Grb10 (growth factor receptor bound protein 10) - Rat Genome Database

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Gene: Grb10 (growth factor receptor bound protein 10) Rattus norvegicus
Analyze
Symbol: Grb10
Name: growth factor receptor bound protein 10
RGD ID: 1566234
Description: Enables insulin receptor binding activity. Involved in insulin receptor signaling pathway; negative regulation of glycogen biosynthetic process; and positive regulation of phosphorylation. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Orthologous to human GRB10 (growth factor receptor bound protein 10); PARTICIPATES IN insulin signaling pathway; insulin-like growth factor signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GRB10 adapter protein; Growth factor receptor-bound protein 10; LOC498416; RGD1566234; similar to Grb10 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81490,708,653 - 90,816,399 (-)NCBIGRCr8
mRatBN7.21486,495,051 - 86,602,800 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1486,495,054 - 86,602,806 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1490,900,844 - 91,008,544 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01492,145,178 - 92,252,882 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01488,612,820 - 88,720,522 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01492,021,851 - 92,122,249 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1492,021,851 - 92,117,923 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01491,818,383 - 91,914,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41492,814,797 - 92,911,442 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1485,495,882 - 85,591,916 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-phenylbutyric acid  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-(hydroxymethyl)cytosine  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
ethanol  (ISO)
fenpyroximate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
hydroquinone  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP)
N(4)-hydroxycytidine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentane-2,3-dione  (EXP)
perfluorooctanoic acid  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP,ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiophenes  (ISO)
thiram  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1. Liu M, etal., Cell Metab. 2014 Jun 3;19(6):967-80. doi: 10.1016/j.cmet.2014.03.018. Epub 2014 Apr 17.
3. Specific inhibition by hGRB10zeta of insulin-induced glycogen synthase activation: evidence for a novel signaling pathway. Mounier C, etal., Mol Cell Endocrinol. 2001 Feb 28;173(1-2):15-27.
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Regulation of insulin receptor function. Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91.
Additional References at PubMed
PMID:9062339   PMID:12771153   PMID:15060076   PMID:15664450   PMID:17376403   PMID:19648926   PMID:20878056   PMID:23614367   PMID:24149516   PMID:26941017  


Genomics

Comparative Map Data
Grb10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81490,708,653 - 90,816,399 (-)NCBIGRCr8
mRatBN7.21486,495,051 - 86,602,800 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1486,495,054 - 86,602,806 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1490,900,844 - 91,008,544 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01492,145,178 - 92,252,882 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01488,612,820 - 88,720,522 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01492,021,851 - 92,122,249 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1492,021,851 - 92,117,923 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01491,818,383 - 91,914,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41492,814,797 - 92,911,442 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1485,495,882 - 85,591,916 (-)NCBICelera
Cytogenetic Map14q21NCBI
GRB10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38750,590,068 - 50,793,453 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl750,590,063 - 50,793,462 (-)EnsemblGRCh38hg38GRCh38
GRCh37750,657,765 - 50,861,150 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36750,625,259 - 50,828,652 (-)NCBINCBI36Build 36hg18NCBI36
Build 34750,431,974 - 50,574,259NCBI
Celera750,722,672 - 50,926,043 (-)NCBICelera
Cytogenetic Map7p12.1NCBI
HuRef750,507,724 - 50,673,735 (-)NCBIHuRef
CHM1_1750,660,053 - 50,863,458 (-)NCBICHM1_1
T2T-CHM13v2.0750,751,214 - 50,954,643 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2750,663,826 - 50,867,195 (-)NCBI
Grb10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391111,880,499 - 11,987,428 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1111,880,508 - 11,988,683 (-)EnsemblGRCm39 Ensembl
GRCm381111,930,499 - 12,037,428 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1111,930,508 - 12,038,683 (-)EnsemblGRCm38mm10GRCm38
MGSCv371111,830,502 - 11,937,423 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361111,830,511 - 11,937,358 (-)NCBIMGSCv36mm8
