Igfbp1 (insulin-like growth factor binding protein 1) - Rat Genome Database

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Gene: Igfbp1 (insulin-like growth factor binding protein 1) Rattus norvegicus
Analyze
Symbol: Igfbp1
Name: insulin-like growth factor binding protein 1
RGD ID: 2872
Description: Predicted to enable insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in several processes, including aging; insulin receptor signaling pathway; and positive regulation of cell growth. Located in extracellular space. Human ortholog(s) of this gene implicated in diabetic angiopathy. Orthologous to human IGFBP1 (insulin like growth factor binding protein 1); PARTICIPATES IN forkhead class A signaling pathway; hypoxia inducible factor pathway; insulin-like growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IBP-1; IBP1; IGF-binding protein 1; IGF-BP25; IGFBA; IGFBP-1; insulin-like growth factor-binding protein 1; placental protein 12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21482,047,415 - 82,052,482 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1482,047,415 - 82,052,482 (+)Ensembl
Rnor_6.01487,448,716 - 87,453,783 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1487,448,692 - 87,453,785 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01481,083,056 - 81,088,123 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41487,950,222 - 87,955,289 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11487,969,366 - 87,974,434 (+)NCBI
Celera1481,092,381 - 81,126,760 (+)NCBICelera
RH 3.4 Map14605.9RGD
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1-methylphenanthrene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2'-bipyridine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-butoxyethanol  (ISO)
2-hydroxy-17beta-estradiol  (ISO)
2-nitrofluorene  (EXP)
28-Homobrassinolide  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
8-Br-cAMP  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
Archazolid B  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
azoxystrobin  (EXP)
bacitracin  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
chenodeoxycholic acid  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
cholesterol  (ISO)
choline  (ISO)
chromium(3+) trichloride  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clotrimazole  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
curcumin  (ISO)
cyanamide  (EXP)
cyclosporin A  (EXP,ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
enalapril  (EXP)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
folic acid  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP,ISO)
genistein  (EXP)
gentamycin  (EXP)
glycidol  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (EXP)
GW 4064  (ISO)
hydrogen peroxide  (EXP)
imidacloprid  (EXP)
indirubin  (ISO)
indole-3-methanol  (EXP)
ketamine  (EXP)
ketoconazole  (EXP)
kynurenine  (ISO)
L-methionine  (ISO)
L-tryptophan  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lisinopril dihydrate  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methylarsonic acid  (ISO)
methylmercury(1+)  (EXP)
microcystin-LR  (ISO)
mifepristone  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nefazodone  (ISO)
nickel dichloride  (ISO)
nicotinamide  (ISO)
nitrofen  (EXP)
ochratoxin A  (EXP,ISO)
orphenadrine  (EXP)
oxazepam  (ISO)
oxycodone  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium bromate  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (EXP)
rifampicin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
silicon dioxide  (ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
starch  (EXP)
stavudine  (EXP)
succimer  (ISO)
Sunset Yellow FCF  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
thiabendazole  (EXP)
thioacetamide  (EXP,ISO)
tianeptine  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
Triptolide  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vancomycin  (EXP,ISO)
vandetanib  (ISO)
vemurafenib  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,IDA,ISO)
Golgi apparatus  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Duan C and Xu Q, Gen Comp Endocrinol. 2005 May 15;142(1-2):44-52. Epub 2005 Feb 5.
2. Finlay D, etal., BMC Mol Biol. 2004 Sep 6;5:15.
3. Frystyk J, etal., Endocrinology. 1998 Oct;139(10):4286-92.
4. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. GOA data from the GO Consortium
6. Kaulsay KK, etal., Eur J Endocrinol. 1999 Feb;140(2):164-8.
7. Kong SE, etal., Am J Physiol Endocrinol Metab 2002 Oct;283(4):E692-701.
8. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9. Lacson R, etal., Biochim Biophys Acta 1994 May 17;1218(1):95-8.
