Gck (glucokinase) - Rat Genome Database

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Gene: Gck (glucokinase) Rattus norvegicus
Analyze
Symbol: Gck
Name: glucokinase
RGD ID: 2670
Description: Enables several functions, including D-glucose binding activity; adenyl ribonucleotide binding activity; and hexokinase activity. Involved in several processes, including hexose metabolic process; positive regulation of phosphate metabolic process; and regulation of secretion by cell. Located in several cellular components, including actin filament; basal cortex; and secretory granule. Used to study obesity; steatotic liver disease; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in artery disease (multiple) and glucose metabolism disease (multiple). Orthologous to human GCK (glucokinase); PARTICIPATES IN glycogen biosynthetic pathway; glycogen metabolic pathway; glycolysis pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GLK; glucokinase variant 3; GLUKA; hexokinase type IV; hexokinase-4; hexokinase-D; HK IV; HK4; RNGK2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   Pancm5   Niddm37  
Candidate Gene For: Niddm37
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81484,999,019 - 85,041,098 (-)NCBIGRCr8
mRatBN7.21480,785,060 - 80,829,842 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1480,785,060 - 80,826,995 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1485,187,142 - 85,229,037 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01486,427,238 - 86,469,134 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01482,876,552 - 82,918,448 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01486,149,146 - 86,191,589 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1486,148,928 - 86,190,659 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01486,832,735 - 86,875,295 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41486,572,518 - 86,587,723 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11486,591,662 - 86,606,868 (-)NCBI
Celera1479,669,432 - 79,710,739 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-methylphenanthrene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (EXP,ISO)
aconitine  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alloxan  (EXP,ISO)
ammonium chloride  (EXP)
anthracen-2-amine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (EXP)
bellidifolin  (ISO)
benzamide  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
boric acid  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chloroform  (EXP)
chlorothalonil  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corn oil  (EXP)
Cuprizon  (EXP)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dichlorvos  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
dorsomorphin  (EXP)
duvoglustat  (ISO)
ebselen  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
ethanol  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
Ginsenoside Rh4  (EXP,ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glycine betaine  (ISO)
herbicide  (ISO)
hesperidin  (ISO)
hydrazine  (EXP)
inulin  (ISO)
ketoconazole  (EXP)
L-leucine  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
metformin  (EXP,ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (EXP)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
naringin  (ISO)
nefazodone  (EXP)
nerolidol  (EXP)
Nonylphenol  (EXP)
ochratoxin A  (EXP)
ozone  (EXP)
paracetamol  (ISO)
penconazole  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP)
pirinixic acid  (ISO)
pravastatin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
procymidone  (ISO)
Repaglinide  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rotenone  (EXP)
selenomethionine  (ISO)
sevoflurane  (EXP)
sodium arsenite  (ISO)
streptozocin  (EXP,ISO)
styrene  (EXP)
tamoxifen  (ISO)
taurine  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
theophylline  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vanillic acid  (ISO)
WIN 55212-2  (ISO)
zaragozic acid A  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin filament  (IDA)
basal cortex  (IDA)
cell cortex  (IDA)
cytoplasm  (IDA,IEA)
cytosol  (IBA,IEA,ISO)
mitochondrion  (IBA,IEA,ISO)
nucleoplasm  (IDA)
nucleus  (IDA,IEA,ISO)
secretory granule  (IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. The amino acid sequence of rat liver glucokinase deduced from cloned cDNA. Andreone TL, etal., J Biol Chem 1989 Jan 5;264(1):363-9.
2. Glucokinase regulatory protein is associated with mitochondria in hepatocytes. Arden C, etal., FEBS Lett. 2006 Apr 3;580(8):2065-70. Epub 2006 Mar 10.
3. Interaction of glucokinase with the liver regulatory protein is conferred by leucine-asparagine motifs of the enzyme. Baltrusch S, etal., Diabetes. 2005 Oct;54(10):2829-37.
