Igfbp1 (insulin-like growth factor binding protein 1) - Rat Genome Database

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Gene: Igfbp1 (insulin-like growth factor binding protein 1) Rattus norvegicus
Symbol: Igfbp1
Name: insulin-like growth factor binding protein 1
RGD ID: 2872
Description: Predicted to enable insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in several processes, including insulin receptor signaling pathway; positive regulation of cell growth; and tissue regeneration. Located in extracellular space. Human ortholog(s) of this gene implicated in diabetic angiopathy. Orthologous to human IGFBP1 (insulin like growth factor binding protein 1); PARTICIPATES IN forkhead class A signaling pathway; hypoxia inducible factor pathway; insulin-like growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
Previously known as: IBP-1; IBP1; IGF-binding protein 1; IGF-BP25; IGFBA; IGFBP-1; insulin-like growth factor-binding protein 1; placental protein 12
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Niddm37
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21482,047,415 - 82,052,482 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1482,047,415 - 82,052,482 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1486,448,608 - 86,453,531 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01487,688,457 - 87,693,380 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01484,137,002 - 84,142,071 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01487,448,716 - 87,453,783 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1487,448,692 - 87,453,785 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01481,083,056 - 81,088,123 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41487,950,222 - 87,955,289 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11487,969,366 - 87,974,434 (+)NCBI
Celera1481,092,381 - 81,126,760 (+)NCBICelera
RH 3.4 Map14605.9RGD
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1-methylphenanthrene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2'-bipyridine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-butoxyethanol  (ISO)
2-hydroxy-17beta-estradiol  (ISO)
2-nitrofluorene  (EXP)
28-Homobrassinolide  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
8-Br-cAMP  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
Archazolid B  (ISO)
aristolochic acids  (EXP)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
azoxystrobin  (EXP)
bacitracin  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
chenodeoxycholic acid  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
cholesterol  (ISO)
choline  (ISO)
chromium(3+) trichloride  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clotrimazole  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
cortisol  (ISO)
curcumin  (ISO)
cyanamide  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
enalapril  (EXP)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
folic acid  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP,ISO)
genistein  (EXP)
gentamycin  (EXP)
glycidol  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (EXP)
GW 4064  (ISO)
hydrogen peroxide  (EXP)
imidacloprid  (EXP)
indirubin  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
ketamine  (EXP)
ketoconazole  (EXP)
kynurenine  (ISO)
L-methionine  (ISO)
L-tryptophan  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lisinopril dihydrate  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methylarsonic acid  (ISO)
methylmercury(1+)  (EXP)
microcystin-LR  (ISO)
mifepristone  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nefazodone  (ISO)
nickel dichloride  (ISO)
nicotinamide  (ISO)
nitrofen  (EXP)
ochratoxin A  (EXP,ISO)
orphenadrine  (EXP)
oxazepam  (ISO)
oxycodone  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium bromate  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (EXP)
rifampicin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
silicon dioxide  (ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sotorasib  (ISO)
starch  (EXP)
stavudine  (EXP)
succimer  (ISO)
Sunset Yellow FCF  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
thiabendazole  (EXP)
thioacetamide  (EXP,ISO)
tianeptine  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
trametinib  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
Triptolide  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vancomycin  (EXP,ISO)
vandetanib  (ISO)
vemurafenib  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,IDA,ISO)
Golgi apparatus  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions. Duan C and Xu Q, Gen Comp Endocrinol. 2005 May 15;142(1-2):44-52. Epub 2005 Feb 5.
2. Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element. Finlay D, etal., BMC Mol Biol. 2004 Sep 6;5:15.
3. Developmental changes in serum levels of free and total insulin-like growth factor I (IGF-I), IGF-binding protein-1 and -3, and the acid-labile subunit in rats. Frystyk J, etal., Endocrinology. 1998 Oct;139(10):4286-92.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Serum IGF-binding protein-6 and prostate specific antigen in breast cancer. Kaulsay KK, etal., Eur J Endocrinol. 1999 Feb;140(2):164-8.
7. Regulation of the acid-labile subunit in sustained endotoxemia. Kong SE, etal., Am J Physiol Endocrinol Metab 2002 Oct;283(4):E692-701.
8. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9. Dideoxy sequencing and structural analysis of the rat insulin-like growth factor binding protein-1 gene. Lacson R, etal., Biochim Biophys Acta 1994 May 17;1218(1):95-8.