10. Landau D, etal., Endocrinology. 1995 May;136(5):1835-42. doi: 10.1210/endo.136.5.7536658.
11. Lang CH, etal., Am J Physiol Endocrinol Metab. 2000 Jun;278(6):E1087-96.
12. MGD data from the GO Consortium
13. Mohn KL, etal., Mol Cell Biol. 1991 Mar;11(3):1393-401.
14. NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Patel S, etal., Biochem J 2002 Jul 15;365(Pt 2):537-45.
16. Patel S, etal., J Biol Chem 2002 Mar 22;277(12):9889-95.
17. Pazaitou-Panayiotou K, etal., Eur J Endocrinol. 2007 Feb;156(2):187-94.
18. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. Pulford BE and Ishii DN, Endocrinology 2001 Jan;142(1):213-20.
20. RGD automated data pipeline
21. RGD automated import pipeline for gene-chemical interactions
22. Saito T, etal., Zoolog Sci 2003 Apr;20(4):441-7.
23. Scharf JG, etal., Endocrinology. 2004 Jul;145(7):3463-72. Epub 2004 Apr 7.
24. Scharf JG, etal., Endocrinology. 2005 Dec;146(12):5433-43. Epub 2005 Sep 15.
25. Stephens RH, etal., Diabetes. 2005 Dec;54(12):3547-53.
26. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
27. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
28. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
29. Velasco B, etal., Endocrinology. 1998 Mar;139(3):1314-20. doi: 10.1210/endo.139.3.5779.
Additional References at PubMed
PMID:1283442   PMID:1691820   PMID:2164920   PMID:7510770   PMID:7679139   PMID:12670795   PMID:12902319   PMID:15489334   PMID:16455781   PMID:17032741   PMID:17645865   PMID:20345750  
PMID:21550830   PMID:22805023  


Genomics

Candidate Gene Status
Igfbp1 is a candidate Gene for QTL Niddm37
Comparative Map Data
Igfbp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21482,047,415 - 82,052,482 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1482,047,415 - 82,052,482 (+)Ensembl
Rnor_6.01487,448,716 - 87,453,783 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1487,448,692 - 87,453,785 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01481,083,056 - 81,088,123 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41487,950,222 - 87,955,289 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11487,969,366 - 87,974,434 (+)NCBI
Celera1481,092,381 - 81,126,760 (+)NCBICelera
RH 3.4 Map14605.9RGD
Cytogenetic Map14q21NCBI
IGFBP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38745,888,488 - 45,893,660 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl745,888,360 - 45,893,660 (+)EnsemblGRCh38hg38GRCh38
GRCh37745,928,087 - 45,933,259 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36745,894,484 - 45,899,792 (+)NCBINCBI36hg18NCBI36
Build 34745,701,326 - 45,706,499NCBI
Celera746,026,880 - 46,032,188 (+)NCBI
Cytogenetic Map7p12.3NCBI
HuRef745,812,919 - 45,818,173 (+)NCBIHuRef
CHM1_1745,932,162 - 45,937,470 (+)NCBICHM1_1
T2T-CHM13v2.0746,050,207 - 46,055,379 (+)NCBI
CRA_TCAGchr7v2745,967,292 - 45,972,600 (+)NCBI
Igfbp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39117,147,787 - 7,152,546 (+)NCBIGRCm39mm39
GRCm39 Ensembl117,147,782 - 7,152,546 (+)Ensembl
GRCm38117,197,787 - 7,202,546 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl117,197,782 - 7,202,546 (+)EnsemblGRCm38mm10GRCm38
MGSCv37117,097,790 - 7,102,549 (+)NCBIGRCm37mm9NCBIm37
MGSCv36117,097,785 - 7,102,539 (+)NCBImm8
Celera117,672,987 - 7,677,746 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map114.75NCBI
Igfbp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554566,810,056 - 6,815,685 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554566,810,461 - 6,814,944 (-)NCBIChiLan1.0ChiLan1.0
IGFBP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1746,657,834 - 46,663,158 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl746,658,097 - 46,662,584 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0746,538,566 - 46,545,536 (+)NCBIMhudiblu_PPA_v0panPan3
