Dbnl (drebrin-like) - Rat Genome Database
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Gene: Dbnl (drebrin-like) Rattus norvegicus
Analyze
Symbol: Dbnl
Name: drebrin-like
RGD ID: 70941
Description: Exhibits protein C-terminus binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; nervous system development; and podosome assembly. Localizes to dendrite and postsynaptic density. Predicted to colocalize with actin filament. Orthologous to human DBNL (drebrin like); INTERACTS WITH 2-methoxyethanol; acetamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: abp1; actin-binding protein 1; drebrin-like protein; SH3 domain-containing protein 7; Sh3p7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21480,666,115 - 80,681,155 (+)NCBI
Rnor_6.0 Ensembl1486,029,335 - 86,044,364 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01486,029,335 - 86,044,364 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01486,721,144 - 86,736,173 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41486,450,448 - 86,481,863 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11486,469,592 - 86,484,067 (+)NCBI
Celera1479,551,079 - 79,566,108 (+)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:9630982   PMID:10637315   PMID:12913069   PMID:15489334   PMID:16641100   PMID:18829961   PMID:19056867   PMID:22303001   PMID:24802081   PMID:25468996   PMID:28235806   PMID:30053369  


Genomics

Comparative Map Data
Dbnl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21480,666,115 - 80,681,155 (+)NCBI
Rnor_6.0 Ensembl1486,029,335 - 86,044,364 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01486,029,335 - 86,044,364 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01486,721,144 - 86,736,173 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41486,450,448 - 86,481,863 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11486,469,592 - 86,484,067 (+)NCBI
Celera1479,551,079 - 79,566,108 (+)NCBICelera
Cytogenetic Map14q21NCBI
DBNL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl744,044,640 - 44,069,456 (+)EnsemblGRCh38hg38GRCh38
GRCh38744,044,702 - 44,069,456 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37744,084,301 - 44,109,055 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37744,084,239 - 44,101,315 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36744,050,830 - 44,067,840 (+)NCBINCBI36hg18NCBI36
Celera744,182,185 - 44,199,260 (+)NCBI
Cytogenetic Map7p13NCBI
HuRef743,969,523 - 43,986,598 (+)NCBIHuRef
CHM1_1744,088,113 - 44,105,189 (+)NCBICHM1_1
CRA_TCAGchr7v2744,123,733 - 44,140,805 (+)NCBI
Dbnl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39115,730,233 - 5,750,980 (+)NCBIGRCm39mm39
GRCm38115,788,483 - 5,800,980 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl115,788,488 - 5,800,962 (+)EnsemblGRCm38mm10GRCm38
MGSCv37115,688,486 - 5,700,983 (+)NCBIGRCm37mm9NCBIm37
MGSCv36115,688,533 - 5,700,965 (+)NCBImm8
Celera116,278,834 - 6,291,141 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.87NCBI
Dbnl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554567,912,827 - 7,924,787 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554567,912,827 - 7,924,373 (-)NCBIChiLan1.0ChiLan1.0
DBNL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1744,824,537 - 44,842,059 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl744,824,608 - 44,845,891 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0744,753,062 - 44,775,717 (+)NCBIMhudiblu_PPA_v0panPan3
DBNL
(Canis lupus familiaris - dog)
No map positions available.
Dbnl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647819,007,630 - 19,021,068 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DBNL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1848,713,340 - 48,725,697 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11848,713,335 - 48,725,692 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21853,426,424 - 53,438,753 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DBNL
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12114,610,196 - 14,627,363 (-)NCBI
ChlSab1.1 Ensembl2114,608,571 - 14,627,321 (-)Ensembl
Dbnl
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247407,950,552 - 7,960,592 (-)NCBI

