(2,4,5-trichlorophenoxy)acetic acid increases expression ISO RGD:731918 6480464 2 more ... CTD PMID:18579281 1,2-dichloroethane decreases expression ISO RGD:731918 6480464 ethylene dichloride results in decreased expression of SPON2 mRNA CTD PMID:28960355 1,2-dimethylhydrazine increases expression ISO RGD:731918 6480464 1, 2-Dimethylhydrazine results in increased expression of SPON2 mRNA CTD PMID:22206623 17alpha-ethynylestradiol multiple interactions ISO RGD:731918 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SPON2 mRNA CTD PMID:17942748 17beta-estradiol increases expression ISO RGD:731918 6480464 Estradiol results in increased expression of SPON2 mRNA CTD PMID:19484750 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases expression ISO RGD:1352786 6480464 Metribolone results in increased expression of SPON2 mRNA CTD PMID:17010196 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:731918 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SPON2 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of SPON2 mRNA CTD PMID:33387578 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SPON2 mRNA CTD PMID:32109520 , PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1352786 6480464 Tetrachlorodibenzodioxin results in decreased expression of SPON2 mRNA CTD PMID:26238291 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:731918 6480464 Tetrachlorodibenzodioxin affects the expression of SPON2 mRNA CTD PMID:21570461 , PMID:28922406 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1352786 6480464 Tetrachlorodibenzodioxin affects the expression of SPON2 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:731918 6480464 Tetrachlorodibenzodioxin results in decreased expression of SPON2 mRNA CTD PMID:19770486 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:731918 6480464 Tetrachlorodibenzodioxin results in increased expression of SPON2 mRNA CTD PMID:19933214 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of SPON2 mRNA CTD PMID:21346803 3-methylcholanthrene multiple interactions ISO RGD:1352786 6480464 Methylcholanthrene promotes the reaction [AHR protein binds to SPON2 promoter] CTD PMID:20348232 4,4'-sulfonyldiphenol increases expression ISO RGD:731918 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of SPON2 mRNA CTD PMID:30951980 4-hydroxyphenyl retinamide increases expression ISO RGD:731918 6480464 Fenretinide results in increased expression of SPON2 mRNA CTD PMID:28973697 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of SPON2 mRNA CTD PMID:24780913 acrylamide decreases expression ISO RGD:731918 6480464 Acrylamide results in decreased expression of SPON2 mRNA CTD PMID:30807115 aflatoxin B1 decreases methylation ISO RGD:1352786 6480464 Aflatoxin B1 results in decreased methylation of SPON2 gene CTD PMID:27153756 aldrin increases expression ISO RGD:731918 6480464 Aldrin results in increased expression of SPON2 mRNA CTD PMID:18579281 all-trans-retinoic acid increases expression ISO RGD:1352786 6480464 Tretinoin results in increased expression of SPON2 mRNA CTD PMID:16249480 all-trans-retinoic acid decreases expression ISO RGD:1352786 6480464 Tretinoin results in decreased expression of SPON2 mRNA CTD PMID:23830798 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of SPON2 mRNA CTD PMID:16483693 antirheumatic drug increases expression ISO RGD:1352786 6480464 Antirheumatic Agents results in increased expression of SPON2 mRNA CTD PMID:24449571 aristolochic acid A increases expression ISO RGD:1352786 6480464 aristolochic acid I results in increased expression of SPON2 mRNA CTD PMID:33212167 arsenous acid decreases expression ISO RGD:1352786 6480464 Arsenic Trioxide results in decreased expression of SPON2 mRNA CTD PMID:19128835 benzo[a]pyrene increases expression ISO RGD:731918 6480464 Benzo(a)pyrene results in increased expression of SPON2 mRNA CTD PMID:20127859 benzo[a]pyrene affects