds to Zinc] which binds to SLC5A1 promoter], Zinc inhibits the reaction [Cadmium inhibits the reaction [[SP1 protein binds to Zinc] which binds to SLC5A1 promoter]]
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
localized to apical plasma membrane in epithelial cells of small intestine and kidney; amino acid Asp28 is important for localization to the apical plasma membrane