Grb10 (growth factor receptor bound protein 10) - Rat Genome Database

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Gene: Grb10 (growth factor receptor bound protein 10) Rattus norvegicus
Analyze
Symbol: Grb10
Name: growth factor receptor bound protein 10
RGD ID: 1566234
Description: Exhibits insulin receptor binding activity. Involved in insulin receptor signaling pathway; negative regulation of glycogen biosynthetic process; and positive regulation of phosphorylation. Predicted to localize to protein-containing complex. Orthologous to human GRB10 (growth factor receptor bound protein 10); PARTICIPATES IN insulin signaling pathway; insulin-like growth factor signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: GRB10 adapter protein; Growth factor receptor-bound protein 10; LOC498416; RGD1566234; similar to Grb10 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21486,495,054 - 86,602,815 (-)NCBI
Rnor_6.0 Ensembl1492,021,851 - 92,117,923 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01492,021,851 - 92,122,249 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01491,818,383 - 91,914,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41492,814,797 - 92,911,442 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1485,495,882 - 85,591,916 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-phenylbutyric acid  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-(hydroxymethyl)cytosine  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
glycidol  (EXP)
hydroquinone  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctanoic acid  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiophenes  (ISO)
topotecan  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

References

Additional References at PubMed
PMID:9062339   PMID:12771153   PMID:15060076   PMID:15664450   PMID:17376403   PMID:19648926   PMID:20878056   PMID:23614367   PMID:24149516   PMID:26941017  