IGFBP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1161,037,169 - 1,040,996 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl161,037,162 - 1,167,094 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha161,813,131 - 1,816,855 (-)NCBI
ROS_Cfam_1.0161,023,782 - 1,027,506 (-)NCBI
ROS_Cfam_1.0 Ensembl161,023,782 - 1,153,699 (-)Ensembl
UMICH_Zoey_3.1161,014,419 - 1,018,140 (-)NCBI
UNSW_CanFamBas_1.016950,042 - 953,757 (-)NCBI
UU_Cfam_GSD_1.016220,948 - 224,674 (+)NCBI
Igfbp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118101,282,472 - 101,287,845 (+)NCBI
SpeTri2.0NW_00493647820,494,190 - 20,499,001 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGFBP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1850,018,487 - 50,022,799 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11850,018,487 - 50,022,799 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21854,862,385 - 54,866,697 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IGFBP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12112,932,727 - 12,939,078 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2112,932,732 - 12,937,891 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660629,598,999 - 9,604,182 (+)NCBIVero_WHO_p1.0
Igfbp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247406,893,867 - 6,897,377 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247406,893,334 - 6,897,591 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH132476  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21482,052,250 - 82,052,433 (+)MAPPERmRatBN7.2
Rnor_6.01487,453,552 - 87,453,734NCBIRnor6.0
Rnor_5.01481,087,892 - 81,088,074UniSTSRnor5.0
RGSC_v3.41487,955,058 - 87,955,240UniSTSRGSC3.4
Celera1481,126,529 - 81,126,711UniSTS
RH 3.4 Map14600.5UniSTS
Cytogenetic Map14q21UniSTS
RH94795  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21482,047,931 - 82,048,209 (+)MAPPERmRatBN7.2
Rnor_6.01487,449,233 - 87,449,510NCBIRnor6.0
Rnor_5.01481,083,573 - 81,083,850UniSTSRnor5.0
RGSC_v3.41487,950,739 - 87,951,016UniSTSRGSC3.4
Celera1481,122,204 - 81,122,481UniSTS
Cytogenetic Map14q21UniSTS
RH94537  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21482,052,560 - 82,052,725 (+)MAPPERmRatBN7.2
Rnor_6.01487,453,862 - 87,454,026NCBIRnor6.0
Rnor_5.01481,088,202 - 81,088,366UniSTSRnor5.0
RGSC_v3.41487,955,368 - 87,955,532UniSTSRGSC3.4
Celera1481,126,839 - 81,127,003UniSTS
RH 3.4 Map14605.9UniSTS
Cytogenetic Map14q21UniSTS
BF391491  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21482,027,449 - 82,027,610 (+)MAPPERmRatBN7.2
Rnor_6.01487,428,317 - 87,428,477NCBIRnor6.0
Rnor_5.01481,062,657 - 81,062,817UniSTSRnor5.0
RGSC_v3.41487,930,258 - 87,930,418UniSTSRGSC3.4
Celera1481,101,901 - 81,102,061UniSTS
RH 3.4 Map20404.53UniSTS
Cytogenetic Map14q21UniSTS
BI276188  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21482,052,263 - 82,052,433 (+)MAPPERmRatBN7.2
Rnor_6.01487,453,565 - 87,453,734NCBIRnor6.0
Rnor_5.01481,087,905 - 81,088,074UniSTSRnor5.0
RGSC_v3.41487,955,071 - 87,955,240UniSTSRGSC3.4
Celera1481,126,542 - 81,126,711UniSTS
RH 3.4 Map14596.6UniSTS
Cytogenetic Map14q21UniSTS
RH125040  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21482,028,209 - 82,028,331 (+)MAPPERmRatBN7.2
Rnor_6.01487,429,077 - 87,429,198NCBIRnor6.0
Rnor_5.01481,063,417 - 81,063,538UniSTSRnor5.0
RGSC_v3.41487,931,018 - 87,931,139UniSTSRGSC3.4
Celera1481,102,661 - 81,102,782UniSTS
Cytogenetic Map14q21UniSTS
Igfbp1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21482,047,816 - 82,049,376 (+)MAPPERmRatBN7.2
Rnor_6.01487,449,118 - 87,450,677NCBIRnor6.0
Rnor_5.01481,083,458 - 81,085,017UniSTSRnor5.0
RGSC_v3.41487,950,624 - 87,952,183UniSTSRGSC3.4
Celera1481,122,089 - 81,123,648UniSTS
Cytogenetic Map14q21UniSTS
BG074389  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21482,034,144 - 82,035,568 (+)MAPPERmRatBN7.2
Rnor_6.01487,435,010 - 87,436,433NCBIRnor6.0
Rnor_5.01481,069,350 - 81,070,773UniSTSRnor5.0
RGSC_v3.41487,936,951 - 87,938,374UniSTSRGSC3.4
Celera1481,108,594 - 81,110,017UniSTS