methylation ISO RGD:1352786 6480464 Benzo(a)pyrene affects the methylation of SPON2 3' UTR, Benzo(a)pyrene affects the methylation of SPON2 intron CTD PMID:27901495 , PMID:30157460 benzo[a]pyrene multiple interactions ISO RGD:731918 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SPON2 mRNA CTD PMID:27858113 benzo[a]pyrene decreases expression ISO RGD:1352786 6480464 Benzo(a)pyrene results in decreased expression of SPON2 mRNA CTD PMID:26238291 benzo[a]pyrene increases expression ISO RGD:1352786 6480464 Benzo(a)pyrene metabolite results in increased expression of SPON2 mRNA CTD PMID:26314263 benzo[a]pyrene decreases expression ISO RGD:731918 6480464 Benzo(a)pyrene results in decreased expression of SPON2 mRNA CTD PMID:19770486 , PMID:21569818 benzo[a]pyrene affects expression ISO RGD:1352786 6480464 Benzo(a)pyrene affects the expression of SPON2 mRNA CTD PMID:22316170 benzo[a]pyrene affects expression ISO RGD:731918 6480464 Benzo(a)pyrene affects the expression of SPON2 mRNA CTD PMID:22342234 benzo[a]pyrene diol epoxide I increases expression ISO RGD:1352786 6480464 7 more ... CTD PMID:26238291 benzo[b]fluoranthene decreases expression ISO RGD:731918 6480464 benzo(b)fluoranthene results in decreased expression of SPON2 mRNA CTD PMID:26377693 benzo[b]fluoranthene multiple interactions ISO RGD:731918 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SPON2 mRNA CTD PMID:27858113 Benzo[k]fluoranthene decreases expression ISO RGD:731918 6480464 benzo(k)fluoranthene results in decreased expression of SPON2 mRNA CTD PMID:26377693 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:731918 6480464 PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of SPON2 mRNA] CTD PMID:19850644 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of SPON2 mRNA CTD PMID:29945229 bis(2-ethylhexyl) phthalate increases expression ISO RGD:731918 6480464 Diethylhexyl Phthalate results in increased expression of SPON2 mRNA CTD PMID:19850644 bisphenol A increases expression ISO RGD:1352786 6480464 bisphenol A results in increased expression of SPON2 mRNA CTD PMID:25047013 more ... bisphenol A increases expression ISO RGD:731918 6480464 bisphenol A results in increased expression of SPON2 mRNA CTD PMID:30951980 , PMID:34585602 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SPON2 mRNA CTD PMID:30816183 more ... bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of SPON2 gene CTD PMID:28505145 bisphenol F increases expression ISO RGD:731918 6480464 bisphenol F results in increased expression of SPON2 mRNA CTD PMID:30951980 bisphenol F multiple interactions ISO RGD:1352786 6480464 [bisphenol F co-treated with Fulvestrant] results in increased methylation of SPON2 gene CTD PMID:31601247 buta-1,3-diene decreases expression ISO RGD:731918 6480464 1, 3-butadiene results in decreased expression of SPON2 mRNA CTD PMID:29038090 butanal decreases expression ISO RGD:1352786 6480464 butyraldehyde results in decreased expression of SPON2 mRNA CTD PMID:26079696 cadmium atom increases expression ISO RGD:1352786 6480464 Cadmium results in increased expression of SPON2 mRNA CTD PMID:24376830 cadmium dichloride decreases expression ISO RGD:1352786 6480464 Cadmium Chloride results in decreased expression of SPON2 mRNA CTD PMID:21457566 calcitriol decreases expression ISO RGD:1352786 6480464 Calcitriol results in decreased expression of SPON2 mRNA CTD PMID:26485663 carbon nanotube increases expression ISO RGD:731918 6480464 Nanotubes, Carbon results in increased expression of SPON2 mRNA CTD PMID:25554681 carbon nanotube decreases expression ISO RGD:731918 6480464 Nanotubes, Carbon analog results in decreased expression of SPON2 mRNA CTD PMID:25620056 carbon nanotube affects expression ISO RGD:731918 6480464 Nanotubes more ... CTD PMID:25554681 , PMID:25620056 chlordecone decreases expression ISO RGD:731918 6480464 Chlordecone results in decreased expression of