Genomics

Comparative Map Data
Grb10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21486,495,054 - 86,602,815 (-)NCBI
Rnor_6.0 Ensembl1492,021,851 - 92,117,923 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01492,021,851 - 92,122,249 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01491,818,383 - 91,914,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41492,814,797 - 92,911,442 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1485,495,882 - 85,591,916 (-)NCBICelera
Cytogenetic Map14q21NCBI
GRB10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl750,590,063 - 50,793,462 (-)EnsemblGRCh38hg38GRCh38
GRCh38750,590,068 - 50,793,453 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37750,657,765 - 50,861,150 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36750,625,259 - 50,828,652 (-)NCBINCBI36hg18NCBI36
Build 34750,431,974 - 50,574,259NCBI
Celera750,722,672 - 50,926,043 (-)NCBI
Cytogenetic Map7p12.1NCBI
HuRef750,507,724 - 50,673,735 (-)NCBIHuRef
CHM1_1750,660,053 - 50,863,458 (-)NCBICHM1_1
CRA_TCAGchr7v2750,663,826 - 50,867,195 (-)NCBI
Grb10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391111,880,499 - 11,987,428 (-)NCBIGRCm39mm39
GRCm39 Ensembl1111,880,508 - 11,988,683 (-)Ensembl
GRCm381111,930,499 - 12,037,428 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1111,930,508 - 12,038,683 (-)EnsemblGRCm38mm10GRCm38
MGSCv371111,830,502 - 11,937,423 (-)NCBIGRCm37mm9NCBIm37
MGSCv361111,830,511 - 11,937,358 (-)NCBImm8
Celera1112,389,743 - 12,487,174 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map117.15NCBI
Grb10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554563,470,330 - 3,509,667 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554563,405,730 - 3,508,967 (+)NCBIChiLan1.0ChiLan1.0
GRB10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1751,474,166 - 51,676,864 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl751,474,166 - 51,666,638 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0751,230,945 - 51,434,560 (-)NCBIMhudiblu_PPA_v0panPan3
GRB10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1181,890,689 - 2,014,836 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl181,890,792 - 2,014,839 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha181,881,459 - 2,037,594 (-)NCBI
ROS_Cfam_1.0181,948,998 - 2,105,497 (-)NCBI
UMICH_Zoey_3.1181,921,393 - 2,077,726 (-)NCBI
UNSW_CanFamBas_1.0181,917,858 - 2,074,464 (-)NCBI
UU_Cfam_GSD_1.0182,055,100 - 2,210,940 (-)NCBI
Grb10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118105,243,956 - 105,420,568 (-)NCBI
SpeTri2.0NW_0049366861,102,706 - 1,279,594 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRB10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9136,580,362 - 136,742,532 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19136,580,363 - 136,742,552 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29150,268,567 - 150,398,500 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRB10
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,022,483 - 8,225,339 (+)NCBI
ChlSab1.1 Ensembl218,063,238 - 8,225,664 (+)Ensembl
Vero_WHO_p1.0NW_02366606214,134,900 - 14,353,540 (-)NCBI
Grb10
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247403,562,758 - 3,668,761 (+)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1412680424106641756Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1442442731108833671Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1443910761105074364Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1451818462105074364Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1460980905105980905Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1460980905105980905Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1461993178106993178Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1463548095108548095Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1478172765102549388Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)1478172765102549388Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1478172765102549388Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1478172765102549388Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1478172765106641756Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1478446303110402569Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1480049285115493446Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1480049285115493446Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)1485307663106641756Rat
4889951Bss92Bone structure and strength QTL 923.9tibia area (VT:1000281)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)1487458772106641756Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:261
Count of miRNA genes:173
Interacting mature miRNAs:198
Transcripts:ENSRNOT00000044726
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 42 36 27 3 27 8 11 74 35 40 11 8
Low 3 1 21 14 16 14 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001109093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000044726   ⟹   ENSRNOP00000048487
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1492,021,851 - 92,117,923 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085175   ⟹   ENSRNOP00000070674
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1492,023,784 - 92,077,088 (-)Ensembl
RefSeq Acc Id: NM_001109093   ⟹   NP_001102563
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21486,495,054 - 86,591,114 (-)NCBI
Rnor_6.01492,021,851 - 92,117,923 (-)NCBI
Rnor_5.01491,818,383 - 91,914,937 (-)NCBI
RGSC_v3.41492,814,797 - 92,911,442 (-)RGD
Celera1485,495,882 - 85,591,916 (-)RGD
Sequence:
RefSeq Acc Id: XM_008770347   ⟹   XP_008768569
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01492,021,852 - 92,077,028 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770348   ⟹   XP_008768570
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01492,021,852 - 92,077,028 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599333   ⟹   XP_017454822
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01492,021,852 - 92,122,249 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092307   ⟹   XP_038948235
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21486,495,055 - 86,591,301 (-)NCBI
RefSeq Acc Id: XM_039092308   ⟹   XP_038948236
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21486,495,055 - 86,590,687 (-)NCBI
RefSeq Acc Id: XM_039092309   ⟹   XP_038948237
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21486,495,055 - 86,590,687 (-)NCBI
RefSeq Acc Id: XM_039092310   ⟹   XP_038948238
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21486,495,055 - 86,590,026 (-)NCBI
RefSeq Acc Id: XM_039092311   ⟹   XP_038948239
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21486,495,055 - 86,591,301 (-)NCBI
RefSeq Acc Id: XM_039092313   ⟹   XP_038948241
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21486,495,055 - 86,591,319 (-)NCBI
RefSeq Acc Id: XM_039092314   ⟹   XP_038948242
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21486,495,055 - 86,602,815 (-)NCBI
RefSeq Acc Id: XM_039092315   ⟹   XP_038948243
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21486,495,055 - 86,590,686 (-)NCBI
RefSeq Acc Id: XM_039092316   ⟹   XP_038948244
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21486,495,055 - 86,590,686 (-)NCBI
RefSeq Acc Id: XM_039092317   ⟹   XP_038948245
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21486,495,055 - 86,590,025 (-)NCBI
RefSeq Acc Id: XM_039092318   ⟹   XP_038948246
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21486,495,055 - 86,602,815 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001102563   ⟸   NM_001109093
- UniProtKB: D3ZEA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768570   ⟸   XM_008770348
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008768569   ⟸   XM_008770347
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017454822   ⟸   XM_017599333
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000070674   ⟸   ENSRNOT00000085175
RefSeq Acc Id: ENSRNOP00000048487   ⟸   ENSRNOT00000044726
RefSeq Acc Id: XP_038948242   ⟸   XM_039092314
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038948246   ⟸   XM_039092318
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038948241   ⟸   XM_039092313
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038948239   ⟸   XM_039092311
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038948235   ⟸   XM_039092307
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038948236   ⟸   XM_039092308
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038948237   ⟸   XM_039092309
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038948243   ⟸   XM_039092315
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038948244   ⟸   XM_039092316
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038948238   ⟸   XM_039092310
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038948245   ⟸   XM_039092317
- Peptide Label: isoform X5
Protein Domains
PH   Ras-associating   SH2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566234 AgrOrtholog
Ensembl Genes ENSRNOG00000004290 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000048487 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000070674 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044726 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000085175 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BPS-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GRB/APBB1IP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Grb10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Grb10_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_APBB1IP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:498416 UniProtKB/TrEMBL
NCBI Gene 498416 ENTREZGENE
PANTHER PTHR11243 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11243:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00788 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grb10 PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00314 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JYJ1_RAT UniProtKB/TrEMBL
  D3ZEA3 ENTREZGENE, UniProtKB/TrEMBL
  GRB10_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Grb10  growth factor receptor bound protein 10  RGD1566234_predicted  similar to Grb10 protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1566234_predicted  similar to Grb10 protein (predicted)  LOC498416  similar to Grb10 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498416  similar to Grb10 protein      Symbol and Name status set to provisional 70820 PROVISIONAL