4. Differences in regulatory properties between human and rat glucokinase regulatory protein. Brocklehurst KJ, etal., Biochem J. 2004 Mar 1;378(Pt 2):693-7.
5. Evolution and regulatory role of the hexokinases. Cardenas ML, etal., Biochim Biophys Acta. 1998 Mar 5;1401(3):242-64.
6. Nucleotide(-258) G-to-A transition variant of the liver glucokinase gene is associated with essential hypertension. Chiang FT, etal., Am J Hypertens. 1997 Sep;10(9 Pt 1):1049-52.
7. Fructose is a good substrate for rat liver 'glucokinase' (hexokinase D). Cárdenas ML, etal., Biochem J. 1984 Sep 1;222(2):363-70. doi: 10.1042/bj2220363.
8. Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans. De Ceuninck F, etal., Br J Pharmacol. 2013 Jan;168(2):339-53. doi: 10.1111/j.1476-5381.2012.02184.x.
9. Glucokinase is the likely mediator of glucosensing in both glucose-excited and glucose-inhibited central neurons. Dunn-Meynell AA, etal., Diabetes 2002 Jul;51(7):2056-65.
10. Pharmacokinetic and pharmacodynamic properties of the glucokinase activator MK-0941 in rodent models of type 2 diabetes and healthy dogs. Eiki J, etal., Mol Pharmacol. 2011 Dec;80(6):1156-65. doi: 10.1124/mol.111.074401. Epub 2011 Sep 21.
11. Cyclic adenosine 3',5'-monophosphate increases pancreatic glucokinase activity and gene expression. Fernandez-Mejia C, etal., Endocrinology 2001 Apr;142(4):1448-52.
12. Defect in glucokinase translocation in Zucker diabetic fatty rats. Fujimoto Y, etal., Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E414-23. Epub 2004 May 11.
13. Chronic treatment with a glucokinase activator delays the onset of hyperglycaemia and preserves beta cell mass in the Zucker diabetic fatty rat. Futamura M, etal., Diabetologia. 2012 Apr;55(4):1071-80. doi: 10.1007/s00125-011-2439-3. Epub 2012 Jan 11.
14. An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism. Futamura M, etal., J Biol Chem. 2006 Oct 6;.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Familial hyperinsulinism caused by an activating glucokinase mutation. Glaser B, etal., N Engl J Med. 1998 Jan 22;338(4):226-30.
17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. Relationships between concentration of hepatic intermediary metabolites and induction of the key glycolytic enzymes in vivo. Gunn JM and Taylor CB, Biochem J. 1973 Nov;136(3):455-65.
19. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
20. Alternative splicing of glucokinase mRNA in rat liver. Hayzer DJ and Iynedjian PB, Biochem J 1990 Aug 15;270(1):261-3.
21. Substrate-induced nuclear export and peripheral compartmentalization of hepatic glucokinase correlates with glycogen deposition. Jetton TL, etal., Int J Exp Diabetes Res. 2001;2(3):173-86.
22. Hypermethylation of hepatic glucokinase and L-type pyruvate kinase promoters in high-fat diet-induced obese rats. Jiang M, etal., Endocrinology. 2011 Apr;152(4):1284-9. doi: 10.1210/en.2010-1162. Epub 2011 Jan 14.
23. Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator. Johnson D, etal., Diabetes. 2007 Jun;56(6):1694-702. Epub 2007 Mar 14.
24. Nutrient-dependent distribution of insulin and glucokinase immunoreactivities in rat pancreatic beta cells. Jorns A, etal., Virchows Arch. 1999 Jan;434(1):75-82.
25. Glucokinase is a critical regulator of ventromedial hypothalamic neuronal glucosensing. Kang L, etal., Diabetes. 2006 Feb;55(2):412-20.
26. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
27. Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia. Levin BE, etal., Diabetes. 2008 May;57(5):1371-9. Epub 2008 Feb 21.