SPON2 mRNA CTD PMID:33711761 chloroethene increases expression ISO RGD:731918 6480464 Vinyl Chloride results in increased expression of SPON2 mRNA CTD PMID:18579281 chloroprene decreases expression ISO RGD:731918 6480464 Chloroprene results in decreased expression of SPON2 mRNA CTD PMID:23125180 chloroprene decreases expression EXP 6480464 Chloroprene results in decreased expression of SPON2 mRNA CTD PMID:23125180 chromium(6+) affects expression ISO RGD:731918 6480464 chromium hexavalent ion affects the expression of SPON2 mRNA CTD PMID:28472532 chrysene multiple interactions ISO RGD:731918 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SPON2 mRNA CTD PMID:27858113 ciguatoxin CTX1B affects expression ISO RGD:731918 6480464 Ciguatoxins affects the expression of SPON2 mRNA CTD PMID:18353800 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of SPON2 mRNA CTD PMID:22023808 clofibrate increases expression ISO RGD:731918 6480464 Clofibrate results in increased expression of SPON2 mRNA CTD PMID:23811191 copper(II) sulfate increases expression ISO RGD:731918 6480464 Copper Sulfate results in increased expression of SPON2 mRNA CTD PMID:18579281 cyclosporin A decreases expression ISO RGD:731918 6480464 Cyclosporine results in decreased expression of SPON2 mRNA CTD PMID:19770486 cyclosporin A decreases expression ISO RGD:1352786 6480464 Cyclosporine results in decreased expression of SPON2 mRNA CTD PMID:20106945 more ... dexamethasone decreases expression ISO RGD:731918 6480464 Dexamethasone results in decreased expression of SPON2 mRNA CTD PMID:22733784 diarsenic trioxide decreases expression ISO RGD:1352786 6480464 Arsenic Trioxide results in decreased expression of SPON2 mRNA CTD PMID:19128835 dibenz[a,h]anthracene decreases expression ISO RGD:731918 6480464 1 more ... CTD PMID:26377693 dichloroacetic acid increases expression ISO RGD:731918 6480464 Dichloroacetic Acid results in increased expression of SPON2 mRNA CTD PMID:28962523 dicrotophos decreases expression ISO RGD:1352786 6480464 dicrotophos results in decreased expression of SPON2 mRNA CTD PMID:28302478 disodium selenite multiple interactions ISO RGD:731918 6480464 [ptaquiloside co-treated with Sodium Selenite] results in decreased expression of SPON2 mRNA CTD PMID:23274088 diuron decreases expression EXP 6480464 Diuron results in decreased expression of SPON2 mRNA CTD PMID:25152437 diuron increases expression EXP 6480464 Diuron results in increased expression of SPON2 mRNA CTD PMID:21551480 dorsomorphin multiple interactions ISO RGD:1352786 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of SPON2 mRNA CTD PMID:29391264 epoxiconazole increases expression ISO RGD:731918 6480464 epoxiconazole results in increased expression of SPON2 mRNA CTD PMID:35436446 ethyl methanesulfonate decreases expression ISO RGD:1352786 6480464 Ethyl Methanesulfonate results in decreased expression of SPON2 mRNA CTD PMID:23649840 fulvestrant multiple interactions ISO RGD:1352786 6480464 [bisphenol F co-treated with Fulvestrant] results in increased methylation of SPON2 gene CTD PMID:31601247 furan increases expression ISO RGD:731918 6480464 furan results in increased expression of SPON2 mRNA CTD PMID:24183702 graphene oxide decreases expression ISO RGD:731918 6480464 graphene oxide results in decreased expression of SPON2 mRNA CTD PMID:33227293 leflunomide decreases expression EXP 6480464 leflunomide results in decreased expression of SPON2 mRNA CTD PMID:24136188 lipopolysaccharide decreases expression ISO RGD:1352786 6480464 Lipopolysaccharides results in decreased expression of SPON2 mRNA CTD PMID:18192897 , PMID:35811015 lipopolysaccharide multiple interactions ISO RGD:1352786 6480464 [S-(1, 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of SPON2 mRNA CTD PMID:35811015 methotrexate affects expression ISO RGD:731918 6480464 Methotrexate affects the expression of SPON2 mRNA CTD