Celera1112,389,743 - 12,487,174 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map117.15NCBI
Grb10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554563,470,330 - 3,509,667 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554563,405,730 - 3,508,967 (+)NCBIChiLan1.0ChiLan1.0
GRB10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2655,467,134 - 55,670,188 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17103,791,857 - 103,995,352 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0751,230,945 - 51,434,560 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1751,474,166 - 51,676,864 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl751,474,166 - 51,666,638 (-)Ensemblpanpan1.1panPan2
GRB10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1181,890,689 - 2,014,836 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl181,890,792 - 2,014,839 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha181,881,459 - 2,037,594 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0181,948,998 - 2,105,497 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl181,949,030 - 2,072,043 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1181,921,393 - 2,077,726 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0181,917,858 - 2,074,464 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0182,055,100 - 2,210,940 (-)NCBIUU_Cfam_GSD_1.0
Grb10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118105,243,956 - 105,420,568 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366861,201,882 - 1,279,600 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366861,102,706 - 1,279,594 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRB10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9136,580,362 - 136,741,756 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19136,580,363 - 136,742,552 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29150,268,567 - 150,398,500 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRB10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,022,483 - 8,225,339 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl218,063,238 - 8,225,664 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606214,134,900 - 14,353,540 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grb10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247403,628,252 - 3,668,151 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247403,562,758 - 3,668,761 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grb10
298 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:261
Count of miRNA genes:173
Interacting mature miRNAs:198
Transcripts:ENSRNOT00000044726
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
4889951Bss92Bone structure and strength QTL 923.9tibia area (VT:1000281)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)148205747195876975Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001401403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000044726   ⟹   ENSRNOP00000048487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1486,495,054 - 86,591,114 (-)Ensembl
Rnor_6.0 Ensembl1492,021,851 - 92,117,923 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085175   ⟹   ENSRNOP00000070674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1486,495,064 - 86,602,806 (-)Ensembl
Rnor_6.0 Ensembl1492,023,784 - 92,077,088 (-)Ensembl
RefSeq Acc Id: NM_001401403   ⟹   NP_001388332
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,708,653 - 90,816,387 (-)NCBI
mRatBN7.21486,495,051 - 86,602,800 (-)NCBI
RefSeq Acc Id: NM_001401404   ⟹   NP_001388333
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,708,653 - 90,816,387 (-)NCBI
mRatBN7.21486,495,051 - 86,602,800 (-)NCBI
RefSeq Acc Id: XM_039092307   ⟹   XP_038948235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,708,662 - 90,804,836 (-)NCBI
mRatBN7.21486,495,055 - 86,591,301 (-)NCBI
RefSeq Acc Id: XM_039092308   ⟹   XP_038948236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,708,662 - 90,804,241 (-)NCBI
mRatBN7.21486,495,055 - 86,590,687 (-)NCBI
RefSeq Acc Id: XM_039092309   ⟹   XP_038948237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,708,662 - 90,804,241 (-)NCBI
mRatBN7.21486,495,055 - 86,590,687 (-)NCBI
RefSeq Acc Id: XM_039092310   ⟹   XP_038948238
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,708,662 - 90,803,490 (-)NCBI
mRatBN7.21486,495,055 - 86,590,026 (-)NCBI
RefSeq Acc Id: XM_039092311   ⟹   XP_038948239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,708,662 - 90,804,832 (-)NCBI
mRatBN7.21486,495,055 - 86,591,301 (-)NCBI
RefSeq Acc Id: XM_039092313   ⟹   XP_038948241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,708,662 - 90,804,843 (-)NCBI
mRatBN7.21486,495,055 - 86,591,319 (-)NCBI
RefSeq Acc Id: XM_039092315   ⟹   XP_038948243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,708,662 - 90,804,236 (-)NCBI
mRatBN7.21486,495,055 - 86,590,686 (-)NCBI