10. Expression of insulin-like growth factor binding proteins in the rat kidney: effects of long-term diabetes. Landau D, etal., Endocrinology. 1995 May;136(5):1835-42. doi: 10.1210/endo.136.5.7536658.
11. Acute response of IGF-I and IGF binding proteins induced by thermal injury. Lang CH, etal., Am J Physiol Endocrinol Metab. 2000 Jun;278(6):E1087-96.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. The gene encoding rat insulinlike growth factor-binding protein 1 is rapidly and highly induced in regenerating liver. Mohn KL, etal., Mol Cell Biol. 1991 Mar;11(3):1393-401.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Insulin regulation of hepatic insulin-like growth factor-binding protein-1 (IGFBP-1) gene expression and mammalian target of rapamycin (mTOR) signalling is impaired by the presence of hydrogen peroxide. Patel S, etal., Biochem J 2002 Jul 15;365(Pt 2):537-45.
16. Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase activity. Patel S, etal., J Biol Chem 2002 Mar 22;277(12):9889-95.
17. Growth hormone-binding protein is directly and IGFBP-3 is inversely associated with risk of female breast cancer. Pazaitou-Panayiotou K, etal., Eur J Endocrinol. 2007 Feb;156(2):187-94.
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. Uptake of circulating insulin-like growth factors (IGFs) into cerebrospinal fluid appears to be independent of the IGF receptors as well as IGF-binding proteins. Pulford BE and Ishii DN, Endocrinology 2001 Jan;142(1):213-20.
20. GOA pipeline RGD automated data pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Changes in the mRNA expressions of insulin-like growth factors, their receptors, and binding proteins during the postnatal development of rat masseter muscle. Saito T, etal., Zoolog Sci 2003 Apr;20(4):441-7.
23. Insulin-like growth factor (IGF)-binding protein-1 is highly induced during acute carbon tetrachloride liver injury and potentiates the IGF-I-stimulated activation of rat hepatic stellate cells. Scharf JG, etal., Endocrinology. 2004 Jul;145(7):3463-72. Epub 2004 Apr 7.
24. Oxygen-dependent modulation of insulin-like growth factor binding protein biosynthesis in primary cultures of rat hepatocytes. Scharf JG, etal., Endocrinology. 2005 Dec;146(12):5433-43. Epub 2005 Sep 15.
25. Polymorphisms in IGF-binding protein 1 are associated with impaired renal function in type 2 diabetes. Stephens RH, etal., Diabetes. 2005 Dec;54(12):3547-53.
26. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
27. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
28. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
29. Growth hormone gene expression and secretion in aging rats is age dependent and not age-associated weight increase related. Velasco B, etal., Endocrinology. 1998 Mar;139(3):1314-20. doi: 10.1210/endo.139.3.5779.
Additional References at PubMed
PMID:1283442   PMID:1691820   PMID:2164920   PMID:7510770   PMID:7679139   PMID:12670795   PMID:12902319   PMID:15489334   PMID:16455781   PMID:17032741   PMID:17645865   PMID:20345750  
PMID:21550830   PMID:22805023  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21482,047,415 - 82,052,482 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1482,047,415 - 82,052,482 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1486,448,608 - 86,453,531 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01487,688,457 - 87,693,380 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01484,137,002 - 84,142,071 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01487,448,716 - 87,453,783 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1487,448,692 - 87,453,785 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01481,083,056 - 81,088,123 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41487,950,222 - 87,955,289 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11487,969,366 - 87,974,434 (+)NCBI
Celera1481,092,381 - 81,126,760 (+)NCBICelera
RH 3.4 Map14605.9RGD
Cytogenetic Map14q21NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38745,888,488 - 45,893,660 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl745,888,360 - 45,893,660 (+)EnsemblGRCh38hg38GRCh38
GRCh37745,928,087 - 45,933,259 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36745,894,484 - 45,899,792 (+)NCBINCBI36Build 36hg18NCBI36
Build 34745,701,326 - 45,706,499NCBI
Celera746,026,880 - 46,032,188 (+)NCBICelera
Cytogenetic Map7p12.3NCBI