PMID:18502557 mitoxantrone affects response to substance ISO RGD:1352786 6480464 SPON2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 monosodium L-glutamate decreases expression ISO RGD:731918 6480464 Sodium Glutamate results in decreased expression of SPON2 mRNA CTD PMID:22078008 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:731918 6480464 MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SPON2 mRNA] CTD PMID:25566086 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal decreases expression ISO RGD:731918 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SPON2 mRNA CTD PMID:25566086 N-ethyl-N-nitrosourea increases mutagenesis ISO RGD:731918 6480464 Ethylnitrosourea results in increased mutagenesis of SPON2 intron CTD PMID:27776689 naphthalene increases expression ISO RGD:731918 6480464 naphthalene results in increased expression of SPON2 mRNA CTD PMID:18978301 nickel atom decreases expression ISO RGD:1352786 6480464 Nickel results in decreased expression of SPON2 mRNA CTD PMID:23195993 , PMID:25583101 ochratoxin A increases expression ISO RGD:1352786 6480464 ochratoxin A metabolite results in increased expression of SPON2 mRNA, ochratoxin A results in increased expression of SPON2 mRNA CTD PMID:26314263 , PMID:29098329 ochratoxin A increases acetylation ISO RGD:1352786 6480464 ochratoxin A results in increased acetylation of SPON2 promoter CTD PMID:29098329 ochratoxin A multiple interactions ISO RGD:1352786 6480464 [ochratoxin A results in increased acetylation of SPON2 promoter] which results in increased expression of SPON2 mRNA CTD PMID:29098329 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of SPON2 mRNA CTD PMID:25729387 ozone decreases expression EXP 6480464 Ozone results in decreased expression of SPON2 mRNA CTD PMID:26667333 , PMID:28623178 paracetamol affects expression ISO RGD:731918 6480464 Acetaminophen affects the expression of SPON2 mRNA CTD PMID:17562736 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of SPON2 mRNA CTD PMID:33387578 paracetamol increases expression ISO RGD:1352786 6480464 Acetaminophen results in increased expression of SPON2 mRNA CTD PMID:26690555 paracetamol decreases expression ISO RGD:1352786 6480464 Acetaminophen results in decreased expression of SPON2 mRNA CTD PMID:21420995 more ... paraquat increases expression EXP 6480464 Paraquat results in increased expression of SPON2 mRNA CTD PMID:32680482 pentanal decreases expression ISO RGD:1352786 6480464 pentanal results in decreased expression of SPON2 mRNA CTD PMID:26079696 phenobarbital affects expression ISO RGD:731918 6480464 Phenobarbital affects the expression of SPON2 mRNA CTD PMID:23091169 phenylmercury acetate decreases expression ISO RGD:1352786 6480464 Phenylmercuric Acetate results in decreased expression of SPON2 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1352786 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SPON2 mRNA CTD PMID:27188386 pirinixic acid multiple interactions ISO RGD:731918 6480464 [pirinixic acid co-treated with PPARA] results in increased expression of SPON2 mRNA CTD PMID:20813756 pirinixic acid increases expression ISO RGD:731918 6480464 pirinixic acid results in increased expression of SPON2 mRNA CTD PMID:18301758 more ... pirinixic acid multiple interactions ISO RGD:1352786 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SPON2 mRNA CTD PMID:19710929 progesterone decreases expression ISO RGD:1352786 6480464 Progesterone results in decreased expression of SPON2 mRNA CTD PMID:18070364 propanal decreases expression ISO RGD:1352786 6480464 propionaldehyde results in decreased expression of SPON2 mRNA CTD PMID:26079696 Ptaquiloside multiple interactions ISO RGD:731918 6480464 [ptaquiloside co-treated with Sodium Selenite] results in decreased expression of SPON2 mRNA CTD PMID:23274088 quercetin multiple interactions ISO RGD:731918 6480464 [Quercetin co-treated with