28. Iron increases liver injury through oxidative/nitrative stress in diabetic rats: Involvement of nitrotyrosination of glucokinase. Li X, etal., Biochimie. 2012 Dec;94(12):2620-7. doi: 10.1016/j.biochi.2012.07.019. Epub 2012 Aug 1.
29. An alternate promoter in the glucokinase gene is active in the pancreatic beta cell. Magnuson MA and Shelton KD, J Biol Chem 1989 Sep 25;264(27):15936-42.
30. Islet adaptive changes to fructose-induced insulin resistance: beta-cell mass, glucokinase, glucose metabolism, and insulin secretion. Maiztegui B, etal., J Endocrinol. 2009 Feb;200(2):139-49. doi: 10.1677/JOE-08-0386. Epub 2008 Nov 27.
31. G(-30)A polymorphism in the pancreatic promoter of the glucokinase gene associated with angiographic coronary artery disease and type 2 diabetes mellitus. Marz W, etal., Circulation. 2004 Jun 15;109(23):2844-9. Epub 2004 Jun 1.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. Kinetic studies of rat liver hexokinase D ('glucokinase') in non-co-operative conditions show an ordered mechanism with MgADP as the last product to be released. Monasterio O and Cardenas ML, Biochem J. 2003 Apr 1;371(Pt 1):29-38.
34. A novel cytosolic dual specificity phosphatase, interacting with glucokinase, increases glucose phosphorylation rate. Munoz-Alonso MJ, etal., J Biol Chem 2000 Oct 20;275(42):32406-12.
35. Co-localization of glucokinase with actin filaments. Murata T, etal., FEBS Lett. 1997 Apr 7;406(1-2):109-13.
36. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
37. Mutations in the glucokinase gene are not a major cause of late-onset type 2 (non-insulin-dependent) diabetes mellitus in Japanese subjects. Nishi S, etal., Diabet Med. 1994 Mar;11(2):193-7.
38. Neonatal diabetes mellitus due to complete glucokinase deficiency. Njolstad PR, etal., N Engl J Med. 2001 May 24;344(21):1588-92.
39. Polymorphic microsatellite repeat markers at the glucokinase gene locus are positively associated with NIDDM in Japanese. Noda K, etal., Diabetes. 1993 Aug;42(8):1147-52.
40. The islet beta-cell: fuel responsive and vulnerable. Nolan CJ and Prentki M, Trends Endocrinol Metab. 2008 Oct;19(8):285-91. Epub 2008 Sep 6.
41. Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia. O'Doherty RM, etal., Diabetes. 1999 Oct;48(10):2022-7.
42. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
43. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
44. Contributions of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2 to the elevated glycolysis in hepatocytes from Zucker fa/fa rats. Payne VA, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R618-25. Epub 2007 Jun 6.
45. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
46. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
47. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
48. GOA pipeline RGD automated data pipeline
49. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
50. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
51. Glucokinase and glucokinase regulatory proteins are functionally coexpressed before birth in the rat brain. Roncero I, etal., J Neuroendocrinol. 2009 Dec;21(12):973-81. doi: 10.1111/j.1365-2826.2009.01919.x. Epub 2009 Oct 6.
52. Effects of glucose and insulin on glucokinase activity in rat hypothalamus. Sanz C, etal., J Endocrinol. 2007 May;193(2):259-67.
53. Common variants in MODY genes increase the risk of gestational diabetes mellitus. Shaat N, etal., Diabetologia. 2006 Jul;49(7):1545-51. Epub 2006 Apr 26.
54. Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase. Shiota C, etal., J Biol Chem. 1999 Dec 24;274(52):37125-30.
55. Identification of glucokinase mutations in subjects with gestational diabetes mellitus. Stoffel M, etal., Diabetes. 1993 Jun;42(6):937-40.
