Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Igfbp3 (insulin-like growth factor binding protein 3) Rattus norvegicus
Symbol: Igfbp3
Name: insulin-like growth factor binding protein 3
Description: Exhibits insulin-like growth factor II binding activity. Involved in several processes, including cellular response to Thyroglobulin triiodothyronine; positive regulation of apoptotic process; and response to peptide hormone. Localizes to several cellular components, including insulin-like growth factor binary complex; insulin-like growth factor ternary complex; and platelet alpha granule. Used to study impotence. Biomarker of congenital diaphragmatic hernia; impotence; and obesity. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Orthologous to human IGFBP3 (insulin like growth factor binding protein 3); PARTICIPATES IN insulin-like growth factor signaling pathway; p53 signaling pathway; INTERACTS WITH (+)-pilocarpine; (R)-lipoic acid; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IBP-3; IGF-binding protein 3; IGF-BP3; IGFBP-3; Insulin-like growth factor-binding protein (IGF-BP3); insulin-like growth factor-binding protein 3; MGC156773
Homo sapiens (human) : IGFBP3 (insulin like growth factor binding protein 3)  HGNC  Alliance
Mus musculus (house mouse) : Igfbp3 (insulin-like growth factor binding protein 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Igfbp3 (insulin like growth factor binding protein 3)
Pan paniscus (bonobo/pygmy chimpanzee) : IGFBP3 (insulin like growth factor binding protein 3)
Canis lupus familiaris (dog) : IGFBP3 (insulin like growth factor binding protein 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Igfbp3 (insulin like growth factor binding protein 3)
Sus scrofa (pig) : IGFBP3 (insulin like growth factor binding protein 3)
Chlorocebus sabaeus (African green monkey) : IGFBP3 (insulin like growth factor binding protein 3)
Heterocephalus glaber (naked mole-rat) : Igfbp3 (insulin like growth factor binding protein 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01487,457,647 - 87,465,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1487,457,647 - 87,465,374 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01481,091,987 - 81,099,675 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41487,959,153 - 87,967,085 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11487,978,297 - 87,986,223 (-)NCBI
Celera1481,130,767 - 81,138,473 (-)NCBICelera
Cytogenetic Map14q21NCBI
RH 3.4 Map14598.5RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Igfbp3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2874
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.