Dnaaf10 (dynein axonemal assembly factor 10) - Rat Genome Database

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Gene: Dnaaf10 (dynein axonemal assembly factor 10) Rattus norvegicus
Analyze
Symbol: Dnaaf10
Name: dynein axonemal assembly factor 10
RGD ID: 1563863
Description: Predicted to enable ubiquitin binding activity. Predicted to be part of RPAP3/R2TP/prefoldin-like complex. Orthologous to human DNAAF10 (dynein axonemal assembly factor 10); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide.
Type: protein-coding (Ensembl: lncRNA)
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC498418; LOC498418; RGD1563863; similar to expressed sequence AI553587; uncharacterized protein LOC498418; WD repeat domain 92; WD repeat-containing protein 92; Wdr92
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81495,820,272 - 95,841,449 (+)NCBIGRCr8
mRatBN7.21491,618,649 - 91,639,828 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1491,636,157 - 91,639,831 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1495,925,809 - 95,947,056 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01497,170,145 - 97,191,392 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01493,635,211 - 93,656,458 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014100,373,129 - 100,394,143 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14100,373,129 - 100,394,145 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014100,145,261 - 100,166,378 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41498,111,358 - 98,132,525 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1490,664,802 - 90,685,803 (+)NCBICelera
Cytogenetic Map14q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Dnaaf10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81495,820,272 - 95,841,449 (+)NCBIGRCr8
mRatBN7.21491,618,649 - 91,639,828 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1491,636,157 - 91,639,831 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1495,925,809 - 95,947,056 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01497,170,145 - 97,191,392 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01493,635,211 - 93,656,458 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014100,373,129 - 100,394,143 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14100,373,129 - 100,394,145 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014100,145,261 - 100,166,378 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41498,111,358 - 98,132,525 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1490,664,802 - 90,685,803 (+)NCBICelera
Cytogenetic Map14q22NCBI
DNAAF10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38268,129,805 - 68,157,527 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl268,122,936 - 68,157,549 (-)EnsemblGRCh38hg38GRCh38
GRCh37268,356,937 - 68,384,659 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36268,210,785 - 68,238,160 (-)NCBINCBI36Build 36hg18NCBI36
Celera268,206,901 - 68,234,275 (-)NCBICelera
Cytogenetic Map2p14NCBI
HuRef268,094,729 - 68,122,177 (-)NCBIHuRef
CHM1_1268,278,447 - 68,315,494 (-)NCBICHM1_1
T2T-CHM13v2.0268,140,355 - 68,168,077 (-)NCBIT2T-CHM13v2.0
Dnaaf10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391117,161,893 - 17,185,200 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1117,132,107 - 17,183,796 (+)EnsemblGRCm39 Ensembl
GRCm381117,211,893 - 17,235,200 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1117,182,107 - 17,233,796 (+)EnsemblGRCm38mm10GRCm38
MGSCv371117,111,896 - 17,135,203 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361117,111,921 - 17,133,799 (+)NCBIMGSCv36mm8
Celera1117,586,420 - 17,609,603 (+)NCBICelera
Cytogenetic Map11A2NCBI
cM Map119.75NCBI
Dnaaf10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542416,706,264 - 16,730,308 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542416,706,272 - 16,727,483 (+)NCBIChiLan1.0ChiLan1.0
DNAAF10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21258,247,101 - 58,274,829 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A58,251,049 - 58,278,777 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A68,181,897 - 68,209,630 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A69,306,837 - 69,426,023 (-)NCBIpanpan1.1PanPan1.1panPan2
DNAAF10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11067,208,705 - 67,230,953 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1067,209,669 - 67,230,958 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1067,099,996 - 67,122,017 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01068,228,325 - 68,250,152 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1068,228,858 - 68,250,157 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11067,912,743 - 67,934,743 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01068,210,410 - 68,232,322 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01068,505,825 - 68,528,060 (-)NCBIUU_Cfam_GSD_1.0
Dnaaf10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629215,960,929 - 15,983,338 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649112,587,859 - 12,610,159 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649112,587,699 - 12,610,386 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNAAF10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl374,085,227 - 74,108,927 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1374,085,133 - 74,108,929 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2377,617,092 - 77,640,829 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNAAF10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11438,927,332 - 38,963,435 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1438,927,511 - 38,955,001 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604573,021,214 - 73,048,536 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnaaf10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247625,170,863 - 5,196,034 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247625,170,852 - 5,194,752 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dnaaf10
259 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:251
Count of miRNA genes:176
Interacting mature miRNAs:197
Transcripts:ENSRNOT00000029980
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
4889951Bss92Bone structure and strength QTL 923.9tibia area (VT:1000281)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)148205747195876975Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat

