GCK (glucokinase) - Rat Genome Database

Name: GCK
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: GCK (glucokinase) Homo sapiens

Analyze

Symbol:

GCK

Name:

glucokinase

RGD ID:

735697

HGNC Page

HGNC:4195

Description:

Enables ATP binding activity; glucokinase activity; and glucose binding activity. Involved in several processes, including detection of glucose; positive regulation of insulin secretion; and regulation of glucose metabolic process. Located in cytosol. Implicated in artery disease (multiple); familial hyperinsulinemic hypoglycemia 3; and glucose metabolism disease (multiple).

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

ATP:D-hexose 6-phosphotransferase; FGQTL3; GK; GLK; glucokinase (hexokinase 4); hexokinase D, pancreatic isozyme; hexokinase type IV; hexokinase-4; hexokinase-D; HHF3; HK IV; HK4; HKIV; HXKP; LGLK; MODY2; PNDM1

RGD Orthologs

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Gck (glucokinase)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Gck (glucokinase)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Chinchilla lanigera (long-tailed chinchilla):	Gck (glucokinase)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	GCK (glucokinase)	NCBI	Ortholog
Canis lupus familiaris (dog):	GCK (glucokinase)	HGNC	EggNOG, Ensembl, NCBI, OrthoDB, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gck (glucokinase)	NCBI	Ortholog
Sus scrofa (pig):	GCK (glucokinase)	HGNC	NCBI
Chlorocebus sabaeus (green monkey):	GCK (glucokinase)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Gck (glucokinase)	NCBI	Ortholog
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Gck (glucokinase)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gck (glucokinase)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gck (glucokinase (hexokinase 4))	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Saccharomyces cerevisiae (baker's yeast):	EMI2	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Hex-A	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Hex-C	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Hex-t2	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	hxk-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	GLK1	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	HXK1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Hex-t1	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	HXK2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	44,143,213 - 44,189,439 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	7	44,143,213 - 44,198,170 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	44,182,812 - 44,229,038 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	44,150,395 - 44,195,563 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	43,957,109 - 43,972,127	NCBI
Celera	7	44,281,829 - 44,326,987 (-)	NCBI		Celera
Cytogenetic Map	7	p13	NCBI
HuRef	7	44,069,141 - 44,114,301 (-)	NCBI		HuRef
CHM1_1	7	44,187,724 - 44,232,886 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	44,301,768 - 44,348,026 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	44,223,370 - 44,268,527 (-)	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Congenital Hyperinsulinism (EXP)

coronary artery disease (IAGP)

diabetes mellitus (IAGP)

Experimental Diabetes Mellitus (EXP)

Experimental Liver Cirrhosis (EXP)

familial hyperinsulinemic hypoglycemia 3 (IAGP)

fatty liver disease (ISO)

genetic disease (IAGP)

gestational diabetes (IAGP)

hyperglycemia (EXP,ISO)

hyperinsulinemic hypoglycemia (ISS)

hyperinsulinism (IAGP)

hypertension (IAGP)

hypoglycemia (IAGP)

Insulin Resistance (ISO)

Liver Injury (ISO)

maturity-onset diabetes of the young (IAGP)

maturity-onset diabetes of the young type 1 (IAGP)

maturity-onset diabetes of the young type 2 (EXP,IAGP)

maturity-onset diabetes of the young type 3 (IAGP)

neonatal diabetes (IAGP)

obesity (ISO)

permanent neonatal diabetes mellitus (EXP,IAGP)

Permanent Neonatal Diabetes Mellitus 1 (IAGP)

pleomorphic xanthoastrocytoma (IAGP)

transient neonatal diabetes mellitus (IAGP)

type 2 diabetes mellitus (EXP,IAGP,ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-methylphenanthrene (EXP)

1-naphthyl isothiocyanate (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

1H-pyrazole (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2,4,6-trinitrotoluene (ISO)

2,4-dinitrotoluene (ISO)

2,6-dinitrotoluene (ISO)

2-amino-2-deoxy-D-glucopyranose (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3-chloropropane-1,2-diol (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (EXP)

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (EXP)

6-propyl-2-thiouracil (ISO)

8-Br-cAMP (EXP)

9-cis-retinoic acid (ISO)

aconitine (ISO)

acrylamide (ISO)

aflatoxin B1 (EXP,ISO)

aldehydo-D-glucosamine (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (EXP)

alloxan (ISO)

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

Manual Human Phenotype Annotations - RGD

Imported Human Phenotype Annotations - HPO

Imported Human Phenotype Annotations - ClinVar

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