Position Markers
D14Mgh1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01486,048,043 - 86,048,147NCBIRnor6.0
Rnor_5.01486,739,852 - 86,739,956UniSTSRnor5.0
RGSC_v3.41486,469,093 - 86,469,197UniSTSRGSC3.4
Celera1479,569,638 - 79,569,742UniSTS
RH 3.4 Map14571.5UniSTS
RH 3.4 Map14571.5RGD
RH 2.0 Map14702.9RGD
SHRSP x BN Map1444.8999RGD
Cytogenetic Map14q21-q22UniSTS
Cytogenetic Map14q21UniSTS
D14Rat19  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01486,047,530 - 86,047,691NCBIRnor6.0
Rnor_5.01486,739,339 - 86,739,500UniSTSRnor5.0
RGSC_v3.41486,468,542 - 86,468,937RGDRGSC3.4
RGSC_v3.41486,468,580 - 86,468,741UniSTSRGSC3.4
RGSC_v3.11486,487,725 - 86,487,886RGD
RH 3.4 Map14571.5RGD
RH 3.4 Map14571.5UniSTS
RH 2.0 Map14702.7RGD
SHRSP x BN Map1445.38RGD
Cytogenetic Map14q21-q22UniSTS
Cytogenetic Map14q21UniSTS
AW532217  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01486,054,068 - 86,054,166NCBIRnor6.0
Rnor_5.01486,745,877 - 86,745,975UniSTSRnor5.0
RGSC_v3.41486,475,118 - 86,475,216UniSTSRGSC3.4
Celera1479,575,631 - 79,575,729UniSTS
RH 3.4 Map14572.7UniSTS
Cytogenetic Map14q21UniSTS
AW527377  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01486,046,159 - 86,046,322NCBIRnor6.0
Rnor_5.01486,737,968 - 86,738,131UniSTSRnor5.0
RGSC_v3.41486,467,209 - 86,467,372UniSTSRGSC3.4
Celera1479,567,903 - 79,568,066UniSTS
RH 3.4 Map14571.5UniSTS
Cytogenetic Map14q21UniSTS
Cytogenetic Map14q21-q22UniSTS
AI713198  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01486,044,139 - 86,044,293NCBIRnor6.0
Rnor_5.01486,735,948 - 86,736,102UniSTSRnor5.0
RGSC_v3.41486,465,189 - 86,465,343UniSTSRGSC3.4
Celera1479,565,883 - 79,566,037UniSTS
RH 3.4 Map14573.2UniSTS
Cytogenetic Map14q21UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1412680424106641756Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143259392686191589Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1442442731108833671Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1443910761105074364Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1451818462105074364Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1460980905105980905Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1460980905105980905Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)146187332388870994Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1461993178106993178Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1463548095108548095Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147339146788870994Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1478172765102549388Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)1478172765102549388Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1478172765102549388Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1478172765102549388Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1478172765106641756Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1478446303110402569Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1480049285115493446Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1480049285115493446Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)1485307663106641756Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:293
Count of miRNA genes:183
Interacting mature miRNAs:201
Transcripts:ENSRNOT00000017375
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 57 41 19 41 8 11 74 35 41 11 8
Low 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001277211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001277212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001277213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB009346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB038364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB038365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC128636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000017375   ⟹   ENSRNOP00000017375
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1486,029,335 - 86,044,364 (+)Ensembl
RefSeq Acc Id: NM_001277211   ⟹   NP_001264140
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21480,666,124 - 80,681,155 (+)NCBI
Rnor_6.01486,029,335 - 86,044,364 (+)NCBI
Rnor_5.01486,721,144 - 86,736,173 (+)NCBI
Celera1479,551,079 - 79,566,108 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001277212   ⟹   NP_001264141
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21480,666,124 - 80,681,155 (+)NCBI
Rnor_6.01486,029,335 - 86,044,364 (+)NCBI
Rnor_5.01486,721,144 - 86,736,173 (+)NCBI
Celera1479,551,079 - 79,566,108 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001277213   ⟹   NP_001264142
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21480,666,124 - 80,681,155 (+)NCBI
Rnor_6.01486,029,335 - 86,044,364 (+)NCBI
Rnor_5.01486,721,144 - 86,736,173 (+)NCBI
Celera1479,551,079 - 79,566,108 (+)NCBI
Sequence:
RefSeq Acc Id: NM_031352   ⟹   NP_112642
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21480,666,124 - 80,681,155 (+)NCBI
Rnor_6.01486,029,335 - 86,044,364 (+)NCBI
Rnor_5.01486,721,144 - 86,736,173 (+)NCBI
RGSC_v3.41486,450,448 - 86,481,863 (+)RGD
Celera1479,551,079 - 79,566,108 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039092498   ⟹   XP_038948426
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21480,676,097 - 80,681,155 (+)NCBI
RefSeq Acc Id: XM_039092499   ⟹   XP_038948427
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21480,666,115 - 80,678,024 (+)NCBI
RefSeq Acc Id: XM_039092500   ⟹   XP_038948428
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21480,666,115 - 80,678,024 (+)NCBI
RefSeq Acc Id: XM_039092501   ⟹   XP_038948429
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21480,666,115 - 80,678,024 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_112642   ⟸   NM_031352
- Peptide Label: isoform 2
- UniProtKB: Q9JHL4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001264140   ⟸   NM_001277211
- Peptide Label: isoform 1
- UniProtKB: Q9JHL4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001264141   ⟸   NM_001277212
- Peptide Label: isoform 3
- UniProtKB: Q9JHL4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001264142   ⟸   NM_001277213
- Peptide Label: isoform 4
- UniProtKB: Q9JHL4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017375   ⟸   ENSRNOT00000017375
RefSeq Acc Id: XP_038948427   ⟸   XM_039092499
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038948428   ⟸   XM_039092500
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038948429   ⟸   XM_039092501
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038948426   ⟸   XM_039092498
- Peptide Label: isoform X1
Protein Domains
ADF-H   SH3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699461
Promoter ID:EPDNEW_R9985
Type:initiation region
Name:Dbnl_1
Description:drebrin-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01486,029,375 - 86,029,435EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
14 86732497 86732498 A G snv SR/JrHsd (MCW), FHH/EurMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70941 AgrOrtholog
Ensembl Genes ENSRNOG00000012378 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000017375 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017375 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.20.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7104722 IMAGE-MGC_LOAD
InterPro ADF-H UniProtKB/Swiss-Prot
  ADF-H/Gelsolin-like_dom_sf UniProtKB/Swiss-Prot
  Dbnl UniProtKB/Swiss-Prot
  Drebrin-like_SH3 UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
KEGG Report rno:83527 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91641 IMAGE-MGC_LOAD
NCBI Gene 83527 ENTREZGENE
PANTHER PTHR10829:SF12 UniProtKB/Swiss-Prot
Pfam Cofilin_ADF UniProtKB/Swiss-Prot
  SH3_9 UniProtKB/Swiss-Prot
PhenoGen Dbnl PhenoGen
PROSITE ADF_H UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
SMART ADF UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot
UniProt DBNL_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9JM66 UniProtKB/Swiss-Prot
  Q9JM67 UniProtKB/Swiss-Prot
  Q9JM74 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Dbnl  drebrin-like      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a drebrin homology sequence and a cortactin homology sequence (SH3 domain) 70709