56. Two microsatellite repeat polymorphisms flanking opposite ends of the human glucokinase gene: use in haplotype analysis of Welsh Caucasians with type 2 (non-insulin-dependent) diabetes mellitus. Tanizawa Y, etal., Diabetologia. 1993 May;36(5):409-13.
57. Glucokinase is located in secretory granules of pancreatic D-cells. Toyoda Y, etal., FEBS Lett. 1997 Oct 6;415(3):281-4.
58. Glucokinase is concentrated in insulin-secretory granules of pancreatic B-cells. Toyoda Y, etal., Histochem Cell Biol. 1999 Jul;112(1):35-40.
59. Identification of fructose 6-phosphate- and fructose 1-phosphate-binding residues in the regulatory protein of glucokinase. Veiga-da-Cunha M and Van Schaftingen E, J Biol Chem 2002 Mar 8;277(10):8466-73. Epub 2001 Dec 27.
60. Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus. Vionnet N, etal., Nature. 1992 Apr 23;356(6371):721-2.
61. Induction and suppression of the key enzymes of glycolysis and gluconeogenesis in isolated perfused rat liver in response to glucose, fructose and lactate. Wimhurst JM and Manchester KL, Biochem J. 1973 May;134(1):143-56.
62. Sugar specificity of human beta-cell glucokinase: correlation of molecular models with kinetic measurements. Xu LZ, etal., Biochemistry. 1995 May 9;34(18):6083-92. doi: 10.1021/bi00018a011.
63. Kinetic behaviour of liver glucokinase in diabetes. I. Alteration in streptozotocin-diabetic rats. Zahner D and Malaisse WJ, Diabetes Res. 1990 Jul;14(3):101-8.
Additional References at PubMed
PMID:141272   PMID:1999433   PMID:2590200   PMID:2662183   PMID:3931624   PMID:7510884   PMID:7553875   PMID:7556622   PMID:7665557   PMID:8132752   PMID:8446612   PMID:8530440  
PMID:8878425   PMID:8954920   PMID:9357804   PMID:9662046   PMID:9867845   PMID:9873043   PMID:10713097   PMID:11042116   PMID:11950391   PMID:12031952   PMID:12242462   PMID:12519761  
PMID:12931191   PMID:12941786   PMID:14505487   PMID:14651853   PMID:14674713   PMID:14706571   PMID:14749268   PMID:15111491   PMID:15123649   PMID:15479952   PMID:15707679   PMID:15983194  
PMID:16173921   PMID:16834571   PMID:17204595   PMID:17317782   PMID:17414058   PMID:17415548   PMID:17712721   PMID:17889836   PMID:17994217   PMID:18039179   PMID:18084728   PMID:18165236  
PMID:18199594   PMID:18322640   PMID:18477811   PMID:18496667   PMID:18612599   PMID:18812575   PMID:19146401   PMID:19173678   PMID:19366697   PMID:19560332   PMID:19604517   PMID:20401447  
PMID:20531973   PMID:20668700   PMID:21488089   PMID:22044397   PMID:22611063   PMID:22698525   PMID:22778220   PMID:23085254   PMID:24187134   PMID:24772484   PMID:24793715   PMID:25074928  
PMID:25485685   PMID:25906449   PMID:30146176   PMID:32188779   PMID:37093431   PMID:38875221  


Genomics

Comparative Map Data
Gck
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81484,999,019 - 85,041,098 (-)NCBIGRCr8
mRatBN7.21480,785,060 - 80,829,842 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1480,785,060 - 80,826,995 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1485,187,142 - 85,229,037 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01486,427,238 - 86,469,134 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01482,876,552 - 82,918,448 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01486,149,146 - 86,191,589 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1486,148,928 - 86,190,659 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01486,832,735 - 86,875,295 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41486,572,518 - 86,587,723 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11486,591,662 - 86,606,868 (-)NCBI
Celera1479,669,432 - 79,710,739 (-)NCBICelera
Cytogenetic Map14q21NCBI
GCK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38744,143,213 - 44,189,439 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl744,143,213 - 44,198,170 (-)EnsemblGRCh38hg38GRCh38
