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Gene: GCK (glucokinase) Homo sapiens
Symbol: GCK
Name: glucokinase
Description: Exhibits ATP binding activity; glucokinase activity; and glucose binding activity. Involved in several processes, including detection of glucose; positive regulation of insulin secretion; and regulation of glucose metabolic process. Localizes to the cytosol. Implicated in artery disease (multiple); familial hyperinsulinemic hypoglycemia 3; and glucose metabolism disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATP:D-hexose 6-phosphotransferase; FGQTL3; GK; GLK; glucokinase (hexokinase 4); hexokinase D, pancreatic isozyme; hexokinase type IV; hexokinase-4; hexokinase-D; HHF3; HK IV; HK4; HKIV; HXKP; LGLK; MODY2
Mus musculus (house mouse) : Gck (glucokinase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gck (glucokinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gck (glucokinase)
Pan paniscus (bonobo/pygmy chimpanzee) : GCK (glucokinase)
Canis lupus familiaris (dog) : GCK (glucokinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gck (glucokinase)
Sus scrofa (pig) : GCK (glucokinase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl744,143,213 - 44,198,170 (-)Ensembl
GRCh38744,143,213 - 44,189,439 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37744,183,870 - 44,229,022 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36744,150,395 - 44,195,563 (-)NCBINCBI36hg18NCBI36
Build 34743,957,109 - 43,972,127NCBI
Celera744,281,829 - 44,326,987 (-)NCBI
Cytogenetic Map7p13NCBI
HuRef744,069,141 - 44,114,301 (-)NCBIHuRef
CHM1_1744,187,724 - 44,232,886 (-)NCBICHM1_1
CRA_TCAGchr7v2744,223,370 - 44,268,527 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GCK
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735697
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.