Cytogenetic Map14q21UniSTS
Igfbp1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21482,050,373 - 82,051,888 (+)MAPPERmRatBN7.2
Rnor_6.01487,451,675 - 87,453,189NCBIRnor6.0
Rnor_5.01481,086,015 - 81,087,529UniSTSRnor5.0
RGSC_v3.41487,953,181 - 87,954,695UniSTSRGSC3.4
Celera1481,124,646 - 81,126,166UniSTS
Cytogenetic Map14q21UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:57
Count of miRNA genes:51
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000011338
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 4 4 4
Medium 32 32 32 23 2
Low 1 3 7 5 5 2 2 29 12 27 2 2
Below cutoff 2 27 10 9 4 4 44 9 5 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000077177   ⟹   ENSRNOP00000069247
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1482,047,415 - 82,052,482 (+)Ensembl
Rnor_6.0 Ensembl1487,448,692 - 87,453,785 (+)Ensembl
RefSeq Acc Id: NM_013144   ⟹   NP_037276
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21482,047,415 - 82,052,482 (+)NCBI
Rnor_6.01487,448,716 - 87,453,783 (+)NCBI
Rnor_5.01481,083,056 - 81,088,123 (+)NCBI
RGSC_v3.41487,950,222 - 87,955,289 (+)RGD
Celera1481,092,381 - 81,126,760 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037276   ⟸   NM_013144
- Peptide Label: precursor
- UniProtKB: P21743 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069247   ⟸   ENSRNOT00000077177
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21743-F1-model_v2 AlphaFold P21743 1-272 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699483
Promoter ID:EPDNEW_R10006
Type:single initiation site
Name:Igfbp1_1
Description:insulin-like growth factor binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01487,448,703 - 87,448,763EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2872 AgrOrtholog
BioCyc Gene G2FUF-15048 BioCyc
Ensembl Genes ENSRNOG00000058780 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000069247 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000077177 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.800.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7129185 IMAGE-MGC_LOAD
InterPro Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  IGFBP-like UniProtKB/Swiss-Prot
  IGFBP1 UniProtKB/Swiss-Prot
  IGFBP_1-6_chordata UniProtKB/Swiss-Prot
  Insulin_GF-bd_Cys-rich_CS UniProtKB/Swiss-Prot
  Thyroglobulin_1 UniProtKB/Swiss-Prot
  Thyroglobulin_1_sf UniProtKB/Swiss-Prot
KEGG Report rno:25685 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93595 IMAGE-MGC_LOAD
NCBI Gene 25685 ENTREZGENE
Pfam IGFBP UniProtKB/Swiss-Prot
  Thyroglobulin_1 UniProtKB/Swiss-Prot
PhenoGen Igfbp1 PhenoGen
PRINTS IGFBPFAMILY UniProtKB/Swiss-Prot
  IGFBPFAMILY1 UniProtKB/Swiss-Prot
PROSITE IGFBP_N_1 UniProtKB/Swiss-Prot
  IGFBP_N_2 UniProtKB/Swiss-Prot
  THYROGLOBULIN_1_1 UniProtKB/Swiss-Prot
  THYROGLOBULIN_1_2 UniProtKB/Swiss-Prot
SMART SM00121 UniProtKB/Swiss-Prot
  SM00211 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot
  SSF57610 UniProtKB/Swiss-Prot
TIGR TC204944
UniProt IBP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Igfbp1  insulin-like growth factor binding protein 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease duplicated in an atypical Silver Russel syndrome 61526
gene_disease duplicated in an atypical Silver Russel syndrome 70249
gene_expression expressed in liver, decidua, kidney and amniotic fluid 61526
gene_expression expressed in liver, decidua, kidney and amniotic fluid 70249
gene_expression induced expression during regeneration of hepatocytes after liver damage 61526
gene_expression induced expression during regeneration of hepatocytes after liver damage 70249
gene_process regulates somatic growth and cellular proliferation 61526
gene_process regulates somatic growth and cellular proliferation 70249
gene_regulation regulated by insulin and corticoids 61526
gene_regulation regulated by insulin and corticoids 70249
gene_transcript contains 4 exons and 3 introns 728989