GRCh37744,182,812 - 44,229,038 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36744,150,395 - 44,195,563 (-)NCBINCBI36Build 36hg18NCBI36
Build 34743,957,109 - 43,972,127NCBI
Celera744,281,829 - 44,326,987 (-)NCBICelera
Cytogenetic Map7p13NCBI
HuRef744,069,141 - 44,114,301 (-)NCBIHuRef
CHM1_1744,187,724 - 44,232,886 (-)NCBICHM1_1
T2T-CHM13v2.0744,301,768 - 44,348,026 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2744,223,370 - 44,268,527 (-)NCBI
Gck
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39115,850,816 - 5,900,081 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl115,850,820 - 5,900,081 (-)EnsemblGRCm39 Ensembl
GRCm38115,900,816 - 5,950,081 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl115,900,820 - 5,950,081 (-)EnsemblGRCm38mm10GRCm38
MGSCv37115,800,826 - 5,849,602 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36115,800,826 - 5,849,602 (-)NCBIMGSCv36mm8
Celera116,392,658 - 6,441,626 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.88NCBI
Gck
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554567,783,760 - 7,842,129 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554567,784,269 - 7,838,260 (+)NCBIChiLan1.0ChiLan1.0
GCK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2649,055,783 - 49,100,854 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1797,380,522 - 97,425,594 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0744,857,604 - 44,903,683 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1744,924,922 - 44,971,365 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl744,926,848 - 44,937,751 (-)Ensemblpanpan1.1panPan2
GCK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha162,080,944 - 2,123,987 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01614,737,904 - 14,781,009 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1614,738,733 - 14,780,998 (+)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.01614,369,169 - 14,412,232 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01614,349,631 - 14,392,705 (+)NCBIUU_Cfam_GSD_1.0
Gck
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511899,892,708 - 99,947,669 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647819,105,361 - 19,158,733 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647819,104,477 - 19,118,915 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GCK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12114,475,723 - 14,523,086 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2114,507,902 - 14,523,850 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660627,992,041 - 8,048,141 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gck
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247407,852,390 - 7,886,758 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247407,844,496 - 7,885,900 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gck
111 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:389
Count of miRNA genes:208
Interacting mature miRNAs:244
Transcripts:ENSRNOT00000019625
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat

Markers in Region
D14Arb12   No map positions available.
RH94778  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21480,785,215 - 80,785,414 (+)MAPPERmRatBN7.2
Rnor_6.01486,149,302 - 86,149,500NCBIRnor6.0
Rnor_5.01486,833,120 - 86,833,318UniSTSRnor5.0
RGSC_v3.41486,572,674 - 86,572,872UniSTSRGSC3.4
Celera1479,669,588 - 79,669,786UniSTS
Cytogenetic Map14q21UniSTS
PMC133987P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21480,800,288 - 80,800,545 (+)MAPPERmRatBN7.2
Rnor_6.01486,164,371 - 86,164,627NCBIRnor6.0
Rnor_5.01486,848,747 - 86,849,003UniSTSRnor5.0
RGSC_v3.41486,587,743 - 86,587,999UniSTSRGSC3.4
Celera1479,684,656 - 79,684,912UniSTS
Cytogenetic Map14q21UniSTS
RH94415  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21480,785,080 - 80,785,259 (+)MAPPERmRatBN7.2