Markers in Region
RH133644  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21491,639,543 - 91,639,753 (+)MAPPERmRatBN7.2
Rnor_6.014100,393,863 - 100,394,072NCBIRnor6.0
Rnor_5.014100,145,336 - 100,145,545UniSTSRnor5.0
RGSC_v3.41498,132,245 - 98,132,454UniSTSRGSC3.4
Celera1490,685,523 - 90,685,732UniSTS
RH 3.4 Map14699.7UniSTS
Cytogenetic Map14q22UniSTS
BI277192  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21491,637,357 - 91,638,071 (+)MAPPERmRatBN7.2
Rnor_6.014100,391,678 - 100,392,391NCBIRnor6.0
Rnor_5.014100,147,017 - 100,147,730UniSTSRnor5.0
RGSC_v3.41498,130,060 - 98,130,773UniSTSRGSC3.4
Celera1490,683,338 - 90,684,051UniSTS
RH 3.4 Map14735.09UniSTS
Cytogenetic Map14q22UniSTS


Sequence


Ensembl Acc Id: ENSRNOT00000029980   ⟹   ENSRNOP00000031351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1491,636,157 - 91,639,831 (+)Ensembl
Rnor_6.0 Ensembl14100,373,129 - 100,394,145 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1491,636,222 - 91,636,687 (+)Ensembl
RefSeq Acc Id: NM_001127559   ⟹   NP_001121031
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81495,820,272 - 95,841,445 (+)NCBI
mRatBN7.21491,618,649 - 91,639,824 (+)NCBI
Rnor_6.014100,373,129 - 100,394,143 (+)NCBI
Rnor_5.014100,145,261 - 100,166,378 (-)NCBI
RGSC_v3.41498,111,358 - 98,132,525 (+)RGD
Celera1490,664,802 - 90,685,803 (+)RGD
Sequence:
RefSeq Acc Id: XM_063273493   ⟹   XP_063129563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81495,820,314 - 95,841,449 (+)NCBI
RefSeq Acc Id: XM_063273494   ⟹   XP_063129564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81495,821,031 - 95,841,449 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001121031 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129563 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129564 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI62042 (Get FASTA)   NCBI Sequence Viewer  
  EDL97911 (Get FASTA)   NCBI Sequence Viewer  
  EDL97912 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001121031   ⟸   NM_001127559
- UniProtKB: B1WC85 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000031351   ⟸   ENSRNOT00000029980
RefSeq Acc Id: XP_063129563   ⟸   XM_063273493
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063129564   ⟸   XM_063273494
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1WC85-F1-model_v2 AlphaFold B1WC85 1-357 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699504
Promoter ID:EPDNEW_R10027
Type:initiation region
Name:Wdr92_1
Description:WD repeat domain 92
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.014100,373,130 - 100,373,190EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563863 AgrOrtholog
BioCyc Gene G2FUF-14933 BioCyc
Ensembl Genes ENSRNOG00000022857 Ensembl
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7105425 IMAGE-MGC_LOAD
InterPro WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report rno:498418 UniProtKB/TrEMBL
MGC_CLONE MGC:187995 IMAGE-MGC_LOAD
NCBI Gene 498418 ENTREZGENE
PANTHER DYNEIN AXONEMAL ASSEMBLY FACTOR 10 UniProtKB/TrEMBL
  MRNA EXPORT FACTOR AND BUB3 UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PhenoGen Dnaaf10 PhenoGen
PROSITE WD_REPEATS_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022857 RatGTEx
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP WD40_like UniProtKB/TrEMBL
UniProt B1WC85 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-28 Dnaaf10  dynein axonemal assembly factor 10  Wdr92  WD repeat domain 92  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-12 Wdr92  WD repeat domain 92  RGD1563863  similar to expressed sequence AI553587  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1563863  similar to expressed sequence AI553587   RGD1563863_predicted  similar to expressed sequence AI553587 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1563863_predicted  similar to expressed sequence AI553587 (predicted)  LOC498418  similar to expressed sequence AI553587  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498418  similar to expressed sequence AI553587      Symbol and Name status set to provisional 70820 PROVISIONAL