Dietary Fats] affects the expression of SPON2 mRNA CTD PMID:23359794 quinolin-8-ol increases expression ISO RGD:1352786 6480464 Oxyquinoline results in increased expression of SPON2 mRNA CTD PMID:21632981 S-(1,2-dichlorovinyl)-L-cysteine multiple interactions ISO RGD:1352786 6480464 [S-(1, 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of SPON2 mRNA CTD PMID:35811015 SB 431542 multiple interactions ISO RGD:1352786 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide decreases expression ISO RGD:1352786 6480464 Silicon Dioxide analog results in decreased expression of SPON2 mRNA CTD PMID:25895662 silicon dioxide decreases expression EXP 6480464 Silicon Dioxide results in decreased expression of SPON2 mRNA CTD PMID:22431001 silicon dioxide increases expression ISO RGD:1352786 6480464 Silicon Dioxide analog results in increased expression of SPON2 mRNA CTD PMID:23806026 simvastatin increases expression ISO RGD:1352786 6480464 Simvastatin results in increased expression of SPON2 mRNA CTD PMID:17428261 sodium arsenate decreases expression ISO RGD:731918 6480464 sodium arsenate results in decreased expression of SPON2 mRNA CTD PMID:21795629 sodium arsenite decreases expression ISO RGD:1352786 6480464 sodium arsenite results in decreased expression of SPON2 mRNA CTD PMID:29301061 sulforaphane decreases expression ISO RGD:1352786 6480464 sulforaphane results in decreased expression of SPON2 mRNA CTD PMID:31838189 tamoxifen increases expression ISO RGD:731918 6480464 Tamoxifen results in increased expression of SPON2 mRNA CTD PMID:25123088 tetrachloroethene increases expression ISO RGD:731918 6480464 Tetrachloroethylene results in increased expression of SPON2 mRNA CTD PMID:28973375 tetrachloromethane affects expression ISO RGD:731918 6480464 Carbon Tetrachloride affects the expression of SPON2 mRNA CTD PMID:17484886 tetraphene decreases expression ISO RGD:731918 6480464 benz(a)anthracene results in decreased expression of SPON2 mRNA CTD PMID:26377693 tetraphene multiple interactions ISO RGD:731918 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SPON2 mRNA CTD PMID:27858113 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of SPON2 mRNA CTD PMID:34492290 titanium dioxide decreases expression ISO RGD:731918 6480464 titanium dioxide results in decreased expression of SPON2 mRNA CTD PMID:19464567 more ... titanium dioxide affects expression EXP 6480464 titanium dioxide affects the expression of SPON2 mRNA CTD PMID:30012374 titanium dioxide increases expression ISO RGD:731918 6480464 titanium dioxide results in increased expression of SPON2 mRNA CTD PMID:23557971 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of SPON2 mRNA CTD PMID:25729387 tributylstannane increases expression EXP 6480464 tributyltin results in increased expression of SPON2 mRNA CTD PMID:21683754 trichloroethene increases expression ISO RGD:731918 6480464 Trichloroethylene results in increased expression of SPON2 mRNA CTD PMID:25549359 triclosan increases expression ISO RGD:1352786 6480464 Triclosan results in increased expression of SPON2 mRNA CTD PMID:30510588 urethane increases expression ISO RGD:1352786 6480464 Urethane results in increased expression of SPON2 mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:731918 6480464 Valproic Acid affects the expression of SPON2 mRNA CTD PMID:17292431 , PMID:17963808 valproic acid affects expression ISO RGD:1352786 6480464 Valproic Acid affects the expression of SPON2 mRNA CTD PMID:25979313 valproic acid increases methylation ISO RGD:1352786 6480464 Valproic Acid results in increased methylation of SPON2 gene CTD PMID:29154799 valproic acid decreases expression ISO RGD:1352786 6480464 Valproic Acid results in decreased expression of SPON2 mRNA CTD PMID:23179753 more ... valproic acid multiple interactions ISO RGD:1352786 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SPON2 mRNA CTD PMID:27188386