Rnor_6.01486,149,167 - 86,149,345NCBIRnor6.0
Rnor_5.01486,832,985 - 86,833,163UniSTSRnor5.0
RGSC_v3.41486,572,539 - 86,572,717UniSTSRGSC3.4
Celera1479,669,453 - 79,669,631UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 2 49 113 83 82 57 8 57 6 175 77 93 30 53 25

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC110110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB877580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC934989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ026953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M30770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M58759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X53588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X53589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X53590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X94615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000080147   ⟹   ENSRNOP00000068656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1480,785,060 - 80,800,286 (-)Ensembl
Rnor_6.0 Ensembl1486,149,146 - 86,164,368 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086343   ⟹   ENSRNOP00000071435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1480,785,060 - 80,800,286 (-)Ensembl
Rnor_6.0 Ensembl1486,148,928 - 86,164,341 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086474   ⟹   ENSRNOP00000069954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1480,785,060 - 80,826,995 (-)Ensembl
Rnor_6.0 Ensembl1486,149,146 - 86,190,659 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103985   ⟹   ENSRNOP00000079626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1480,785,060 - 80,796,376 (-)Ensembl
RefSeq Acc Id: NM_001270849   ⟹   NP_001257778
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,999,020 - 85,014,242 (-)NCBI
mRatBN7.21480,785,060 - 80,800,286 (-)NCBI
Rnor_6.01486,149,146 - 86,164,368 (-)NCBI
Rnor_5.01486,832,735 - 86,875,295 (-)NCBI
Celera1479,669,432 - 79,684,653 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270850   ⟹   NP_001257779
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,999,020 - 85,040,949 (-)NCBI
mRatBN7.21480,785,060 - 80,826,995 (-)NCBI
Rnor_6.01486,149,146 - 86,190,659 (-)NCBI
Rnor_5.01486,832,735 - 86,875,295 (-)NCBI
Celera1479,669,432 - 79,710,739 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012565   ⟹   NP_036697
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,999,020 - 85,014,242 (-)NCBI
mRatBN7.21480,785,060 - 80,800,286 (-)NCBI
Rnor_6.01486,149,146 - 86,164,368 (-)NCBI
Rnor_5.01486,832,735 - 86,875,295 (-)NCBI
RGSC_v3.41486,572,518 - 86,587,723 (-)RGD
Celera1479,669,432 - 79,684,653 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251179   ⟹   XP_006251241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,999,019 - 85,041,098 (-)NCBI
mRatBN7.21480,785,897 - 80,829,842 (-)NCBI
Rnor_6.01486,149,151 - 86,191,589 (-)NCBI
Rnor_5.01486,832,735 - 86,875,295 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039091619   ⟹   XP_038947547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,999,019 - 85,013,834 (-)NCBI
mRatBN7.21480,785,897 - 80,795,924 (-)NCBI
RefSeq Acc Id: XM_063272864   ⟹   XP_063128934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,999,019 - 85,013,834 (-)NCBI
RefSeq Acc Id: NP_036697   ⟸   NM_012565
- Peptide Label: isoform 2
- UniProtKB: A6IKR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257779   ⟸   NM_001270850
- Peptide Label: isoform 3
- UniProtKB: A6IKQ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257778   ⟸   NM_001270849
- Peptide Label: isoform 1
- UniProtKB: Q64596 (UniProtKB/TrEMBL),   Q63219 (UniProtKB/TrEMBL),   A6IKR2 (UniProtKB/TrEMBL),   A0A8I6G3J1 (UniProtKB/TrEMBL),   A0A0G2JTC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251241   ⟸   XM_006251179
- Peptide Label: isoform X2