HuRef745,812,919 - 45,818,173 (+)NCBIHuRef
CHM1_1745,932,162 - 45,937,470 (+)NCBICHM1_1
T2T-CHM13v2.0746,047,763 - 46,055,379 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2745,967,292 - 45,972,600 (+)NCBI
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39117,147,787 - 7,152,546 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl117,147,782 - 7,152,546 (+)EnsemblGRCm39 Ensembl
GRCm38117,197,787 - 7,202,546 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl117,197,782 - 7,202,546 (+)EnsemblGRCm38mm10GRCm38
MGSCv37117,097,790 - 7,102,549 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36117,097,785 - 7,102,539 (+)NCBIMGSCv36mm8
Celera117,672,987 - 7,677,746 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map114.75NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554566,810,056 - 6,815,685 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554566,810,461 - 6,814,944 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1799,095,242 - 99,103,537 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0746,538,566 - 46,545,536 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1746,657,834 - 46,663,158 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl746,658,097 - 46,662,584 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1161,037,169 - 1,040,996 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl161,037,162 - 1,167,094 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha161,813,131 - 1,816,855 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0161,023,782 - 1,027,506 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl161,023,782 - 1,153,699 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1161,014,419 - 1,018,140 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.016950,042 - 953,757 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.016220,948 - 224,674 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405118101,282,472 - 101,287,845 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647820,494,203 - 20,499,001 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647820,494,190 - 20,499,001 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1850,018,487 - 50,022,799 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11850,018,487 - 50,022,799 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21854,862,385 - 54,866,697 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12112,932,727 - 12,939,078 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2112,932,732 - 12,937,891 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660629,598,999 - 9,604,182 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247406,893,867 - 6,897,377 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247406,893,334 - 6,897,591 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Igfbp1
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:57
Count of miRNA genes:51
Interacting mature miRNAs:53
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21482,052,250 - 82,052,433 (+)MAPPERmRatBN7.2
Rnor_6.01487,453,552 - 87,453,734NCBIRnor6.0
Rnor_5.01481,087,892 - 81,088,074UniSTSRnor5.0
RGSC_v3.41487,955,058 - 87,955,240UniSTSRGSC3.4
Celera1481,126,529 - 81,126,711UniSTS
RH 3.4 Map14600.5UniSTS
Cytogenetic Map14q21UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21482,047,931 - 82,048,209 (+)MAPPERmRatBN7.2
Rnor_6.01487,449,233 - 87,449,510NCBIRnor6.0
Rnor_5.01481,083,573 - 81,083,850UniSTSRnor5.0
RGSC_v3.41487,950,739 - 87,951,016UniSTSRGSC3.4
Celera1481,122,204 - 81,122,481UniSTS
Cytogenetic Map14q21UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21482,052,560 - 82,052,725 (+)MAPPERmRatBN7.2
Rnor_6.01487,453,862 - 87,454,026NCBIRnor6.0
Rnor_5.01481,088,202 - 81,088,366UniSTSRnor5.0
RGSC_v3.41487,955,368 - 87,955,532UniSTSRGSC3.4
Celera1481,126,839 - 81,127,003UniSTS
RH 3.4 Map14605.9UniSTS
Cytogenetic Map14q21UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21482,027,449 - 82,027,610 (+)MAPPERmRatBN7.2
Rnor_6.01487,428,317 - 87,428,477NCBIRnor6.0
Rnor_5.01481,062,657 - 81,062,817UniSTSRnor5.0
RGSC_v3.41487,930,258 - 87,930,418UniSTSRGSC3.4
Celera1481,101,901 - 81,102,061UniSTS
RH 3.4 Map20404.53UniSTS
Cytogenetic Map14q21UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21482,052,263 - 82,052,433 (+)MAPPERmRatBN7.2
Rnor_6.01487,453,565 - 87,453,734NCBIRnor6.0
Rnor_5.01481,087,905 - 81,088,074UniSTSRnor5.0
RGSC_v3.41487,955,071 - 87,955,240UniSTSRGSC3.4