RefSeq Acc Id: XM_039092316   ⟹   XP_038948244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,708,662 - 90,804,236 (-)NCBI
mRatBN7.21486,495,055 - 86,590,686 (-)NCBI
RefSeq Acc Id: XM_039092317   ⟹   XP_038948245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,708,662 - 90,803,484 (-)NCBI
mRatBN7.21486,495,055 - 86,590,025 (-)NCBI
RefSeq Acc Id: XM_063273486   ⟹   XP_063129556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,708,662 - 90,805,930 (-)NCBI
RefSeq Acc Id: XM_063273487   ⟹   XP_063129557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,708,662 - 90,805,981 (-)NCBI
RefSeq Acc Id: XM_063273488   ⟹   XP_063129558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,708,662 - 90,808,250 (-)NCBI
RefSeq Acc Id: XM_063273489   ⟹   XP_063129559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,708,662 - 90,816,399 (-)NCBI
RefSeq Acc Id: XM_063273490   ⟹   XP_063129560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,708,662 - 90,804,838 (-)NCBI
RefSeq Acc Id: XM_063273491   ⟹   XP_063129561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,708,662 - 90,816,399 (-)NCBI
RefSeq Acc Id: XM_063273492   ⟹   XP_063129562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81490,708,662 - 90,805,933 (-)NCBI
Ensembl Acc Id: ENSRNOP00000070674   ⟸   ENSRNOT00000085175
Ensembl Acc Id: ENSRNOP00000048487   ⟸   ENSRNOT00000044726
RefSeq Acc Id: XP_038948241   ⟸   XM_039092313
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038948239   ⟸   XM_039092311
- Peptide Label: isoform X2
- UniProtKB: A0A9M1XG80 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948235   ⟸   XM_039092307
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038948236   ⟸   XM_039092308
- Peptide Label: isoform X4
- UniProtKB: A0A0G2JYJ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948237   ⟸   XM_039092309
- Peptide Label: isoform X4
- UniProtKB: A0A0G2JYJ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948243   ⟸   XM_039092315
- Peptide Label: isoform X5
- UniProtKB: P0CE43 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038948244   ⟸   XM_039092316
- Peptide Label: isoform X5
- UniProtKB: P0CE43 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038948238   ⟸   XM_039092310
- Peptide Label: isoform X4
- UniProtKB: A0A0G2JYJ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948245   ⟸   XM_039092317
- Peptide Label: isoform X5
- UniProtKB: P0CE43 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001388332   ⟸   NM_001401403
- Peptide Label: isoform 1
- UniProtKB: P0CE43 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001388333   ⟸   NM_001401404
- Peptide Label: isoform 2
- UniProtKB: A0A0G2JYJ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129561   ⟸   XM_063273491
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063129559   ⟸   XM_063273489
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063129558   ⟸   XM_063273488
- Peptide Label: isoform X5
- UniProtKB: P0CE43 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063129557   ⟸   XM_063273487
- Peptide Label: isoform X5
- UniProtKB: P0CE43 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063129562   ⟸   XM_063273492
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063129556   ⟸   XM_063273486
- Peptide Label: isoform X4
- UniProtKB: A0A0G2JYJ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129560   ⟸   XM_063273490
- Peptide Label: isoform X7
Protein Domains
PH   Ras-associating   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0CE43-F1-model_v2 AlphaFold P0CE43 1-599 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566234 AgrOrtholog
BioCyc Gene G2FUF-14986 BioCyc
Ensembl Genes ENSRNOG00000004290 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044726.5 UniProtKB/TrEMBL
  ENSRNOT00000085175.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BPS-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GRB/APBB1IP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Grb10_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_APBB1IP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 498416 ENTREZGENE
PANTHER PTHR11243 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11243:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00788 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grb10 PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004290 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00314 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JYJ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A9M1XG80 ENTREZGENE, UniProtKB/TrEMBL
  GRB10_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Grb10  growth factor receptor bound protein 10  RGD1566234_predicted  similar to Grb10 protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1566234_predicted  similar to Grb10 protein (predicted)  LOC498416  similar to Grb10 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498416  similar to Grb10 protein      Symbol and Name status set to provisional 70820 PROVISIONAL