- UniProtKB: P17711 (UniProtKB/Swiss-Prot),   P17712 (UniProtKB/Swiss-Prot),   X2G6B3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068656   ⟸   ENSRNOT00000080147
Ensembl Acc Id: ENSRNOP00000069954   ⟸   ENSRNOT00000086474
Ensembl Acc Id: ENSRNOP00000071435   ⟸   ENSRNOT00000086343
RefSeq Acc Id: XP_038947547   ⟸   XM_039091619
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000079626   ⟸   ENSRNOT00000103985
RefSeq Acc Id: XP_063128934   ⟸   XM_063272864
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G3J1 (UniProtKB/TrEMBL)
Protein Domains
Hexokinase   Hexokinase C-terminal   Hexokinase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17712-F1-model_v2 AlphaFold P17712 1-465 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699466
Promoter ID:EPDNEW_R9990
Type:initiation region
Name:Gck_1
Description:glucokinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01486,164,387 - 86,164,447EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2670 AgrOrtholog
BioCyc Gene G2FUF-15110 BioCyc
BioCyc Pathway ANAGLYCOLYSIS-PWY [glycolysis III (from glucose)] BioCyc
  PWY-3861 [mannitol degradation II] BioCyc
  PWY-5941 [glycogen degradation II] BioCyc
  PWY3O-1743 [D-mannose degradation II] BioCyc
  UDPNACETYLGALSYN-PWY [UDP-N-acetyl-D-glucosamine biosynthesis II] BioCyc
BioCyc Pathway Image ANAGLYCOLYSIS-PWY BioCyc
  PWY-3861 BioCyc
  PWY-5941 BioCyc
  PWY3O-1743 BioCyc
  UDPNACETYLGALSYN-PWY BioCyc
Ensembl Genes ENSRNOG00000061527 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000080147 ENTREZGENE
  ENSRNOT00000086343 ENTREZGENE
  ENSRNOT00000086343.2 UniProtKB/Swiss-Prot
  ENSRNOT00000086474 ENTREZGENE
  ENSRNOT00000086474.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.420.40 UniProtKB/Swiss-Prot
  3.40.367.20 UniProtKB/Swiss-Prot
InterPro ATPase_NBD UniProtKB/Swiss-Prot
  Hexokinase UniProtKB/Swiss-Prot
  Hexokinase_BS UniProtKB/Swiss-Prot
  Hexokinase_C UniProtKB/Swiss-Prot
  Hexokinase_N UniProtKB/Swiss-Prot
KEGG Report rno:24385 UniProtKB/Swiss-Prot
NCBI Gene 24385 ENTREZGENE
PANTHER PTHR19443 UniProtKB/Swiss-Prot
  PTHR19443:SF3 UniProtKB/Swiss-Prot
Pfam Hexokinase_1 UniProtKB/Swiss-Prot
  Hexokinase_2 UniProtKB/Swiss-Prot
PharmGKB GCK RGD
PhenoGen Gck PhenoGen
PRINTS HEXOKINASE UniProtKB/Swiss-Prot
PROSITE HEXOKINASE_1 UniProtKB/Swiss-Prot
  HEXOKINASE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000061527 RatGTEx
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot
UniProt A0A0G2JTC6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G3J1 ENTREZGENE, UniProtKB/TrEMBL
  A6IKQ9 ENTREZGENE, UniProtKB/TrEMBL
  A6IKR1 ENTREZGENE, UniProtKB/TrEMBL
  A6IKR2 ENTREZGENE, UniProtKB/TrEMBL
  HXK4_RAT UniProtKB/Swiss-Prot
  P17711 ENTREZGENE
  P17712 ENTREZGENE
  Q63219 ENTREZGENE
  Q64596 ENTREZGENE
  X2G6B3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P17711 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gck  Glucokinase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutations in humans cause maturity-onset diabetes of the youth or hyperinsulinemia 628440
gene_expression expressed in hepatocytes, pancreatic beta-cells, and neuroendocrine cells of the brain and gut 628440
gene_process mediates glucose homeostasis and insulin secretion in response to glucose in the beta-cells; controls glucose uptake in the liver 628440
gene_regulation mRNA level is decreased by glucagon through increases in cAMP 628440
gene_regulation in the liver, insulin and glucagon mediate the activity at the level of gene transcription in response to fasting and refeeding; in pancreatic beta-cells, glucose levels modulate the activity 628440
gene_regulation cAMP represses gene expression in the liver but increases the mRNA level in pancreatic beta-cells 628440
gene_transcript contains two distinct promoters for a tissue-specific control of the expression 628440