Celera1481,126,542 - 81,126,711UniSTS
RH 3.4 Map14596.6UniSTS
Cytogenetic Map14q21UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21482,028,209 - 82,028,331 (+)MAPPERmRatBN7.2
Rnor_6.01487,429,077 - 87,429,198NCBIRnor6.0
Rnor_5.01481,063,417 - 81,063,538UniSTSRnor5.0
RGSC_v3.41487,931,018 - 87,931,139UniSTSRGSC3.4
Celera1481,102,661 - 81,102,782UniSTS
Cytogenetic Map14q21UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21482,047,816 - 82,049,376 (+)MAPPERmRatBN7.2
Rnor_6.01487,449,118 - 87,450,677NCBIRnor6.0
Rnor_5.01481,083,458 - 81,085,017UniSTSRnor5.0
RGSC_v3.41487,950,624 - 87,952,183UniSTSRGSC3.4
Celera1481,122,089 - 81,123,648UniSTS
Cytogenetic Map14q21UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21482,034,144 - 82,035,568 (+)MAPPERmRatBN7.2
Rnor_6.01487,435,010 - 87,436,433NCBIRnor6.0
Rnor_5.01481,069,350 - 81,070,773UniSTSRnor5.0
RGSC_v3.41487,936,951 - 87,938,374UniSTSRGSC3.4
Celera1481,108,594 - 81,110,017UniSTS
Cytogenetic Map14q21UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21482,050,373 - 82,051,888 (+)MAPPERmRatBN7.2
Rnor_6.01487,451,675 - 87,453,189NCBIRnor6.0
Rnor_5.01481,086,015 - 81,087,529UniSTSRnor5.0
RGSC_v3.41487,953,181 - 87,954,695UniSTSRGSC3.4
Celera1481,124,646 - 81,126,166UniSTS
Cytogenetic Map14q21UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 4 4 4
Medium 32 32 32 23 2
Low 1 3 7 5 5 2 2 29 12 27 2 2
Below cutoff 2 27 10 9 4 4 44 9 5 4


RefSeq Acc Id: ENSRNOT00000077177   ⟹   ENSRNOP00000069247
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1482,047,415 - 82,052,482 (+)Ensembl
Rnor_6.0 Ensembl1487,448,692 - 87,453,785 (+)Ensembl
RefSeq Acc Id: NM_013144   ⟹   NP_037276
Rat AssemblyChrPosition (strand)Source
mRatBN7.21482,047,415 - 82,052,482 (+)NCBI
Rnor_6.01487,448,716 - 87,453,783 (+)NCBI
Rnor_5.01481,083,056 - 81,088,123 (+)NCBI
RGSC_v3.41487,950,222 - 87,955,289 (+)RGD
Celera1481,092,381 - 81,126,760 (+)RGD
RefSeq Acc Id: NP_037276   ⟸   NM_013144
- Peptide Label: precursor
- UniProtKB: P21743 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069247   ⟸   ENSRNOT00000077177
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21743-F1-model_v2 AlphaFold P21743 1-272 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2872 AgrOrtholog
BioCyc Gene G2FUF-15048 BioCyc
Ensembl Genes ENSRNOG00000058780 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000069247 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000077177 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot
  4.10.800.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  IGFBP-like UniProtKB/Swiss-Prot
  IGFBP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_1-6_chordata UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_GF-bd_Cys-rich_CS UniProtKB/Swiss-Prot
  Thyroglobulin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thyroglobulin_1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25685 UniProtKB/Swiss-Prot
Pfam IGFBP UniProtKB/Swiss-Prot
  Thyroglobulin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Igfbp1 PhenoGen
  IGFBPFAMILY1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IGFBP_N_1 UniProtKB/Swiss-Prot
  IGFBP_N_2 UniProtKB/Swiss-Prot
  THYROGLOBULIN_1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYROGLOBULIN_1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00121 UniProtKB/Swiss-Prot
  SM00211 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot
  SSF57610 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204944
UniProt A6KJ73_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Igfbp1  insulin-like growth factor binding protein 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease duplicated in an atypical Silver Russel syndrome 61526
gene_disease duplicated in an atypical Silver Russel syndrome 70249
gene_expression expressed in liver, decidua, kidney and amniotic fluid 61526
gene_expression expressed in liver, decidua, kidney and amniotic fluid 70249
gene_expression induced expression during regeneration of hepatocytes after liver damage 61526
gene_expression induced expression during regeneration of hepatocytes after liver damage 70249
gene_process regulates somatic growth and cellular proliferation 61526
gene_process regulates somatic growth and cellular proliferation 70249
gene_regulation regulated by insulin and corticoids 61526
gene_regulation regulated by insulin and corticoids 70249
gene_transcript contains 4 exons and 3 introns 728989